PE20141562A1 - Anticuerpos anti-htra1 y metodos de uso - Google Patents

Anticuerpos anti-htra1 y metodos de uso

Info

Publication number
PE20141562A1
PE20141562A1 PE2014000524A PE2014000524A PE20141562A1 PE 20141562 A1 PE20141562 A1 PE 20141562A1 PE 2014000524 A PE2014000524 A PE 2014000524A PE 2014000524 A PE2014000524 A PE 2014000524A PE 20141562 A1 PE20141562 A1 PE 20141562A1
Authority
PE
Peru
Prior art keywords
hvr
htra1
seq
including seq
methods
Prior art date
Application number
PE2014000524A
Other languages
English (en)
Inventor
Yan Wu
Lookeren-Campagne Menno Van
Daniel Kirchhofer
Michael Terry Lipari
Jr Kenneth J Katschke
Paul M Moran
Scott Stawicki
Wei-Ching Liang
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20141562A1 publication Critical patent/PE20141562A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

SE REFIERE A ANTICUERPOS AISLADOS QUE SE CARACTERIZA PORQUE SE UNE A UN EPITOPO QUE INCLUYE N224, K248, O AMBOS DE HTRA1 CON UNA RELACION DE 1 DOMINIO VARIABLE A UNA SUBUNIDAD DE UN TRIMERO HTRA1 Y NO EVITA LA FORMACION DEL TRIMERO DE HTRA1. DICHO ANTICUERPO COMPRENDE: A) HVR-H1 QUE COMPRENDE SEQ ID NO: 20; B) HVR-H2 QUE COMPRENDE SEQ ID NO: 5; C) HVR-H3 QUE COMPRENDE SEQ ID NO: 6, D) HVR-L1 QUE COMPRENDE SEQ ID NO: 18; E) HVR-L2 QUE COMPRENDE SEQ ID NO: 2; F) HVR-L3 QUE COMPRENDE SEQ ID NO: 19. SE REFIERE TAMBIEN A UN METODO PARA PRODUCIR DICHO ANTICUERPO Y A UNA COMPOSICION FARMACEUTICA QUE ES UTIL PARA EL TRATAMIENTO DE LA DEGENERACION MACULAR RELACIONADA CON LA EDAD.
PE2014000524A 2011-10-14 2012-10-12 Anticuerpos anti-htra1 y metodos de uso PE20141562A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161547649P 2011-10-14 2011-10-14

Publications (1)

Publication Number Publication Date
PE20141562A1 true PE20141562A1 (es) 2014-11-12

Family

ID=48082468

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014000524A PE20141562A1 (es) 2011-10-14 2012-10-12 Anticuerpos anti-htra1 y metodos de uso

Country Status (32)

Country Link
US (3) US9738727B2 (es)
EP (2) EP3461839A1 (es)
JP (2) JP6532678B2 (es)
KR (2) KR102102862B1 (es)
CN (2) CN103917556B (es)
AR (1) AR088322A1 (es)
AU (2) AU2012322618A1 (es)
BR (1) BR112014008862A2 (es)
CA (1) CA2850032C (es)
CL (1) CL2014000888A1 (es)
CO (1) CO7020870A2 (es)
CR (1) CR20140212A (es)
DK (1) DK2766393T3 (es)
EA (1) EA201490778A1 (es)
ES (1) ES2687951T3 (es)
HK (1) HK1255608A1 (es)
HR (1) HRP20181457T1 (es)
HU (1) HUE039133T2 (es)
IL (1) IL232055B (es)
LT (1) LT2766393T (es)
MA (1) MA35712B1 (es)
MX (1) MX2014004022A (es)
PE (1) PE20141562A1 (es)
PL (1) PL2766393T3 (es)
PT (1) PT2766393T (es)
RS (1) RS57645B1 (es)
SG (1) SG11201401477XA (es)
SI (1) SI2766393T1 (es)
TR (1) TR201811270T4 (es)
TW (1) TW201321414A (es)
WO (1) WO2013055998A1 (es)
ZA (1) ZA201402172B (es)

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JP6463359B2 (ja) 2013-08-12 2019-01-30 ジェネンテック， インコーポレイテッド 補体関連病態を治療するための組成物及び方法
BR112016025312A2 (pt) 2014-05-01 2017-10-17 Genentech Inc variantes de anticorpo, anticorpo anti-fator d, formulação farmacêutica, dispositivo de distribuição, utilização da formulação e de uma composição, composição e método de tratamento de uma desordem
PE20170910A1 (es) 2014-11-10 2017-07-12 Genentech Inc Anticuerpos anti-interleucina-33 y sus usos
NZ741780A (en) * 2015-10-30 2019-11-29 Genentech Inc Anti-htra1 antibodies and methods of use thereof
US10654932B2 (en) 2015-10-30 2020-05-19 Genentech, Inc. Anti-factor D antibody variant conjugates and uses thereof
CN108289951A (zh) 2015-10-30 2018-07-17 豪夫迈·罗氏有限公司 抗-因子d抗体和缀合物
JP2018531980A (ja) 2015-10-30 2018-11-01 ジェネンテック， インコーポレイテッド 抗ｄ因子抗体製剤
WO2017222914A1 (en) 2016-06-21 2017-12-28 Inception 4, Inc. Carbocyclic prolinamide derivatives
PT3472149T (pt) 2016-06-21 2023-11-23 Orion Opthalmology Llc Derivados de prolinamida heterocíclicos
JP2018096930A (ja) * 2016-12-16 2018-06-21 公益財団法人ヒューマンサイエンス振興財団 加齢黄斑変性の診断マーカー、診断キット、診断補助方法、及び、発症リスク判定方法
ES2966319T3 (es) * 2016-12-22 2024-04-19 Daiichi Sankyo Co Ltd Péptido para el tratamiento de la degeneración macular asociada con la edad
WO2018183216A1 (en) 2017-03-27 2018-10-04 The Schepens Eye Research Institute, Inc. Notch3 agonist compositions and methods for treating small vessel diseases
JP2021507253A (ja) * 2017-12-21 2021-02-22 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｈｔｒａ１ ｒｎａアンタゴニストについてのコンパニオン診断
TW202015718A (zh) 2018-06-21 2020-05-01 日商第一三共股份有限公司 視網膜色素變性治療用胜肽
TW202039585A (zh) * 2018-11-16 2020-11-01 美商雙子治療公司 靶向htra1之基於抗體之療法及使用方法
WO2020109343A1 (en) 2018-11-29 2020-06-04 F. Hoffmann-La Roche Ag Combination therapy for treatment of macular degeneration
KR20210142092A (ko) * 2018-12-24 2021-11-24 비스테라, 인크. 에피토프 및 파라토프를 확인하는 방법
CN113966401A (zh) * 2019-04-10 2022-01-21 犹他大学研究基金会 用于治疗amd的htra1调节
CN115605507A (zh) 2020-03-13 2023-01-13 基因泰克公司（Us） 抗白介素-33抗体及其用途
JP2023536629A (ja) * 2020-08-04 2023-08-28 エグゼリクシス， インコーポレイテッド Ｃｄ４７結合性作用剤およびその使用
TW202246351A (zh) * 2021-02-08 2022-12-01 美商恩格姆生物製藥公司 Htra1結合劑及其使用方法

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