MX2018015683A - Composiciones y métodos para el agotamiento de células. - Google Patents
Composiciones y métodos para el agotamiento de células.Info
- Publication number
- MX2018015683A MX2018015683A MX2018015683A MX2018015683A MX2018015683A MX 2018015683 A MX2018015683 A MX 2018015683A MX 2018015683 A MX2018015683 A MX 2018015683A MX 2018015683 A MX2018015683 A MX 2018015683A MX 2018015683 A MX2018015683 A MX 2018015683A
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- compositions
- depleting
- hematopoietic stem
- methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 210000004027 cell Anatomy 0.000 abstract 5
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 abstract 3
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 abstract 3
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 abstract 3
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 abstract 3
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 abstract 3
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 abstract 3
- 230000000779 depleting effect Effects 0.000 abstract 3
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000562 conjugate Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 208000018706 hematopoietic system disease Diseases 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
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Abstract
La invención proporciona composiciones y métodos útiles para el agotamiento de células, tal como células CD45+, CD135+, CD34+, CD90+, y/o CD110+, y para el tratamiento de diversas enfermedades hematopoyéticas, trastornos metabólicos, cáncer y enfermedades autoinmunitarias, entre otras. En la presente se describen anticuerpos, fragmentos de unión a antígeno, ligandos, y conjugados de los mismos que se pueden aplicar para efectuar el tratamiento de estas condiciones, por ejemplo, por el agotamiento de una población de células CD45+, CD135+, CD34+, CD90+, o CD110+ en un paciente, tal como un humano. La$ composiciones y métodos descritos en la presente se pueden utilizar para tratar un trastorno directamente, por ejemplo, por el agotamiento de una población de células CD45+, CD135+, CD34+, CD90+, o CD110+ cancerosas o células autoinmunes. Las composiciones y métodos descritos en la presente también se pueden utilizar para preparar a un paciente para la terapia de trasplante de células madre hematopoyéticas y para mejorar el injerto funcionante de trasplantes de células madre hematopoyéticas al agotar selectivamente células madre hematopoyéticas endógenas antes del procedimiento de trasplante.
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2017
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2018
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2019
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2020
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2022
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2023
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EP3471772A4 (en) | 2020-03-18 |
JP2019522050A (ja) | 2019-08-08 |
US20190328901A1 (en) | 2019-10-31 |
CA3028145A1 (en) | 2017-12-21 |
CN109641051A (zh) | 2019-04-16 |
AU2017204139B2 (en) | 2018-08-09 |
SG11201811292RA (en) | 2019-01-30 |
US20190192682A1 (en) | 2019-06-27 |
WO2017219025A1 (en) | 2017-12-21 |
AU2018208749A1 (en) | 2018-08-16 |
BR112018076263A2 (pt) | 2019-03-26 |
MA45407A (fr) | 2019-04-24 |
KR20230082055A (ko) | 2023-06-08 |
KR20190039085A (ko) | 2019-04-10 |
AU2018208749B2 (en) | 2020-09-03 |
IL263743A (en) | 2019-01-31 |
JP2024037832A (ja) | 2024-03-19 |
AU2020217338A1 (en) | 2020-08-27 |
AU2017204139A1 (en) | 2018-01-18 |
JP2022163075A (ja) | 2022-10-25 |
US20200376134A1 (en) | 2020-12-03 |
EP3471772A1 (en) | 2019-04-24 |
US10624973B2 (en) | 2020-04-21 |
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