US5776093A
(en)
*
|
1985-07-05 |
1998-07-07 |
Immunomedics, Inc. |
Method for imaging and treating organs and tissues
|
US6168778B1
(en)
|
1990-06-11 |
2001-01-02 |
Nexstar Pharmaceuticals, Inc. |
Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes
|
US6582959B2
(en)
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
US6762290B1
(en)
|
1999-07-29 |
2004-07-13 |
Gilead Sciences, Inc. |
High affinity vascular endothelial growth factor (VEGF) receptor nucleic acid ligands and inhibitors
|
US5660827A
(en)
*
|
1992-03-05 |
1997-08-26 |
Board Of Regents, The University Of Texas System |
Antibodies that bind to endoglin
|
US6036955A
(en)
*
|
1992-03-05 |
2000-03-14 |
The Scripps Research Institute |
Kits and methods for the specific coagulation of vasculature
|
US5965132A
(en)
*
|
1992-03-05 |
1999-10-12 |
Board Of Regents, The University Of Texas System |
Methods and compositions for targeting the vasculature of solid tumors
|
US6749853B1
(en)
|
1992-03-05 |
2004-06-15 |
Board Of Regents, The University Of Texas System |
Combined methods and compositions for coagulation and tumor treatment
|
US6093399A
(en)
*
|
1992-03-05 |
2000-07-25 |
Board Of Regents, The University Of Texas System |
Methods and compositions for the specific coagulation of vasculature
|
US5877289A
(en)
*
|
1992-03-05 |
1999-03-02 |
The Scripps Research Institute |
Tissue factor compositions and ligands for the specific coagulation of vasculature
|
US6004555A
(en)
*
|
1992-03-05 |
1999-12-21 |
Board Of Regents, The University Of Texas System |
Methods for the specific coagulation of vasculature
|
DE69332948T2
(de)
*
|
1992-03-05 |
2003-11-27 |
Board Of Regents, The University Of Texas System |
Verwendung von Immunokonjugate zur Diagnose und/oder Therapie der vaskularisierten Tumoren
|
US5776755A
(en)
*
|
1992-10-09 |
1998-07-07 |
Helsinki University Licensing, Ltd. |
FLT4, a receptor tyrosine kinase
|
US6107046A
(en)
*
|
1992-10-09 |
2000-08-22 |
Orion Corporation |
Antibodies to Flt4, a receptor tyrosine kinase and uses thereof
|
US6824777B1
(en)
|
1992-10-09 |
2004-11-30 |
Licentia Ltd. |
Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
|
US5712395A
(en)
*
|
1992-11-13 |
1998-01-27 |
Yissum Research Development Corp. |
Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
US5763441A
(en)
*
|
1992-11-13 |
1998-06-09 |
Sugen, Inc. |
Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
|
US5981569A
(en)
*
|
1992-11-13 |
1999-11-09 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease
|
US5792771A
(en)
*
|
1992-11-13 |
1998-08-11 |
Sugen, Inc. |
Quinazoline compounds and compositions thereof for the treatment of disease
|
DE69434115T2
(de)
*
|
1993-03-25 |
2005-10-27 |
Merck & Co., Inc. |
Inhibitor des wachstumsfaktors für gefässendothelzellen
|
US6306829B1
(en)
|
1995-12-08 |
2001-10-23 |
Hybridon, Inc. |
Modified VEGF oligonucleotides for treatment of skin disorders
|
US5731294A
(en)
*
|
1993-07-27 |
1998-03-24 |
Hybridon, Inc. |
Inhibition of neovasularization using VEGF-specific oligonucleotides
|
WO1995006131A1
(en)
*
|
1993-08-23 |
1995-03-02 |
Monash University |
A method for the assay, prophylaxis and/or treatment of human disease conditions
|
US5840301A
(en)
*
|
1994-02-10 |
1998-11-24 |
Imclone Systems Incorporated |
Methods of use of chimerized, humanized, and single chain antibodies specific to VEGF receptors
|
US6811779B2
(en)
|
1994-02-10 |
2004-11-02 |
Imclone Systems Incorporated |
Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy
|
US6448077B1
(en)
*
|
1994-02-10 |
2002-09-10 |
Imclone Systems, Inc. |
Chimeric and humanized monoclonal antibodies specific to VEGF receptors
|
AUPM379394A0
(en)
*
|
1994-02-10 |
1994-03-03 |
Ludwig Institute For Cancer Research |
Immunointeractive molecules - i
|
US5861499A
(en)
|
1994-02-10 |
1999-01-19 |
Imclone Systems Incorporated |
Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain
|
GB9410533D0
(en)
*
|
1994-05-26 |
1994-07-13 |
Lynxvale Ltd |
In situ hybridisation and immuno-Chemical localisation of a growth factor
|
NZ288235A
(en)
*
|
1994-06-09 |
1999-05-28 |
Orion Corp |
Monoclonal antibody directed against the receptor tyrosine kinase flt4 and use in diagnosis and therapy
|
WO1996006641A1
(en)
*
|
1994-08-29 |
1996-03-07 |
Prizm Pharmaceuticals, Inc. |
Conjugates of vascular endothelial growth factor with targeted agents
|
EP0804728A1
(en)
*
|
1994-12-23 |
1997-11-05 |
Ludwig Institute For Cancer Research |
Assay, receptor proteins and ligands
|
IL117645A
(en)
*
|
1995-03-30 |
2005-08-31 |
Genentech Inc |
Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
|
WO1996040629A1
(en)
*
|
1995-06-07 |
1996-12-19 |
Sugen, Inc. |
Tyrphostin-like compounds for the treatment of cell proliferative disorders or cell differentiation disorders
|
US6906093B2
(en)
|
1995-06-07 |
2005-06-14 |
Sugen, Inc. |
Indolinone combinatorial libraries and related products and methods for the treatment of disease
|
US5650415A
(en)
*
|
1995-06-07 |
1997-07-22 |
Sugen, Inc. |
Quinoline compounds
|
US5773459A
(en)
*
|
1995-06-07 |
1998-06-30 |
Sugen, Inc. |
Urea- and thiourea-type compounds
|
US6316635B1
(en)
|
1995-06-07 |
2001-11-13 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
CA2222545A1
(en)
*
|
1995-06-07 |
1996-12-19 |
Sugen, Inc. |
Quinazolines and pharmaceutical compositions
|
US6147106A
(en)
|
1997-08-20 |
2000-11-14 |
Sugen, Inc. |
Indolinone combinatorial libraries and related products and methods for the treatment of disease
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
US5710173A
(en)
*
|
1995-06-07 |
1998-01-20 |
Sugen, Inc. |
Thienyl compounds for inhibition of cell proliferative disorders
|
US5888765A
(en)
*
|
1995-06-23 |
1999-03-30 |
President And Fellows Of Harvard College |
Endothelial-cell specific promoter
|
JPH11509088A
(ja)
*
|
1995-06-23 |
1999-08-17 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
血管内皮増殖因子受容体をコードする遺伝子の転写調節
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
US5730977A
(en)
*
|
1995-08-21 |
1998-03-24 |
Mitsui Toatsu Chemicals, Inc. |
Anti-VEGF human monoclonal antibody
|
EP0848755B2
(en)
|
1995-09-08 |
2011-02-09 |
Genentech, Inc. |
Vegf-related protein
|
JPH09154588A
(ja)
*
|
1995-10-07 |
1997-06-17 |
Toagosei Co Ltd |
Vegf結合性ポリペプチド
|
US5942385A
(en)
*
|
1996-03-21 |
1999-08-24 |
Sugen, Inc. |
Method for molecular diagnosis of tumor angiogenesis and metastasis
|
US6030955A
(en)
*
|
1996-03-21 |
2000-02-29 |
The Trustees Of Columbia University In The City Of New York And Imclone Systems, Inc. |
Methods of affecting intracellular phosphorylation of tyrosine using phosphorothioate oligonucleotides, and antiangiogenic and antiproliferative uses thereof
|
US6696448B2
(en)
|
1996-06-05 |
2004-02-24 |
Sugen, Inc. |
3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
|
ES2242227T5
(es)
|
1996-07-15 |
2011-12-09 |
Chugai Seiyaku Kabushiki Kaisha |
Nuevo factor de tipo vegf.
