EA201000130A1 - Бициклические гетероарильные соединения и их применение в качестве ингибиторов киназы - Google Patents
Бициклические гетероарильные соединения и их применение в качестве ингибиторов киназыInfo
- Publication number
- EA201000130A1 EA201000130A1 EA201000130A EA201000130A EA201000130A1 EA 201000130 A1 EA201000130 A1 EA 201000130A1 EA 201000130 A EA201000130 A EA 201000130A EA 201000130 A EA201000130 A EA 201000130A EA 201000130 A1 EA201000130 A1 EA 201000130A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- kinase inhibitors
- compounds
- heteroaril
- bicyclic
- application
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
В заявке описаны соединения - ингибиторы фосфатидилинозит (PI) 3-киназы, их фармацевтически приемлемые соли и пролекарства; композиции этих новых соединений по отдельности или в комбинации по меньшей мере с одним дополнительным терапевтическим средством с фармацевтически приемлемым носителем; и применение этих новых соединений по отдельности или в комбинации по меньшей мере с одним дополнительным терапевтическим средством для профилактики или лечения пролиферативных заболеваний, характеризующихся аномальной активностью факторов роста, протеинсерин/треонинкиназ и фосфолипидкиназ.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07112688 | 2007-07-18 | ||
PCT/EP2008/059298 WO2009010530A1 (en) | 2007-07-18 | 2008-07-16 | Bicyclic heteroaryl compounds and their use as kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201000130A1 true EA201000130A1 (ru) | 2010-08-30 |
Family
ID=38800784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201000130A EA201000130A1 (ru) | 2007-07-18 | 2008-07-16 | Бициклические гетероарильные соединения и их применение в качестве ингибиторов киназы |
Country Status (15)
Country | Link |
---|---|
US (1) | US8053574B2 (ru) |
EP (1) | EP2178868A1 (ru) |
JP (1) | JP2010533680A (ru) |
KR (1) | KR20100049073A (ru) |
CN (1) | CN101801966A (ru) |
AR (1) | AR067562A1 (ru) |
AU (1) | AU2008277628B2 (ru) |
BR (1) | BRPI0813831A2 (ru) |
CA (1) | CA2693232A1 (ru) |
CL (1) | CL2008002097A1 (ru) |
EA (1) | EA201000130A1 (ru) |
MX (1) | MX2010000716A (ru) |
PE (1) | PE20090492A1 (ru) |
TW (1) | TW200908969A (ru) |
WO (1) | WO2009010530A1 (ru) |
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2008
- 2008-07-16 KR KR1020107003426A patent/KR20100049073A/ko not_active Application Discontinuation
- 2008-07-16 MX MX2010000716A patent/MX2010000716A/es not_active Application Discontinuation
- 2008-07-16 PE PE2008001205A patent/PE20090492A1/es not_active Application Discontinuation
- 2008-07-16 CN CN200880107620A patent/CN101801966A/zh active Pending
- 2008-07-16 AU AU2008277628A patent/AU2008277628B2/en not_active Expired - Fee Related
- 2008-07-16 EA EA201000130A patent/EA201000130A1/ru unknown
- 2008-07-16 BR BRPI0813831-1A2A patent/BRPI0813831A2/pt not_active IP Right Cessation
- 2008-07-16 US US12/669,536 patent/US8053574B2/en not_active Expired - Fee Related
- 2008-07-16 WO PCT/EP2008/059298 patent/WO2009010530A1/en active Application Filing
- 2008-07-16 EP EP08775120A patent/EP2178868A1/en not_active Withdrawn
- 2008-07-16 CA CA2693232A patent/CA2693232A1/en not_active Abandoned
- 2008-07-16 JP JP2010516500A patent/JP2010533680A/ja not_active Withdrawn
- 2008-07-16 AR ARP080103052A patent/AR067562A1/es not_active Application Discontinuation
- 2008-07-17 CL CL2008002097A patent/CL2008002097A1/es unknown
- 2008-07-17 TW TW097127181A patent/TW200908969A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP2178868A1 (en) | 2010-04-28 |
JP2010533680A (ja) | 2010-10-28 |
US8053574B2 (en) | 2011-11-08 |
US20100197682A1 (en) | 2010-08-05 |
WO2009010530A1 (en) | 2009-01-22 |
BRPI0813831A2 (pt) | 2015-01-06 |
CN101801966A (zh) | 2010-08-11 |
AR067562A1 (es) | 2009-10-14 |
CA2693232A1 (en) | 2009-01-22 |
PE20090492A1 (es) | 2009-05-27 |
AU2008277628B2 (en) | 2012-03-15 |
CL2008002097A1 (es) | 2009-02-20 |
AU2008277628A1 (en) | 2009-01-22 |
KR20100049073A (ko) | 2010-05-11 |
MX2010000716A (es) | 2010-03-26 |
TW200908969A (en) | 2009-03-01 |
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