FR2922550B1 - Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet - Google Patents
Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmetInfo
- Publication number
- FR2922550B1 FR2922550B1 FR0707314A FR0707314A FR2922550B1 FR 2922550 B1 FR2922550 B1 FR 2922550B1 FR 0707314 A FR0707314 A FR 0707314A FR 0707314 A FR0707314 A FR 0707314A FR 2922550 B1 FR2922550 B1 FR 2922550B1
- Authority
- FR
- France
- Prior art keywords
- novel
- heteroalkyloxy
- benzothiazole
- medicaments
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0707314A FR2922550B1 (fr) | 2007-10-19 | 2007-10-19 | Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet |
PA20088798901A PA8798901A1 (es) | 2007-10-19 | 2008-10-15 | Nuevos derivados de 6- aril/heteroalquiloxi benzotiazol y bencimidazol, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nueva utilizacion principalmente como inhibidores de cmet" |
AU2008346313A AU2008346313A1 (en) | 2007-10-19 | 2008-10-16 | 6-aryl/heteroalkyloxy benzothiazole and benzimidazole derivatives, method for preparing same, application thereof as drugs, pharmaceutical compositions and novel use in particular as c-Met inhibitors |
EP08869645A EP2205568A1 (fr) | 2007-10-19 | 2008-10-16 | Derives de 6-aryl/heter0alkyl0xy benzothiazole et benzimidazole, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet |
KR1020107010820A KR20100075644A (ko) | 2007-10-19 | 2008-10-16 | 6-아릴/헤테로알킬옥시 벤조티아졸 및 벤즈이미다졸 유도체, 이들의 제조 방법, 약물로서의 이들의 적용, 제약 조성물, 및 특히 c-MET 억제제로서의 신규 용도 |
CA2702791A CA2702791A1 (fr) | 2007-10-19 | 2008-10-16 | Derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet |
JP2010529425A JP2011500651A (ja) | 2007-10-19 | 2008-10-16 | 6−アリール/ヘテロアルキルオキシベンゾチアゾールおよびベンゾイミダゾール誘導体、これらの調製方法、薬物としてのこれらの用途、医薬組成物、ならびに特にc−met阻害剤としての新規使用 |
RU2010119934/04A RU2010119934A (ru) | 2007-10-19 | 2008-10-16 | Производные 6-арил/гетероалкилокси бензотиазола и бензимидазола, способ их получения, их применение в качестве лекарственных средств, фармацевтические композиции и новое применение, в частности, в качестве ингибиторов смет |
MX2010004293A MX2010004293A (es) | 2007-10-19 | 2008-10-16 | Derivados de 6-aril/heteroalquiloxi benzotiazol y bencimidazol, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nuevo uso principalmente como inhibidores de cmet. |
CN200880112247A CN101827827A (zh) | 2007-10-19 | 2008-10-16 | 6-芳基/杂烷氧基苯并噻唑和苯并咪唑的衍生物、其制备方法、其作为药物的应用、药物组合物和尤其作为cmet抑制剂的新用途 |
PCT/FR2008/001450 WO2009087305A1 (fr) | 2007-10-19 | 2008-10-16 | Derives de 6-aryl/heter0alkyl0xy benzothiazole et benzimidazole, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet |
ARP080104536A AR068912A1 (es) | 2007-10-19 | 2008-10-17 | Derivados de 6- aril/ heteroarilquiloxi benzotiazol y bencimidazol, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y utilizacion como inhibidores de cmet |
TW097140026A TW200922565A (en) | 2007-10-19 | 2008-10-17 | Novel derivatives of 6-aryl/heteroalkyloxy benzothiazole and benzimidazole, their method of preparation, their application as medicinal products, pharmaceutical compositions and novel use notably as c-MET inhibitors |
CL2008003093A CL2008003093A1 (es) | 2007-10-19 | 2008-10-17 | Compuestos derivados de 6-aril/heteroalquiloxi benzotiazol y bencimidazol; procedimiento de preparacion; composicion farmaceutica, y uso para el tratamiento o la prevencion de trastornos de los vasos sanguineos, alergias, asma, trombosis, artritis reumatoide y cancer, entre otras. |
