HUP0303034A2 - Új 7-azaindol-származékok, foszfodiészteráz-4 inhibitorjakénti alkalmazásuk és eljárás az előállításukra - Google Patents
Új 7-azaindol-származékok, foszfodiészteráz-4 inhibitorjakénti alkalmazásuk és eljárás az előállításukraInfo
- Publication number
- HUP0303034A2 HUP0303034A2 HU0303034A HUP0303034A HUP0303034A2 HU P0303034 A2 HUP0303034 A2 HU P0303034A2 HU 0303034 A HU0303034 A HU 0303034A HU P0303034 A HUP0303034 A HU P0303034A HU P0303034 A2 HUP0303034 A2 HU P0303034A2
- Authority
- HU
- Hungary
- Prior art keywords
- phosphodiesterase
- inhibitors
- azaindole
- derivatives
- novel
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- MVXVYAKCVDQRLW-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridine Chemical class C1=CN=C2NC=CC2=C1 MVXVYAKCVDQRLW-UHFFFAOYSA-N 0.000 abstract 1
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 abstract 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Diabetes (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
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- Dermatology (AREA)
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Abstract
A találmány (1) általános képletű szubsztituált 7-azaindol-származékokra, előállításukra alkalmas eljárásra, valamint avegyületek foszfodiészteráz-4 inhibitorjakénti gyógyászatialkalmazására vonatkozik. Az (1) általános képletben R1 adott esetbenszubsztituált alkil- vagy alkenilcsoport, R2 jelentése adott esetbenszubsztituált alkil-, fenil-, piridilcsoport vagy (a), (b), (c), (d)képletű csoport vagy a kapcsolódó nitrogénatommal együtt (e), (f), (g)vagy (h) képletű csoportot alkot. A vegyületek olyan betegségekkezelésére alkalmazhatók, amelyek esetén a foszfodiészteráz 4 gátlásakívánatos. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10053275A DE10053275A1 (de) | 2000-10-27 | 2000-10-27 | Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung |
US24434200P | 2000-10-30 | 2000-10-30 | |
PCT/EP2001/012376 WO2002034747A1 (de) | 2000-10-27 | 2001-10-25 | Neue 7-azaindole, deren verwendung als inhibitoren der phosphodiesterase 4 und verfahren zu deren herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0303034A2 true HUP0303034A2 (hu) | 2003-12-29 |
HUP0303034A3 HUP0303034A3 (en) | 2012-12-28 |
Family
ID=26007507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0303034A HUP0303034A3 (en) | 2000-10-27 | 2001-10-25 | Novel 7-azaindole-derivatives, use thereof as phosphodiesterase 4 inhibitors and method for producing the same |
Country Status (28)
Country | Link |
---|---|
US (3) | US7169787B2 (hu) |
EP (1) | EP1330455B1 (hu) |
JP (1) | JP4233322B2 (hu) |
KR (2) | KR100837099B1 (hu) |
CN (1) | CN1247576C (hu) |
AR (1) | AR034269A1 (hu) |
AT (1) | ATE301121T1 (hu) |
AU (2) | AU2175302A (hu) |
BG (1) | BG66169B1 (hu) |
BR (1) | BR0114903A (hu) |
CA (1) | CA2428468C (hu) |
CZ (1) | CZ20031146A3 (hu) |
DE (1) | DE50106993D1 (hu) |
DK (1) | DK1330455T3 (hu) |
EE (1) | EE05271B1 (hu) |
ES (1) | ES2246349T3 (hu) |
HK (1) | HK1053839A1 (hu) |
HR (1) | HRP20030427B1 (hu) |
HU (1) | HUP0303034A3 (hu) |
IL (2) | IL155386A0 (hu) |
MX (1) | MXPA03003624A (hu) |
NO (1) | NO324947B1 (hu) |
NZ (1) | NZ525369A (hu) |
PL (1) | PL213999B1 (hu) |
PT (1) | PT1330455E (hu) |
SK (1) | SK287774B6 (hu) |
TW (1) | TWI262920B (hu) |
WO (1) | WO2002034747A1 (hu) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040014761A1 (en) * | 1997-10-28 | 2004-01-22 | Place Virgil A. | Treatment of female sexual dysfunction with phosphodiesterase inhibitors |
AU2003290652B2 (en) * | 2002-11-06 | 2008-06-19 | Celgene Corporation | Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases |
