CN110172090B - Cd134单克隆抗体及其制备方法和癌症治疗中的应用 - Google Patents
Cd134单克隆抗体及其制备方法和癌症治疗中的应用 Download PDFInfo
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- A—HUMAN NECESSITIES
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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Abstract
Description
类型 | cpm值 |
T | 527±21 |
DC+T | 5825±66 |
鼠IgG | 6240±102 |
本发明OX40单克隆抗体 | 728±48 |
对照OX40单克隆抗体 | 1944±112 |
Claims (4)
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US20230295324A1 (en) * | 2020-06-30 | 2023-09-21 | Harbour Biomed (Shanghai) Co., Ltd | Ox40-targeted antibody, and preparation method therefor and application thereof |
CN111763258B (zh) * | 2020-09-01 | 2020-12-29 | 北京百奥赛图基因生物技术有限公司 | 抗ox40抗体及其用途 |
CN112794907B (zh) * | 2020-12-03 | 2022-09-06 | 安徽安科生物工程(集团)股份有限公司 | 一株全人源抗人huOX40单克隆抗体 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2018027204A1 (en) * | 2016-08-05 | 2018-02-08 | Genentech, Inc. | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
CN109232738A (zh) * | 2017-07-11 | 2019-01-18 | 南京金斯瑞生物科技有限公司 | 高亲和力、高特异性、多抗原识别表位的具有更高功能性的抗人ox40抗体 |
CN109562165A (zh) * | 2016-07-20 | 2019-04-02 | Igm生物科学股份有限公司 | 多聚ox40结合分子及其用途 |
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MX2010006466A (es) * | 2007-12-14 | 2010-09-28 | Bristol Myers Squibb Co | Moleculas de union al receptor ox40 de humano. |
SG11201507781VA (en) * | 2013-03-18 | 2015-10-29 | Biocerox Prod Bv | Humanized anti-cd134 (ox40) antibodies and uses thereof |
UA121112C2 (uk) * | 2014-03-31 | 2020-04-10 | Дженентек, Інк. | Антитіло до ox40 та його застосування |
US20180237534A1 (en) * | 2015-05-29 | 2018-08-23 | Bristol-Myers Squibb Company | Antibodies against ox40 and uses thereof |
EP3363816A4 (en) * | 2015-10-15 | 2019-10-09 | Dingfu Biotarget Co., Ltd. | ANTI-OX40 ANTIBODIES AND USES THEREOF |
RU2753493C2 (ru) * | 2016-12-15 | 2021-08-17 | Эббви Байотерапьютикс Инк. | Анти-ох40 антитела и их применение |
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CN109562165A (zh) * | 2016-07-20 | 2019-04-02 | Igm生物科学股份有限公司 | 多聚ox40结合分子及其用途 |
WO2018027204A1 (en) * | 2016-08-05 | 2018-02-08 | Genentech, Inc. | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
CN109232738A (zh) * | 2017-07-11 | 2019-01-18 | 南京金斯瑞生物科技有限公司 | 高亲和力、高特异性、多抗原识别表位的具有更高功能性的抗人ox40抗体 |
Non-Patent Citations (1)
Title |
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Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members;Yanli Yang等;《MABS》;20190620;Structure of ternary Fab/Fab/receptor complex reveals epitope insights into clustering mechanism * |
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