HUP0300359A2 - 2-Benzotiazolil-karbamid-származékok és protein kináz inhibitorként történő felhasználásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents

2-Benzotiazolil-karbamid-származékok és protein kináz inhibitorként történő felhasználásuk és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0300359A2
HUP0300359A2 HU0300359A HUP0300359A HUP0300359A2 HU P0300359 A2 HUP0300359 A2 HU P0300359A2 HU 0300359 A HU0300359 A HU 0300359A HU P0300359 A HUP0300359 A HU P0300359A HU P0300359 A2 HUP0300359 A2 HU P0300359A2
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HU
Hungary
Prior art keywords
heterocyclic
alkyl
aryl
group
alkenyl
Prior art date
Application number
HU0300359A
Other languages
English (en)
Inventor
Lee D. Arnold
Kevin P. Cusack
Anna M. Ericsson
Barbara Scott
Original Assignee
Abbott Gmbh & Co. Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co. Kg. filed Critical Abbott Gmbh & Co. Kg.
Publication of HUP0300359A2 publication Critical patent/HUP0300359A2/hu

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Abstract

A találmány tárgya (I) általános képletű 2-benzotiazolilkarbamid-származékok, racém-diasztereomer elegyei, optikailag aktív izomerjei,prodrugjai, izotópjai vagy gyógyászatilag elfogadható sói, ezekizomerjei, prodrugjai és izotópjai, ahol a szubsztituensek jelentéseaz alábbiakban megadott. A találmány szerinti vegyületekszerin/treonin és tirozin kináz inhibitorként hasznosíthatók.Különösen hasznosak olyan tirozin kinázok inhibitoraiként, amelyek atúlburjánzásos betegségek, különösen a rák, valamint az angiogenezisfolyamatában fontosak. A találmány kiterjed a vegyületeket tartalmazógyógyszerkészítményekre is. Q jelentése hidrogénatom vagyvegyértékvonal, amely X1-gyel együtt és a két nitrogénatommal együtt,amelyekhez Q és X1 kapcsolódik, és a C=Y csoporttal együtt, melyhez akét nitrogénatom kapcsolódik a) képletű csoportot képezhet, ahol Q1jelentése 1-6 szénatomos alkilcsoport; Y jelentése oxigén- vagykénatom; W jelentése hidrogén-, klór-, bróm-, jódatom, nitro-, ciano-,SCN, OCF3, -Xq-(C(R10)2)a-Y1q-(C(R10)2)a-Z1q képletű csoport vagyadott esetben szubsztituált alkil-, alkenil-, alkinil-, heterociklusosalkenil- vagy heterociklusos alkinilcsoport, R1 és R2 egymástólfüggetlenül hidrogén- vagy halogénatom, hidroxil-, nitro-,cianocsoport, vagy COOH, COOX3, SX3, SO2X3, SOX3, C(O)X3, NHC(O)X3,C(O)NHX3, NHSO2X3 vagy adott esetben szubsztituált alkil-, alkenil-,alkinil-, alkoxi-, aminocsoport, NHX3, NX3X3, alkil-amino-, aril-amino-, heterociklusos amino-, alkil-tio-, alkil-szulfanáto-, aril-,aril-oxi-, aril-alkil-, aril-alkenil-, aril-alkinil-, aril-alkoxi-,heterociklusos, heterociklusos oxi-, heterociklusos alkil-,heterociklusos alkenil-, heterociklusos alkinil-, heterociklusosalkoxi-, heterociklusos tio-, heterociklusos szulfinil-,heterociklusos szulfonil-, cikloalkil- vagy -(CH2)m-(CHX2)CN- csoport;R3 jelentése hidrogénatom vagy adott esetben szubsztituált karbonil-,alkil-, alkenil-, alkinil-, cikloalkil-, aril-, aril-alkil-,heterociklusos, heterociklusos alkil-, heterociklusos heterociklus,heterociklusos cikloalkil-, amino-, alkil-amino-, aril-amino-,alkoxi-, tio-alkoxi- vagy acilcsoport; vagy R3 és X1 a nitrogénatommalegyütt, melyhez kapcsolódik, képezhet f), g) vagy h) képletűcsoportot, ahol Z minden esetben egymástól függetlenül lehet oxo- vagyadott esetben szubsztituált -C(O)-(1-6 szénatomos alkil)-, -C(O)aril-,-C(O)N-(1-6 szénatomos alkil)-, -C(O)N-aril-, 1-6 szénatomos alkil-,2-6 szénatomos alkenil-, 2-6 szénatomos alkinil-, amino-, mono- vagydi-1-6 szénatomos alkil-amino-, -COO-(1-6 szénatomos alkil)-,piridil-, fenil-, fenil-(1-6 szénatomos alkil)- vagy fenil-(1-6szénatomos alkenil)-csoport. Ó
HU0300359A 2000-02-07 2001-02-06 2-Benzotiazolil-karbamid-származékok és protein kináz inhibitorként történő felhasználásuk és ezeket tartalmazó gyógyszerkészítmények HUP0300359A2 (hu)

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