NO943653L - Rekombinante, humane HIV-nöytraliserende monoklonale antistoffer for forebyggelse og behandling av HIV-infeksjon - Google Patents

Rekombinante, humane HIV-nöytraliserende monoklonale antistoffer for forebyggelse og behandling av HIV-infeksjon

Info

Publication number
NO943653L
NO943653L NO943653A NO943653A NO943653L NO 943653 L NO943653 L NO 943653L NO 943653 A NO943653 A NO 943653A NO 943653 A NO943653 A NO 943653A NO 943653 L NO943653 L NO 943653L
Authority
NO
Norway
Prior art keywords
prevention
treatment
monoclonal antibodies
hiv
neutralizing monoclonal
Prior art date
Application number
NO943653A
Other languages
English (en)
Other versions
NO943653D0 (no
Inventor
Emilio A Emini
Anthony J Conley
George E Mark
L Syd Johnson
David S Pfarr
Original Assignee
Merck & Co Inc
Medimmune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Medimmune Inc filed Critical Merck & Co Inc
Publication of NO943653D0 publication Critical patent/NO943653D0/no
Publication of NO943653L publication Critical patent/NO943653L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Rekombinante, humane HTV-naytraliserende monoklonale antistoffer for forebyggelse og behandling av HTV-infeksjon Rekombinante, humane immun- globulinmolekyler som er nøytraliser- ende for HIV-1, fremgangsmåter for fremstilling av immunglobulinene og fremgangsmåter for forebyggelse av HIV- 1-infeksjon ved anvendelse av immunglo- bulinene. DNA-konstruksjoner innehold- ende de komplementaritetsbestemmende områder (CDR) og rammeverk (FR) for det native, humane antistoff, kombineres med andre konstante områder og uttryk- kes i rekombinante vertsceller. Disse rekombinante antistoffer er anvendelige for behandling og forebyggelse av HIV- 1-infeksjon in vlvo.
NO943653A 1992-04-01 1994-09-30 Rekombinante, humane HIV-nöytraliserende monoklonale antistoffer for forebyggelse og behandling av HIV-infeksjon NO943653L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86170192A 1992-04-01 1992-04-01
PCT/US1993/002629 WO1993019785A1 (en) 1992-04-01 1993-03-23 Recombinant human hiv-neutralizing monoclonal antibodies for prevention and treatment of hiv infection

Publications (2)

Publication Number Publication Date
NO943653D0 NO943653D0 (no) 1994-09-30
NO943653L true NO943653L (no) 1994-11-30

Family

ID=25336532

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943653A NO943653L (no) 1992-04-01 1994-09-30 Rekombinante, humane HIV-nöytraliserende monoklonale antistoffer for forebyggelse og behandling av HIV-infeksjon

Country Status (19)

Country Link
EP (1) EP0577243A3 (no)
JP (1) JPH06217791A (no)
KR (1) KR950700761A (no)
CN (1) CN1081716A (no)
AU (2) AU3928593A (no)
BG (1) BG99074A (no)
CA (1) CA2093099A1 (no)
CZ (1) CZ239694A3 (no)
FI (1) FI944561A (no)
HU (1) HUT70461A (no)
IL (1) IL105145A0 (no)
MX (1) MX9301858A (no)
NO (1) NO943653L (no)
NZ (1) NZ251582A (no)
RU (1) RU94045907A (no)
SK (1) SK116294A3 (no)
WO (1) WO1993019785A1 (no)
YU (1) YU22693A (no)
ZA (1) ZA932308B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003500003A (ja) * 1998-10-30 2003-01-07 ノボザイムス アクティーゼルスカブ 低いアレルゲン性のタンパク質変異型
RU2221873C2 (ru) * 2001-04-24 2004-01-20 Закрытое акционерное общество "АСГЛ-Фармацевтические Инновации" Способ получения каталитических антител (варианты), антигены для иммунизации и нуклеотидная последовательность
US7560529B2 (en) 2001-04-24 2009-07-14 FDS Pharma Method for producing catalytic antibodies (variants), antigens for immunization and nucleotide sequence
FR2844455B1 (fr) * 2002-09-13 2007-12-14 Lab Francais Du Fractionnement Traitement des pathologies echappant a la reponse immune par des anticorps optimises
JP4922613B2 (ja) * 2003-02-20 2012-04-25 一般財団法人化学及血清療法研究所 モノクローナル抗体製剤の奏効性を向上させる方法
EP2192918A1 (en) * 2007-08-24 2010-06-09 Novartis Ag Hiv env proteins with modifications in the v3 loop
ES2467108T3 (es) 2008-12-09 2014-06-11 Gilead Sciences, Inc. Moduladores de receptores tipo toll
US10421803B2 (en) 2014-01-31 2019-09-24 The Rockefeller University Broadly neutralizing glycan-dependent 8ANC195 antibody variants that bind to an epitope spanning both HIV-1 Env subunits
EA201790024A1 (ru) 2014-07-11 2017-07-31 Джилид Сайэнс, Инк. Модуляторы toll-подобных рецепторов для лечения вич
EA201790369A1 (ru) 2014-09-16 2017-10-31 Джилид Сайэнс, Инк. Твердые формы модулятора толл-подобного рецептора
WO2021227138A1 (zh) * 2020-05-09 2021-11-18 江苏省疾病预防控制中心(江苏省公共卫生研究院) 针对新型冠状病毒的单克隆抗体或其抗原结合部分

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0366718B1 (en) * 1987-05-29 1995-05-10 Tanox Biosystems, Inc. Monoclonal antibodies neutralizing hiv-1
EP0311228A3 (en) * 1987-10-09 1990-05-02 Repligen Corporation Recombinant polypeptides and their uses, including assay for aids virus
IL94624A0 (en) * 1989-06-05 1991-04-15 Repligen Corp Human monoclonal antibodies to hiv-1 mn qq120
WO1991019797A1 (en) * 1990-06-15 1991-12-26 New York University Heterohybridomas producing human monoclonal antibodies to hiv-1
CA2128879A1 (en) * 1992-01-29 1993-08-05 Marie E. Beckner Aamp-1, a protein with local homologies to hiv-1 env and nef proteins

Also Published As

Publication number Publication date
SK116294A3 (en) 1996-11-06
NO943653D0 (no) 1994-09-30
IL105145A0 (en) 1993-07-08
WO1993019785A1 (en) 1993-10-14
MX9301858A (es) 1994-03-31
HUT70461A (en) 1995-10-30
BG99074A (en) 1995-11-30
CZ239694A3 (en) 1995-07-12
AU658987B2 (en) 1995-05-04
EP0577243A2 (en) 1994-01-05
FI944561A0 (fi) 1994-09-30
HU9402824D0 (en) 1994-11-28
YU22693A (sh) 1997-01-08
AU3563093A (en) 1993-10-07
FI944561A (fi) 1994-09-30
CN1081716A (zh) 1994-02-09
EP0577243A3 (en) 1994-11-02
NZ251582A (en) 1997-07-27
RU94045907A (ru) 1996-11-10
ZA932308B (en) 1994-09-30
JPH06217791A (ja) 1994-08-09
CA2093099A1 (en) 1993-10-02
KR950700761A (ko) 1995-02-20
AU3928593A (en) 1993-11-08

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