|
US6051698A
(en)
*
|
1997-06-06 |
2000-04-18 |
Janjic; Nebojsa |
Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
|
US6426335B1
(en)
|
1997-10-17 |
2002-07-30 |
Gilead Sciences, Inc. |
Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
|
CA2275708A1
(en)
*
|
1996-12-23 |
1998-07-02 |
Cambridge University Technical Services Limited |
Diagnosis and treatment of pathological pregnancies
|
WO1998031794A1
(fr)
|
1997-01-17 |
1998-07-23 |
Toa Gosei Co., Ltd. |
Polypeptide liant le facteur vegf
|
PT988056E
(pt)
|
1997-01-22 |
2003-09-30 |
Univ Texas |
Metodos e composicoes de factor tecidual para o tratamento da coagulacao e de tumores
|
US6670337B1
(en)
|
1998-01-29 |
2003-12-30 |
Yeda Reaearch And Development Co., Ltd. |
Facilitation of wound healing with CM101/GBS toxin
|
US6028060A
(en)
|
1997-01-29 |
2000-02-22 |
Vanderbilt University |
Treatment of chronic inflammatory diseases with CM101/GBS toxin
|
US5858991A
(en)
*
|
1997-01-29 |
1999-01-12 |
Vanderbilt University |
Facilitation of wound healing with CM101/GBS toxin
|
US5981508A
(en)
|
1997-01-29 |
1999-11-09 |
Vanderbilt University |
Facilitation of repair of neural injury with CM101/GBS toxin
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
US20020032315A1
(en)
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
NZ500078A
(en)
|
1997-04-07 |
2001-10-26 |
Genentech Inc |
Humanized anti-VEGF antibodies and their use in inhibiting VEGF-induced angiogenesis in mammals
|
US7365166B2
(en)
|
1997-04-07 |
2008-04-29 |
Genentech, Inc. |
Anti-VEGF antibodies
|
US6884879B1
(en)
*
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
BRPI9809388B8
(pt)
*
|
1997-04-07 |
2021-05-25 |
Genentech Inc |
anticorpos humanizados e métodos para a formação de anticorpos humanizados.
|
US6486185B1
(en)
|
1997-05-07 |
2002-11-26 |
Sugen, Inc. |
3-heteroarylidene-2-indolinone protein kinase inhibitors
|
US6316429B1
(en)
|
1997-05-07 |
2001-11-13 |
Sugen, Inc. |
Bicyclic protein kinase inhibitors
|
WO1998051344A1
(en)
*
|
1997-05-12 |
1998-11-19 |
The Kennedy Institute Of Rheumatology |
Suppression of tumor necrosis factor alpha and vascular endothelial growth factor in therapy
|
US6987113B2
(en)
|
1997-06-11 |
2006-01-17 |
Sugen, Inc. |
Tyrosine kinase inhibitors
|
US6130238A
(en)
*
|
1997-06-20 |
2000-10-10 |
Sugen, Inc. |
3-(cyclohexanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors
|
US6114371A
(en)
*
|
1997-06-20 |
2000-09-05 |
Sugen, Inc. |
3-(cyclohexanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors
|
US6051593A
(en)
|
1997-06-20 |
2000-04-18 |
Sugen, Inc. |
3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
|
US6313158B1
(en)
|
1997-06-20 |
2001-11-06 |
Sugen, Inc. |
Bioavailability of 3-heteroarylidenyl-2-indolinones active as protein tyrosine kinase inhibitors
|
WO1999007701A1
(en)
|
1997-08-05 |
1999-02-18 |
Sugen, Inc. |
Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors
|
JPH1180024A
(ja)
*
|
1997-09-12 |
1999-03-23 |
Toagosei Co Ltd |
角膜血管新生阻害剤
|
US6133305A
(en)
|
1997-09-26 |
2000-10-17 |
Sugen, Inc. |
3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity
|
DE19744531A1
(de)
*
|
1997-10-09 |
1999-05-27 |
Klaus Dr Rer Nat Bosslet |
Bindemoleküle gegen Rezeptor-Ligand-Komplexe
|
US6455283B1
(en)
*
|
1998-03-17 |
2002-09-24 |
Genentech, Inc. |
Nucleic acids encoding vascular endothelial cell growth factor-E (VEGF-E)
|
US6225346B1
(en)
|
1997-10-24 |
2001-05-01 |
Sugen, Inc. |
Tyrphostin like compounds
|
US6531502B1
(en)
|
1998-01-21 |
2003-03-11 |
Sugen, Inc. |
3-Methylidenyl-2-indolinone modulators of protein kinase
|
EP2311495B1
(en)
|
1998-03-24 |
2014-09-24 |
Chugai Seiyaku Kabushiki Kaisha |
Vascularization inhibitors
|
US6514981B1
(en)
|
1998-04-02 |
2003-02-04 |
Sugen, Inc. |
Methods of modulating tyrosine protein kinase function with indolinone compounds
|
US6887674B1
(en)
|
1998-04-13 |
2005-05-03 |
California Institute Of Technology |
Artery- and vein-specific proteins and uses therefor
|
US6864227B1
(en)
|
1998-04-13 |
2005-03-08 |
California Institute Of Technology |
Artery-and vein-specific proteins and uses therefor
|
SK287132B6
(sk)
|
1998-05-29 |
2009-12-07 |
Sugen, Inc. |
Farmaceutická kompozícia obsahujúca pyrolom substituovaný 2-indolinón, súprava obsahujúca uvedenú kompozíciu a použitie pyrolom substituovaného 2-indolinónu
|
US6525072B1
(en)
|
1998-08-31 |
2003-02-25 |
Sugen, Inc. |
Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity
|
WO2000014105A1
(en)
|
1998-09-08 |
2000-03-16 |
Agouron Pharmaceuticals, Inc. |
Modifications of the vegf receptor-2 protein and methods of use
|
US6680335B2
(en)
|
1998-09-28 |
2004-01-20 |
Sugen, Inc. |
Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
|
JP3762222B2
(ja)
|
1998-10-07 |
2006-04-05 |
ストライカー・コーポレーション |
改変型TGF−βスーパーファミリータンパク質
|
DK1119371T3
(da)
|
1998-10-09 |
2011-03-07 |
Vegenics Ltd |
Flt4 (VEGFR-3) som et mål for tumorbilleddannelse og antitumorterapi
|
IL143596A0
(en)
*
|
1998-12-22 |
2002-04-21 |
Genentech Inc |
Vascular endothelial cell growth factor antagonists and uses thereof
|
US6689806B1
(en)
|
1999-03-24 |
2004-02-10 |
Sugen, Inc. |
Indolinone compounds as kinase inhibitors
|
US6342221B1
(en)
|
1999-04-28 |
2002-01-29 |
Board Of Regents, The University Of Texas System |
Antibody conjugate compositions for selectively inhibiting VEGF
|
US6703020B1
(en)
|
1999-04-28 |
2004-03-09 |
Board Of Regents, The University Of Texas System |
Antibody conjugate methods for selectively inhibiting VEGF
|
IT1306704B1
(it)
*
|
1999-05-26 |
2001-10-02 |
Sirs Societa Italiana Per La R |
Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf.
|
AU5250200A
(en)
*
|
1999-06-17 |
2001-01-09 |
Kyowa Hakko Kogyo Co. Ltd. |
Diagnostics and remedies for diseases with participation of macrocytes/macrophages
|
US6921763B2
(en)
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
US6878733B1
(en)
|
1999-11-24 |
2005-04-12 |
Sugen, Inc. |
Formulations for pharmaceutical agents ionizable as free acids or free bases
|
WO2001045689A2
(en)
|
1999-12-22 |
2001-06-28 |
Sugen, Inc. |
Indolinone derivatives for modulation of c-kit tyrosine protein kinase
|
MXPA02007632A
(es)
|
2000-02-07 |
2004-08-23 |
Abbott Gmbh & Co Kg |
Derivados de 2-benzotiazolil urea y su uso como inhibidores de proteina cinasa.
