HU221343B1 - Use of anti-vegf antibodies for the treatment of cancer - Google Patents
Use of anti-vegf antibodies for the treatment of cancer Download PDFInfo
- Publication number
- HU221343B1 HU221343B1 HU9501201A HU9501201A HU221343B1 HU 221343 B1 HU221343 B1 HU 221343B1 HU 9501201 A HU9501201 A HU 9501201A HU 9501201 A HU9501201 A HU 9501201A HU 221343 B1 HU221343 B1 HU 221343B1
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- Hungary
- Prior art keywords
- hvegf
- antibody
- cells
- antibodies
- hvegfr
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (11)
- SZABADALMI IGÉNYPONTOK1. A hVEGF-antagonista, amely egy anti-VEGF antitest, alkalmazása rák kezelésére szolgáló gyógyszerek készítésére.
- 2. Az 1. igénypont szerinti alkalmazás, ahol az antitest anti-hVEGF antitest.
- 3. Az 1. vagy 2. igénypont szerinti alkalmazás, ahol az antitest monoklonális antitest.
- 4. Az 1-3. igénypontok bármelyike szerinti alkalmazás, ahol az antitest humanizált antitest.
- 5. Az 1-4. igénypontok bármelyike szerinti alkalmazás, ahol az antitestet olyan mennyiségben alkalmazzák, amely megfelelő valamely daganat méretének csökkentésére.
- 6. Az 5. igénypont szerinti alkalmazás, ahol a daganat rosszindulatú szilárd daganat.
- 7. Az 5. vagy 6. igénypont szerinti alkalmazás, ahol az antitest a daganat méretét a VEGF-közvetített neovaszkularizáció gátlásával csökkenti.
- 8. Az 1-7. igénypontok bármelyike szerinti alkalmazás, ahol az antitest valamely citotoxikus résszel van összekapcsolva.
- 9. A 8. igénypont szerinti alkalmazás, ahol a citotoxikus rész valamely fehérje-citotoxin vagy a monoklonális antitest Fc-tartománya.
- 10. Az 1-9. igénypontok bármelyike szerinti alkalmazás, ahol a gyógyszer olyan módon van kiszerelve, hogy lehetőség legyen sorozatos beadásra vagy más szerrel való kombinált beadásra rák kezelésére.
- 11. Az 1 -10. igénypontok bármelyike szerinti alkalmazás, ahol a gyógyszer olyan módon van kiszerelve, hogy lehetőség legyen sorozatos beadásra vagy kombinálásra radiológiai kezeléssel.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1992/009218 WO1994010202A1 (en) | 1992-10-28 | 1992-10-28 | Vascular endothelial cell growth factor antagonists |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9501201D0 HU9501201D0 (en) | 1995-06-28 |
HUT70810A HUT70810A (en) | 1995-11-28 |
HU221343B1 true HU221343B1 (en) | 2002-09-28 |
Family
ID=44652081
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9501201A HU221343B1 (en) | 1992-10-28 | 1992-10-28 | Use of anti-vegf antibodies for the treatment of cancer |
HU0102070A HU225646B1 (en) | 1992-10-28 | 1992-10-28 | Hvegf receptors as vascular endothelial cell growth factor antagonists |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0102070A HU225646B1 (en) | 1992-10-28 | 1992-10-28 | Hvegf receptors as vascular endothelial cell growth factor antagonists |
Country Status (18)
Country | Link |
---|---|
EP (4) | EP0666868B2 (hu) |
JP (1) | JP3398382B2 (hu) |
KR (1) | KR100335584B1 (hu) |
AT (4) | ATE498632T1 (hu) |
AU (1) | AU687727B2 (hu) |
BG (1) | BG99605A (hu) |
BR (1) | BR9207175A (hu) |
CA (1) | CA2145985C (hu) |
CZ (1) | CZ291047B6 (hu) |
