CN111989095A - 预防或治疗肿瘤疗法副作用的方法 - Google Patents
预防或治疗肿瘤疗法副作用的方法 Download PDFInfo
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- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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Abstract
本发明公开了一氧化氮释放剂在制备药物中的用途,所述药物用于预防或治疗与施用VEGFR抑制剂和/或VEGF抑制剂相关的疾病或病症。本申请还提供预防或者治疗与施用VEGFR抑制剂和/或VEGF抑制剂相关的疾病或病症的方法,所述方法可包括向有需要的受试者施用预防或治疗有效量的一氧化氮释放剂。
Description
PCT国内申请,说明书已公开。
Claims (74)
- PCT国内申请,权利要求书已公开。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111376089.8A CN113975264A (zh) | 2018-04-16 | 2019-04-15 | 预防或治疗肿瘤疗法副作用的方法 |
CN202111372390.1A CN114028568A (zh) | 2018-04-16 | 2019-04-15 | 预防或治疗肿瘤疗法副作用的方法 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN201810339975 | 2018-04-16 | ||
CN2018103399755 | 2018-04-16 | ||
PCT/CN2019/082623 WO2019201195A1 (zh) | 2018-04-16 | 2019-04-15 | 预防或治疗肿瘤疗法副作用的方法 |
Related Child Applications (2)
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CN202111372390.1A Division CN114028568A (zh) | 2018-04-16 | 2019-04-15 | 预防或治疗肿瘤疗法副作用的方法 |
CN202111376089.8A Division CN113975264A (zh) | 2018-04-16 | 2019-04-15 | 预防或治疗肿瘤疗法副作用的方法 |
Publications (1)
Publication Number | Publication Date |
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CN111989095A true CN111989095A (zh) | 2020-11-24 |
Family
ID=68239371
Family Applications (3)
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CN202111376089.8A Pending CN113975264A (zh) | 2018-04-16 | 2019-04-15 | 预防或治疗肿瘤疗法副作用的方法 |
CN201980025735.0A Pending CN111989095A (zh) | 2018-04-16 | 2019-04-15 | 预防或治疗肿瘤疗法副作用的方法 |
CN202111372390.1A Pending CN114028568A (zh) | 2018-04-16 | 2019-04-15 | 预防或治疗肿瘤疗法副作用的方法 |
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CN202111376089.8A Pending CN113975264A (zh) | 2018-04-16 | 2019-04-15 | 预防或治疗肿瘤疗法副作用的方法 |
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CN202111372390.1A Pending CN114028568A (zh) | 2018-04-16 | 2019-04-15 | 预防或治疗肿瘤疗法副作用的方法 |
Country Status (9)
Country | Link |
---|---|
US (2) | US10987336B2 (zh) |
EP (1) | EP3782618A4 (zh) |
JP (1) | JP7520366B2 (zh) |
KR (1) | KR20200144116A (zh) |
CN (3) | CN113975264A (zh) |
AU (1) | AU2019254237A1 (zh) |
CA (1) | CA3097067A1 (zh) |
TW (1) | TW201943428A (zh) |
WO (1) | WO2019201195A1 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021073535A1 (zh) * | 2019-10-16 | 2021-04-22 | 上海岸阔医药科技有限公司 | 预防或治疗与vegfr和/或vegf被抑制相关疾病的方法 |
CN111569078A (zh) * | 2020-06-18 | 2020-08-25 | 上海馨颖生物技术有限公司 | Sirt1抑制剂在vegfr抑制剂与免疫检查点抑制剂联用引起的副作用上的应用 |
EP4212160A4 (en) * | 2020-09-09 | 2024-10-09 | Shenzhen Chipscreen Biosciences Co Ltd | USE OF CHIAURANIB IN COMBINATION WITH AN IMMUNE CHECKPOINT INHIBITOR IN ANTITUMOR THERAPY |
KR102511934B1 (ko) * | 2021-04-27 | 2023-03-21 | 재단법인 아산사회복지재단 | 피부 색소침착의 예방, 개선, 또는 치료용 조성물 |
CN118742325A (zh) * | 2022-01-28 | 2024-10-01 | 上海岸阔医药科技有限公司 | 预防或治疗与抗肿瘤剂相关的疾病或病症的方法 |
WO2023182856A1 (ko) * | 2022-03-24 | 2023-09-28 | 서울대학교산학협력단 | 로-키나제 억제제를 포함하는 켈로이드 등 피부 섬유화 질환의 예방 또는 치료용 약학적 조성물 및 그의 용도 |
CN117180246B (zh) * | 2023-11-02 | 2024-01-26 | 西北农林科技大学深圳研究院 | 异甘草素在制备防治虾白斑综合征药物中的应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2978412A2 (en) * | 2013-03-25 | 2016-02-03 | Sloan Kettering Institute For Cancer Research | Articles and methods for preventing and treating dermatologic adverse events |
