AR082693A1 - Terapia de combinacion de un anticuerpo anti-cd20 afucosilado con un anticuerpo anti-vegf - Google Patents
Terapia de combinacion de un anticuerpo anti-cd20 afucosilado con un anticuerpo anti-vegfInfo
- Publication number
- AR082693A1 AR082693A1 ARP110102963A ARP110102963A AR082693A1 AR 082693 A1 AR082693 A1 AR 082693A1 AR P110102963 A ARP110102963 A AR P110102963A AR P110102963 A ARP110102963 A AR P110102963A AR 082693 A1 AR082693 A1 AR 082693A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibody
- combination therapy
- afucosilated
- vegf
- afucosylated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
Abstract
Terapia de combinación de un anticuerpo anti-CD20 afucosilado con un anticuerpo anti-VEGF para el tratamiento del cáncer, especialmente a la terapia de combinación de los cánceres que expresan CD20 con un anticuerpo B-Ly1 afucosilado humanizado y un anticuerpo anti-VEGF.Reivindicación 8: Una composición que comprende un anticuerpo B-Ly1 humanizado que está afucosilado con una cantidad de fucosa del 60% o menos de la cantidad total de oligosacáridos (azúcares) en la Asn297, y bevacizumab o un anticuerpo de serie B20, para el tratamiento del cáncer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10173108 | 2010-08-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR082693A1 true AR082693A1 (es) | 2012-12-26 |
Family
ID=42731850
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110102963A AR082693A1 (es) | 2010-08-17 | 2011-08-15 | Terapia de combinacion de un anticuerpo anti-cd20 afucosilado con un anticuerpo anti-vegf |
Country Status (13)
Country | Link |
---|---|
US (3) | US20130183290A1 (es) |
EP (1) | EP2605793A1 (es) |
JP (2) | JP5778279B2 (es) |
KR (1) | KR101522113B1 (es) |
CN (1) | CN103096926B (es) |
AR (1) | AR082693A1 (es) |
BR (1) | BR112013002441A2 (es) |
CA (1) | CA2807243C (es) |
HK (1) | HK1180228A1 (es) |
MX (1) | MX347463B (es) |
RU (1) | RU2615459C2 (es) |
TW (1) | TW201208703A (es) |
WO (1) | WO2012022747A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ME01775B (me) | 2003-11-05 | 2011-02-28 | Glycart Biotechnology Ag | Cd20 antitijela sa povećanim afinitetom vezivanja za fc receptor i efektornom funkcijom |
CN105143268A (zh) * | 2013-05-02 | 2015-12-09 | 豪夫迈·罗氏有限公司 | 无岩藻糖基化cd20抗体与cd22抗体-药物缀合物的组合疗法 |
BR122023002590B1 (pt) * | 2013-07-05 | 2023-12-05 | Genmab A/S | Anticorpo humanizado ou quimérico de ligação ao cd3 humano, anticorpo biespecífico, microrganismo, composição, composição farmacêutica, uso dos mesmos, método para produzir um anticorpo, composição de diagnóstico, método in vitro para detectar a presença de antígeno cd3, ou uma célula expressando cd3, em uma amostra, kit para detectar a presença de antígeno cd3, ou uma célula que expressa cd3, em uma amostra e anticorpo anti-idiotípico |
WO2018106931A1 (en) | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
US20210138213A1 (en) | 2017-03-30 | 2021-05-13 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
US20230009902A1 (en) | 2018-06-20 | 2023-01-12 | Progenity, Inc. | Treatment of a disease or condition in a tissue orginating from the endoderm |
EP3883635A1 (en) | 2018-11-19 | 2021-09-29 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
Family Cites Families (44)
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US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
US6582959B2 (en) | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
US20030206899A1 (en) | 1991-03-29 | 2003-11-06 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
HU225646B1 (en) | 1992-10-28 | 2007-05-29 | Genentech Inc | Hvegf receptors as vascular endothelial cell growth factor antagonists |
US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
US6750334B1 (en) | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
IL132239A0 (en) | 1997-04-07 | 2001-03-19 | Genentech Inc | Humanized antibodies and methods for forming humanized antibodies |
US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
WO1998045331A2 (en) | 1997-04-07 | 1998-10-15 | Genentech, Inc. | Anti-vegf antibodies |
US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
ES2434961T5 (es) | 1998-04-20 | 2018-01-18 | Roche Glycart Ag | Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo |
MXPA00011248A (es) | 1998-05-15 | 2004-09-06 | Imclone Systems Inc | Tratamientos de tumores humanos con radiacion e inhibidores de tirosina cinasas de recptor de factor de crecimiento. |
WO2000035956A1 (fr) | 1998-12-16 | 2000-06-22 | Kyowa Hakko Kogyo Co., Ltd. | Anticorps monoclonal anti-vegf humain |
ES2420835T3 (es) | 1999-04-09 | 2013-08-27 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para controlar la actividad de las moléculas inmunofuncionales |