|
US8263739B2
(en)
|
2000-06-02 |
2012-09-11 |
Bracco Suisse Sa |
Compounds for targeting endothelial cells, compositions containing the same and methods for their use
|
EP2286843A3
(en)
|
2000-06-02 |
2011-08-03 |
Bracco Suisse SA |
Compounds for targeting endothelial cells
|
US6726918B1
(en)
|
2000-07-05 |
2004-04-27 |
Oculex Pharmaceuticals, Inc. |
Methods for treating inflammation-mediated conditions of the eye
|
EP1311277A4
(en)
*
|
2000-07-18 |
2004-08-25 |
Joslin Diabetes Center Inc |
FIBROSIS MODULATION METHOD
|
AU3649502A
(en)
|
2000-11-29 |
2002-06-11 |
Oculex Pharm Inc |
Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
|
JP4669984B2
(ja)
|
2001-01-19 |
2011-04-13 |
ベジェニクス リミテッド |
腫瘍画像化のターゲットとしてのF1t4(VEGFR−3)および抗腫瘍療法
|
LT3351246T
(lt)
|
2001-02-19 |
2019-07-10 |
Novartis Pharma Ag |
Rapamicino darinys, skirtas kieto naviko, susijusio su nereguliuojama angiogeneze, gydymui
|
MXPA03008560A
(es)
|
2001-03-22 |
2004-06-30 |
Abbot Gmbh & Co Kg |
Pirazolopirimidinas como agentes terapeuticos.
|
SK14042003A3
(sk)
|
2001-05-16 |
2004-05-04 |
Novartis Ag |
Kombinácia N-{5-[4-metylpiperazinometyl)benzoylamido]-2- metylfenyl}-4-(3-pyridyl)-2-pyrimidínamínu chemoterapeutického činidla a farmaceutický prostriedok, ktorý ju obsahuje
|
WO2002102972A2
(en)
|
2001-06-20 |
2002-12-27 |
Prochon Biotech Ltd. |
Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
|
TWI315982B
(en)
|
2001-07-19 |
2009-10-21 |
Novartis Ag |
Combinations comprising epothilones and pharmaceutical uses thereof
|
US7005444B2
(en)
|
2001-09-27 |
2006-02-28 |
Allergan, Inc. |
3-(heteroarylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors
|
AU2002341881B2
(en)
|
2001-09-27 |
2008-05-08 |
Allergan, Inc. |
3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
|
US20050123925A1
(en)
|
2002-11-15 |
2005-06-09 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
US7211240B2
(en)
|
2002-03-01 |
2007-05-01 |
Bracco International B.V. |
Multivalent constructs for therapeutic and diagnostic applications
|
US8623822B2
(en)
|
2002-03-01 |
2014-01-07 |
Bracco Suisse Sa |
KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
|
US7666979B2
(en)
|
2002-03-01 |
2010-02-23 |
Bracco International B.V. |
Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
|
EP1587944A4
(en)
|
2002-03-01 |
2007-03-21 |
Dyax Corp |
KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
|
US7794693B2
(en)
|
2002-03-01 |
2010-09-14 |
Bracco International B.V. |
Targeting vector-phospholipid conjugates
|
US7985402B2
(en)
|
2002-03-01 |
2011-07-26 |
Bracco Suisse Sa |
Targeting vector-phospholipid conjugates
|
US7261876B2
(en)
|
2002-03-01 |
2007-08-28 |
Bracco International Bv |
Multivalent constructs for therapeutic and diagnostic applications
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
US6541504B1
(en)
|
2002-04-03 |
2003-04-01 |
Allergan Sales, Llc |
(3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
|
EP1944026B1
(en)
|
2002-05-16 |
2013-06-26 |
Novartis AG |
Use of EDG receptor binding agents in cancer
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
SI1523496T1
(sl)
|
2002-07-18 |
2011-11-30 |
Merus B V |
Rekombinantno proizvajanje zmesi protiteles
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
WO2004045531A2
(en)
|
2002-11-14 |
2004-06-03 |
Cornell Research Foundation, Inc. |
Protection of cardiac myocardium
|
US6699863B1
(en)
|
2002-11-27 |
2004-03-02 |
Allergan, Inc. |
Kinase inhibitors for the treatment of disease
|
US6747025B1
(en)
|
2002-11-27 |
2004-06-08 |
Allergan, Inc. |
Kinase inhibitors for the treatment of disease
|
CU23204A1
(es)
*
|
2002-12-27 |
2007-05-18 |
Ct Ingenieria Genetica Biotech |
Combinaciones de factores reguladores del crecimiento y hormonas para el tratamiento de neoplasias
|
US20050048099A1
(en)
|
2003-01-09 |
2005-03-03 |
Allergan, Inc. |
Ocular implant made by a double extrusion process
|
DK1603570T5
(da)
|
2003-02-26 |
2013-12-09 |
Sugen Inc |
Aminoheteroarylforbindelser som proteinkinaseinhibitorer
|
DK2949658T3
(en)
|
2003-03-03 |
2018-10-01 |
Dyax Corp |
Peptides that specifically bind HGF receptor (cMet) and uses thereof
|
JP2006521111A
(ja)
|
2003-03-12 |
2006-09-21 |
バスジーン セラピューティクス, インコーポレイテッド |
血管形成及び腫瘍増殖阻害用ポリペプチド化合物及びその応用
|
US7381410B2
(en)
|
2003-03-12 |
2008-06-03 |
Vasgene Therapeutics, Inc. |
Polypeptide compounds for inhibiting angiogenesis and tumor growth
|
SI2368553T1
(sl)
|
2003-04-08 |
2015-05-29 |
Progenics Pharmaceuticals, Inc. |
Farmacevtske formulacije, vsebujoče metilnatrekson
|
CL2004001120A1
(es)
|
2003-05-19 |
2005-04-15 |
Irm Llc |
Compuestos derivados de amina sustituidas con heterociclos, inmunosupresores; composicion farmaceutica; y uso para tratar enfermedades mediadas por interacciones de linfocito, tales como enfermedades autoinmunes, inflamatorias, infecciosas, cancer.
