HUP0301236A2 - Szubsztituált kinazolinszármazékok és felhasználásuk inhibitorokként - Google Patents

Szubsztituált kinazolinszármazékok és felhasználásuk inhibitorokként

Info

Publication number
HUP0301236A2
HUP0301236A2 HU0301236A HUP0301236A HUP0301236A2 HU P0301236 A2 HUP0301236 A2 HU P0301236A2 HU 0301236 A HU0301236 A HU 0301236A HU P0301236 A HUP0301236 A HU P0301236A HU P0301236 A2 HUP0301236 A2 HU P0301236A2
Authority
HU
Hungary
Prior art keywords
compounds
inhibitors
quinazoline derivatives
general formula
substituted quinazoline
Prior art date
Application number
HU0301236A
Other languages
English (en)
Inventor
Frederic Jung
Andrew Mortlock
Original Assignee
Astrazeneca Ab,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, filed Critical Astrazeneca Ab,
Publication of HUP0301236A2 publication Critical patent/HUP0301236A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

A találmány tárgyát képezi az (I) általános képletű vegyületek,továbbá sóik, észtereik és amidjaik felhasználása az aurora2 kináztgátló gyógyszerkészítmények gyártásához - a képletben X O, S, S(O),S(O)2 vagy NR6 csoportot és az utóbbiban R6 hidrogénatomot vagy 1-6szénatomos alkilcsoportot jelent; R5 adott esetben szubsztituáltöttagú heteroaromás gyűrűt jelent; és R1, R2, R3 és R4 jelentéseegymástól függetlenül halogénatom, cianocsoport, nitrocsoport,trifluor-metil-csoport, 1-3 szénatomos alkilcsoport vagy -NR7R8 vagy -X1-R9 általános képletű csoport. Az (I) általános képletű vegyületekegyes képviselői újak. A találmány ezekre az új vegyületekre iskiterjed. Ó
HU0301236A 2000-06-28 2001-06-21 Szubsztituált kinazolinszármazékok és felhasználásuk inhibitorokként HUP0301236A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00401842 2000-06-28
PCT/SE2001/001450 WO2002000649A1 (en) 2000-06-28 2001-06-21 Substituted quinazoline derivatives and their use as inhibitors

Publications (1)

Publication Number Publication Date
HUP0301236A2 true HUP0301236A2 (hu) 2003-10-28

Family

ID=8173742

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301236A HUP0301236A2 (hu) 2000-06-28 2001-06-21 Szubsztituált kinazolinszármazékok és felhasználásuk inhibitorokként

Country Status (27)

Country Link
US (2) US6919338B2 (hu)
EP (1) EP1299381B1 (hu)
JP (1) JP2004501914A (hu)
KR (1) KR20030014411A (hu)
CN (1) CN1267431C (hu)
AR (1) AR030432A1 (hu)
AT (1) ATE394102T1 (hu)
AU (1) AU2001266505A1 (hu)
BG (1) BG107376A (hu)
BR (1) BR0111754A (hu)
CA (1) CA2412592A1 (hu)
CZ (1) CZ20024120A3 (hu)
DE (1) DE60133897D1 (hu)
EE (1) EE200200715A (hu)
ES (1) ES2305081T3 (hu)
HK (1) HK1053124A1 (hu)
HU (1) HUP0301236A2 (hu)
IL (1) IL153246A0 (hu)
IS (1) IS6656A (hu)
MX (1) MXPA02011974A (hu)
NO (1) NO20026010L (hu)
NZ (1) NZ522696A (hu)
PL (1) PL360439A1 (hu)
RU (1) RU2283311C2 (hu)
SK (1) SK18102002A3 (hu)
WO (1) WO2002000649A1 (hu)
ZA (1) ZA200209412B (hu)

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Also Published As

Publication number Publication date
AU2001266505A1 (en) 2002-01-08
NO20026010D0 (no) 2002-12-13
MXPA02011974A (es) 2004-09-06
US6919338B2 (en) 2005-07-19
IL153246A0 (en) 2003-07-06
DE60133897D1 (de) 2008-06-19
HK1053124A1 (en) 2003-10-10
IS6656A (is) 2002-12-17
AR030432A1 (es) 2003-08-20
CN1496364A (zh) 2004-05-12
EP1299381A1 (en) 2003-04-09
ES2305081T3 (es) 2008-11-01
WO2002000649A1 (en) 2002-01-03
NO20026010L (no) 2002-12-13
RU2283311C2 (ru) 2006-09-10
CN1267431C (zh) 2006-08-02
WO2002000649A9 (en) 2007-09-20
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JP2004501914A (ja) 2004-01-22
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BG107376A (bg) 2003-09-30
PL360439A1 (en) 2004-09-06
ATE394102T1 (de) 2008-05-15
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