EE05271B1 - 7-asaindoolid, meetod nende snteesimiseks, nende kasutamine TNFa v?i fosfodiesteraas-4 inhibeerivate ravimite valmistamiseks ning neid sisaldavad ravimid - Google Patents
7-asaindoolid, meetod nende snteesimiseks, nende kasutamine TNFa v?i fosfodiesteraas-4 inhibeerivate ravimite valmistamiseks ning neid sisaldavad ravimidInfo
- Publication number
- EE05271B1 EE05271B1 EEP200300166A EEP200300166A EE05271B1 EE 05271 B1 EE05271 B1 EE 05271B1 EE P200300166 A EEP200300166 A EE P200300166A EE P200300166 A EEP200300166 A EE P200300166A EE 05271 B1 EE05271 B1 EE 05271B1
- Authority
- EE
- Estonia
- Prior art keywords
- drugs
- azaindoles
- phosphodiesterase
- synthesis
- preparation
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 2
- 229940079593 drug Drugs 0.000 title 2
- MVXVYAKCVDQRLW-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridine Chemical class C1=CN=C2NC=CC2=C1 MVXVYAKCVDQRLW-UHFFFAOYSA-N 0.000 title 1
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 title 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 title 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 title 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- AIDS & HIV (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10053275A DE10053275A1 (de) | 2000-10-27 | 2000-10-27 | Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung |
| US24434200P | 2000-10-30 | 2000-10-30 | |
| PCT/EP2001/012376 WO2002034747A1 (de) | 2000-10-27 | 2001-10-25 | Neue 7-azaindole, deren verwendung als inhibitoren der phosphodiesterase 4 und verfahren zu deren herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200300166A EE200300166A (et) | 2003-08-15 |
| EE05271B1 true EE05271B1 (et) | 2010-02-15 |
Family
ID=26007507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200300166A EE05271B1 (et) | 2000-10-27 | 2001-10-25 | 7-asaindoolid, meetod nende snteesimiseks, nende kasutamine TNFa v?i fosfodiesteraas-4 inhibeerivate ravimite valmistamiseks ning neid sisaldavad ravimid |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US7169787B2 (et) |
| EP (1) | EP1330455B1 (et) |
| JP (1) | JP4233322B2 (et) |
| KR (2) | KR100837099B1 (et) |
| CN (1) | CN1247576C (et) |
| AR (1) | AR034269A1 (et) |
| AT (1) | ATE301121T1 (et) |
| AU (2) | AU2002221753B2 (et) |
| BG (1) | BG66169B1 (et) |
| BR (1) | BR0114903A (et) |
| CA (1) | CA2428468C (et) |
| CZ (1) | CZ20031146A3 (et) |
| DE (1) | DE50106993D1 (et) |
| DK (1) | DK1330455T3 (et) |
| EE (1) | EE05271B1 (et) |
| ES (1) | ES2246349T3 (et) |
| HK (1) | HK1053839A1 (et) |
| HR (1) | HRP20030427B1 (et) |
| HU (1) | HUP0303034A3 (et) |
| IL (2) | IL155386A0 (et) |
| MX (1) | MXPA03003624A (et) |
| NO (1) | NO324947B1 (et) |
| NZ (1) | NZ525369A (et) |
| PL (1) | PL213999B1 (et) |
| PT (1) | PT1330455E (et) |
| SK (1) | SK287774B6 (et) |
| TW (1) | TWI262920B (et) |
| WO (1) | WO2002034747A1 (et) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040014761A1 (en) * | 1997-10-28 | 2004-01-22 | Place Virgil A. | Treatment of female sexual dysfunction with phosphodiesterase inhibitors |
| KR20090048520A (ko) * | 2002-11-06 | 2009-05-13 | 셀진 코포레이션 | 암 및 다른 질환의 치료 및 관리를 위한 선택적 시토킨 억제 약물의 사용 방법 및 그 조성물 |
| DE10318610A1 (de) | 2003-04-24 | 2004-11-11 | Elbion Ag | 7-Azaindole und deren Verwendung als Therapeutika |
| US20050054691A1 (en) * | 2003-08-29 | 2005-03-10 | St. Jude Children's Research Hospital | Carboxylesterase inhibitors |
| SG146624A1 (en) * | 2003-09-11 | 2008-10-30 | Kemia Inc | Cytokine inhibitors |
| WO2006078287A2 (en) | 2004-05-06 | 2006-07-27 | Plexxikon, Inc. | Pde4b inhibitors and uses therefor |
| MY144903A (en) | 2004-06-17 | 2011-11-30 | Novartis Ag | Pyrrolopyridine derivatives and their use as crth2 antagonists |
| EP1786813A2 (en) * | 2004-09-03 | 2007-05-23 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