|
MY150088A
(en)
|
2003-05-19 |
2013-11-29 |
Irm Llc |
Immunosuppressant compounds and compositions
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
AU2004242614B2
(en)
|
2003-05-30 |
2011-09-22 |
Merus N.V. |
Fab library for the preparation of anti vegf and anti rabies virus fabs
|
KR20120104408A
(ko)
|
2003-05-30 |
2012-09-20 |
제넨테크, 인크. |
항-vegf 항체를 사용한 치료
|
BRPI0411250A
(pt)
|
2003-06-09 |
2006-08-29 |
Samuel Waksal |
método de inibição de receptor tirosina cinase com um antagonista extracelular e um antagonista intracellular
|
CA2534509A1
(en)
|
2003-08-06 |
2005-02-24 |
Sugen, Inc. |
Geometrically restricted 3-cyclopentylidene-1,3-dihydroindol-2-ones as potent protein kinase inhibitors
|
GB0320238D0
(en)
*
|
2003-08-29 |
2003-10-01 |
Medical Res Council |
Treatment of disease
|
CA2545187A1
(en)
*
|
2003-11-10 |
2005-05-26 |
Greenville Hospital System |
Vegf receptor antagonists
|
KR20070034465A
(ko)
|
2004-03-12 |
2007-03-28 |
바스진 테라퓨틱스, 인크. |
혈관형성 및 종양 성장을 억제하기 위한 폴리펩티드 화합물
|
NZ549787A
(en)
|
2004-03-12 |
2010-05-28 |
Vasgene Therapeutics Inc |
Antibodies binding to EphB4 for inhibiting angiogenesis and tumor growth
|
US8685435B2
(en)
|
2004-04-30 |
2014-04-01 |
Allergan, Inc. |
Extended release biodegradable ocular implants
|
US20050244469A1
(en)
|
2004-04-30 |
2005-11-03 |
Allergan, Inc. |
Extended therapeutic effect ocular implant treatments
|
EA012622B1
(ru)
|
2004-06-01 |
2009-10-30 |
Домэнтис Лимитед |
Биспецифичные гибридные антитела с увеличенным периодом полувыведения из сыворотки
|
GB0512324D0
(en)
|
2005-06-16 |
2005-07-27 |
Novartis Ag |
Organic compounds
|
SI1771474T1
(sl)
|
2004-07-20 |
2010-06-30 |
Genentech Inc |
Inhibitorji angiopoetinu podobnega proteina kombinacije in njihova uporaba
|
US8604185B2
(en)
|
2004-07-20 |
2013-12-10 |
Genentech, Inc. |
Inhibitors of angiopoietin-like 4 protein, combinations, and their use
|
BRPI0515264B1
(pt)
|
2004-09-13 |
2018-12-18 |
Genzyme Corp |
proteína de fusão de acordo com fórmula x-y-z, composição, molécula de ácido nucleico, seus usos e método de multimerização de um polipeptídeo x
|
WO2006034455A2
(en)
|
2004-09-23 |
2006-03-30 |
Vasgene Therapeutics, Inc. |
Polipeptide compounds for inhibiting angiogenesis and tumor growth
|
EP2311433A3
(en)
|
2004-10-21 |
2011-08-10 |
Genentech, Inc. |
Method for treating intraocular neovascular diseases
|
SI1819358T1
(sl)
|
2004-11-18 |
2014-10-30 |
Imclone Llc |
Protitelesa proti receptorju 1 za vaskularni endotelijski rastni dejavnik (vegfr-1)
|
US20080161251A1
(en)
|
2005-01-21 |
2008-07-03 |
Astex Therapeutics Limited |
Pharmaceutical Compounds
|
US8518962B2
(en)
|
2005-03-07 |
2013-08-27 |
The University Of Chicago |
Use of opioid antagonists
|
US8524731B2
(en)
|
2005-03-07 |
2013-09-03 |
The University Of Chicago |
Use of opioid antagonists to attenuate endothelial cell proliferation and migration
|
US9662325B2
(en)
|
2005-03-07 |
2017-05-30 |
The University Of Chicago |
Use of opioid antagonists to attenuate endothelial cell proliferation and migration
|
ES2714198T3
(es)
|
2005-03-07 |
2019-05-27 |
Univ Chicago |
Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
AR057035A1
(es)
|
2005-05-25 |
2007-11-14 |
Progenics Pharm Inc |
SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
|
AR057325A1
(es)
|
2005-05-25 |
2007-11-28 |
Progenics Pharm Inc |
Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
|
WO2007038459A2
(en)
|
2005-09-27 |
2007-04-05 |
Novartis Ag |
Carboxyamine compounds and their use in the treatment of hdac dependent diseases
|
JP2009516671A
(ja)
|
2005-11-21 |
2009-04-23 |
ノバルティス アクチエンゲゼルシャフト |
mTOR阻害剤を使用する神経内分泌腫瘍処置
|
KR101589391B1
(ko)
|
2006-01-05 |
2016-01-29 |
제넨테크, 인크. |
항-ephb4 항체 및 그의 사용 방법
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
US8338415B2
(en)
|
2006-01-24 |
2012-12-25 |
Allergan, Inc. |
Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-one's and derivatives thereof as kinase inhibitors
|
TW200812615A
(en)
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
US7977351B2
(en)
|
2006-03-22 |
2011-07-12 |
Allergan, Inc. |
Heteroaryl dihydroindolones as kinase inhibitors
|
MX2008012715A
(es)
|
2006-04-05 |
2008-10-14 |
Novartis Ag |
Combinaciones de agentes terapeuticos para el tratamiento de cancer.
|
TW200808739A
(en)
|
2006-04-06 |
2008-02-16 |
Novartis Vaccines & Diagnostic |
Quinazolines for PDK1 inhibition
|
PE20080695A1
(es)
|
2006-04-27 |
2008-06-28 |
Banyu Pharma Co Ltd |
Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
|
WO2007128820A1
(en)
|
2006-05-09 |
2007-11-15 |
Novartis Ag |
Combination comprising an iron chelator and an anti-neoplastic agent and use thereof
|
AU2007319672B2
(en)
|
2006-06-06 |
2011-06-30 |
Genentech, Inc. |
Anti-DLL4 antibodies and methods using same
|
GB0612721D0
(en)
|
2006-06-27 |
2006-08-09 |
Novartis Ag |
Organic compounds
|
US20080050385A1
(en)
|
2006-08-21 |
2008-02-28 |
Thomas Friess |
Tumor therapy with an anti-vegf antibody
|
JP2008081492A
(ja)
|
2006-08-31 |
2008-04-10 |
Banyu Pharmaceut Co Ltd |
オーロラa選択的阻害作用を有する新規アミノピリジン誘導体
|
DE602007013441D1
(de)
|
2006-09-29 |
2011-05-05 |
Novartis Ag |
Pyrazolopyrimidine als pi3k-lipidkinasehemmer
|
JP5528806B2
(ja)
|
2006-10-12 |
2014-06-25 |
アステックス、セラピューティックス、リミテッド |
複合薬剤
|
EP2073807A1
(en)
|
2006-10-12 |
2009-07-01 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
CA2669704A1
(en)
|
2006-11-16 |
2008-05-22 |
Allergan, Inc. |
Sulfoximines as kinase inhibitors
|
US8558002B2
(en)
|
2006-11-16 |
2013-10-15 |
Allergan, Inc. |
Sulfoximines as kinase inhibitors
|
SI2101807T1
(sl)
|
2006-12-19 |
2016-08-31 |
Genentech, Inc. |
VEGF-specifični antagonisti za adjuvansno in neoadjuvansno terapijo in zdravljenje tumorjev v zgodnjem stadiju
|
US7977336B2
(en)
|
2006-12-28 |
2011-07-12 |
Banyu Pharmaceutical Co. Ltd |
Aminopyrimidine derivatives as PLK1 inhibitors
|
KR20090110913A
(ko)
|
2007-02-15 |
2009-10-23 |
노파르티스 아게 |
Lbh589와 암을 치료하기 위한 다른 치료제와의 조합물
|
EP3064503A1
(en)
|
2007-03-29 |
2016-09-07 |
