PE20161571A1 - Anticuerpos anti-ox40 y metodos de uso - Google Patents
Anticuerpos anti-ox40 y metodos de usoInfo
- Publication number
- PE20161571A1 PE20161571A1 PE2016001873A PE2016001873A PE20161571A1 PE 20161571 A1 PE20161571 A1 PE 20161571A1 PE 2016001873 A PE2016001873 A PE 2016001873A PE 2016001873 A PE2016001873 A PE 2016001873A PE 20161571 A1 PE20161571 A1 PE 20161571A1
- Authority
- PE
- Peru
- Prior art keywords
- hvr
- seq
- sequence
- amino acids
- iii
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
SE REFIERE A UN ANTICUERPO AGONISTA ANTI-OX40 HUMANO QUE COMPRENDE: A) UN DOMINIO VARIABLE DE CADENA PESADA QUE COMPRENDE i) HVR-H1 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID NO: 2, 8 O 9, ii) HVR-H2 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID NO: 3, 10, 11, 12, 13 O 14, Y iii) HVR-H3 QUE COMPRENDE UNA SECUENCIA DE AMINOACIDOS DE SEQ ID NO: 4, 15 O 19; Y B) UN DOMINIO VARIABLE DE CADENA LIGERA QUE COMPRENDE i) HVR-L1 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID NO: 5, ii) HVR-L2 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID NO: 6, Y iii) HVR-L3 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID NO: 7, 22, 23, 24, 25, 26, 27 O 28; DONDE EL ANTICUERPO REDUCE LAS CELULAS QUE EXPRESAN OX40 HUMANO IN VITRO. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA UTIL EN EL TRATAMIENTO DE CANCER
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461973193P | 2014-03-31 | 2014-03-31 | |
| US201461989448P | 2014-05-06 | 2014-05-06 | |
| US201462073873P | 2014-10-31 | 2014-10-31 | |
| US201462080171P | 2014-11-14 | 2014-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20161571A1 true PE20161571A1 (es) | 2017-02-07 |
Family
ID=52829446
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2016001873A PE20161571A1 (es) | 2014-03-31 | 2015-03-30 | Anticuerpos anti-ox40 y metodos de uso |
| PE2020001996A PE20211291A1 (es) | 2014-03-31 | 2015-03-30 | Anticuerpos anti-ox40 y metodos de uso |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2020001996A PE20211291A1 (es) | 2014-03-31 | 2015-03-30 | Anticuerpos anti-ox40 y metodos de uso |
Country Status (29)
| Country | Link |
|---|---|
| EP (2) | EP3632934A1 (es) |
| JP (2) | JP6637439B2 (es) |
| KR (1) | KR20160145624A (es) |
| CN (1) | CN106103486B (es) |
| AU (1) | AU2015241037B2 (es) |
| BR (1) | BR112016022658A2 (es) |
| CA (1) | CA2943262A1 (es) |
| CL (1) | CL2016002462A1 (es) |
| CR (1) | CR20160500A (es) |
| DK (1) | DK3126394T3 (es) |
| EA (1) | EA201691974A1 (es) |
| ES (1) | ES2763898T3 (es) |
| HR (1) | HRP20192285T1 (es) |
| HU (1) | HUE046767T2 (es) |
| IL (1) | IL247898A0 (es) |
| LT (1) | LT3126394T (es) |
| MA (2) | MA51552A (es) |
| MX (1) | MX2016012781A (es) |
| PE (2) | PE20161571A1 (es) |
| PH (1) | PH12016501894A1 (es) |
| PL (1) | PL3126394T3 (es) |
| PT (1) | PT3126394T (es) |
| RS (1) | RS59738B1 (es) |
| SG (1) | SG11201607969XA (es) |
| SI (1) | SI3126394T1 (es) |
| TW (1) | TWI680985B (es) |
| UA (1) | UA121112C2 (es) |
| WO (1) | WO2015153513A1 (es) |
| ZA (1) | ZA201606630B (es) |
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- 2015-03-30 LT LTEP15716335.3T patent/LT3126394T/lt unknown
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- 2015-03-30 CA CA2943262A patent/CA2943262A1/en not_active Abandoned
- 2015-03-30 SG SG11201607969XA patent/SG11201607969XA/en unknown
- 2015-03-31 TW TW104110569A patent/TWI680985B/zh active
-
2016
- 2016-09-19 IL IL247898A patent/IL247898A0/en unknown
- 2016-09-23 ZA ZA2016/06630A patent/ZA201606630B/en unknown
- 2016-09-26 PH PH12016501894A patent/PH12016501894A1/en unknown
- 2016-09-29 CL CL2016002462A patent/CL2016002462A1/es unknown
-
2019
- 2019-12-18 HR HRP20192285TT patent/HRP20192285T1/hr unknown
- 2019-12-20 JP JP2019230794A patent/JP2020072678A/ja active Pending
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