MA45407A - Compositions et méthodes de déplétion de cellules - Google Patents

Compositions et méthodes de déplétion de cellules

Info

Publication number
MA45407A
MA45407A MA045407A MA45407A MA45407A MA 45407 A MA45407 A MA 45407A MA 045407 A MA045407 A MA 045407A MA 45407 A MA45407 A MA 45407A MA 45407 A MA45407 A MA 45407A
Authority
MA
Morocco
Prior art keywords
compositions
methods
cell deletion
deletion
cell
Prior art date
Application number
MA045407A
Other languages
English (en)
Inventor
Adam Hartigan
Dwight Morrow
Andrew Nixon
Original Assignee
Magenta Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magenta Therapeutics Inc filed Critical Magenta Therapeutics Inc
Publication of MA45407A publication Critical patent/MA45407A/fr

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    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3439699A4 (fr) 2016-04-04 2019-11-20 Hemogenyx LLC Procédé d'élimination de cellules souches hématopoïétique/progéniteurs hématopoïétiques (csh/ph) chez un patient à l'aide d'anticorps bispécifiques
CN111164211B (zh) 2017-07-18 2024-08-02 杰特贝林基因治疗股份有限公司 用于治疗β-血红蛋白病的组合物和方法
EP3796942A1 (fr) * 2018-05-23 2021-03-31 ADC Therapeutics SA Adjuvant moléculaire
CA3107383A1 (fr) * 2018-07-23 2020-01-30 Magenta Therapeutics, Inc. Utilisation d'un conjugue anticorps anti-cd5 -medicament (adc) dans une therapie cellulaire allogenique
WO2020023559A1 (fr) * 2018-07-23 2020-01-30 Magenta Therapeutics, Inc. Utilisation d'un conjugué médicament anticorps anti-cd2 (adc) dans une thérapie cellulaire allogénique
CA3117367A1 (fr) * 2018-10-30 2020-05-07 Magenta Therapeutics, Inc. Anticorps anti-cd45 et leurs conjugues
MX2021004579A (es) * 2018-10-30 2021-07-06 Magenta Therapeutics Inc Métodos para trasplante de células madre hematopoyéticas alogénicas.
AU2019417697A1 (en) 2018-12-23 2021-07-08 Csl Behring L.L.C. Haematopoietic stem cell-gene therapy for wiskott-aldrich syndrome
JP2022518150A (ja) * 2019-01-07 2022-03-14 マジェンタ セラピューティクス インコーポレイテッド 細胞療法での抗ｃｄ４５抗体－薬物結合体（ａｄｃ）の使用経験
EP3958878A4 (fr) * 2019-04-24 2022-12-28 Magenta Therapeutics, Inc. Méthodes de conditionnement pour thérapie génique
WO2020219959A1 (fr) * 2019-04-24 2020-10-29 Magenta Therapeutics, Inc. Conjugués anticorps anti-cd45-médicaments et leurs utilisations
JP2022530100A (ja) * 2019-04-25 2022-06-27 アクティニウム ファーマシューティカルズ インコーポレイテッド 悪性および非悪性血液疾患の治療のための免疫枯渇の組成物および方法
MX2021014729A (es) * 2019-06-04 2022-02-25 Magenta Therapeutics Inc Metodos y composiciones para tratar enfermedades autoinmunitarias.
CA3142513A1 (fr) * 2019-06-25 2020-12-30 Gilead Sciences, Inc. Proteines de fusion flt3l-fc et procedes d'utilisation
EP3997128A4 (fr) * 2019-07-09 2023-10-18 Hemogenyx Pharmaceuticals Llc Procédé d'élimination de cellules souches hématopoïétique/progéniteurs hématopoïétiques (csh/ph) chez un patient à l'aide d'anticorps bispécifiques
EP4003418A4 (fr) * 2019-07-30 2023-08-16 DendroCyte BioTech Pty Ltd Immunoconjugué
WO2021087368A2 (fr) * 2019-11-01 2021-05-06 Magenta Therapeutics, Inc. Anticorps anti-cd45 et leurs conjugués
JP2023514347A (ja) * 2020-02-18 2023-04-05 マジェンタ セラピューティクス インコーポレイテッド 同種移植のための組成物及び方法
CA3240875A1 (fr) 2021-12-23 2023-06-29 Stefanie Urlinger Variants de proteine de surface cellulaire discernable de cd45 destines a etre utilises en therapie cellulaire

