NO20021382L - Fremgangsmåter og mikroorganismer for fremstilling av panto- forbindelser - Google Patents

Fremgangsmåter og mikroorganismer for fremstilling av panto- forbindelser

Info

Publication number
NO20021382L
NO20021382L NO20021382A NO20021382A NO20021382L NO 20021382 L NO20021382 L NO 20021382L NO 20021382 A NO20021382 A NO 20021382A NO 20021382 A NO20021382 A NO 20021382A NO 20021382 L NO20021382 L NO 20021382L
Authority
NO
Norway
Prior art keywords
panto
microorganisms
compounds
preparation
methods
Prior art date
Application number
NO20021382A
Other languages
English (en)
Other versions
NO20021382D0 (no
Inventor
R Rogers Yocum
Thomas A Patterson
Theron Hermann
Janice G Pero
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of NO20021382D0 publication Critical patent/NO20021382D0/no
Publication of NO20021382L publication Critical patent/NO20021382L/no

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/02Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1003Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014Hydroxymethyl-, formyl-transferases (2.1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/06Alanine; Leucine; Isoleucine; Serine; Homoserine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/04Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
NO20021382A 1999-09-21 2002-03-20 Fremgangsmåter og mikroorganismer for fremstilling av panto- forbindelser NO20021382L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40049499A 1999-09-21 1999-09-21
US21007200P 2000-06-07 2000-06-07
US22183600P 2000-07-28 2000-07-28
US22786000P 2000-08-24 2000-08-24
PCT/US2000/025993 WO2001021772A2 (en) 1999-09-21 2000-09-21 Methods and microorganisms for production of panto-compounds

Publications (2)

Publication Number Publication Date
NO20021382D0 NO20021382D0 (no) 2002-03-20
NO20021382L true NO20021382L (no) 2002-05-16

Family

ID=27498789

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021382A NO20021382L (no) 1999-09-21 2002-03-20 Fremgangsmåter og mikroorganismer for fremstilling av panto- forbindelser

Country Status (16)

Country Link
EP (2) EP2163629B1 (no)
JP (1) JP5392957B2 (no)
KR (1) KR20020092912A (no)
CN (1) CN1420931A (no)
AU (1) AU7708700A (no)
BR (1) BRPI0014115B8 (no)
CA (1) CA2385497A1 (no)
CZ (1) CZ20021013A3 (no)
HU (1) HU230509B1 (no)
IL (1) IL148786A0 (no)
MX (1) MXPA02003017A (no)
NO (1) NO20021382L (no)
PL (1) PL356566A1 (no)
SK (1) SK5222002A3 (no)
TR (1) TR200200751T2 (no)
WO (1) WO2001021772A2 (no)

Families Citing this family (61)

