BR112018076263A2 - composições e métodos para a depleção de células - Google Patents

composições e métodos para a depleção de células

Info

Publication number
BR112018076263A2
BR112018076263A2 BR112018076263-6A BR112018076263A BR112018076263A2 BR 112018076263 A2 BR112018076263 A2 BR 112018076263A2 BR 112018076263 A BR112018076263 A BR 112018076263A BR 112018076263 A2 BR112018076263 A2 BR 112018076263A2
Authority
BR
Brazil
Prior art keywords
compositions
cells
depleting
hematopoietic stem
methods
Prior art date
Application number
BR112018076263-6A
Other languages
English (en)
Inventor
Nixon Andrew
Morrow Dwight
Hartigan Adam
Original Assignee
Magenta Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magenta Therapeutics, Inc. filed Critical Magenta Therapeutics, Inc.
Publication of BR112018076263A2 publication Critical patent/BR112018076263A2/pt

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    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract

a presente invenção refere-se a composições e métodos úteis para a depleção de células, tais como células cd45+, cd135+, cd34+, cd90+ e/ou cd110+, e para o tratamento de vias doenças hematopoiéticas, distúrbios metabólicos, cânceres e doenças autoimunes, entre outras. são aqui descritos anticorpos, fragmentos de ligação ao antígeno, ligandos e seus conjugados que podem ser aplicados para efetuar o tratamento destas condições, por exemplo, depletando uma população de células cd45+, cd135+, cd34+, cd90+ ou cd110+ em um paciente, tal como um humano. as composições e métodos aqui descritos podem ser utilizados para tratar um distúrbio diretamente, por exemplo, depletando uma população de células cancerosas cd45+, cd135+, cd34+, cd90+ ou cd110+ ou células autoimunes. as composições e métodos aqui descritos também podem ser utilizados para preparar um paciente para terapia de transplante de células-tronco hematopoiéticas e para melhorar o enxerto de transplantes de células-tronco hematopoiéticas depletando seletivamente células-tronco hematopoiéticas endógenas antes do procedimento de transplante.
BR112018076263-6A 2016-06-17 2017-06-19 composições e métodos para a depleção de células BR112018076263A2 (pt)

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