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6074650A (en) 1985-06-24 2000-06-13 Hoechst Aktiengesellschaft Membrane anchor/active compound conjugate, its preparation and its uses
AU5186090A (en) 1989-02-23 1990-09-26 Colorado State University Research Foundation Gnrh analogs for destroying gonadotrophs
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
US6024957A (en) 1993-06-02 2000-02-15 Research Corporation Technologies, Inc. Immunomodulators and methods for the prevention and reversal of organ transplant rejection using same
US6106834A (en) 1993-06-02 2000-08-22 Research Corporation Technologies, Inc. Use of anti-CD45 leukocyte antigen antibodies for immunomodulation
GB9323199D0 (en) 1993-11-10 1994-01-05 Falkenberg J H F Leukaemia treatment
US6759509B1 (en) 1996-11-05 2004-07-06 Bristol-Myers Squibb Company Branched peptide linkers
US20110045005A1 (en) 2001-10-19 2011-02-24 Craig Crowley Compositions and methods for the treatment of tumor of hematopoietic origin
AU2002351204B2 (en) * 2001-12-03 2008-07-10 Abgenix, Inc. Anti-CD45RB antibodies for use in treating autoimmune disease and transplant rejection
MY143963A (en) * 2003-09-18 2011-07-29 Novartis Ag Therapeutic binding molecules
JP5064037B2 (ja) 2004-02-23 2012-10-31 ジェネンテック， インコーポレイテッド 複素環式自壊的リンカーおよび結合体
EP1661584A1 (fr) 2004-11-26 2006-05-31 Heinz Dr. Faulstich Application de conjuguées d' amatoxines et de phallotoxines avec des macromolécules pour la thérapie du cancer et de l'Inflammation
US7947839B2 (en) 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
WO2007087453A2 (fr) 2006-01-27 2007-08-02 Cellerant Therapeutics, Inc. Compositions et méthodes de traitement de troubles prolifératifs hématologiques
CA2645347A1 (fr) 2006-03-10 2007-09-20 Diatos Medicaments anticancereux conjugues a un anticorps au moyen d'un lieur dissociable par une enzyme
ES2371085T3 (es) 2006-05-27 2011-12-27 Faulstich, Heinz, Dr. Utilización de conjugados de amatoxinas o falotoxinas con macromoléculas para la terapia tumoral y de la inflamación.
EP2447282B1 (fr) 2006-05-30 2016-01-27 Genentech, Inc. Anti-CD22 Anticorps, immuno-conjugués et utilisations associées
AU2007307652A1 (en) * 2006-10-10 2008-04-17 Squicor Compositions and methods for treating and diagnosing cancers
EP3255061B1 (fr) * 2006-11-03 2021-06-16 The Board of Trustees of the Leland Stanford Junior University Immunodéplétion sélective de niche de cellules souches endogènes pour greffe
ES2523915T5 (es) 2006-12-01 2022-05-26 Seagen Inc Agentes de unión a la diana variantes y usos de los mismos
CN102369218B (zh) * 2009-04-01 2014-07-16 霍夫曼-拉罗奇有限公司 抗-FcRH5抗体和免疫缀合物以及应用方法
EP3192529B1 (fr) 2009-04-08 2020-03-25 Faulstich, Heinz, Dr. Constituants thérapeutiques contenant de l'amatoxine de liaison à la surface cellulaire destinés à la thérapie des tumeurs
WO2010115630A1 (fr) 2009-04-08 2010-10-14 Deutsches Krebsforschungszentrum Fractions contenant de l'amatoxine de liaison a une cible pour le traitement du cancer
KR101671360B1 (ko) 2010-04-15 2016-11-01 시애틀 지네틱스, 인크. 표적화된 피롤로벤조디아제핀 접합체
ES2402254T3 (es) 2010-09-30 2013-04-30 Heidelberg Pharma Ag Conjugados de amatoxinas con ligadores mejorados
EP2497499A1 (fr) * 2011-03-10 2012-09-12 Heidelberg Pharma GmbH Conjugués d'amatoxine avec liens améliorés