Progenics Pharmaceuticals, Inc. |
Peripheral opioid receptor antagonists and uses thereof
|
PT2139890E
(pt)
|
2007-03-29 |
2014-09-03 |
Wyeth Llc |
Antagonistas do receptor opióide periférico e respectivas utilizações
|
MX2009010550A
(es)
|
2007-03-29 |
2009-12-14 |
Progenics Pharm Inc |
Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
|
US8318163B2
(en)
|
2007-05-17 |
2012-11-27 |
Genentech, Inc. |
Anti-pan neuropilin antibody and binding fragments thereof
|
US8231892B2
(en)
|
2007-05-24 |
2012-07-31 |
Allergan, Inc. |
Biodegradable drug delivery system
|
PE20090321A1
(es)
|
2007-06-04 |
2009-04-20 |
Genentech Inc |
Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
|
KR100883430B1
(ko)
|
2007-06-13 |
2009-02-12 |
한국생명공학연구원 |
혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도
|
EP2185594B1
(en)
|
2007-08-13 |
2016-04-06 |
VasGene Therapeutics, Inc. |
Cancer treatment using humanized antibodies that bind to ephb4
|
JPWO2009054332A1
(ja)
|
2007-10-23 |
2011-03-03 |
萬有製薬株式会社 |
ピリドン置換ジヒドロピラゾロピリミジノン誘導体
|
AU2008324789A1
(en)
|
2007-11-09 |
2009-05-14 |
Genentech, Inc. |
Activin receptor-like kinase-1 antagonist compositions and methods of use
|
CN103169973A
(zh)
|
2007-11-12 |
2013-06-26 |
彼帕科学公司 |
使用4-碘-3-硝基苯甲酰胺化合物与抗肿瘤剂组合治疗乳腺癌
|
AR069501A1
(es)
|
2007-11-30 |
2010-01-27 |
Genentech Inc |
Anticuerpos anti- vegf (factor de crecimiento endotelial vascular)
|
AU2008340053A1
(en)
|
2007-12-20 |
2009-07-02 |
Novartis Ag |
Thiazole derivatives used as PI 3 kinase inhibitors
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
CA2713568C
(en)
|
2008-02-06 |
2016-09-20 |
Progenics Pharmaceuticals, Inc. |
Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
|
WO2009117669A2
(en)
|
2008-03-21 |
2009-09-24 |
The University Of Chicago |
Treatment with opioid antagonists and mtor inhibitors
|
EA019033B1
(ru)
|
2008-03-26 |
2013-12-30 |
Новартис Аг |
Ингибиторы дезацетилазы в, основанные на гидроксамате
|
SI2274008T1
(sl)
|
2008-03-27 |
2014-08-29 |
Zymogenetics, Inc. |
Sestavki in metode za zaviranje PDGFRBETA in VEGF-A
|
EP3216803B1
(en)
|
2008-06-25 |
2020-03-11 |
Novartis Ag |
Stable and soluble antibodies inhibiting vegf
|
WO2010010153A1
(en)
|
2008-07-23 |
2010-01-28 |
F. Hoffmann-La Roche Ag |
Identification of subjects being susceptible to anti-angiogenesis therapy
|
CA2676881C
(en)
|
2008-09-30 |
2017-04-25 |
Wyeth |
Peripheral opioid receptor antagonists and uses thereof
|
US8268314B2
(en)
|
2008-10-08 |
2012-09-18 |
Hoffmann-La Roche Inc. |
Bispecific anti-VEGF/anti-ANG-2 antibodies
|
PE20110707A1
(es)
|
2008-10-14 |
2011-10-11 |
Genentech Inc |
Variantes de inmunoglobulinas
|
EP2344161B1
(en)
|
2008-10-16 |
2018-12-19 |
Celator Pharmaceuticals, Inc. |
Combinations of a liposomal water-soluble camptothecin with cetuximab or bevacizumab
|
AU2009316409A1
(en)
|
2008-11-22 |
2010-05-27 |
Genentech, Inc. |
Use of anti-VEGF antibody in combination with chemotherapy for treating breast cancer
|
RU2011129229A
(ru)
|
2008-12-18 |
2013-01-27 |
Новартис Аг |
Новые соли
|
IL294514A
(en)
|
2008-12-18 |
2022-09-01 |
Novartis Ag |
1-[4-[1[(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl]-azetidine-3-carboxylic acid mipomarate salt
|
CA2746764A1
(en)
|
2008-12-18 |
2010-06-24 |
Novartis Ag |
New polymorphic form of 1- (4- { l- [ (e) -4-cyclohexyl--3-trifluoromethyl-benzyloxyimino] -ethyl) -2-ethyl-benzy l) -azetidine-3-carboxylic
|
KR20140020368A
(ko)
|
2008-12-23 |
2014-02-18 |
제넨테크, 인크. |
암 환자에서의 진단 목적용 방법 및 조성물
|
PT2391366E
(pt)
|
2009-01-29 |
2013-02-05 |
Novartis Ag |
Benzimidazoles substituídos para o tratamento de astrocitomas
|
WO2010091234A2
(en)
|
2009-02-06 |
2010-08-12 |
The General Hospital Corporation |
Methods of treating vascular lesions
|
JP2012518598A
(ja)
|
2009-02-25 |
2012-08-16 |
Msd株式会社 |
ピリミドピリミドインダゾール誘導体
|
EP2403339B1
(en)
|
2009-03-06 |
2017-01-18 |
Merck Sharp & Dohme Corp. |
Combination cancer therapy with an akt inhibitor and other anticancer agents
|
SG175004A1
(en)
|
2009-04-02 |
2011-11-28 |
Roche Glycart Ag |
Multispecific antibodies comprising full length antibodies and single chain fab fragments
|
WO2010115589A1
(en)
|
2009-04-07 |
2010-10-14 |
Roche Glycart Ag |
Trivalent, bispecific antibodies
|
MX2011010570A
(es)
|
2009-05-08 |
2011-10-19 |
Genentech Inc |
Anticuerpos anti-egfl7 humanizados y metodos de uso de los mismos.
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
GEP20156250B
(en)
|
2009-06-26 |
2015-02-25 |
Novartis Ag |
1,3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
|
EP2450055B1
(en)
*
|
2009-06-30 |
2018-01-03 |
Obshestvo S OgranichennoyOtvetstvennostiu"OncoMax" |
Method for suppressing renal tumor growth by blocking fibroblast growth factor receptor
|
US8293753B2
(en)
|
2009-07-02 |
2012-10-23 |
Novartis Ag |
Substituted 2-carboxamide cycloamino ureas
|
JP6095367B2
(ja)
|
2009-07-13 |
2017-03-15 |
ジェネンテック, インコーポレイテッド |
癌治療のための診断方法および組成物
|
TW201106972A
(en)
|
2009-07-27 |
2011-03-01 |
Genentech Inc |
Combination treatments
|
EP2459591B1
(en)
|
2009-07-31 |
2014-08-20 |
Genentech, Inc. |
Inhibition of tumor metastasis using anti-g-csf-antibodies
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
EP2464649A1
(en)
|
2009-08-12 |
2012-06-20 |
Novartis AG |
Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
|
CN102573909A
(zh)
|
2009-08-15 |
2012-07-11 |
霍夫曼-拉罗奇有限公司 |
抗血管发生疗法用于治疗先前治疗过的乳腺癌
|
NZ598220A
(en)
|
2009-08-17 |
2014-02-28 |
Intellikine Llc |
Heterocyclic compounds and uses thereof
|
CA2771432A1
(en)
|
2009-08-20 |
2011-02-24 |
Novartis Ag |
Heterocyclic oxime compounds
|
EA201200321A1
(ru)
|
2009-08-26 |
2012-09-28 |
Новартис Аг |
Тетразамещенные гетероарильные соединения и их применение в качестве модуляторов mdm2 и/или mdm4
|
WO2011028642A1
(en)
|
2009-09-04 |
2011-03-10 |
University Of Louisville Research Foundation, Inc. |
Genetic determinants of prostate cancer risk
|
MX2012002997A
(es)
|
2009-09-10 |
2012-08-01 |
Novartis Ag |
Derivados de eter de los heteroarilos biciclicos.
