FR2933980B1 - Nouveaux derives triazolo°4,3-a!pyridine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met - Google Patents

Nouveaux derives triazolo°4,3-a!pyridine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met

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Publication number
FR2933980B1
FR2933980B1 FR0804084A FR0804084A FR2933980B1 FR 2933980 B1 FR2933980 B1 FR 2933980B1 FR 0804084 A FR0804084 A FR 0804084A FR 0804084 A FR0804084 A FR 0804084A FR 2933980 B1 FR2933980 B1 FR 2933980B1
Authority
FR
France
Prior art keywords
novel
medicaments
preparation
pharmaceutical compositions
pyridine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0804084A
Other languages
English (en)
Other versions
FR2933980A1 (fr
Inventor
Dominique Damour
Sylvie Wentzler
Eric Bacque
Conception Nemecek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0804084A priority Critical patent/FR2933980B1/fr
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to JP2011517978A priority patent/JP2011528337A/ja
Priority to EP09736253A priority patent/EP2310366A2/fr
Priority to PE2011000048A priority patent/PE20110560A1/es
Priority to CN2009801365397A priority patent/CN102159543A/zh
Priority to CA2730959A priority patent/CA2730959A1/fr
Priority to BRPI0916464-2A priority patent/BRPI0916464A2/pt
Priority to AU2009272516A priority patent/AU2009272516A1/en
Priority to TW098124130A priority patent/TW201008938A/zh
Priority to KR1020117003697A priority patent/KR20110039558A/ko
Priority to EA201170222A priority patent/EA201170222A1/ru
Priority to US13/054,663 priority patent/US20110263594A1/en
Priority to PCT/FR2009/051406 priority patent/WO2010007316A2/fr
Priority to MX2011000671A priority patent/MX2011000671A/es
Priority to ARP090102727A priority patent/AR072819A1/es
Priority to UY0001031996A priority patent/UY31996A/es
Publication of FR2933980A1 publication Critical patent/FR2933980A1/fr
Priority to IL210688A priority patent/IL210688A0/en
Priority to CO11004610A priority patent/CO6331463A2/es
Priority to CL2011000119A priority patent/CL2011000119A1/es
Priority to MA33625A priority patent/MA32570B1/fr
Publication of FR2933980B1 publication Critical patent/FR2933980B1/fr
Application granted granted Critical
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0804084A 2008-07-18 2008-07-18 Nouveaux derives triazolo°4,3-a!pyridine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met Expired - Fee Related FR2933980B1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR0804084A FR2933980B1 (fr) 2008-07-18 2008-07-18 Nouveaux derives triazolo°4,3-a!pyridine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
TW098124130A TW201008938A (en) 2008-07-18 2009-07-16 Novel triazolo[4,3-a]pyridine derivatives, process for the preparation thereof, use thereof as medicaments, pharmaceutical compositions and novel use, in particular as MET inhibitors
PE2011000048A PE20110560A1 (es) 2008-07-18 2009-07-16 NUEVOS DERIVADOS DE TRIAZOLO[4,3-a]PIRIDINA, SU PROCEDIMIENTO DE PREPARACION, SU APLICACION COMO MEDICAMENTOS, COMPOSICIONES FARMACEUTICAS Y NUEVA UTILIZACION PARTICULARMENTE COMO INHIBIDORES DE MET
CN2009801365397A CN102159543A (zh) 2008-07-18 2009-07-16 新颖的三唑并[4,3-a]吡啶衍生物，其制备方法，其作为药物的用途，药物组合物及新颖的尤其是作为MET抑制剂的用途
CA2730959A CA2730959A1 (fr) 2008-07-18 2009-07-16 Nouveaux derives triazolo[4,3-a]pyridine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
BRPI0916464-2A BRPI0916464A2 (pt) 2008-07-18 2009-07-16 derivados triazolo(4,3-a) piridina, o respectivo processo de preparo, a respectiva aplicação como medicamentos, composições farmacêuticas e utilização notadamente como inibidores de met
AU2009272516A AU2009272516A1 (en) 2008-07-18 2009-07-16 Novel triazolo(4,3-a)pyridine derivatives, process for the preparation thereof, use thereof as medicaments, pharmaceutical compositions and novel use, in particular as MET inhibitors
EP09736253A EP2310366A2 (fr) 2008-07-18 2009-07-16 NOUVEAUX DERIVES TRIAZOLO(4,3-a)PYRIDINE,LEUR PROCEDE DE PREPARATION,LEUR APPLICATION A TITRE DE MEDICAMENTS,COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET
KR1020117003697A KR20110039558A (ko) 2008-07-18 2009-07-16 신규 트리아졸로(4,3-ａ)피리딘 유도체, 그의 제조 방법, 의약으로서의 그의 용도, 제약 조성물, 및 특히 ｍｅｔ 억제제로서의 신규 용도
EA201170222A EA201170222A1 (ru) 2008-07-18 2009-07-16 НОВЫЕ ПРОИЗВОДНЫЕ ТРИАЗОЛО[4,3-a]ПИРИДИНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И НОВОЕ ПРИМЕНЕНИЕ, В ЧАСТНОСТИ, В КАЧЕСТВЕ ИНГИБИТОРОВ МЕТ
JP2011517978A JP2011528337A (ja) 2008-07-18 2009-07-16 新規トリアゾロ［４，３−ａ］ピリジン誘導体、これらの調製方法、医薬としてのこれらの使用、医薬組成物および、特にｍｅｔ阻害剤としての、新規使用
US13/054,663 US20110263594A1 (en) 2008-07-18 2009-07-16 Novel triazolo(4,3-a)pyridine derivatives, process for the preparation thereof, use thereof as medicaments, pharmaceutical compositions and novel use, in particular as met inhibitors
PCT/FR2009/051406 WO2010007316A2 (fr) 2008-07-18 2009-07-16 NOUVEAUX DERIVES TRIAZOLO(4,3-a)PYRIDINE,LEUR PROCEDE DE PREPARATION,LEUR APPLICATION A TITRE DE MEDICAMENTS,COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET
MX2011000671A MX2011000671A (es) 2008-07-18 2009-07-16 Nuevos derivados de triazolo [4,3-a] piridina su procedimiento de preparacion, su uso como medicamentos, composiciones farmaceuticas y nuevo uso particularmente como inhibidores de met.
ARP090102727A AR072819A1 (es) 2008-07-18 2009-07-17 Derivados de triazolo[4,3-a]piridina,procedimiento de preparacion,intermediarios de dicho proceso,composiciones farmaceuticas que los comprenden y uso de los mismos, como inhibidores de la proteinquinasa met,para el tratamiento de canceres,psoriasis,enfermedades del sistema nervioso central y otras
UY0001031996A UY31996A (es) 2008-07-18 2009-07-17 Nuevos derivados de triazolo[4,3-a]piridina, y sus nuevos usos como inhibidores de met
IL210688A IL210688A0 (en) 2008-07-18 2011-01-16 Novel triazolo(4,3-a)pyridine derivatives, process for the preparation thereof, use thereof as medicaments, pharmaceutical compositions and novel use, in particular as met inhibitors
CO11004610A CO6331463A2 (es) 2008-07-18 2011-01-18 Nuevos derivados de triazolo(4,3-a)piridina, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nueva utilizacion particularmente como inhibidores de met
CL2011000119A CL2011000119A1 (es) 2008-07-18 2011-01-18 Compuestos derivados de triazolo[4,3-a]piridina; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer.
MA33625A MA32570B1 (fr) 2008-07-18 2011-02-15 NOUVEAUX DERIVES TRIAZOLO(4,3-a)PYRIDINE,LEUR PROCEDE DE PREPARATION,LEUR APPLICATION A TITRE DE MEDICAMENTS,COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0804084A FR2933980B1 (fr) 2008-07-18 2008-07-18 Nouveaux derives triazolo°4,3-a!pyridine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met