Family Cites Families (143)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2833010A (en) | 1954-02-01 | 1958-05-06 | Rosenthal Harry | Laundry clip |
CA1163561A (en) | 1979-11-06 | 1984-03-13 | Cyril Boroda | Preparation containing nitroglycerine and optionally other medicaments and preparation thereof |
US4450175A (en) | 1982-09-23 | 1984-05-22 | Warshaw Thelma G | Method and compositions for treating acne |
US6582959B2 (en) | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
US20030206899A1 (en) | 1991-03-29 | 2003-11-06 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
DK0666868T4 (da) | 1992-10-28 | 2006-09-18 | Genentech Inc | Anvendelse af anti-VEGF-antistoffer til behandling af cancer |
US5698589A (en) | 1993-06-01 | 1997-12-16 | International Medical Innovations, Inc. | Water-based topical cream containing nitroglycerin and method of preparation and use thereof |
US5504117A (en) | 1994-05-27 | 1996-04-02 | Neptune Pharmaceutical Corporation | Pharmacologic preparation for the treatment of anal disorders |
WO1995032715A1 (en) | 1994-05-27 | 1995-12-07 | Neptune Pharmaceutical Corporation | Nitric oxide donor composition and method for treatment of anal disorders |
IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
BRPI9809388B8 (pt) | 1997-04-07 | 2021-05-25 | Genentech Inc | anticorpos humanizados e métodos para a formação de anticorpos humanizados. |
US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
NZ500078A (en) | 1997-04-07 | 2001-10-26 | Genentech Inc | Humanized anti-VEGF antibodies and their use in inhibiting VEGF-induced angiogenesis in mammals |
GB9802078D0 (en) | 1998-01-30 | 1998-03-25 | Futura Medical Limited | Preparation for treatment of erectile dysfunction |
US6103275A (en) | 1998-06-10 | 2000-08-15 | Nitric Oxide Solutions | Systems and methods for topical treatment with nitric oxide |
GB9818524D0 (en) | 1998-08-25 | 1998-10-21 | Futura Medical Limited | Inorgasmia treatment |
US6492398B1 (en) | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
GB9904930D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Thiazoloindolinone compounds |
US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
US20040191276A1 (en) | 1999-11-30 | 2004-09-30 | Cutispharma, Inc. | Compositions and kits for compounding pharmaceuticals |
US20020049188A1 (en) | 1999-12-15 | 2002-04-25 | Azarnoff Daniel L. | Nitroglycerin ointment for treatment of pain associated with anal disease |
US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
AU2001243657A1 (en) | 2000-03-20 | 2001-10-03 | Osi Pharmaceuticals, Inc | Combined treatment with keratinocyte growth factor and epidermal growth factor inhibitor |
JP2003531179A (ja) * | 2000-04-26 | 2003-10-21 | クイーンズ ユニバーシティ アット キングストン | 悪性細胞表現型に対し一酸化窒素模倣体を使用する処方および方法 |
EP1286654A1 (de) | 2000-05-24 | 2003-03-05 | MERCK PATENT GmbH | Verwendung von aryloximen zur prophylaxe und/oder behandlung von erythembildung und/oder entzündungsreaktionen der haut |
WO2002013982A1 (en) | 2000-08-11 | 2002-02-21 | Whitlock David R | Compositions including ammonia oxidizing bacteria to increase production of nitric oxide and nitric oxide precursors and methods of using same |