DE10318610A1 (de) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 7-Azaindole und deren Verwendung als Therapeutika |
US20050054691A1 (en) * | 2003-08-29 | 2005-03-10 | St. Jude Children's Research Hospital | Carboxylesterase inhibitors |
JP4895811B2 (ja) * | 2003-09-11 | 2012-03-14 | ケミア,インコーポレイテッド | サイトカイン阻害剤 |
EP1742627A4 (en) * | 2004-05-06 | 2009-08-26 | Plexxikon Inc | PDE4B HEMMER AND ITS USE |
MY144903A (en) | 2004-06-17 | 2011-11-30 | Novartis Ag | Pyrrolopyridine derivatives and their use as crth2 antagonists |
US7605168B2 (en) * | 2004-09-03 | 2009-10-20 | Plexxikon, Inc. | PDE4B inhibitors |
MX2008006076A (es) | 2005-11-09 | 2008-12-16 | Combinatorx Inc | Metodos, composiciones y kits para el tratamiento de condiciones medicas. |
GB0525143D0 (en) | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
CA2651732C (en) | 2006-05-18 | 2014-10-14 | Mannkind Corporation | Intracellular kinase inhibitors |
WO2008026687A1 (fr) | 2006-09-01 | 2008-03-06 | Kyorin Pharmaceutical Co., Ltd. | Dérivé de pyrazolopyridine carboxamide et inhibiteur de phosphodiestérase (pde) comprenant le dérivé |
US8012992B2 (en) | 2008-06-30 | 2011-09-06 | Allergan, Inc. | Aza-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
US8252774B2 (en) * | 2008-09-22 | 2012-08-28 | Isis Innovation Ltd. | 5-azaindole bisphosphonates |
CA2771939A1 (en) * | 2009-08-26 | 2011-03-03 | Nycomed Gmbh | Methylpyrrolopyridinecarboxamides |
WO2012072727A1 (en) * | 2010-12-03 | 2012-06-07 | Biotie Therapies Gmbh | Crystalline modification of n-(3,5-dichloropyridin-4-yl)-[1-(4 -fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide as inhibitor of pde4 |
WO2012080329A1 (en) * | 2010-12-17 | 2012-06-21 | Biotie Therapies Gmbh | Formulations of n-(3,5-dichloropyridin-4-yl)-[1-(4-fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide |
CN102584842A (zh) * | 2011-01-17 | 2012-07-18 | 北京大学 | 取代吲哚并内酰胺衍生物的制备及作为抗疟疾剂的用途 |
US10208043B2 (en) | 2012-08-22 | 2019-02-19 | Cornell University | Methods for inhibiting fascin |
CA2940144C (en) * | 2014-02-20 | 2023-06-13 | Cornell University | Substituted indazol-3-yl derivatives and pharmaceutical compositions thereof useful as inhibitor of fascin |
CA3154278A1 (en) * | 2018-10-12 | 2020-04-16 | Corey Hopkins | Phosphodiesterase inhibitors |
Family Cites Families (14)
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GB1141949A (en) | 1966-02-23 | 1969-02-05 | Sterling Drug Inc | 7-azaindole derivatives |
WO1991009598A1 (en) | 1990-01-05 | 1991-07-11 | Pfizer Inc. | Azaoxindole derivatives |
US5023265A (en) * | 1990-06-01 | 1991-06-11 | Schering Corporation | Substituted 1-H-pyrrolopyridine-3-carboxamides |
US5811432A (en) * | 1990-11-09 | 1998-09-22 | Pfizer Inc | Azaoxindole derivatives |
NZ254881A (en) | 1992-07-28 | 1996-09-25 | Rhone Poulenc Rorer Ltd | Diether, dithioether or diether thioether derivatives of 1,2-dihydroxybenzenes substituted in position-4 by an (hetero)aryl-containing group; |
WO1994003427A1 (en) | 1992-08-06 | 1994-02-17 | Warner-Lambert Company | 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties |
JP3119758B2 (ja) * | 1993-02-24 | 2000-12-25 | 日清製粉株式会社 | 7−アザインドール誘導体及びこれを有効成分とする抗潰瘍薬 |
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GB9420521D0 (en) | 1994-10-12 | 1994-11-30 | Smithkline Beecham Plc | Novel compounds |
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JP3601898B2 (ja) | 1996-02-14 | 2004-12-15 | 俊隆 鍋島 | 薬物依存形成抑制剤 |
AUPO282996A0 (en) | 1996-10-07 | 1996-10-31 | Fujisawa Pharmaceutical Co., Ltd. | Novel compounds |
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