PE2008001795A PE20090876A1 (es) | 2007-10-19 | 2008-10-17 | Nuevos derivados de 6-aril/heteroalquiloxi benzotiazol y bencimidazol, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nueva utilizacion principalmente como inhibidores de cmet |
UY31412A UY31412A1 (es) | 2007-10-19 | 2008-10-20 | Nuevos derivados de 6-aril/heteroalquiloxi benzotiazol y bencimidazol, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmacéuticas y nueva utilizacion principalmente como inhibidores de cmet |
IL205097A IL205097A0 (en) | 2007-10-19 | 2010-04-14 | 6-aryl/heteroalkyloxy benzothiazole and benzimidazole derivatives, method for preparing same, application thereof as drugs, pharmaceutical compositions and novel use in particular as c-met inhibitors |
US12/761,973 US8188078B2 (en) | 2007-10-19 | 2010-04-16 | 6-aryl/heteroalkyloxy benzothiazole and benzimidazole derivatives, method for preparing same, application thereof as drugs, pharmaceutical compositions and novel use in particular as C-MET inhibitors |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0707314A FR2922550B1 (fr) | 2007-10-19 | 2007-10-19 | Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2922550A1 FR2922550A1 (fr) | 2009-04-24 |
FR2922550B1 true FR2922550B1 (fr) | 2009-11-27 |
Family
ID=39304632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0707314A Expired - Fee Related FR2922550B1 (fr) | 2007-10-19 | 2007-10-19 | Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet |
Country Status (18)
Country | Link |
---|---|
US (1) | US8188078B2 (fr) |
EP (1) | EP2205568A1 (fr) |
JP (1) | JP2011500651A (fr) |
KR (1) | KR20100075644A (fr) |
CN (1) | CN101827827A (fr) |
AR (1) | AR068912A1 (fr) |
AU (1) | AU2008346313A1 (fr) |
CA (1) | CA2702791A1 (fr) |
CL (1) | CL2008003093A1 (fr) |
FR (1) | FR2922550B1 (fr) |
IL (1) | IL205097A0 (fr) |
MX (1) | MX2010004293A (fr) |
PA (1) | PA8798901A1 (fr) |
PE (1) | PE20090876A1 (fr) |
RU (1) | RU2010119934A (fr) |
TW (1) | TW200922565A (fr) |
UY (1) | UY31412A1 (fr) |
WO (1) | WO2009087305A1 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1847543A1 (fr) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidines pour le traitement de maladies inflammatoires |
KR20100075930A (ko) | 2007-10-19 | 2010-07-05 | 베링거 인겔하임 인터내셔날 게엠베하 | 헤테로사이클-치환된 피페라지노-디하이드로티에노피리미딘 |
UA99309C2 (ru) | 2007-10-19 | 2012-08-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Замещенные пиперидинодигидротиенопиримидины |
US8486948B2 (en) | 2007-10-19 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Piperazinodihydrothienopyrimidine derivatives |
FR2953720B1 (fr) * | 2009-12-11 | 2012-05-11 | Oreal | Utilisation de derives de benzyloxy-ethylamines comme conservateur, |
WO2011138751A2 (fr) | 2010-05-04 | 2011-11-10 | Pfizer Inc. | Dérivés hétérocycliques destinés au traitement de maladies |
US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
CN103242237A (zh) * | 2013-05-10 | 2013-08-14 | 常州亚邦齐晖医药化工有限公司 | 一种驱虫药芬苯达唑的制备新方法 |
CN104876878B (zh) * | 2014-02-27 | 2018-04-27 | 中国科学院广州生物医药与健康研究院 | 5-芳基酚-2烷基取代脲苯并咪唑类化合物及其应用 |
ES2764299T3 (es) | 2014-12-09 | 2020-06-02 | Inst Nat Sante Rech Med | Anticuerpos monoclonales humanos contra AXL |
WO2016135041A1 (fr) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Protéines de fusion et anticorps les contenant pour favoriser l'apoptose |
ES2910071T3 (es) | 2018-03-08 | 2022-05-11 | Incyte Corp | Compuestos de aminopirazina diol como inhibidores de PI3K-Y |
WO2020010003A1 (fr) | 2018-07-02 | 2020-01-09 | Incyte Corporation | DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ |
CN110903246A (zh) * | 2019-12-19 | 2020-03-24 | 赵洁 | 一种用于治疗甲状腺癌的化合物及其组合物和医药用途 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2499995A1 (fr) | 1981-02-13 | 1982-08-20 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkylthiomethyl 7-amino thiazolylacetamido cephalosporanique, leur preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus. |
LT4726B (lt) * | 1998-12-29 | 2000-11-27 | Biochemijos Institutas | 5-pakeisti arilalkiloksibenzimidazol-2-ilkarbamino rūgščių metilo esteriai, turintys antihelmintinį aktyvumą |
AU2001236698A1 (en) * | 2000-02-07 | 2001-08-14 | Abbott Gesellschaft Mit Beschrankter Haftung & Company Kommanditgesellschaft | 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors |
EP1298125A1 (fr) | 2001-09-26 | 2003-04-02 | Aventis Pharma S.A. | Benzimidazoles substitués et leur usage comme traitement du cancer |
FR2868421B1 (fr) | 2004-04-01 | 2008-08-01 | Aventis Pharma Sa | Nouveaux benzothiazoles et leur utilisation comme medicaments |
EP1674466A1 (fr) * | 2004-12-27 | 2006-06-28 | 4Sc Ag | Derives benzazoles 2,5- et 2-6-disubstitues utiles comme des inhibiteurs de la proteine kinase |
WO2006108059A1 (fr) * | 2005-04-06 | 2006-10-12 | Exelixis, Inc. | Modulateurs c-met modulators et procedes d’utilisation |
FR2891273B1 (fr) * | 2005-09-27 | 2007-11-23 | Aventis Pharma Sa | NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet |
-
2007
- 2007-10-19 FR FR0707314A patent/FR2922550B1/fr not_active Expired - Fee Related
-
2008
- 2008-10-15 PA PA20088798901A patent/PA8798901A1/es unknown
- 2008-10-16 WO PCT/FR2008/001450 patent/WO2009087305A1/fr active Application Filing
- 2008-10-16 MX MX2010004293A patent/MX2010004293A/es not_active Application Discontinuation
- 2008-10-16 EP EP08869645A patent/EP2205568A1/fr not_active Withdrawn
- 2008-10-16 JP JP2010529425A patent/JP2011500651A/ja not_active Withdrawn
- 2008-10-16 RU RU2010119934/04A patent/RU2010119934A/ru not_active Application Discontinuation
- 2008-10-16 CA CA2702791A patent/CA2702791A1/fr not_active Abandoned
- 2008-10-16 CN CN200880112247A patent/CN101827827A/zh active Pending
- 2008-10-16 KR KR1020107010820A patent/KR20100075644A/ko not_active Application Discontinuation
- 2008-10-16 AU AU2008346313A patent/AU2008346313A1/en not_active Abandoned
- 2008-10-17 AR ARP080104536A patent/AR068912A1/es unknown
- 2008-10-17 PE PE2008001795A patent/PE20090876A1/es not_active Application Discontinuation
- 2008-10-17 CL CL2008003093A patent/CL2008003093A1/es unknown
- 2008-10-17 TW TW097140026A patent/TW200922565A/zh unknown
- 2008-10-20 UY UY31412A patent/UY31412A1/es not_active Application Discontinuation
-
2010
- 2010-04-14 IL IL205097A patent/IL205097A0/en unknown
- 2010-04-16 US US12/761,973 patent/US8188078B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PA8798901A1 (es) | 2009-07-23 |
CA2702791A1 (fr) | 2009-07-16 |
WO2009087305A1 (fr) | 2009-07-16 |
MX2010004293A (es) | 2010-05-17 |
TW200922565A (en) | 2009-06-01 |
PE20090876A1 (es) | 2009-08-03 |
CN101827827A (zh) | 2010-09-08 |
UY31412A1 (es) | 2009-05-29 |
AR068912A1 (es) | 2009-12-16 |
IL205097A0 (en) | 2010-11-30 |
AU2008346313A1 (en) | 2009-07-16 |
CL2008003093A1 (es) | 2010-06-11 |
JP2011500651A (ja) | 2011-01-06 |
US8188078B2 (en) | 2012-05-29 |
EP2205568A1 (fr) | 2010-07-14 |
FR2922550A1 (fr) | 2009-04-24 |
US20100273793A1 (en) | 2010-10-28 |
KR20100075644A (ko) | 2010-07-02 |
RU2010119934A (ru) | 2011-11-27 |
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