US6780849B2 (en) | 2000-12-21 | 2004-08-24 | Scimed Life Systems, Inc. | Lipid-based nitric oxide donors |
IL157734A0 (en) | 2001-03-06 | 2004-03-28 | Cellegy Pharma Inc | Pharmaceutical compositions for the treatment of urogenital disorders |
US20050244382A9 (en) | 2002-01-11 | 2005-11-03 | Whitlock David R | Compositions including ammonia oxidizing bacteria and methods of using same |
US6979688B2 (en) | 2002-02-12 | 2005-12-27 | Ford John P | Treatment method against side-effects of chemotherapy |
US7816366B2 (en) | 2002-02-12 | 2010-10-19 | Asymmetric Therapeutics, Llc | Compositions and methods for treating and preventing dermatoses |
US6995165B2 (en) | 2002-02-12 | 2006-02-07 | Ford John P | Methods, compositions, and kits for organ protection during systemic anticancer therapy |
CA2480832A1 (en) | 2002-04-05 | 2003-10-23 | Nitromed, Inc. | Nitric oxide donors, compositions and methods of use |
AU2003252033A1 (en) | 2002-07-19 | 2004-02-09 | University Of North Carolina At Chapel Hill | Surface-localized release of an anti-biofouling agent via micropatterning |
KR20120104408A (ko) | 2003-05-30 | 2012-09-20 | 제넨테크, 인크. | 항-vegf 항체를 사용한 치료 |
MXPA05014212A (es) | 2003-07-03 | 2006-08-11 | Univ St Andrews | Zeolitas para suministro de oxido nitrico. |
WO2005044853A2 (en) | 2003-11-01 | 2005-05-19 | Genentech, Inc. | Anti-vegf antibodies |
US20050106667A1 (en) | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
CN1997731A (zh) | 2003-09-26 | 2007-07-11 | 大卫·R·怀特洛克 | 使用氨氧化细菌的方法 |
CA2539974A1 (en) | 2003-09-26 | 2005-04-07 | David R. Whitlock | Methods of using ammonia oxidizing bacteria |
EP1732577B1 (en) | 2004-02-23 | 2013-04-10 | Strategic Science & Technologies, LLC | Topical delivery of l-arginine to improve body and skin appearance |
CN1568943A (zh) | 2004-04-26 | 2005-01-26 | 江苏省药物研究所 | 硝酸甘油软膏及其制备方法和应用 |
US20060009360A1 (en) | 2004-06-25 | 2006-01-12 | Robert Pifer | New adjuvant composition |
ATE429255T1 (de) | 2005-03-24 | 2009-05-15 | Nolabs Ab | Kosmetische behandlung mit stickoxid, vorrichtung zur durchführung dieser behandlung und herstellungsverfahren dafür |
EP1704876A1 (en) | 2005-03-24 | 2006-09-27 | NOLabs AB | Cosmetic treatment, device for performing said treatment and manufacturing method thereof |
EP2494965A3 (en) | 2005-04-15 | 2013-01-02 | The Albert Einstein College Of Medicine Of Yeshiva University | Vitamin K for Prevention and Treatment of Skin Rash Secondary to Anti-EGFR Therapy |
CN117534755A (zh) | 2005-05-09 | 2024-02-09 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
EP1883614A4 (en) | 2005-05-23 | 2010-04-14 | Nicox Sa | ORGANIC NITRIC OXIDES IMPROVING SALTS FROM NON-SUBSTITUTE INFLAMMATORY COMPOUNDS AND COMPOSITIONS AND USES THEREOF |
WO2006128121A2 (en) | 2005-05-27 | 2006-11-30 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
KR101888321B1 (ko) | 2005-07-01 | 2018-08-13 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
EP2251688A1 (en) | 2005-10-11 | 2010-11-17 | Merck Patent GmbH | EGFR dependent modulation of chemokine expression and influence on therapy and diagnosis of tumors and side effects thereof |
