MXPA02007632A - Derivados de 2-benzotiazolil urea y su uso como inhibidores de proteina cinasa. - Google Patents
Derivados de 2-benzotiazolil urea y su uso como inhibidores de proteina cinasa.Info
- Publication number
- MXPA02007632A MXPA02007632A MXPA02007632A MXPA02007632A MXPA02007632A MX PA02007632 A MXPA02007632 A MX PA02007632A MX PA02007632 A MXPA02007632 A MX PA02007632A MX PA02007632 A MXPA02007632 A MX PA02007632A MX PA02007632 A MXPA02007632 A MX PA02007632A
- Authority
- MX
- Mexico
- Prior art keywords
- protein kinase
- kinase inhibitors
- urea derivatives
- inhibitors
- benzothiazolyl urea
- Prior art date
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- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract
La presente invencion es dirigida a un compuesto de formula (l), mezclas racemicas-diastereomericas del mismo, isomeros opticos del mismo, promedicamentos del mismo, isotopos del mismo o sales farmaceuticamente aceptables de dicho compuesto, isomeros, promedicamentos e isotopos, en donde las variables son definidas en la presente. Los compuestos de esta invencion son utiles como inhibidores de serina/treonina y tirosina cinasas. En particular, compuestos de esta invencion son utiles como inhibidores de tirosina cinasas, que son importantes en enfermedades hiper-proliferativas, especialmente en cancer y en el proceso de angiogenesis. (ver formula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18084100P | 2000-02-07 | 2000-02-07 | |
PCT/US2001/003803 WO2001057008A1 (en) | 2000-02-07 | 2001-02-06 | 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
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MXPA02007632A true MXPA02007632A (es) | 2004-08-23 |
Family
ID=22661941
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA02007632A MXPA02007632A (es) | 2000-02-07 | 2001-02-06 | Derivados de 2-benzotiazolil urea y su uso como inhibidores de proteina cinasa. |
Country Status (18)
Country | Link |
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US (1) | US7091227B2 (es) |
EP (1) | EP1254123A1 (es) |
JP (1) | JP2003521543A (es) |
KR (1) | KR20020084116A (es) |
CN (1) | CN1422262A (es) |
AR (1) | AR030189A1 (es) |
AU (1) | AU2001236698A1 (es) |
BG (1) | BG107062A (es) |
BR (1) | BR0108085A (es) |
CA (1) | CA2398754A1 (es) |
HU (1) | HUP0300359A2 (es) |
IL (1) | IL151045A0 (es) |
MX (1) | MXPA02007632A (es) |
NO (1) | NO20023713L (es) |
PL (1) | PL357099A1 (es) |
SK (1) | SK12712002A3 (es) |
WO (1) | WO2001057008A1 (es) |
ZA (1) | ZA200206235B (es) |
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US3810988A (en) * | 1968-11-01 | 1974-05-14 | Ciba Geigy Ag | Control of phytopathogenic fungi with n-benzothiazae-2-yl n-{40 {11 propylure |
CH505543A (de) * | 1968-11-01 | 1971-04-15 | Ciba Geigy Ag | Schädlingsbekämpfungsmittel |
JPS53124265A (en) * | 1977-04-06 | 1978-10-30 | Nippon Tokushu Noyaku Seizo Kk | Urea or thiourea type compounds, their preparation and insecticides contaning the same as active agent |
JPS57175189A (en) * | 1981-04-21 | 1982-10-28 | Kyowa Hakko Kogyo Co Ltd | Benzothiazole derivative and its preparation |
US4966849A (en) | 1985-09-20 | 1990-10-30 | President And Fellows Of Harvard College | CDNA and genes for human angiogenin (angiogenesis factor) and methods of expression |
JPS62187842A (ja) * | 1985-10-25 | 1987-08-17 | Konishiroku Photo Ind Co Ltd | ハロゲン化銀写真感光材料 |
US5217999A (en) | 1987-12-24 | 1993-06-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Styryl compounds which inhibit EGF receptor protein tyrosine kinase |
EP0526488B1 (en) | 1990-04-02 | 1994-11-30 | Pfizer Inc. | Benzylphosphonic acid tyrosine kinase inhibitors |
US5302606A (en) | 1990-04-16 | 1994-04-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase |
US5409930A (en) | 1991-05-10 | 1995-04-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
CA2108889A1 (en) | 1991-05-29 | 1992-11-30 | Robert Lee Dow | Tricyclic polyhydroxylic tyrosine kinase inhibitors |
GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
CZ283965B6 (cs) | 1992-08-06 | 1998-07-15 | Warner-Lambert Company | 2-thioindolové, 2-indolinthionové a polysulfidové sloučeniny, 2-selenoindolové, 2-indolinselenonové a selenidové sloučeniny a farmaceutické prostředky na jejich bázi |
US5330992A (en) | 1992-10-23 | 1994-07-19 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolinones |
DE69232539T3 (de) | 1992-10-28 | 2007-01-04 | Genentech, Inc., South San Francisco | Verwendung von anti-VEGF Antikörpern zur Behandlung von Krebs |
GB9226855D0 (en) | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
DE69734149T2 (de) | 1996-03-15 | 2006-07-06 | Astrazeneca Ab | Cinoline derivate und verwendung als heilmittel |
EP0915698A4 (en) | 1996-05-01 | 1999-08-11 | Lilly Co Eli | TREATMENT PROCEDURE FOR VEGF-RELATED DISEASES |
UA54427C2 (uk) | 1996-05-01 | 2003-03-17 | Елі Ліллі Енд Компані | Спосіб лікування очних захворювань, які пов'язані з фактором васкулярного ендотеліального росту |
GB9707800D0 (en) | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
TW513418B (en) * | 1996-07-31 | 2002-12-11 | Otsuka Pharma Co Ltd | Thiazole derivatives, their production and use |
EP1749836B1 (en) | 1996-08-23 | 2009-06-17 | Vegenics Limited | Recombinant vascular endothelial cell growth factor D (VEGF-D) |
US6093742A (en) | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
JPH11130761A (ja) * | 1997-10-24 | 1999-05-18 | Otsuka Pharmaceut Co Ltd | ベンゾチアゾール誘導体 |
AU744281B2 (en) * | 1997-11-10 | 2002-02-21 | Bristol-Myers Squibb Company | Benzothiazole protein tyrosine kinase inhibitors |
JPH11222431A (ja) * | 1998-01-30 | 1999-08-17 | Otsuka Pharmaceut Co Ltd | 医薬組成物 |
AU6314900A (en) | 1999-07-26 | 2001-02-13 | Banyu Pharmaceutical Co., Ltd. | Biarylurea derivatives |
-
2001
- 2001-02-06 SK SK1271-2002A patent/SK12712002A3/sk unknown
- 2001-02-06 AU AU2001236698A patent/AU2001236698A1/en not_active Abandoned
- 2001-02-06 BR BR0108085-7A patent/BR0108085A/pt not_active Application Discontinuation
- 2001-02-06 US US09/777,554 patent/US7091227B2/en not_active Expired - Lifetime
- 2001-02-06 EP EP01908878A patent/EP1254123A1/en not_active Withdrawn
- 2001-02-06 HU HU0300359A patent/HUP0300359A2/hu unknown
- 2001-02-06 WO PCT/US2001/003803 patent/WO2001057008A1/en not_active Application Discontinuation
- 2001-02-06 CN CN01807734A patent/CN1422262A/zh active Pending
- 2001-02-06 KR KR1020027010188A patent/KR20020084116A/ko not_active Application Discontinuation
- 2001-02-06 MX MXPA02007632A patent/MXPA02007632A/es unknown
- 2001-02-06 CA CA002398754A patent/CA2398754A1/en not_active Abandoned
- 2001-02-06 PL PL01357099A patent/PL357099A1/xx not_active Application Discontinuation
- 2001-02-06 JP JP2001556858A patent/JP2003521543A/ja not_active Withdrawn
- 2001-02-06 IL IL15104501A patent/IL151045A0/xx unknown
- 2001-02-07 AR ARP010100543A patent/AR030189A1/es unknown
-
2002
- 2002-08-05 ZA ZA200206235A patent/ZA200206235B/en unknown
- 2002-08-06 NO NO20023713A patent/NO20023713L/no not_active Application Discontinuation
- 2002-09-04 BG BG107062A patent/BG107062A/bg unknown
Also Published As
Publication number | Publication date |
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CA2398754A1 (en) | 2001-08-09 |
AU2001236698A1 (en) | 2001-08-14 |
NO20023713D0 (no) | 2002-08-06 |
CN1422262A (zh) | 2003-06-04 |
NO20023713L (no) | 2002-10-04 |
BG107062A (bg) | 2003-04-30 |
AR030189A1 (es) | 2003-08-13 |
WO2001057008A1 (en) | 2001-08-09 |
BR0108085A (pt) | 2003-03-18 |
IL151045A0 (en) | 2003-04-10 |
SK12712002A3 (sk) | 2003-02-04 |
EP1254123A1 (en) | 2002-11-06 |
US20030153568A1 (en) | 2003-08-14 |
ZA200206235B (en) | 2004-02-13 |
KR20020084116A (ko) | 2002-11-04 |
JP2003521543A (ja) | 2003-07-15 |
HUP0300359A2 (hu) | 2003-06-28 |
PL357099A1 (en) | 2004-07-12 |
US7091227B2 (en) | 2006-08-15 |
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