|
CN102597776A
(zh)
|
2009-09-11 |
2012-07-18 |
霍夫曼-拉罗奇有限公司 |
鉴定响应抗癌剂的可能性升高的患者的方法
|
RU2573915C2
(ru)
|
2009-09-16 |
2016-01-27 |
Дженентек, Инк. |
Содержащие суперспираль и/или привязку белковые комплексы и их применение
|
CN102612566B
(zh)
|
2009-09-17 |
2016-02-17 |
霍夫曼-拉罗奇有限公司 |
用于癌症患者中诊断学用途的方法和组合物
|
WO2011056497A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Activin receptor type iib compositions and methods of use
|
WO2011056502A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Bone morphogenetic protein receptor type ii compositions and methods of use
|
PE20121471A1
(es)
|
2009-11-04 |
2012-11-01 |
Novartis Ag |
Derivados de sulfonamida heterociclicos utiles como inhibidores de mek
|
US20120289501A1
(en)
|
2009-11-25 |
2012-11-15 |
Novartis Ag |
Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls
|
PE20121384A1
(es)
|
2009-12-08 |
2012-10-13 |
Novartis Ag |
Derivados de sulfonamida heterociclicos
|
ES2565208T3
(es)
|
2009-12-11 |
2016-04-01 |
F. Hoffmann-La Roche Ag |
Anticuerpos anti-VEGF-C y métodos de uso de los mismos
|
RU2609658C2
(ru)
|
2009-12-21 |
2017-02-02 |
Дженентек, Инк. |
Состав, содержащий антитело
|
US8440693B2
(en)
|
2009-12-22 |
2013-05-14 |
Novartis Ag |
Substituted isoquinolinones and quinazolinones
|
CU24130B1
(es)
|
2009-12-22 |
2015-09-29 |
Novartis Ag |
Isoquinolinonas y quinazolinonas sustituidas
|
CN103068849B
(zh)
|
2009-12-23 |
2016-04-06 |
霍夫曼-拉罗奇有限公司 |
抗Bv8抗体及其用途
|
RU2012140447A
(ru)
|
2010-02-23 |
2014-03-27 |
Дженентек, Инк. |
Антиангиогенная терапия для лечения рака яичника
|
AR080794A1
(es)
|
2010-03-26 |
2012-05-09 |
Hoffmann La Roche |
Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2
|
AR080793A1
(es)
|
2010-03-26 |
2012-05-09 |
Roche Glycart Ag |
Anticuerpos biespecificos
|
WO2011153224A2
(en)
|
2010-06-02 |
2011-12-08 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
WO2011153243A2
(en)
|
2010-06-02 |
2011-12-08 |
Genentech, Inc. |
Anti-angiogenesis therapy for treating gastric cancer
|
JP2013532149A
(ja)
|
2010-06-17 |
2013-08-15 |
ノバルティス アーゲー |
ピペリジニル置換1,3−ジヒドロ−ベンゾイミダゾール−2−イリデンアミン誘導体
|
EP2582680A1
(en)
|
2010-06-17 |
2013-04-24 |
Novartis AG |
Biphenyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
|
KR20130091745A
(ko)
|
2010-07-19 |
2013-08-19 |
에프. 호프만-라 로슈 아게 |
항암요법에 반응할 가능성이 증가된 환자를 확인하는 방법
|
WO2012010549A1
(en)
|
2010-07-19 |
2012-01-26 |
F. Hoffmann-La Roche Ag |
Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy
|
AR082418A1
(es)
|
2010-08-02 |
2012-12-05 |
Novartis Ag |
Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
|
LT2601214T
(lt)
|
2010-08-06 |
2018-02-26 |
Genzyme Corporation |
Vegf antagonistų kompozicijos ir jų panaudojimas
|
AR082693A1
(es)
|
2010-08-17 |
2012-12-26 |
Roche Glycart Ag |
Terapia de combinacion de un anticuerpo anti-cd20 afucosilado con un anticuerpo anti-vegf
|
CA2807278A1
(en)
|
2010-08-24 |
2012-03-01 |
F. Hoffmann - La Roche Ag |
Bispecific antibodies comprising a disulfide stabilized - fv fragment
|
EP2627648A1
(en)
|
2010-09-16 |
2013-08-21 |
Novartis AG |
17aHYDROXYLASE/C17,20-LYASE INHIBITORS
|
EP2447301A1
(de)
|
2010-10-29 |
2012-05-02 |
Rhein Chemie Rheinau GmbH |
Verfahren zur Herstellung von Gusspolyamiden
|
JP5945277B2
(ja)
|
2010-11-15 |
2016-07-05 |
ファイブ プライム セラピューティックス インコーポレイテッド |
Fgfr1細胞外ドメイン併用療法
|
EP2655413B1
(en)
|
2010-12-23 |
2019-01-16 |
F.Hoffmann-La Roche Ag |
Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
|
WO2012092539A2
(en)
|
2010-12-31 |
2012-07-05 |
Takeda Pharmaceutical Company Limited |
Antibodies to dll4 and uses thereof
|
AU2012213080B2
(en)
|
2011-01-31 |
2014-03-27 |
Novartis Ag |
Novel heterocyclic derivatives
|
JP2014505088A
(ja)
|
2011-02-10 |
2014-02-27 |
ノバルティス アーゲー |
C−METチロシンキナーゼ阻害剤としての[1,2,4]トリアゾロ[4,3−b]ピリダジン化合物
|
JP5808826B2
(ja)
|
2011-02-23 |
2015-11-10 |
インテリカイン, エルエルシー |
複素環化合物およびその使用
|
RU2607038C2
(ru)
|
2011-02-28 |
2017-01-10 |
Ф. Хоффманн-Ля Рош Аг |
Антигенсвязывающие белки
|
CA2824824A1
(en)
|
2011-02-28 |
2012-09-07 |
F. Hoffmann-La Roche Ag |
Monovalent antigen binding proteins
|
US20130338152A1
(en)
|
2011-03-08 |
2013-12-19 |
Irm Llc |
Fluorophenyl bicyclic heteroaryl compounds
|
ES2692268T3
(es)
|
2011-03-29 |
2018-12-03 |
Roche Glycart Ag |
Variantes de Fc de anticuerpo
|
HUE036513T2
(hu)
|
2011-04-01 |
2018-07-30 |
Genentech Inc |
AKT inhibitor vegyület és abirateron kombinációja terápiás kezelésekben való alkalmazásra
|
CN108341863A
(zh)
|
2011-04-20 |
2018-07-31 |
阿塞勒隆制药公司 |
内皮糖蛋白多肽及其用途
|
ES2656218T3
(es)
|
2011-04-28 |
2018-02-26 |
Novartis Ag |
Inhibidores de 17 alfa-hidroxilasa/C17,20-liasa
|
WO2012151317A1
(en)
|
2011-05-03 |
2012-11-08 |
Genentech, Inc. |
Vascular disruption agents and uses thereof
|
EA201391820A1
(ru)
|
2011-06-09 |
2014-12-30 |
Новартис Аг |
Гетероциклические сульфонамидные производные
|
WO2012175520A1
(en)
|
2011-06-20 |
2012-12-27 |
Novartis Ag |
Hydroxy substituted isoquinolinone derivatives
|
US8859586B2
(en)
|
2011-06-20 |
2014-10-14 |
Novartis Ag |
Cyclohexyl isoquinolinone compounds
|
MX2014001736A
(es)
|
2011-08-17 |
2014-03-31 |
Genentech Inc |
Inhibicion de angiogenesis en tumores refractarios.
|
UY34329A
(es)
|
2011-09-15 |
2013-04-30 |
Novartis Ag |
Compuestos de triazolopiridina
|
WO2013061305A1
(en)
|
2011-10-28 |
2013-05-02 |
Novartis Ag |
Novel purine derivatives and their use in the treatment of disease
|
JP5992054B2
(ja)
|
2011-11-29 |
2016-09-14 |
ノバルティス アーゲー |
ピラゾロピロリジン化合物
|
WO2013082511A1
(en)
|
2011-12-02 |
2013-06-06 |
Genentech, Inc. |
Methods for overcoming tumor resistance to vegf antagonists
|
BR112014015322A2
(pt)
|
2011-12-23 |
2017-06-13 |
Novartis Ag |
compostos e composições para inibir a interação de bcl2 com parceiros de ligação
|
MX2014007729A
(es)
|
2011-12-23 |
2015-01-12 |
Novartis Ag |
Compuestos para inhibir la interaccion de bcl2 con los componentes de enlace.
