SG11201811292RA - Compositions and methods for the depletion of cells - Google Patents
Compositions and methods for the depletion of cellsInfo
- Publication number
- SG11201811292RA SG11201811292RA SG11201811292RA SG11201811292RA SG11201811292RA SG 11201811292R A SG11201811292R A SG 11201811292RA SG 11201811292R A SG11201811292R A SG 11201811292RA SG 11201811292R A SG11201811292R A SG 11201811292RA SG 11201811292R A SG11201811292R A SG 11201811292RA
- Authority
- SG
- Singapore
- Prior art keywords
- cells
- international
- compositions
- isotype
- december
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 5
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 abstract 6
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 abstract 6
- 210000004027 cell Anatomy 0.000 abstract 6
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 abstract 3
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 abstract 3
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 abstract 3
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 abstract 3
- 230000000779 depleting effect Effects 0.000 abstract 3
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000001363 autoimmune Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000003833 cell viability Effects 0.000 abstract 1
- 239000000562 conjugate Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 208000018706 hematopoietic system disease Diseases 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004020 luminiscence type Methods 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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Abstract
Luminescence (7) 800000 600000 400000 200000 0 43- Isotype Abi CD45 Abi -str• Isotype Ab2 CD45 Ab2 Isotype Ab3 CD45 Ab3 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 21 December 2017 (21.12.2017) WIP01 PCT IiiimmomiolollmolommoololommoillonnovoimIE (10) International Publication Number WO 2017/219025 Al (51) International Patent Classification: A61K 39/395 (2006.01) Cl 2N 5/00 (2006.01) CO7K 16/28 (2006.01) (21) International Application Number: PCT/US2017/038151 (22) International Filing Date: 19 June 2017 (19.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/351,725 17 June 2016 (17.06.2016) US 62/351,778 17 June 2016 (17.06.2016) US 62/437,729 22 December 2016 (22.12.2016) US 62/437,756 22 December 2016 (22.12.2016) US 62/448,768 20 January 2017 (20.01.2017) US 62/448,782 20 January 2017 (20.01.2017) US (71) Applicant: MAGENTA THERAPEUTICS, INC. [US/US]; 50 Hampshire Street, 8th Floor, Cambridge, MA 02139 (US). (72) Inventors: NIXON, Andrew; 41 Evergreen Lane, Hanover, MA 02339 (US). MORROW, Dwight; 1230 Wa- terford Road, West Chester, PA 19380 (US). HARTIGAN, Adam; 84 Harvard Avenue, Apt. 2, Brookline, MA 02446 (US). (74) Agent: COWLES, Cristin H. et al.; Womble Bond Dick- inson (US) LLP, P.O. Box 7037, Atlanta, GA 30357-0037 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (54) Title: COMPOSITIONS AND METHODS FOR THE DEPLETION OF CELLS FIG. 1 Reh Cell Viability CD45-Saporin -12 -10 -8 Concentration LOG(M) (57) : The invention provides compositions and methods useful for the depletion of cells, such as CD45+, CD135+, CD34+, CD90+, and/or CD110+ cells, and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune O diseases, among others. Described herein are antibodies, antigen-binding fragments, ligands, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD45+, CD135+, CD34+, CD90+, or CD110+ cells in a patient, such as a human. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD45+, CD135+, CD34+, CD90+, or CD110+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the O engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant [Continued on next page] WO 2017/219025 Al MIDEDIMOMOIDEIRMEM001101ROMMOMEEM DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) procedure.
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WO2018134787A2 (en) | 2017-01-20 | 2018-07-26 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd137+ cells |
JP7321934B2 (en) | 2017-01-30 | 2023-08-07 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Non-genotoxic transplant conditioning regimens for stem cell transplantation |
EP3661938A1 (en) | 2017-08-07 | 2020-06-10 | Heidelberg Pharma Research GmbH | Novel method for synthesizing amanitins |
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2017
- 2017-06-19 SG SG11201811292RA patent/SG11201811292RA/en unknown
- 2017-06-19 US US16/310,738 patent/US20190328901A1/en not_active Abandoned
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- 2017-06-19 CN CN201780050855.7A patent/CN109641051A/en active Pending
- 2017-06-19 KR KR1020237017708A patent/KR20230082055A/en not_active Application Discontinuation
- 2017-06-19 WO PCT/US2017/038151 patent/WO2017219025A1/en active Application Filing
- 2017-06-19 MX MX2018015683A patent/MX2018015683A/en unknown
- 2017-06-19 EP EP17814261.8A patent/EP3471772A4/en active Pending
- 2017-06-19 AU AU2017204139A patent/AU2017204139B2/en active Active
- 2017-06-19 CA CA3028145A patent/CA3028145A1/en active Pending
- 2017-06-19 KR KR1020197001536A patent/KR20190039085A/en not_active Application Discontinuation
- 2017-06-19 BR BR112018076263-6A patent/BR112018076263A2/en unknown
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2018
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- 2018-12-16 IL IL263743A patent/IL263743A/en unknown
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2019
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2020
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- 2020-08-11 AU AU2020217338A patent/AU2020217338A1/en not_active Abandoned
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2022
- 2022-07-21 JP JP2022116511A patent/JP2022163075A/en active Pending
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EP3471772A4 (en) | 2020-03-18 |
JP2019522050A (en) | 2019-08-08 |
US20190328901A1 (en) | 2019-10-31 |
CA3028145A1 (en) | 2017-12-21 |
CN109641051A (en) | 2019-04-16 |
AU2017204139B2 (en) | 2018-08-09 |
US20190192682A1 (en) | 2019-06-27 |
WO2017219025A1 (en) | 2017-12-21 |
AU2018208749A1 (en) | 2018-08-16 |
BR112018076263A2 (en) | 2019-03-26 |
MA45407A (en) | 2019-04-24 |
KR20230082055A (en) | 2023-06-08 |
KR20190039085A (en) | 2019-04-10 |
AU2018208749B2 (en) | 2020-09-03 |
IL263743A (en) | 2019-01-31 |
JP2024037832A (en) | 2024-03-19 |
AU2020217338A1 (en) | 2020-08-27 |
MX2018015683A (en) | 2019-05-27 |
AU2017204139A1 (en) | 2018-01-18 |
JP2022163075A (en) | 2022-10-25 |
US20200376134A1 (en) | 2020-12-03 |
EP3471772A1 (en) | 2019-04-24 |
US10624973B2 (en) | 2020-04-21 |
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