BR112014008981A2 - pirrolobenzodiazepinas - Google Patents

pirrolobenzodiazepinas

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Publication number
BR112014008981A2
BR112014008981A2 BR112014008981A BR112014008981A BR112014008981A2 BR 112014008981 A2 BR112014008981 A2 BR 112014008981A2 BR 112014008981 A BR112014008981 A BR 112014008981A BR 112014008981 A BR112014008981 A BR 112014008981A BR 112014008981 A2 BR112014008981 A2 BR 112014008981A2
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BR
Brazil
Prior art keywords
single bond
group
halo
nitro
alkyl
Prior art date
Application number
BR112014008981A
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English (en)
Inventor
Wilson Howard Philip
Original Assignee
Spirogen Sàrl
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Publication date
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Publication of BR112014008981A2 publication Critical patent/BR112014008981A2/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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Abstract

resumo “pirrolobenzodiazepinas” um composto com a fórmula i: em que: r2 é da fórmula ii: onde a é um grupo arila c5-7, x é selecionado a partir do grupo compreendendo: nhnh2, conhnh2, , , e: q1 é uma ligação única, e q2 é selecionado a partir de uma ligação única e -z-(ch2)n-, onde z é selecionado a partir de uma ligação única, o, s e nh e n é a partir de 1 a 3; ou q1 é -ch=ch-, e q2 é uma ligação única; r12 é um grupo arila c5-10, opcionalmente substituído por um ou mais substituintes selecionados a partir do grupo compreendendo: halo, nitro, ciano, éter, alquila c1-7, heterociclila c3-7 e bis-óxi-alquileno c1-3; r6 e r9 são independentemente selecionados de h, r, oh, or, sh, sr, nh2, nhr, nrr’, nitro, me3sn e halo; onde r e r’ são independentemente selecionados de grupos alquila c1-12, heterociclila c3-20 e arila c5-20 opcionalmente substituídos; r7 é selecionado de h, r, oh, or, sh, sr, nh2, nhr, nhrr’, nitro, me3sn e halo; ou: r10 é h, e r11 é oh, ora, onde ra é alquila c1-4; r10 e r11 formam uma ligação dupla nitrogênio-carbono entre os átomos de nitrogênio e carbono aos quais eles são ligados; ou r10 é h e r11 é sozm, onde z é 2 ou 3 e m é um cátion monovalente farmaceuticamente aceitável; r” é um grupo alquileno c3-12, cuja cadeia pode ser interrompida por um ou mais heteroátomos, e/ou anéis aromáticos; y e y’ são selecionados de o, s, ou nh; r6’, r7’, r9’ são selecionados dos mesmos grupos como r6, r7 e r9 respectivamente e r10’ e r11’ são os mesmos como r10 e r11, em que se r11 e r11’ são sozm, m pode representar um cátion divalente farmaceuticamente aceitável.
BR112014008981A 2011-10-14 2012-10-12 pirrolobenzodiazepinas BR112014008981A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161547204P 2011-10-14 2011-10-14
PCT/EP2012/070231 WO2013053871A1 (en) 2011-10-14 2012-10-12 Pyrrolobenzodiazepines

Publications (1)

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BR112014008981A2 true BR112014008981A2 (pt) 2017-05-02

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ID=47019018

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BR112014008981A BR112014008981A2 (pt) 2011-10-14 2012-10-12 pirrolobenzodiazepinas

Country Status (9)

Country Link
US (1) US9388187B2 (pt)
EP (1) EP2751110B1 (pt)
JP (1) JP6117801B2 (pt)
CN (2) CN103998449A (pt)
AU (1) AU2012322932B2 (pt)
BR (1) BR112014008981A2 (pt)
CA (1) CA2850264C (pt)
EA (1) EA027386B1 (pt)
WO (1) WO2013053871A1 (pt)

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US20140234346A1 (en) 2014-08-21
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