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US6830898B2 (en) 2000-08-24 2004-12-14 Omnigene Bioproducts, Inc. Microorganisms and assays for the identification of antibiotics
DE10101501A1 (de) * 2001-01-12 2002-08-01 Forschungszentrum Juelich Gmbh Verfahren zur fermentativen Herstellung von Pantothensäure
JP4217070B2 (ja) * 2001-01-19 2009-01-28 ビーエーエスエフ ソシエタス・ヨーロピア パントテネートの産生増強法
JP4229700B2 (ja) * 2001-01-19 2009-02-25 ビーエーエスエフ ソシエタス・ヨーロピア パントテネートの産生増強のための微生物と方法
DE10108225A1 (de) 2001-02-21 2002-10-10 Basf Ag Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
EE200300405A (et) * 2001-02-21 2003-12-15 Basf Aktiengesellschaft Meetod loomasööda lisandina kasutatava D-pantoteenhappe ja/või tema soolade saamiseks
HU230180B1 (hu) * 2001-02-21 2015-09-28 Basf Ag Eljárás D-pantoténsav és/vagy sói előállítására állati takarmányadalékként
DE10108223A1 (de) 2001-02-21 2002-10-10 Basf Ag Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
EP1247868A3 (de) * 2001-04-03 2002-10-30 Degussa AG Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10132178A1 (de) 2001-07-03 2003-01-23 Degussa Verfahren zur fermantativen Herstellung von D-Pantothensäure und/oder deren Salzen
EP1402046A1 (en) * 2001-07-03 2004-03-31 Degussa AG Process for the fermentative preparation of d-pantothenic acid and/or salts thereof
US20040197878A1 (en) * 2001-07-03 2004-10-07 Daniela Kruse Process for the fermentative preparation of d-pantothenic acid and/or salts thereof
AU2002316940A1 (en) * 2001-07-07 2003-01-29 Degussa Ag Process for the preparation of d-pantothenic acid and/or salts thereof
EP1672073A1 (en) * 2001-07-07 2006-06-21 Degussa AG Process for the preparation of D-pantothenic acid and/or salts thereof
ES2329778T3 (es) * 2002-01-18 2009-12-01 Novozymes A/S 2,3-aminomutasa de alanina.
CA2491137A1 (en) * 2002-07-03 2004-01-15 Basf Aktiengesellschaft Microorganisms and processes for enhanced production of pantothenate
CN1788089A (zh) 2002-07-03 2006-06-14 巴斯福股份公司 用于提高泛酸产量的微生物和方法
CN1809631B (zh) * 2003-06-18 2010-05-26 帝斯曼知识产权资产管理有限公司 用不能形成芽孢的微生物来生产泛酸盐/酯的方法
EP1876235A4 (en) * 2005-03-29 2008-07-09 Kaneka Corp NOVEL GENE OF PANTOTHENATE KINASE AND USE THEREOF
US8273558B2 (en) 2005-10-26 2012-09-25 Butamax(Tm) Advanced Biofuels Llc Fermentive production of four carbon alcohols
RU2394913C2 (ru) 2005-10-26 2010-07-20 Е.И.Дюпон Де Немур Энд Компани Ферментативное получение четырехуглеродных спиртов
US9303225B2 (en) 2005-10-26 2016-04-05 Butamax Advanced Biofuels Llc Method for the production of isobutanol by recombinant yeast
DE112007001179T5 (de) 2006-05-16 2009-04-02 Dsm Ip Assets B.V. Verfahren zur Herstellung von Panthenol
EP1918383A1 (en) * 2006-11-02 2008-05-07 DSMIP Assets B.V. Semi-continuous fermentation process for pantothenate production
CN103540559A (zh) 2007-02-09 2014-01-29 加利福尼亚大学董事会 利用重组微生物生产生物燃料
DK2164975T3 (da) 2007-07-06 2012-05-29 Basf Se Fremgangsmåde til fremstilling af en koncentreret vandig glukoseopløsning af majs
CN102066551B (zh) * 2008-03-27 2013-10-09 基因组股份公司 用于产生己二酸和其他化合物的微生物
EP2157174A1 (en) 2008-08-12 2010-02-24 DSM IP Assets B.V. Increased production of pantothenate (vitamin B5)
EP2673369B1 (en) * 2011-02-07 2017-04-05 William Marsh Rice University Reverse beta oxidation pathway
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EP2723878B1 (en) 2011-06-21 2020-05-20 DSM IP Assets B.V. Vitamin b5 production
WO2012175574A1 (en) 2011-06-21 2012-12-27 Dsm Ip Assets B.V. Increased pantothenate (vitamin b5) production
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EP3060570B1 (en) 2013-10-25 2018-09-19 Retrophin, Inc. Pantothenate derivatives for the treatment of neurological disorders
CN104593398B (zh) * 2013-11-01 2017-06-06 中国科学院微生物研究所 一种高L‑天冬氨酸α羧化酶活性的工程菌及其在生产β‑丙氨酸中的应用
CN105368758B (zh) * 2015-03-16 2018-06-19 鲁东大学 一株高产天冬氨酸脱羧酶的菌株及用于生产丙氨酸的方法
CN104789564B (zh) * 2015-03-31 2018-04-27 中国农业科学院生物技术研究所 一种启动子和重组表达载体及其用途和表达外源蛋白的方法
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EP3645725A1 (en) 2017-06-30 2020-05-06 PTT Global Chemical Public Company Limited Microorganism with stabilized copy number of functional dna sequence and associated methods
CN108456701B (zh) * 2018-03-23 2020-10-16 精晶药业股份有限公司 一种d-泛解酸内酯的制备方法
EP3810786A4 (en) * 2018-06-25 2022-06-08 Lygos, Inc. RECOMBINANT HOST CELLS AND METHODS FOR PRODUCTION OF ASPARTIC ACID AND BETA-ALANINE
SG11202012136YA (en) * 2018-07-09 2021-01-28 Codexis Inc Engineered pantothenate kinase variant enzymes
EP4114917A4 (en) 2020-03-06 2024-08-21 GEVO, Inc. Novel nkr variants for increased production of isobutanol
EP4174185A4 (en) * 2020-06-28 2024-05-22 Mint Biotechnologies Co., Ltd. Methods for preparing pantoic acid, pantothenic acid and panthenol as well as salts thereof
KR102389327B1 (ko) * 2020-07-01 2022-04-20 씨제이제일제당 (주) 3-메틸-2-옥소뷰타노에이트 하이드록시 메틸트랜스퍼라아제의 활성이 강화된 미생물, 및 이의 용도
CN115109736B (zh) * 2021-03-23 2024-05-07 中国科学院天津工业生物技术研究所 一种产泛解酸的微生物及其构建方法和应用
EP4108654A1 (en) 2021-06-23 2022-12-28 DSM IP Assets B.V. Production of panthenol
EP4323331A1 (en) 2021-04-15 2024-02-21 DSM IP Assets B.V. Production of panthenol
CN114085820B (zh) * 2021-11-19 2023-10-20 万华化学集团股份有限公司 来源于Candida viswanathii的酮基泛解酸内酯还原酶
CN114437988B (zh) * 2022-02-28 2023-05-23 贵州医科大学 纤维素降解菌及菌剂、制备方法、应用和降解酒糟的方法
CN115595328B (zh) * 2022-03-07 2026-02-13 中国科学院微生物研究所 天冬氨酸脱羧酶在发酵生产维生素b5中的应用
CN115595314B (zh) * 2022-03-07 2025-06-24 中国科学院微生物研究所 表达天冬氨酸脱氢酶的工程菌及发酵生产维生素b5的方法
KR20250110877A (ko) 2022-11-21 2025-07-21 디에스엠 아이피 어셋츠 비.브이. 판테놀 제조
EP4378923A1 (en) 2022-12-01 2024-06-05 DSM IP Assets B.V. Production of panthenol
KR102879057B1 (ko) 2023-01-27 2025-10-30 씨제이제일제당 (주) 아르카노박테리움 포시시마일 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도
KR102879056B1 (ko) 2023-01-27 2025-10-30 씨제이제일제당 (주) 글루타미시박터 할로피토콜라 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도
CN116590209A (zh) * 2023-06-13 2023-08-15 浙江工业大学 一种产d-泛酸的基因工程菌、构建方法及应用
CN119709733B (zh) * 2023-09-28 2025-11-28 安徽华恒生物科技股份有限公司 一种动态调控系统、泛解酸生产菌株及其制备方法和应用
CN119220576B (zh) * 2024-12-03 2025-07-25 浙江工业大学 基于一碳单位供应的产d-泛酸基因工程菌及构建与应用
CN120060194B (zh) * 2025-02-27 2025-10-28 中国农业科学院植物保护研究所 一种用于提高放线菌聚酮类天然产物产量的组合模块及含有其重组菌的构建与应用
CN121046335B (zh) * 2025-11-06 2026-02-24 诸城市浩天药业有限公司 一种耐热、半衰期长的泛酸合成酶突变体

