JOP20200303A1 - عوامل ربط psma واستخداماتها - Google Patents

عوامل ربط psma واستخداماتها

Info

Publication number
JOP20200303A1
JOP20200303A1 JOP/2020/0303A JOP20200303A JOP20200303A1 JO P20200303 A1 JOP20200303 A1 JO P20200303A1 JO P20200303 A JOP20200303 A JO P20200303A JO P20200303 A1 JOP20200303 A1 JO P20200303A1
Authority
JO
Jordan
Prior art keywords
binding agents
psma binding
psma
antibodies
fragments
Prior art date
Application number
JOP/2020/0303A
Other languages
English (en)
Inventor
Glenn Mark Anderson
Richard Stephen Tawadros
John Michael Jones
Derrick Lemon Domingo
Cardoso Rosa Maria Fernandes
Ellen Chi
Tammy Bush
Judith Ann Connor
Theresa Marie Mcdevitt
Hong Mimi Zhou
Bethany Kay Mattson
Colleen Kane
Thai Quang Dinh
Jill Marie Mooney
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of JOP20200303A1 publication Critical patent/JOP20200303A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

يتعلق الاختراع الحالي بأجسام مضادة ترتبط نوعيًا بـ PSMA، أو PSMA وCD3، وعديدات نوكليوتيد تشفر الأجسام المضادة أو أجزاء منها، وطريقة تحضير واستخدام ما سبق.
JOP/2020/0303A 2018-05-24 2019-05-21 عوامل ربط psma واستخداماتها JOP20200303A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862676099P 2018-05-24 2018-05-24
PCT/IB2019/054189 WO2019224718A2 (en) 2018-05-24 2019-05-21 Psma binding agents and uses thereof

Publications (1)

Publication Number Publication Date
JOP20200303A1 true JOP20200303A1 (ar) 2020-11-23

Family

ID=67253934

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2020/0303A JOP20200303A1 (ar) 2018-05-24 2019-05-21 عوامل ربط psma واستخداماتها

Country Status (25)

Country Link
US (1) US11746157B2 (ar)
EP (1) EP3802609A2 (ar)
JP (1) JP7361727B2 (ar)
KR (1) KR20210015902A (ar)
CN (1) CN112513085A (ar)
AR (1) AR116173A1 (ar)
AU (1) AU2019274657A1 (ar)
BR (1) BR112020023872A2 (ar)
CA (1) CA3101272A1 (ar)
CL (1) CL2020003031A1 (ar)
CR (1) CR20200563A (ar)
DO (1) DOP2020000216A (ar)
EA (1) EA202092839A1 (ar)
EC (1) ECSP20082991A (ar)
IL (1) IL278888A (ar)
JO (1) JOP20200303A1 (ar)
MA (1) MA52777A (ar)
MX (1) MX2020012598A (ar)
NI (1) NI202000086A (ar)
PE (1) PE20211916A1 (ar)
PH (1) PH12020551997A1 (ar)
SG (1) SG11202011633SA (ar)
TW (1) TW202016135A (ar)
UY (1) UY38244A (ar)
WO (1) WO2019224718A2 (ar)

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BR112020023872A2 (pt) 2021-02-17
EP3802609A2 (en) 2021-04-14
PE20211916A1 (es) 2021-09-28
NI202000086A (es) 2021-03-23
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