PE20120553A1 - Anticuerpos anti-fgfr3 - Google Patents
Anticuerpos anti-fgfr3Info
- Publication number
- PE20120553A1 PE20120553A1 PE2011001694A PE2011001694A PE20120553A1 PE 20120553 A1 PE20120553 A1 PE 20120553A1 PE 2011001694 A PE2011001694 A PE 2011001694A PE 2011001694 A PE2011001694 A PE 2011001694A PE 20120553 A1 PE20120553 A1 PE 20120553A1
- Authority
- PE
- Peru
- Prior art keywords
- hvr
- sequence
- seq
- refers
- chain variable
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3038—Kidney, bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
SE REFIERE A UN ANTICUERPO MONOCLONAL QUIMERICO HUMANIZADO QUE ES ANTAGONISTA ANTI-FGFR3 QUE COMPRENDE: i) HVR-H1 QUE COMPRENDE LA SECUENCIA SEC ID Nº: 149, ii) HVR-H2 QUE COMPRENDE LA SECUENCIA SEC ID Nº: 150, iii) HVR-H3 QUE COMPRENDE LA SECUENCIA SEC ID Nº: 151, iv) HVR-L1 QUE COMPRENDE LA SECUENCIA SEC ID Nº: 146, v) HVR-L2 QUE COMPRENDE LA SECUENCIA SEC ID Nº: 147, Y vi) HVR-L3 QUE COMPRENDE LA SECUENCIA SEC ID Nº: 148; EN DONDE LA REGION VARIABLE DE CADENA PESADA COMPRENDE LA SEC ID Nº: 132 Y LA REGION VARIABLE DE CADENA LIGERA COMPRENDE LA SEC ID Nº: 133. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA UTIL EN EL TRATAMIENTO DE CANCER DE VEJIGA, MIELOMA MULTIPLE
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16322209P | 2009-03-25 | 2009-03-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20120553A1 true PE20120553A1 (es) | 2012-05-18 |
Family
ID=42340706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001694A PE20120553A1 (es) | 2009-03-25 | 2010-03-24 | Anticuerpos anti-fgfr3 |
Country Status (29)
Country | Link |
---|---|
US (10) | US8410250B2 (es) |
EP (3) | EP2411414B1 (es) |
JP (1) | JP5757534B2 (es) |
KR (2) | KR101822663B1 (es) |
CN (2) | CN102378767B (es) |
AR (2) | AR075939A1 (es) |
AU (1) | AU2010229994B2 (es) |
BR (1) | BRPI1006448B1 (es) |
CA (1) | CA2754163C (es) |
CO (1) | CO6450665A2 (es) |
DK (2) | DK3702371T3 (es) |
EC (1) | ECSP11011417A (es) |
ES (2) | ES2932874T3 (es) |
HK (1) | HK1167666A1 (es) |
HR (2) | HRP20221471T1 (es) |
HU (2) | HUE025726T2 (es) |
IL (2) | IL214433A (es) |
LT (1) | LT3702371T (es) |
MA (1) | MA33208B1 (es) |
MX (2) | MX2011009961A (es) |
NZ (1) | NZ594339A (es) |
PE (1) | PE20120553A1 (es) |
RU (1) | RU2568066C2 (es) |
SG (1) | SG174904A1 (es) |
SI (2) | SI2411414T1 (es) |
TW (1) | TWI507205B (es) |
UA (1) | UA104459C2 (es) |
WO (1) | WO2010111367A1 (es) |
ZA (1) | ZA201105574B (es) |
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WO2013088191A1 (en) | 2011-12-12 | 2013-06-20 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Antagonist of the fibroblast growth factor receptor 3 (fgfr3) for use in the treatment or the prevention of skeletal disorders linked with abnormal activation of fgfr3 |
EP2837685B1 (en) * | 2012-04-09 | 2020-09-09 | Daiichi Sankyo Company, Limited | Anti-fgfr2 antibody |
CN104797936B (zh) * | 2012-07-24 | 2017-11-24 | 纽约市哥伦比亚大学理事会 | 融合蛋白及其方法 |
US20150203589A1 (en) | 2012-07-24 | 2015-07-23 | The Trustees Of Columbia University In The City Of New York | Fusion proteins and methods thereof |
KR20150037876A (ko) * | 2012-07-27 | 2015-04-08 | 제넨테크, 인크. | Fgfr3 관련 상태의 치료 방법 |
KR102134088B1 (ko) | 2012-08-24 | 2020-07-14 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신 |
TWI606066B (zh) * | 2012-09-27 | 2017-11-21 | 中外製藥股份有限公司 | FGFR3 Fusion Gene and Its Targeted Medicine |
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ES2768618T3 (es) * | 2013-10-08 | 2020-06-23 | Daiichi Sankyo Co Ltd | Combinación de anticuerpo anti-FGFR2 y otro agente |
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MA44179B1 (fr) | 2014-05-13 | 2020-10-28 | Univ Pennsylvania | Compositions comprenant un virus adeno-associe exprimant des constructions a double anticorps et leurs utilisations |
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EP3166970B1 (en) | 2014-07-10 | 2021-03-10 | BioArctic AB | Improved a-beta protofibril binding antibodies |
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EP3265462A1 (en) | 2015-03-03 | 2018-01-10 | INSERM - Institut National de la Santé et de la Recherche Médicale | Fgfr3 antagonists |
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- 2011-08-28 EC EC2011011417A patent/ECSP11011417A/es unknown
- 2011-09-01 CO CO11112595A patent/CO6450665A2/es active IP Right Grant
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2012
- 2012-08-10 US US13/572,557 patent/US20120321606A1/en not_active Abandoned
- 2012-08-24 HK HK12108307.7A patent/HK1167666A1/xx unknown
- 2012-10-16 US US13/653,293 patent/US8710189B2/en active Active
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2013
- 2013-02-07 US US13/762,252 patent/US9161977B2/en active Active
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2014
- 2014-03-04 US US14/197,072 patent/US20140187754A1/en not_active Abandoned
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2015
- 2015-09-14 HR HRP20150965TT patent/HRP20150965T1/hr unknown
- 2015-10-19 US US14/887,042 patent/US9499623B2/en active Active
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2016
- 2016-09-15 US US15/266,105 patent/US10000571B2/en active Active
- 2016-11-18 US US15/356,483 patent/US10287356B2/en active Active
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2017
- 2017-02-15 IL IL250624A patent/IL250624B/en active IP Right Grant
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2019
- 2019-04-10 US US16/380,865 patent/US11401333B2/en active Active
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2020
- 2020-08-12 AR ARP200102285A patent/AR119754A2/es unknown
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