US20070172847A1 (en) | 2005-11-15 | 2007-07-26 | The Regents Of The University Of California | Molecular signaling pathways triggered by rituximab: prognostic, diagnostic, and therapeutic uses |
NZ573248A (en) | 2006-06-01 | 2011-01-28 | Nobera Pharma Sl | Use of allopurinol (1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) for the treatment of palmar plantar erythrodysesthesia |
US9428582B2 (en) | 2006-07-03 | 2016-08-30 | Genmab A/S | Method of treating rash in patients undergoing anti-EGFR therapy |
GB0616350D0 (en) | 2006-08-17 | 2006-09-27 | Univ St Andrews | Adsorption and release of nitric oxide in metal organic frameworks |
WO2009049208A1 (en) | 2007-10-12 | 2009-04-16 | The University Of North Carolina At Chapel Hill | Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents |
US20090196833A1 (en) | 2008-02-06 | 2009-08-06 | Adherex Technologies Inc. | Compositions comprising topical dpd inhibitors and methods of using same in the treatment of hand-foot syndrome |
CN104548091A (zh) | 2008-02-11 | 2015-04-29 | 治疗科技公司 | 用于肿瘤治疗的单克隆抗体 |
US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
US8815953B2 (en) | 2008-03-13 | 2014-08-26 | Spectrum Pharmaceuticals, Inc. | Formulations of vitamin K analogs for topical use |
FR2929278A1 (fr) | 2008-04-01 | 2009-10-02 | Centre Nat Rech Scient | Solide hybride cristallin poreux pour l'adsorption et la liberation de gaz a interet biologique. |
EP2379070A4 (en) | 2008-07-21 | 2013-11-13 | Imi Internat Medical Innovations D B A Procris Pharmaceuticals | WATER BASED TOPICAL STABLE PHARMACEUTICAL CREAMES AND METHODS FOR PREPARING AND USING SAME |
EA023148B1 (ru) | 2008-08-25 | 2016-04-29 | Эмплиммьюн, Инк. | Композиции на основе антагонистов pd-1 и их применение |
US20100221247A1 (en) * | 2008-09-29 | 2010-09-02 | Robert Bender | Agents and methods for treatment of cancer |
WO2010044875A2 (en) | 2008-10-16 | 2010-04-22 | Novan, Inc. | Nitric oxide releasing particles for oral care applications |
CN102245640B (zh) | 2008-12-09 | 2014-12-31 | 霍夫曼-拉罗奇有限公司 | 抗-pd-l1抗体及它们用于增强t细胞功能的用途 |
EP2201942A1 (de) | 2008-12-23 | 2010-06-30 | Intendis GmbH | Zusammensetzung mit Hanföl für die Behandlung topischer Erkrankungen |
EP2246057A1 (en) * | 2009-04-29 | 2010-11-03 | Nobera Pharma, S.L. | Use of allopurinol for the treatment of hand foot skin reaction |
CA2763299C (en) * | 2009-06-26 | 2015-11-24 | Asan Laboratories Co., Ltd. | Method for treating or ameliorating mucocutaneous or ocular toxicities |
KR20170116231A (ko) | 2009-06-30 | 2017-10-18 | 더만 바이오메디슨 코. 엘티디. | 주사 또는 홍안 관련 피부 질환의 치료를 위한, 베르베린 또는 그의 유사체를 함유하는 조성물 |
ES2958410T3 (es) | 2009-08-21 | 2024-02-08 | Novan Inc | Geles tópicos |
EP2467173B8 (en) | 2009-08-21 | 2019-06-19 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
WO2011047013A1 (en) | 2009-10-13 | 2011-04-21 | Novan, Inc. | Nitric oxide-releasing coatings |
CN102648279B (zh) | 2009-10-16 | 2015-11-25 | 杜克大学 | 用于治疗药物诱发的手足综合征的组合物与方法 |
US20110190244A1 (en) | 2010-02-01 | 2011-08-04 | Peter Maccallum Cancer Institute | Method of treatment of egfr inhibitor toxicity |
WO2011097358A1 (en) | 2010-02-05 | 2011-08-11 | Deland M Maitland | Led treatment of dermatologic toxicities associated with vascular endothelial growth factor inhibitors |