DE (3) | DE69233739D1 (hu) |
DK (4) | DK1167384T3 (hu) |
ES (4) | ES2360641T3 (hu) |
FI (1) | FI951987A (hu) |
HU (2) | HU221343B1 (hu) |
NO (1) | NO321825B1 (hu) |
RO (1) | RO119721B1 (hu) |
SK (1) | SK285035B6 (hu) |
WO (1) | WO1994010202A1 (hu) |
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US6384191B1 (en) * | 1989-07-06 | 2002-05-07 | Regents Of The University Of California | Receptors for fibroblast growth factors |
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SG49753A1 (en) * | 1991-02-22 | 1998-06-15 | American Cyanamid Co | Identification of a novel human receptor tyrosine kinase gene |
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1992
- 1992-10-28 DE DE69233739T patent/DE69233739D1/de not_active Expired - Lifetime
- 1992-10-28 RO RO95-00816A patent/RO119721B1/ro unknown
- 1992-10-28 AT AT08010320T patent/ATE498632T1/de active
- 1992-10-28 ES ES08010320T patent/ES2360641T3/es not_active Expired - Lifetime
- 1992-10-28 DK DK01119430T patent/DK1167384T3/da active
- 1992-10-28 DE DE69232539T patent/DE69232539T3/de not_active Expired - Lifetime
- 1992-10-28 HU HU9501201A patent/HU221343B1/hu active Protection Beyond IP Right Term
- 1992-10-28 CZ CZ19951057A patent/CZ291047B6/cs not_active IP Right Cessation
- 1992-10-28 JP JP51099994A patent/JP3398382B2/ja not_active Expired - Lifetime
- 1992-10-28 AT AT01119430T patent/ATE348110T1/de active
- 1992-10-28 EP EP92923512A patent/EP0666868B2/en not_active Expired - Lifetime
- 1992-10-28 EP EP01119430A patent/EP1167384B1/en not_active Expired - Lifetime
- 1992-10-28 AU AU29289/92A patent/AU687727B2/en not_active Expired
- 1992-10-28 ES ES02006351T patent/ES2309119T3/es not_active Expired - Lifetime
- 1992-10-28 CA CA002145985A patent/CA2145985C/en not_active Expired - Lifetime
- 1992-10-28 EP EP08010320A patent/EP1975181B1/en not_active Revoked
- 1992-10-28 ES ES01119430T patent/ES2278663T3/es not_active Expired - Lifetime
- 1992-10-28 DK DK02006351T patent/DK1238986T3/da active
- 1992-10-28 AT AT92923512T patent/ATE215565T1/de active
- 1992-10-28 SK SK551-95A patent/SK285035B6/sk not_active IP Right Cessation
- 1992-10-28 BR BR9207175A patent/BR9207175A/pt not_active Application Discontinuation
- 1992-10-28 DE DE69233803T patent/DE69233803D1/de not_active Expired - Lifetime
- 1992-10-28 EP EP02006351A patent/EP1238986B1/en not_active Expired - Lifetime
- 1992-10-28 KR KR1019950701621A patent/KR100335584B1/ko not_active IP Right Cessation
- 1992-10-28 ES ES92923512T patent/ES2173873T5/es not_active Expired - Lifetime
- 1992-10-28 AT AT02006351T patent/ATE399181T1/de active
- 1992-10-28 HU HU0102070A patent/HU225646B1/hu unknown
- 1992-10-28 WO PCT/US1992/009218 patent/WO1994010202A1/en active IP Right Grant
- 1992-10-28 DK DK92923512T patent/DK0666868T4/da active
- 1992-10-28 DK DK08010320.3T patent/DK1975181T3/da active
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1995
- 1995-04-26 FI FI951987A patent/FI951987A/fi not_active Application Discontinuation
- 1995-04-27 NO NO19951609A patent/NO321825B1/no not_active IP Right Cessation
- 1995-04-28 BG BG99605A patent/BG99605A/xx unknown
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