DE69232539T2 - Verwendung von anti-VEGF Antikörpern zur Behandlung von Krebs - Google Patents

Verwendung von anti-VEGF Antikörpern zur Behandlung von Krebs

Info

Publication number
DE69232539T2
DE69232539T2 DE69232539T DE69232539T DE69232539T2 DE 69232539 T2 DE69232539 T2 DE 69232539T2 DE 69232539 T DE69232539 T DE 69232539T DE 69232539 T DE69232539 T DE 69232539T DE 69232539 T2 DE69232539 T2 DE 69232539T2
Authority
DE
Germany
Prior art keywords
hvegf
antagonist
treat cancer
hvegfr
tumour
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69232539T
Other languages
English (en)
Other versions
DE69232539D1 (de
DE69232539T3 (de
Inventor
Napoleone Ferrara
Jin Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44652081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69232539(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE69232539D1 publication Critical patent/DE69232539D1/de
Publication of DE69232539T2 publication Critical patent/DE69232539T2/de
Application granted granted Critical
Publication of DE69232539T3 publication Critical patent/DE69232539T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69232539T 1992-10-28 1992-10-28 Verwendung von anti-VEGF Antikörpern zur Behandlung von Krebs Expired - Lifetime DE69232539T3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1992/009218 WO1994010202A1 (en) 1992-10-28 1992-10-28 Vascular endothelial cell growth factor antagonists

Publications (3)

Publication Number Publication Date
DE69232539D1 DE69232539D1 (de) 2002-05-08
DE69232539T2 true DE69232539T2 (de) 2002-11-21
DE69232539T3 DE69232539T3 (de) 2007-01-04

Family

ID=44652081

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69233803T Expired - Lifetime DE69233803D1 (de) 1992-10-28 1992-10-28 Verwendung von vaskulären Endothelwachstumsfaktor-Antagonisten
DE69233739T Expired - Lifetime DE69233739D1 (de) 1992-10-28 1992-10-28 Verwendung von Antagonisten des Zellwachstumsfaktors VEGF
DE69232539T Expired - Lifetime DE69232539T3 (de) 1992-10-28 1992-10-28 Verwendung von anti-VEGF Antikörpern zur Behandlung von Krebs

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69233803T Expired - Lifetime DE69233803D1 (de) 1992-10-28 1992-10-28 Verwendung von vaskulären Endothelwachstumsfaktor-Antagonisten
DE69233739T Expired - Lifetime DE69233739D1 (de) 1992-10-28 1992-10-28 Verwendung von Antagonisten des Zellwachstumsfaktors VEGF

Country Status (18)

Country Link
EP (4) EP1167384B1 (de)
JP (1) JP3398382B2 (de)
KR (1) KR100335584B1 (de)
AT (4) ATE348110T1 (de)
AU (1) AU687727B2 (de)
BG (1) BG99605A (de)
BR (1) BR9207175A (de)
CA (1) CA2145985C (de)
CZ (1) CZ291047B6 (de)
DE (3) DE69233803D1 (de)
DK (4) DK1238986T3 (de)
ES (4) ES2173873T5 (de)
FI (1) FI951987A (de)
HU (2) HU225646B1 (de)
NO (1) NO321825B1 (de)
RO (1) RO119721B1 (de)
SK (1) SK285035B6 (de)
WO (1) WO1994010202A1 (de)

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* Cited by examiner, † Cited by third party
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