MX359513B (es) * 2011-03-23 2018-10-01 Hutchinson Fred Cancer Res Metodo y composiciones para inmunoterapia celular.
SG194875A1 (en) 2011-05-08 2013-12-30 Legochem Biosciences Inc Protein-active agent conjugates and method for preparing the same
BR112014008981A2 (pt) 2011-10-14 2017-05-02 Spirogen Sàrl pirrolobenzodiazepinas
EA036202B1 (ru) 2011-10-14 2020-10-14 Сиэтл Дженетикс, Инк. Пирролбензодиазепины и конъюгаты направленного действия
ES2721882T3 (es) 2011-12-23 2019-08-06 Pfizer Regiones constantes de anticuerpo modificadas por ingeniería genética para conjugación específica de sitio y procedimientos y usos de las mismas
US9504756B2 (en) 2012-05-15 2016-11-29 Seattle Genetics, Inc. Self-stabilizing linker conjugates
EP2684865A1 (fr) 2012-07-13 2014-01-15 Heidelberg Pharma GmbH Procédés de synthèse de bloc de construction dýamatoxine et amatoxine
WO2014043403A1 (fr) 2012-09-12 2014-03-20 Agensys, Inc. Dérivés d'amatoxine et conjugués à base de ceux-ci, à perméabilité cellulaire, en tant qu'inhibiteurs de l'arn polymérase
US9324898B2 (en) * 2012-09-25 2016-04-26 Alliance For Sustainable Energy, Llc Varying cadmium telluride growth temperature during deposition to increase solar cell reliability
IN2015DN02913A (fr) 2012-11-30 2015-09-18 Novartis Ag
KR102503695B1 (ko) 2013-02-28 2023-02-23 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 줄기세포를 동원하기 위한 방법 및 조성물
EP2774624A1 (fr) 2013-03-04 2014-09-10 Heidelberg Pharma GmbH Dérivés d'amatoxine
EP2777714A1 (fr) 2013-03-15 2014-09-17 NBE-Therapeutics LLC Procédé de production d'un conjugué de ligand immunologique/charge utile à l'aide d'une enzyme transpeptidase spécifique pour une séquence
WO2014151030A1 (fr) * 2013-03-15 2014-09-25 Novartis Ag Inhibiteurs de la prolifération cellulaire et leurs conjugués
US9803002B2 (en) 2013-05-31 2017-10-31 Genentench, Inc. Anti-wall teichoic antibodies and conjugates
US11229711B2 (en) 2013-06-06 2022-01-25 Magenta Therapeutics, Inc. Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
US10071170B2 (en) 2013-06-24 2018-09-11 Ablbio Antibody-drug conjugate having improved stability and use thereof
FR3008408B1 (fr) 2013-07-11 2018-03-09 Mc Saf Nouveaux conjugues anticorps-medicament et leur utilisation en therapie
CN105377304B (zh) * 2014-03-10 2018-05-15 海德堡医药有限责任公司 鹅膏毒肽衍生物
CN106573074B (zh) 2014-06-02 2022-04-12 里珍纳龙药品有限公司 生物活性分子偶联物、试剂和制备方法及其治疗用途
WO2016016442A1 (fr) * 2014-08-01 2016-02-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Anticorps anti-cd45rc utile comme médicament
CN106922129B (zh) 2014-10-01 2024-02-20 免疫医疗有限责任公司 轭合多肽的方法
US20190209704A1 (en) 2014-10-20 2019-07-11 Igenica Biotherapeutics, Inc. Novel antibody-drug conjugates and related compounds, compositions and methods of use
US9938323B2 (en) 2014-11-06 2018-04-10 Novartis Ag Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase
EP3026060A1 (fr) * 2014-11-26 2016-06-01 Miltenyi Biotec GmbH Anticorps humanisé, ou fragment de celui-ci spécifique pour CD45R0
US9729129B2 (en) * 2014-12-05 2017-08-08 Bhaskar Gopalan System and method for reducing metastability in CMOS flip-flops
US20160220687A1 (en) 2015-02-02 2016-08-04 National Guard Health Affairs Metalloproteinase-cleavable alpha-amanitin-dendrimer conjugates and method of treating cancer