|
BR112014015339A2
(pt)
|
2011-12-23 |
2017-06-13 |
Novartis Ag |
compostos para inibição da interação de bcl2 com parceiros de ligação
|
JP2015503517A
(ja)
|
2011-12-23 |
2015-02-02 |
ノバルティス アーゲー |
Bcl2と結合相手の相互作用を阻害するための化合物
|
JP2015503516A
(ja)
|
2011-12-23 |
2015-02-02 |
ノバルティス アーゲー |
Bcl2と結合相手の相互作用を阻害するための化合物
|
UY34591A
(es)
|
2012-01-26 |
2013-09-02 |
Novartis Ag |
Compuestos de imidazopirrolidinona
|
JP6486686B2
(ja)
|
2012-02-10 |
2019-03-20 |
ジェネンテック, インコーポレイテッド |
単鎖抗体及び他のヘテロ多量体
|
PT2825558T
(pt)
|
2012-03-13 |
2019-07-11 |
Hoffmann La Roche |
Terapêutica combinada para o tratamento do cancro do ovário
|
CN104245701A
(zh)
|
2012-04-03 |
2014-12-24 |
诺华有限公司 |
有酪氨酸激酶抑制剂的组合产品和其应用
|
EA035344B1
(ru)
|
2012-04-20 |
2020-05-29 |
Мерюс Н.В. |
Способ получения двух антител из одной клетки-хозяина
|
EP2849756A1
(en)
|
2012-05-16 |
2015-03-25 |
Novartis AG |
Dosage regimen for a pi-3 kinase inhibitor
|
WO2013175417A1
(en)
|
2012-05-24 |
2013-11-28 |
Novartis Ag |
Pyrrolopyrrolidinone compounds
|
BR112014029887A8
(pt)
|
2012-05-31 |
2021-09-14 |
Genentech Inc |
Método para tratar ou retardar a progressão do câncer, kits e uso de um antagonista de ligação do eixo pd-1, oxaliplatina, leucovorina e 5-fu
|
CN104395339A
(zh)
|
2012-06-27 |
2015-03-04 |
弗·哈夫曼-拉罗切有限公司 |
用于选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途
|
CA2871882A1
(en)
|
2012-06-27 |
2014-01-03 |
F. Hoffmann-La Roche Ag |
Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
|
RS62509B1
(sr)
|
2012-07-13 |
2021-11-30 |
Roche Glycart Ag |
Bispecifična anti-vegf/anti-ang-2 antitela i njihova upotreba u lečenju očnih vaskularnih bolesti
|
KR20190088571A
(ko)
|
2012-08-07 |
2019-07-26 |
제넨테크, 인크. |
교모세포종의 치료를 위한 조합 요법
|
CA2930987A1
(en)
|
2013-01-11 |
2014-07-17 |
Massachusetts Eye And Ear Infirmary |
Cyp450 lipid metabolites reduce inflammation and angiogenesis
|
WO2014115080A1
(en)
|
2013-01-22 |
2014-07-31 |
Novartis Ag |
Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction
|
EP2948451B1
(en)
|
2013-01-22 |
2017-07-12 |
Novartis AG |
Substituted purinone compounds
|
NZ710658A
(en)
|
2013-02-18 |
2019-12-20 |
Vegenics Pty Ltd |
Ligand binding molecules and uses thereof
|
BR112015022210A8
(pt)
|
2013-03-13 |
2018-01-23 |
Genentech Inc |
formulações de anticorpo
|
EP2968340A4
(en)
|
2013-03-15 |
2016-08-10 |
Intellikine Llc |
COMBINING KINASE INHIBITORS AND USES THEREOF
|
WO2014155268A2
(en)
|
2013-03-25 |
2014-10-02 |
Novartis Ag |
Fgf-r tyrosine kinase activity inhibitors - use in diseases associated with lack of or reduced snf5 activity
|
MX2015015426A
(es)
|
2013-05-23 |
2016-06-10 |
Five Prime Therapeutics Inc |
Metodos de tratamiento de cancer.
|
CN104341504B
(zh)
|
2013-08-06 |
2017-10-24 |
百奥泰生物科技(广州)有限公司 |
双特异性抗体
|
US9227969B2
(en)
|
2013-08-14 |
2016-01-05 |
Novartis Ag |
Compounds and compositions as inhibitors of MEK
|
WO2015022663A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
WO2015022664A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
US10617755B2
(en)
|
2013-08-30 |
2020-04-14 |
Genentech, Inc. |
Combination therapy for the treatment of glioblastoma
|
US10456470B2
(en)
|
2013-08-30 |
2019-10-29 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of glioblastoma
|
EP3055329B1
(en)
|
2013-10-11 |
2018-06-13 |
F. Hoffmann-La Roche AG |
Multispecific domain exchanged common variable light chain antibodies
|
KR20220013459A
(ko)
|
2013-10-25 |
2022-02-04 |
악셀레론 파마 인코포레이티드 |
섬유화 질환을 치료하기 위한 엔도글린 펩티드
|
WO2015071348A1
(en)
|
2013-11-18 |
2015-05-21 |
Formycon Ag |
Pharmaceutical composition of an anti-vegf antibody
|
TW201605450A
(zh)
|
2013-12-03 |
2016-02-16 |
諾華公司 |
Mdm2抑制劑與BRAF抑制劑之組合及其用途
|
KR20160095035A
(ko)
|
2013-12-06 |
2016-08-10 |
노파르티스 아게 |
알파-이소형 선택성 포스파티딜이노시톨 3-키나제 억제제를 위한 투여 요법
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
SG11201606714TA
(en)
|
2014-02-14 |
2016-09-29 |
Andrew S Chi |
Improved methods for the treatment of vascularizing cancers
|
SI3116909T1
(sl)
|
2014-03-14 |
2020-03-31 |
Novartis Ag |
Molekule protiteles na LAG-3 in njih uporaba
|
MA39776A
(fr)
|
2014-03-24 |
2017-02-01 |
Hoffmann La Roche |
Traitement du cancer avec des antagonistes de c-met et corrélation de ces derniers avec l'expression de hgf
|
AU2015241038A1
(en)
|
2014-03-31 |
2016-10-13 |
Genentech, Inc. |
Combination therapy comprising anti-angiogenesis agents and OX40 binding agonists
|
KR20170003973A
(ko)
|
2014-05-12 |
2017-01-10 |
포르미콘 아게 |
Vegf 안타고니스트를 포함하는 사전충전형 플라스틱제 주사기
|
EP3169801A1
(en)
|
2014-07-14 |
2017-05-24 |
F. Hoffmann-La Roche AG |
Diagnostic methods and compositions for treatment of glioblastoma
|
KR20170036037A
(ko)
|
2014-07-31 |
2017-03-31 |
노파르티스 아게 |
조합 요법
|
WO2016025645A1
(en)
|
2014-08-12 |
2016-02-18 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker
|
JP6800141B2
(ja)
|
2014-08-12 |
2020-12-16 |
マサチューセッツ インスティテュート オブ テクノロジー |
Il−2およびインテグリン結合性fc融合タンパク質による相乗的な腫瘍処置
|
CA2960824A1
(en)
|
2014-09-13 |
2016-03-17 |
Novartis Ag |
Combination therapies of alk inhibitors
|
MX2017003121A
(es)
|
2014-09-15 |
2017-08-02 |
Genentech Inc |
Formulaciones de anticuerpos.
|
JP2017535528A
(ja)
|
2014-10-03 |
2017-11-30 |
ノバルティス アーゲー |
組み合わせ治療
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
PE20171067A1
(es)
|
2014-10-14 |
2017-07-24 |
Novartis Ag |
Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas
|
CN107172879B
(zh)
|
2014-11-10 |
2021-11-05 |
豪夫迈·罗氏有限公司 |
抗白细胞介素-33抗体及其用途
|
JP6721590B2
(ja)
|
2014-12-03 |
2020-07-15 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
多重特異性抗体
|
WO2016100882A1
(en)
|
2014-12-19 |
2016-06-23 |
Novartis Ag |
Combination therapies
|
AU2015369624A1
(en)
|
2014-12-23 |
2017-06-08 |
Genentech, Inc. |
Compositions and methods for treating and diagnosing chemotherapy-resistant cancers
|
AU2016274584A1
(en)
|
2015-06-08 |
2018-01-04 |
Genentech, Inc. |
Methods of treating cancer using anti-OX40 antibodies and PD-1 axis binding antagonists
|
JP6878405B2
(ja)
|
2015-07-29 |
2021-05-26 |
ノバルティス アーゲー |
Pd−1に対する抗体分子を含む組み合わせ治療
|
EP3317301B1
(en)
|
2015-07-29 |
2021-04-07 |
Novartis AG |
Combination therapies comprising antibody molecules to lag-3
|
EP3878465A1
(en)
|
2015-07-29 |
2021-09-15 |
Novartis AG |
Combination therapies comprising antibody molecules to tim-3
|
US10421821B2
(en)
|
2015-10-30 |
2019-09-24 |
Genentech, Inc. |
Anti-HtrA1 antibodies and methods of use thereof
|
JP2018532750A
(ja)
|
2015-11-02 |
2018-11-08 |
ノバルティス アーゲー |
ホスファチジルイノシトール3−キナーゼ阻害剤の投薬レジメン
|
CR20180234A
(es)
|
2015-11-03 |
2018-09-11 |
Janssen Biotech Inc |
Anticuerpos que se unen especificamente a pd-1 y sus usos
|
MX2018006092A
(es)
|
2015-11-18 |
2019-01-31 |
Formycon Ag |
Envase farmacéutico precargado que comprende una formulación líquida de un antagonista del vegf.
