SG11201808913WA - Intratumoral administration of particles containing a toll-like receptor 9 agonist and a tumor antigen for treating cancer - Google Patents
Intratumoral administration of particles containing a toll-like receptor 9 agonist and a tumor antigen for treating cancerInfo
- Publication number
- SG11201808913WA SG11201808913WA SG11201808913WA SG11201808913WA SG11201808913WA SG 11201808913W A SG11201808913W A SG 11201808913WA SG 11201808913W A SG11201808913W A SG 11201808913WA SG 11201808913W A SG11201808913W A SG 11201808913WA SG 11201808913W A SG11201808913W A SG 11201808913WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- agonist
- toll
- receptor
- treating cancer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 8
- 239000002245 particle Substances 0.000 title abstract 5
- 229940044655 toll-like receptor 9 agonist Drugs 0.000 title abstract 5
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 230000002601 intratumoral effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 abstract 1
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- LFEUVBZXUFMACD-UHFFFAOYSA-H lead(2+);trioxido(oxo)-$l^{5}-arsane Chemical compound [Pb+2].[Pb+2].[Pb+2].[O-][As]([O-])([O-])=O.[O-][As]([O-])([O-])=O LFEUVBZXUFMACD-UHFFFAOYSA-H 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464484—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/464488—NY-ESO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/804—Blood cells [leukemia, lymphoma]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/39—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by a specific adjuvant, e.g. cytokines or CpG
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
Abstract
II o Unvaccinated D-04-Alum-OVApep SC D61-04-Alum-OVApep IT D61-04-Alum IT ,S - 2000- E1500- - a - .) 1000- E 500- t; 400 300 200 100 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/181128 Al 19 October 2017 (19.10.2017) WIPO I PCT (51) International Patent Classification: A61K 39/00 (2006.01) A61K 47/36 (2006.01) A61K 39/39 (2006.01) A61K 31/711 (2006.01) A61K 47/02 (2006.01) A61P 35/00 (2006.01) A61K 47/10 (2017.01) (21) International Application Number: PCT/US2017/027788 (22) International Filing Date: 14 April 2017 (14.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/323,622 15 April 2016 (15.04.2016) US 62/439,438 27 December 2016 (27.12.2016) US (71) Applicant: DYNAVAX TECHNOLOGIES CORPORA- TION [US/US]; 2929 Seventh Street, Suite 100, Berkeley, CA 94710 (US). (72) Inventors: GUIDUCCI, Cristiana; 1048 Talbot Avenue, Albany, CA 94706 (US). NAIK, Edwina; 5308 Genoa Street, Oakland, CA 94608 (US). MILLEY, Robert, J.; 3061 Bridsall Avenue, Oakland, CA 94619 (US). CHIP- MAN, Stewart, D.; 11042 Forest Ln NE, Bainbridge Is- land, WA 98110 (US). (74) Agents: LEKUTIS, Christine et al.; Morrison & Foerster LLP, 425 Market Street, San Francisco, CA 94105-2482 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) = (54) Title: INTRATUMORAL ADMINISTRATION OF PARTICLES CONTAINING A TOLL-LIKE RECEPTOR 9 AGONIST AND A TUMOR ANTIGEN FOR TREATING CANCER FIG. 11A ns *** (57) : The present disclosure relates to methods for treating cancer by intratumoral delivery of particles containing a Toll- like receptor 9 agonist (TLR9) and a tumor antigen, in which the TLR9 agonist is a polynucleotide or a chimeric compound thereof. The methods of the present disclosure involve injection of the particles into at least one tumor, and are effective for treating both in - jected and uninjected tumors of a mammalian subject. Additionally, the present disclosure provides immunogenic compositions con- taining the particles, as well as methods of manufacture thereof. 1111111111111101110111111111110101111101110111H0111011101111101111111111111111111 W O 20 17 / 18 1128 Al
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662323622P | 2016-04-15 | 2016-04-15 | |
US201662439438P | 2016-12-27 | 2016-12-27 | |
PCT/US2017/027788 WO2017181128A1 (en) | 2016-04-15 | 2017-04-14 | Intratumoral administration of particles containing a toll-like receptor 9 agonist and a tumor antigen for treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201808913WA true SG11201808913WA (en) | 2018-11-29 |
Family
ID=60042047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201808913WA SG11201808913WA (en) | 2016-04-15 | 2017-04-14 | Intratumoral administration of particles containing a toll-like receptor 9 agonist and a tumor antigen for treating cancer |
Country Status (10)
Country | Link |
---|---|
US (1) | US20170326232A1 (en) |
EP (1) | EP3442568A4 (en) |
JP (1) | JP2019515900A (en) |
KR (1) | KR20180129903A (en) |
CN (1) | CN109475612A (en) |
AU (1) | AU2017250348A1 (en) |
CA (1) | CA3020873A1 (en) |
MX (1) | MX2018012391A (en) |
SG (1) | SG11201808913WA (en) |
WO (1) | WO2017181128A1 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20180021700A (en) * | 2015-05-29 | 2018-03-05 | 다이나박스 테크놀로지 코퍼레이션 | Intrapulmonary administration of polynucleotide Toll-like receptor 9 agonists to treat lung cancer |
WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
EP3727447A1 (en) | 2017-12-19 | 2020-10-28 | Massachusetts Institute of Technology | Antigen-adjuvant coupling reagents and methods of use |
WO2019200238A1 (en) | 2018-04-14 | 2019-10-17 | Dynavax Technologies Corporation | Combinations including a cpg-c type oligonucleotide and a histone deacetylase inhibitor for treating cancer |
TW202012395A (en) | 2018-04-14 | 2020-04-01 | 德商4Sc製藥公司 | Pharmaceutical combination products comprising a histone deacetylase (hdac) inhibitor and a tlr7 agonist and/or tlr8 agonist for the treatment of cancer |
WO2020081398A1 (en) | 2018-10-14 | 2020-04-23 | Dynavax Technologies Corporation | Combination including a cpg-c type oligonucleotide and a pd-1 antagonist for treating breast cancer |
SG11202100854TA (en) | 2018-10-16 | 2021-05-28 | US Nano Food & Drug INC | Intratumor injection formulation |
JP2022538974A (en) | 2019-06-26 | 2022-09-07 | マサチューセッツ インスチテュート オブ テクノロジー | Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof |
MX2022005633A (en) * | 2020-01-10 | 2022-06-14 | Sbi Biotech Co Ltd | Novel tlr9 agonists. |
CN114929213A (en) | 2020-04-13 | 2022-08-19 | 美国纳米食品药品公司 | Alkaline chemotherapeutic intratumoral injection composition |
CA3196274A1 (en) * | 2020-09-22 | 2022-03-31 | Trisalus Life Sciences, Inc. | Cancer therapy using toll-like receptor agonists |
KR20230121995A (en) * | 2020-09-22 | 2023-08-22 | 트라이살루스 라이프 사이언시즈, 인크. | Cancer Therapy Using Toll-Like Receptor Agonists |
CN114099535B (en) * | 2020-12-10 | 2023-01-03 | 南京吉迈生物技术有限公司 | Toll-like receptor 9 (TLR 9) agonist hydrogel immunomodulatory compositions |
CA3232439A1 (en) | 2021-09-16 | 2023-03-23 | Toray Industries, Inc. | Medicament for treatment and/or prevention of cancer |
KR20230153790A (en) | 2022-04-29 | 2023-11-07 | 주식회사 레고켐 바이오사이언스 | Imidazo[4,5-c]pyridine derivative compounds as TLR7/8 modulators |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6723832B1 (en) * | 1996-10-03 | 2004-04-20 | Ludwig Institute For Cancer Research | Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof |
CN100546998C (en) * | 2002-12-23 | 2009-10-07 | 戴纳伐克斯技术股份有限公司 | Immunostimulatory sequence oligonucleotides and using method |
US8158768B2 (en) * | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
US20080124366A1 (en) * | 2006-08-06 | 2008-05-29 | Ohlfest John R | Methods and Compositions for Treating Tumors |
BRPI0814899A2 (en) * | 2007-08-21 | 2015-02-03 | Dynavax Tech Corp | COMPOSITION, VACCINE, METHOD FOR SOFTENING ONE OR MORE SYMPTOMS ASSOCIATED WITH INFLUENZA VIRUS INFECTION IN AN INDIVIDUAL AND METHOD TO REDUCE THE PROBABILITY OF INFLUENCE VIRUS INFECTION IN AN INDIVIDUAL " |
WO2010002940A2 (en) * | 2008-06-30 | 2010-01-07 | Dynavax Technologies Corporation | Heterogeneous synthesis of multivalent chimeric immunomodulatory compounds using platform based molecules |
CA2847332A1 (en) * | 2011-08-31 | 2013-03-07 | Mie University | Vaccine preparation for cancer treatment |
BR112015000483B1 (en) * | 2012-07-13 | 2022-05-17 | S-Target Therapeutics Gmbh | IMMUNO REGULATORY OR SENSITIZING VACCINE, KIT TO PREPARE THE VACCINE AND METHOD USED TO PREPARE THE VACCINE TO TRIGGER AN IMMUNE RESPONSE FROM IGG |
WO2016118932A1 (en) * | 2015-01-23 | 2016-07-28 | Dynavax Technologies Corporation | Branched and linear chimeric compounds, polynucleotides, uses and methods for preparation thereof |
US20180117171A1 (en) * | 2015-04-01 | 2018-05-03 | President And Fellows Of Harvard College | Immunoconjugates for programming or reprogramming of cells |
WO2016184862A1 (en) * | 2015-05-18 | 2016-11-24 | Oncoqr Ml Gmbh | Her2/neu immunogenic composition |
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2017
- 2017-04-14 MX MX2018012391A patent/MX2018012391A/en unknown
- 2017-04-14 CN CN201780035693.XA patent/CN109475612A/en active Pending
- 2017-04-14 CA CA3020873A patent/CA3020873A1/en not_active Abandoned
- 2017-04-14 AU AU2017250348A patent/AU2017250348A1/en not_active Abandoned
- 2017-04-14 US US15/488,353 patent/US20170326232A1/en not_active Abandoned
- 2017-04-14 EP EP17783323.3A patent/EP3442568A4/en not_active Withdrawn
- 2017-04-14 JP JP2018553416A patent/JP2019515900A/en active Pending
- 2017-04-14 SG SG11201808913WA patent/SG11201808913WA/en unknown
- 2017-04-14 WO PCT/US2017/027788 patent/WO2017181128A1/en active Application Filing
- 2017-04-14 KR KR1020187031933A patent/KR20180129903A/en unknown
Also Published As
Publication number | Publication date |
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MX2018012391A (en) | 2019-02-14 |
CA3020873A1 (en) | 2017-10-19 |
EP3442568A1 (en) | 2019-02-20 |
JP2019515900A (en) | 2019-06-13 |
EP3442568A4 (en) | 2019-12-18 |
US20170326232A1 (en) | 2017-11-16 |
KR20180129903A (en) | 2018-12-05 |
CN109475612A (en) | 2019-03-15 |
WO2017181128A1 (en) | 2017-10-19 |
AU2017250348A1 (en) | 2018-10-11 |
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