US8795263B2 (en) | 2010-02-05 | 2014-08-05 | M. Maitland DeLand | LED treatment of dermatologic toxicities associated with multikinase inhibitors |
US20110196353A1 (en) | 2010-02-05 | 2011-08-11 | Deland Maitland M | LED Treatment of Dermatologic Toxicities Associated with Epidermal Growth Factor Receptor Inhibitors |
EP2368549A1 (en) | 2010-03-25 | 2011-09-28 | BioAlliance Pharma | Treating hand-foot syndrome and related pathologies using clonidine or its derivatives |
EP2554184B1 (en) | 2010-03-31 | 2016-10-26 | ONO Pharmaceutical Co., Ltd. | Preventive and/or remedy for hand and foot syndrome |
CA2828238A1 (en) | 2010-10-29 | 2012-05-03 | Neurotune Ag | Therapeutic use of dimiracetam to prevent the hand & foot syndrome caused by sorafenib |
US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
CN103429641B (zh) | 2011-01-20 | 2015-08-05 | 诺万公司 | 温度控制的溶胶-凝胶共缩合 |
WO2012118829A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same |
EP2701700A4 (en) | 2011-04-27 | 2015-10-21 | Univ Yale Inc | PHARMACEUTICAL THERAPY FOR INHIBITING CHEMOTHERAPY-INDUCED SIDE EFFECTS AND CORRESPONDING PHARMACEUTICAL COMPOSITIONS, DIAGNOSTICS, SCREENING METHOD AND KITS |
CA2835320A1 (en) | 2011-05-09 | 2012-11-15 | Topical Therapeutic Agent (Tta) Ltd. | Nitric oxide-sequestering topical formulations |
EP2729174A1 (en) | 2011-07-08 | 2014-05-14 | Merck Sharp & Dohme Corp. | Il-23 antagonists for treatment or prevention of skin rash associated with treatment with p13k/akt pathway inhibitors |
EP2748141B1 (en) | 2011-08-24 | 2017-12-06 | Novan, Inc. | Tunable nitric oxide-releasing macromolecules having multiple nitric oxide donor structures |
WO2013063354A1 (en) | 2011-10-27 | 2013-05-02 | Novan, Inc. | Nitric oxide releasing bath compositions and methods of using the same |
WO2013085784A1 (en) | 2011-12-05 | 2013-06-13 | Nioxx Llc | Compositions and methods for topical nitric oxide generation |
EP2601965A1 (en) | 2011-12-06 | 2013-06-12 | Apeiron Biologics AG | Compositions for preventing or treating adverse reactions of EGFR inhibition |
EP2798365A1 (en) | 2011-12-27 | 2014-11-05 | Université Catholique de Louvain | Method for measuring nitric oxide in blood |
WO2013138073A1 (en) | 2012-03-13 | 2013-09-19 | Novan, Inc. | Methods of modulating steroid hormone activity |
JP6265967B2 (ja) | 2012-03-14 | 2018-01-24 | ノヴァン,インコーポレイテッド | 医薬組成物 |
KR20130118282A (ko) | 2012-04-19 | 2013-10-29 | 부산대학교 산학협력단 | Egfqr 억제제 유발 피부 부작용의 예방 또는 치료용 국소용 약학 조성물 |
CN103446261B (zh) | 2012-06-05 | 2015-04-15 | 中国医学科学院肿瘤医院 | 一种预防和/或治疗肿瘤治疗相关皮肤损害的中药组合物 |
CN104755505B (zh) | 2012-08-17 | 2017-03-01 | 北卡罗来纳大学查珀尔希尔分校 | 水溶性的释放一氧化氮的聚葡糖胺和其用途 |
ES2559454T3 (es) | 2012-08-20 | 2016-02-12 | Bionoox Suisse Sa | Composición que comprende dihidroquercetina, alfa-tocoferol y bisabolol |
US9187501B2 (en) | 2012-08-28 | 2015-11-17 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing nanorods and their methods of use |
US8871256B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Methods and systems for treatment of inflammatory diseases with nitric oxide |
US8871254B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system |
US9855211B2 (en) | 2013-02-28 | 2018-01-02 | Novan, Inc. | Topical compositions and methods of using the same |