|
US11654046B2
(en)
|
2015-11-18 |
2023-05-23 |
Sio2 Medical Products, Inc. |
Pharmaceutical package for ophthalmic formulations
|
JP2019501687A
(ja)
|
2015-11-18 |
2019-01-24 |
フォーマイコン アーゲーFormycon Ag |
Vegf拮抗薬を収容したプレフィルドプラスチックシリンジ
|
JP2019503349A
(ja)
|
2015-12-17 |
2019-02-07 |
ノバルティス アーゲー |
Pd−1に対する抗体分子およびその使用
|
CA3011638C
(en)
|
2016-01-26 |
2023-01-10 |
Formycon Ag |
Liquid formulation of a vegf antagonist
|
CN109154613A
(zh)
|
2016-04-15 |
2019-01-04 |
豪夫迈·罗氏有限公司 |
用于监测和治疗癌症的方法
|
JP2019515670A
(ja)
|
2016-04-15 |
2019-06-13 |
ジェネンテック, インコーポレイテッド |
がんをモニタリングし治療するための方法
|
US11512126B2
(en)
|
2016-05-31 |
2022-11-29 |
Mogam Institute For Biomedicak Research |
AB6 family designer ligands of TGF-β superfamily
|
CN109890982B
(zh)
|
2016-07-08 |
2023-07-07 |
基因泰克公司 |
通过nrf2及其下游目标基因的表达状态和突变状态诊断和治疗癌症的方法
|
EP3482205A1
(en)
|
2016-07-08 |
2019-05-15 |
H. Hoffnabb-La Roche Ag |
Use of human epididymis protein 4 (he4) for assessing responsiveness of muc 16-positive cancer treatment
|
MX2019001635A
(es)
|
2016-08-12 |
2019-06-10 |
Genentech Inc |
Terapia de combinacion con un inhibidor de mek, un inhibidor del eje de pd-1, y un inhibidor de vegf.
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
WO2018132516A1
(en)
|
2017-01-10 |
2018-07-19 |
Nodus Therapeutics |
Combination tumor treatment with an integrin-binding-fc fusion protein and immune modulator
|
US10350266B2
(en)
|
2017-01-10 |
2019-07-16 |
Nodus Therapeutics, Inc. |
Method of treating cancer with a multiple integrin binding Fc fusion protein
|
EP3589754B1
(en)
|
2017-03-01 |
2023-06-28 |
F. Hoffmann-La Roche AG |
Diagnostic and therapeutic methods for cancer
|
WO2018215580A1
(en)
|
2017-05-24 |
2018-11-29 |
Formycon Ag |
Method for sterilizing prefilled plastic syringes containing a vegf antagonist
|
WO2018217995A1
(en)
|
2017-05-24 |
2018-11-29 |
Formycon Ag |
Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist
|
EP3630062A2
(en)
|
2017-05-24 |
2020-04-08 |
SiO2 Medical Products, Inc. |
Sterilizable pharmaceutical package for ophthalmic formulations
|
MA49457A
(fr)
|
2017-06-22 |
2020-04-29 |
Novartis Ag |
Molécules d'anticorps se liant à cd73 et leurs utilisations
|
WO2018237173A1
(en)
|
2017-06-22 |
2018-12-27 |
Novartis Ag |
ANTIBODY MOLECULES DIRECTED AGAINST CD73 AND CORRESPONDING USES
|
WO2019020777A1
(en)
|
2017-07-26 |
2019-01-31 |
Formycon Ag |
LIQUID FORMULATION OF A VEGF ANTAGONIST
|
WO2019119486A1
(zh)
|
2017-12-21 |
2019-06-27 |
中国科学院合肥物质科学研究院 |
一类嘧啶类衍生物激酶抑制剂
|
CN111511400A
(zh)
|
2017-12-29 |
2020-08-07 |
豪夫迈·罗氏有限公司 |
抗vegf抗体及其使用方法
|
CN113975264A
(zh)
|
2018-04-16 |
2022-01-28 |
上海岸阔医药科技有限公司 |
预防或治疗肿瘤疗法副作用的方法
|
EA202092839A1
(ru)
|
2018-05-24 |
2021-02-12 |
Янссен Байотек, Инк. |
Агенты, связывающиеся с psma, и виды их применения
|
AR126019A1
(es)
|
2018-05-30 |
2023-09-06 |
Novartis Ag |
Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
|
WO2019232244A2
(en)
|
2018-05-31 |
2019-12-05 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
CN113196061A
(zh)
|
2018-10-18 |
2021-07-30 |
豪夫迈·罗氏有限公司 |
肉瘤样肾癌的诊断和治疗方法
|
CN113747944A
(zh)
|
2019-04-19 |
2021-12-03 |
詹森生物科技公司 |
用抗psma/cd3抗体治疗前列腺癌的方法
|
EP3962947A2
(en)
|
2019-05-03 |
2022-03-09 |
F. Hoffmann-La Roche AG |
Methods of treating cancer with an anti-pd-l1 antibody
|
JP2022548881A
(ja)
|
2019-09-18 |
2022-11-22 |
ノバルティス アーゲー |
Entpd2抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法
|
WO2021097256A1
(en)
|
2019-11-14 |
2021-05-20 |
Cohbar, Inc. |
Cxcr4 antagonist peptides
|
MX2022011156A
(es)
|
2020-03-13 |
2022-10-13 |
Genentech Inc |
Anticuerpos anti-interleucina-33 y usos de estos.
|
EP4127139A1
(en)
|
2020-03-27 |
2023-02-08 |
Mendus B.V. |
Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
|
WO2021202959A1
(en)
|
2020-04-03 |
2021-10-07 |
Genentech, Inc. |
Therapeutic and diagnostic methods for cancer
|
CN116133679A
(zh)
|
2020-06-30 |
2023-05-16 |
门德斯有限公司 |
白血病衍生细胞在卵巢癌疫苗中的用途
|
MX2023005529A
(es)
|
2020-11-13 |
2023-05-25 |
Genentech Inc |
Metodos y composiciones que comprenden un inhibidor de krasg12c y un inhibidor de vegf para tratar tumores solidos.
|
WO2022157715A1
(en)
|
2021-01-22 |
2022-07-28 |
Dcprime B.V. |
Methods of tumor vaccination
|
PE20240761A1
(es)
|
2021-01-28 |
2024-04-17 |
Janssen Biotech Inc |
Proteinas de union a psma y usos de estas
|
JP2024510989A
(ja)
|
2021-03-12 |
2024-03-12 |
メンドゥス・ベスローテン・フェンノートシャップ |
ワクチン接種方法及びcd47遮断薬の使用
|
EP4330436A1
(en)
|
2021-04-30 |
2024-03-06 |
Genentech, Inc. |
Therapeutic and diagnostic methods and compositions for cancer
|
TW202309078A
(zh)
|
2021-07-02 |
2023-03-01 |
美商建南德克公司 |
治療癌症之方法及組成物
|
MX2024001214A
(es)
|
2021-07-28 |
2024-02-12 |
Hoffmann La Roche |
Metodos y composiciones para tratar cancer.
|
WO2023080900A1
(en)
|
2021-11-05 |
2023-05-11 |
Genentech, Inc. |
Methods and compositions for classifying and treating kidney cancer
|
WO2023144973A1
(ja)
|
2022-01-27 |
2023-08-03 |
中外製薬株式会社 |
抗vegf抗体及びパクリタキセルと組み合わせて使用する抗pd-l1抗体を含む医薬組成物
|
CN118742325A
(zh)
|
2022-01-28 |
2024-10-01 |
上海岸阔医药科技有限公司 |
预防或治疗与抗肿瘤剂相关的疾病或病症的方法
|
WO2023155905A1
(zh)
|
2022-02-21 |
2023-08-24 |
上海岸阔医药科技有限公司 |
化合物及其用途
|
WO2023212298A1
(en)
|
2022-04-29 |
2023-11-02 |
Broadwing Bio Llc |
Bispecific antibodies and methods of treating ocular disease
|