AU2016228415B2 (en) 2015-03-09 2021-04-01 Heidelberg Pharma Gmbh Amatoxin-antibody conjugates
BR112017021536A2 (pt) 2015-04-06 2018-07-03 Harvard College composições e métodos para o condicionamento não mieloablativo
WO2016187514A1 (fr) 2015-05-21 2016-11-24 Actinium Pharmaceueuticals, Inc. Administration par perfusion d'anticorps monoclonaux conjugués
WO2017051249A1 (fr) 2015-09-25 2017-03-30 Legochem Biosciences, Inc. Compositions et méthodes associées à des conjugués anticorps anti-cd19-médicaments
MA43354A (fr) 2015-10-16 2018-08-22 Genentech Inc Conjugués médicamenteux à pont disulfure encombré
US10723766B2 (en) 2015-11-27 2020-07-28 Heidelberg Pharma Research Gmbh Derivatives of gamma-amanitin
EP3222292A1 (fr) 2016-03-03 2017-09-27 Heidelberg Pharma GmbH Conjugués d'amanitine
EP3426305A4 (fr) 2016-03-07 2020-01-08 Actinium Pharmaceuticals, Inc. Compositions d'immunoglobulines anti-cd45 radio-marquées stabilisées
KR102295190B1 (ko) 2016-04-20 2021-08-30 항저우 디에이씨 바이오테크 씨오, 엘티디 아마니타 독소의 유도체 및 세포 결합 분자와의 그것의 결합
US10464969B2 (en) 2016-05-05 2019-11-05 Novartis Ag Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase
WO2017205587A1 (fr) 2016-05-27 2017-11-30 Actinium Pharmaceuticals, Inc. Procédés à base d'anticorps à faible dose pour le traitement de malignités hématologiques
US11013816B2 (en) 2016-05-31 2021-05-25 Sorrento Therapeutics, Inc. Antibody drug conjugates having derivatives of amatoxin as the drug
MX2018015684A (es) 2016-06-17 2019-08-29 Magenta Therapeutics Inc Composiciones y metodos para el agotamiento de celulas cd117.
WO2018039810A1 (fr) 2016-08-29 2018-03-08 Pdi Pharm Development International Ag Fourniture d'un produit cellulaire thérapeutiquement actif
US10112266B2 (en) * 2016-09-09 2018-10-30 Baltic Innovation Holding PRO, AS Pressed thermite rod for a self-contained portable cutting device
US20200040093A1 (en) * 2016-10-13 2020-02-06 President And Fellows Of Harvard College Compositions and methods for non-myeloablative conditioning
KR102455175B1 (ko) 2016-12-23 2022-10-17 하이델베르크 파마 리서치 게엠베하 아마니틴 접합체
EP3571230A4 (fr) 2017-01-20 2020-12-16 Magenta Therapeutics, Inc. Compositions et procédés pour la déplétion des cellules cd137+
KR20190109440A (ko) 2017-01-30 2019-09-25 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 줄기 세포 이식을 위한 비-유전독성 컨디셔닝 레지멘
EP3661938A1 (fr) 2017-08-07 2020-06-10 Heidelberg Pharma Research GmbH Nouveau procédé de synthèse d'amanitines

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AU2020217338A1 (en) 2020-08-27
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US20200376134A1 (en) 2020-12-03
CN109641051A (zh) 2019-04-16
WO2017219025A1 (fr) 2017-12-21
JP2019522050A (ja) 2019-08-08
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AU2017204139B2 (en) 2018-08-09
CA3028145A1 (fr) 2017-12-21
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US20190328901A1 (en) 2019-10-31
IL263743A (en) 2019-01-31
SG11201811292RA (en) 2019-01-30
EP3471772A1 (fr) 2019-04-24
MX2018015683A (es) 2019-05-27
AU2018208749A1 (en) 2018-08-16
EP3471772A4 (fr) 2020-03-18
KR20230082055A (ko) 2023-06-08
US20240207428A1 (en) 2024-06-27
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US20190192682A1 (en) 2019-06-27

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