GB201305947D0 (en) | 2013-04-02 | 2013-05-15 | Univ Sheffield | New method 1 |
US20150313896A1 (en) | 2013-07-26 | 2015-11-05 | Galderma Research & Development | Method for treating cell proliferation disorders |
JP6513667B2 (ja) | 2013-08-08 | 2019-05-15 | ノヴァン,インコーポレイテッド | 局所用組成物およびそれを使用する方法 |
US20160263092A1 (en) | 2013-12-19 | 2016-09-15 | Twi Biotechnology, Inc. | Therapeutic uses of berberine formulations |
TW201538156A (zh) | 2013-12-19 | 2015-10-16 | Twi Biotechnology Inc | 小蘗鹼配方及其用途 |
CA2946050C (en) | 2014-04-15 | 2023-08-29 | Aobiome Llc | Ammonia-oxidizing nitrosomonas eutropha strain d23 |
WO2015171872A1 (en) | 2014-05-08 | 2015-11-12 | Aobiome Llc | Systems and methods for detecting nitric oxide |
EP3145519B1 (en) | 2014-05-22 | 2021-08-04 | Aobiome LLC | Systems and methods for storage and delivery of ammonia oxidizing bacteria |
CN106471129A (zh) | 2014-05-22 | 2017-03-01 | Ao生物医学有限责任公司 | 用氨氧化细菌制备材料和测试材料的氨氧化细菌的方法 |
US20170202917A1 (en) | 2014-05-29 | 2017-07-20 | Daewoong Pharmaceutical Co., Ltd. | Pharmaceutical composition for preventing or treating skin rash |
KR20170018964A (ko) | 2014-06-24 | 2017-02-20 | 갈데르마 소시에떼아노님 | 손-발 증후군 및 그와 관련된 증상의 치료방법 |
KR102495101B1 (ko) | 2014-07-11 | 2023-02-02 | 노반, 인크. | 국소 항바이러스 조성물 및 그의 사용 방법 |
WO2016160089A1 (en) | 2015-03-27 | 2016-10-06 | Novan, Inc. | Topical antiviral compositions, delivery systems, and methods of using the same |
WO2016010988A1 (en) | 2014-07-14 | 2016-01-21 | Novan, Inc. | Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same |
CN105813617B (zh) | 2014-08-08 | 2021-05-28 | 诺万公司 | 局部用组合物和使用所述组合物的方法 |
CA2960824A1 (en) * | 2014-09-13 | 2016-03-17 | Novartis Ag | Combination therapies of alk inhibitors |
EP3034092A1 (en) * | 2014-12-17 | 2016-06-22 | Université de Lausanne | Adoptive immunotherapy for treating cancer |
CN204411249U (zh) | 2014-12-26 | 2015-06-24 | 朴瑛 | 一种肿瘤患者化疗后手足综合症的多功能康复装置 |
US20180092948A1 (en) | 2015-04-02 | 2018-04-05 | Aobiome Llc | Production of nitro-fatty acids and nitro-hydrocarbons by ammonia oxidizing bacteria |
EP3313520A4 (en) | 2015-06-24 | 2019-01-02 | TWI Biotechnology, Inc. | Therapeutic uses of berberine formulations |
CN108367029A (zh) | 2015-07-02 | 2018-08-03 | Ao生物医学有限责任公司 | 用于治疗痤疮的氨氧化细菌 |
BR112018000053A2 (pt) | 2015-07-02 | 2018-09-04 | Aobiome Llc | cosméticos compatíveis com o microbioma |
WO2017009824A1 (en) | 2015-07-16 | 2017-01-19 | Neotech-Kordan Group Ltd. | Formulation methods and ointment formulations therein containing uracil, thymine, and/or their derivatives for treatment and prevention of hand-and-foot syndrome |
US10849864B2 (en) | 2015-07-28 | 2020-12-01 | Novan, Inc. | Combinations and methods for the treatment and/or prevention of fungal infections |
MX2018002067A (es) | 2015-08-20 | 2018-09-05 | Foamix Pharmaceuticals Ltd | Manejo con tetraciclina de dermatosis asociada con inhibidor de egfr. |
ES2824532T3 (es) | 2015-11-02 | 2021-05-12 | Univ North Carolina Chapel Hill | Método de producción de partículas de sílice mesoporosas que liberan no mediante una reacción de intercambio iónico aminosilano-tensioactivo |
CN105381070A (zh) | 2015-12-22 | 2016-03-09 | 浙江大学 | 犀角地黄药物组合物在制备预防及治疗表皮生长因子受体抑制剂所致相关皮疹药物中的用途 |