Publications (2)

Publication Number Publication Date
FR2933980A1 FR2933980A1 (fr) 2010-01-22
FR2933980B1 true FR2933980B1 (fr) 2011-07-29

Family

ID=40347781

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0804084A Expired - Fee Related FR2933980B1 (fr) 2008-07-18 2008-07-18 Nouveaux derives triazolo°4,3-a!pyridine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met

Country Status (1)

Country Link
FR (1) FR2933980B1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201321742D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419516A (en) * 1982-06-16 1983-12-06 American Home Products Corporation Antiviral imidazo- and triazolo-pyridines
FR2601952B1 (fr) * 1986-07-23 1988-11-25 Carpibem Nouveaux derives amino alkyl thio de triazolopyridine ou triazoloquinoline, leurs procedes de preparation, medicaments les contenant, utiles notamment comme antalgiques
US5047416A (en) * 1989-07-31 1991-09-10 Merck & Co., Inc. Triazole compounds and their use as transglutaminase inhibitors
AU2001236698A1 (en) * 2000-02-07 2001-08-14 Abbott Gesellschaft Mit Beschrankter Haftung & Company Kommanditgesellschaft 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors
AU2005207946A1 (en) * 2004-01-23 2005-08-11 Amgen Inc. Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer
EP1674466A1 (fr) * 2004-12-27 2006-06-28 4Sc Ag Derives benzazoles 2,5- et 2-6-disubstitues utiles comme des inhibiteurs de la proteine kinase

Also Published As

Publication number Publication date
FR2933980A1 (fr) 2010-01-22

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Effective date: 20130329