| EP2218442A1 (en) | 2005-11-09 | 2010-08-18 | CombinatoRx, Inc. | Methods, compositions, and kits for the treatment of ophthalmic disorders |
| GB0525143D0 (en) | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
| EP2865381A1 (en) | 2006-05-18 | 2015-04-29 | Pharmacyclics, Inc. | ITK inhibitors for treating blood cell malignancies |
| EP2058310A4 (en) | 2006-09-01 | 2010-11-17 | Kyorin Seiyaku Kk | PYRAZOLOPYRIDINCARBOXYL ACID AMID DERIVATIVE AND THE DERIVATIVELY PHOSPHODIESTERASE (PDE) INHIBITOR |
| US8012992B2 (en) | 2008-06-30 | 2011-09-06 | Allergan, Inc. | Aza-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
| ES2478289T3 (es) * | 2008-09-22 | 2014-07-21 | Isis Innovation Ltd | Bisfosfonatos de 5-azaindol |
| US8816085B2 (en) * | 2009-08-26 | 2014-08-26 | Takeda Gmbh | Methylpyrrolopyridinecarboxamides |
| WO2012072727A1 (en) * | 2010-12-03 | 2012-06-07 | Biotie Therapies Gmbh | Crystalline modification of n-(3,5-dichloropyridin-4-yl)-[1-(4 -fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide as inhibitor of pde4 |
| WO2012080329A1 (en) * | 2010-12-17 | 2012-06-21 | Biotie Therapies Gmbh | Formulations of n-(3,5-dichloropyridin-4-yl)-[1-(4-fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide |
| CN102584842A (zh) * | 2011-01-17 | 2012-07-18 | 北京大学 | 取代吲哚并内酰胺衍生物的制备及作为抗疟疾剂的用途 |
| CN113679717A (zh) | 2012-08-22 | 2021-11-23 | 康奈尔大学 | 用于抑制肌成束蛋白的方法 |
| EP3107902B1 (en) * | 2014-02-20 | 2021-04-07 | Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") | Compounds and methods for inhibiting fascin |
| EP3863638B1 (en) * | 2018-10-12 | 2024-06-26 | Board of Regents of the University of Nebraska | Phosphodiesterase inhibitors |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1141949A (en) * | 1966-02-23 | 1969-02-05 | Sterling Drug Inc | 7-azaindole derivatives |
| WO1991009598A1 (en) | 1990-01-05 | 1991-07-11 | Pfizer Inc. | Azaoxindole derivatives |
| US5023265A (en) * | 1990-06-01 | 1991-06-11 | Schering Corporation | Substituted 1-H-pyrrolopyridine-3-carboxamides |
| US5811432A (en) * | 1990-11-09 | 1998-09-22 | Pfizer Inc | Azaoxindole derivatives |
| JP3775684B2 (ja) | 1992-07-28 | 2006-05-17 | ローン−プーラン・ロレ・リミテツド | 脂肪族−またはヘテロ原子−含有連結基によりアリールまたはヘテロアリールに連結されたフェニル含有化合物 |
| AU672224B2 (en) | 1992-08-06 | 1996-09-26 | Warner-Lambert Company | 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and whichhave antitumor properties |
| JP3119758B2 (ja) * | 1993-02-24 | 2000-12-25 | 日清製粉株式会社 | ７−アザインドール誘導体及びこれを有効成分とする抗潰瘍薬 |
| DE69532238T2 (de) | 1994-04-21 | 2004-10-21 | Schering Ag | Pde iv-inhibitoren zur behandlung der multiplen sklerose |
| GB9420521D0 (en) * | 1994-10-12 | 1994-11-30 | Smithkline Beecham Plc | Novel compounds |
| GB9507297D0 (en) | 1995-04-07 | 1995-05-31 | Rh Ne Poulenc Rorer Limited | New composition of matter |
| JPH09169665A (ja) | 1995-12-21 | 1997-06-30 | Kenichi Miyamoto | 骨粗鬆症治療剤 |
| JP3601898B2 (ja) | 1996-02-14 | 2004-12-15 | 俊隆 鍋島 | 薬物依存形成抑制剤 |
| AUPO282996A0 (en) * | 1996-10-07 | 1996-10-31 | Fujisawa Pharmaceutical Co., Ltd. | Novel compounds |
| CA2366615A1 (en) * | 1999-03-10 | 2000-09-14 | Merck & Co., Inc. | 6-azaindole compounds as antagonists of gonadotropin releasing hormone |
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2001
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- 2001-10-25 WO PCT/EP2001/012376 patent/WO2002034747A1/de active IP Right Grant
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2003
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2006
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Legal Events
| Date | Code | Title | Description |
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| KB4A | Valid patent at the end of a year |
Effective date: 20101231 |
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| HC1A | Change of owner name | ||
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20131025 |