JP7090549B2 (ja) | 2016-03-02 | 2022-06-24 | ノヴァン,インコーポレイテッド | 炎症のための治療用組成物およびその治療方法 |
WO2017154001A1 (en) | 2016-03-10 | 2017-09-14 | Lutris Pharma Ltd. | Use of braf inhibitors for treating cutaneous reactions |
WO2017165440A1 (en) | 2016-03-21 | 2017-09-28 | Mayo Foundation For Medical Education And Research | Methods for reducing toxicity of a chemotherapeutic drug |
CA3028423A1 (en) | 2016-06-22 | 2017-12-28 | Medchem Partners, Llc. | Nitric oxide donors |
US20190247446A1 (en) | 2016-07-19 | 2019-08-15 | Aobiome Llc | Ammonia oxidizing microorganisms for use and delivery to the gastrointestinal system |
MX2019003191A (es) | 2016-09-21 | 2019-12-05 | Aobiome Llc | Microorganismos oxidantes de amoníaco para uso y suministro al sistema intranasal. |
AU2017375944A1 (en) | 2016-12-12 | 2019-07-04 | Aobiome Llc | Ammonia oxidizing microorganisms for the regulation of blood pressure |
CN106539924A (zh) | 2016-12-22 | 2017-03-29 | 张丽燕 | 一种预防和缓解化疗所致手足综合症的中药手套和袜子 |
CN107158287A (zh) | 2017-03-25 | 2017-09-15 | 许进秀 | 缓解吉非替尼/厄洛替尼引起的皮肤毒性的中药 |
CN107412455A (zh) | 2017-04-21 | 2017-12-01 | 曹师磊 | 一种治疗皮疹的天然外用药物组合物及其制备方法 |
CN107198718A (zh) | 2017-05-04 | 2017-09-26 | 常州桐树生物科技有限公司 | 一种外用治疗皮疹的中药组合物及其制备方法和应用 |
WO2019059246A1 (ja) | 2017-09-21 | 2019-03-28 | 味の素株式会社 | 手足症候群の予防または改善用組成物 |
TW201927292A (zh) | 2017-12-13 | 2019-07-16 | 大陸商上海小午醫藥科技有限公司 | 一種用於預防或治療與egfr被抑制相關疾病的方法 |
-
2019
- 2019-04-15 CN CN202111376089.8A patent/CN113975264A/zh active Pending
- 2019-04-15 KR KR1020207032592A patent/KR20200144116A/ko not_active Application Discontinuation
- 2019-04-15 AU AU2019254237A patent/AU2019254237A1/en active Pending
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- 2019-04-15 CN CN201980025735.0A patent/CN111989095A/zh active Pending
- 2019-04-15 CN CN202111372390.1A patent/CN114028568A/zh active Pending
- 2019-04-15 TW TW108113059A patent/TW201943428A/zh unknown
- 2019-04-15 CA CA3097067A patent/CA3097067A1/en active Pending
- 2019-04-15 EP EP19789251.6A patent/EP3782618A4/en active Pending
-
2020
- 2020-04-22 US US16/855,677 patent/US10987336B2/en active Active
-
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- 2021-03-29 US US17/216,594 patent/US20210322361A1/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2978412A2 (en) * | 2013-03-25 | 2016-02-03 | Sloan Kettering Institute For Cancer Research | Articles and methods for preventing and treating dermatologic adverse events |
US20160101114A1 (en) * | 2013-03-25 | 2016-04-14 | Sloan-Kettering Institute For Cancer Research | Articles and methods for preventing and treating dermatologic adverse events |
Non-Patent Citations (1)
Title |
---|
ARVIND K. PANDEY: "《Mechanisms of VEGF-Inhibitor Associated Hypertension and Vascular Disease》", 《HYPERTENSION》 * |
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CN113975264A (zh) | 2022-01-28 |
KR20200144116A (ko) | 2020-12-28 |
JP7520366B2 (ja) | 2024-07-23 |
EP3782618A4 (en) | 2022-01-26 |
TW201943428A (zh) | 2019-11-16 |
EP3782618A1 (en) | 2021-02-24 |
US20200253915A1 (en) | 2020-08-13 |
CA3097067A1 (en) | 2019-10-24 |
JP2021521247A (ja) | 2021-08-26 |
WO2019201195A1 (zh) | 2019-10-24 |
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