US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
US20030157108A1 (en) | 2001-10-25 | 2003-08-21 | Genentech, Inc. | Glycoprotein compositions |
US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
CA3029035C (en) | 2002-10-17 | 2023-03-07 | Genmab A/S | Human monoclonal antibodies against cd20 |
BRPI0316779B8 (pt) | 2002-12-16 | 2023-02-28 | Genentech Inc | Anticorpo anti-cd20 humano ou fragmento de ligação ao antígeno do mesmo, seus usos, composição, artigo manufaturado e formulação líquida |
PL224786B1 (pl) | 2003-01-22 | 2017-01-31 | Glycart Biotechnology Ag | Wyizolowany kwas nukleinowy, ssaczy wektor ekspresyjny, komórki gospodarza, fuzja polipeptydowa i sposób jej wytwarzania, sposoby in vitro i ex vivo modyfikowania profilu glikozylacji polipeptydu wytwarzanego przez komórki gospodarza |
CN1829741A (zh) | 2003-05-30 | 2006-09-06 | 健泰科生物技术公司 | 利用抗-vegf抗体的治疗 |
JP2007500508A (ja) | 2003-07-29 | 2007-01-18 | モルフォテック、インク. | 抗体とエフェクター機能が増強された遺伝子組み換え抗体を作成する方法 |
US20050106667A1 (en) | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
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AU2004273791A1 (en) | 2003-09-05 | 2005-03-31 | Genentech, Inc. | Antibodies with altered effector functions |
ME01775B (me) * | 2003-11-05 | 2011-02-28 | Glycart Biotechnology Ag | Cd20 antitijela sa povećanim afinitetom vezivanja za fc receptor i efektornom funkcijom |
WO2005103081A2 (en) | 2004-04-20 | 2005-11-03 | Genmab A/S | Human monoclonal antibodies against cd20 |
US20060009360A1 (en) | 2004-06-25 | 2006-01-12 | Robert Pifer | New adjuvant composition |
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DOP2006000029A (es) * | 2005-02-07 | 2006-08-15 | Genentech Inc | Antibody variants and uses thereof. (variantes de un anticuerpo y usos de las mismas) |
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MX2008001966A (es) * | 2005-08-12 | 2008-03-26 | Regeneron Pharma | Tratamiento de enfermedades mediante administracion subcutanea de un antagonista vegf. |
NO345919B1 (no) | 2005-08-26 | 2021-10-18 | Roche Glycart Ag | Modifiserte antigen-bindende molekyler med endret celle-signaliseringsaktivitet |
US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
US20110243931A1 (en) * | 2007-09-02 | 2011-10-06 | Thomas Friess | Combination therapy with type i and type ii anti-cd20 antibodies |
US20090110688A1 (en) * | 2007-10-24 | 2009-04-30 | Georg Fertig | Combination therapy of type ii anti-cd20 antibody with a proteasome inhibitor |
-
2011
- 2011-08-15 TW TW100129119A patent/TW201208703A/zh unknown
- 2011-08-15 AR ARP110102963A patent/AR082693A1/es unknown
- 2011-08-16 CN CN201180036457.2A patent/CN103096926B/zh not_active Expired - Fee Related
- 2011-08-16 MX MX2013001839A patent/MX347463B/es active IP Right Grant
- 2011-08-16 JP JP2013524442A patent/JP5778279B2/ja not_active Expired - Fee Related
- 2011-08-16 RU RU2013109172A patent/RU2615459C2/ru active
- 2011-08-16 EP EP11743838.2A patent/EP2605793A1/en not_active Ceased
- 2011-08-16 BR BR112013002441A patent/BR112013002441A2/pt not_active Application Discontinuation
- 2011-08-16 WO PCT/EP2011/064097 patent/WO2012022747A1/en active Application Filing
- 2011-08-16 KR KR1020137006530A patent/KR101522113B1/ko active IP Right Grant
- 2011-08-16 CA CA2807243A patent/CA2807243C/en not_active Expired - Fee Related
- 2011-08-17 US US13/211,861 patent/US20130183290A1/en not_active Abandoned
-
2013
- 2013-06-27 HK HK13107550.2A patent/HK1180228A1/zh not_active IP Right Cessation
- 2013-11-27 US US14/092,671 patent/US20140322200A1/en not_active Abandoned
-
2015
- 2015-05-20 JP JP2015102724A patent/JP2015187130A/ja active Pending
- 2015-09-17 US US14/857,112 patent/US20160017050A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2013535511A (ja) | 2013-09-12 |
US20140322200A1 (en) | 2014-10-30 |
KR20130055660A (ko) | 2013-05-28 |
EP2605793A1 (en) | 2013-06-26 |
BR112013002441A2 (pt) | 2016-05-24 |
MX347463B (es) | 2017-04-26 |
RU2615459C2 (ru) | 2017-04-04 |
JP2015187130A (ja) | 2015-10-29 |
US20160017050A1 (en) | 2016-01-21 |
CN103096926B (zh) | 2016-02-10 |
KR101522113B1 (ko) | 2015-05-20 |
TW201208703A (en) | 2012-03-01 |
JP5778279B2 (ja) | 2015-09-16 |
HK1180228A1 (zh) | 2013-10-18 |
CN103096926A (zh) | 2013-05-08 |
CA2807243A1 (en) | 2012-02-23 |
WO2012022747A1 (en) | 2012-02-23 |
MX2013001839A (es) | 2013-03-07 |
RU2013109172A (ru) | 2014-09-27 |
CA2807243C (en) | 2018-09-11 |
US20130183290A1 (en) | 2013-07-18 |
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Legal Events
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