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Also Published As

Publication number Publication date
IL148786A0 (en) 2002-09-12
EP2163629A2 (en) 2010-03-17
EP1214420A2 (en) 2002-06-19
CN1420931A (zh) 2003-05-28
AU7708700A (en) 2001-04-24
PL356566A1 (en) 2004-06-28
BR0014115A (pt) 2002-05-21
CA2385497A1 (en) 2001-03-29
BRPI0014115B1 (pt) 2015-05-05
JP2003527828A (ja) 2003-09-24
SK5222002A3 (en) 2003-03-04
EP2163629A3 (en) 2010-06-02
HU230509B1 (hu) 2016-09-28
WO2001021772A9 (en) 2002-12-05
WO2001021772A3 (en) 2002-03-07
KR20020092912A (ko) 2002-12-12
NO20021382D0 (no) 2002-03-20
BRPI0014115B8 (pt) 2021-05-25
TR200200751T2 (tr) 2004-08-23
JP5392957B2 (ja) 2014-01-22
EP2163629B1 (en) 2017-03-08
EP1214420B1 (en) 2016-03-23
HUP0202705A3 (en) 2011-02-28
WO2001021772A2 (en) 2001-03-29
HUP0202705A2 (hu) 2002-12-28
CZ20021013A3 (en) 2002-12-11
MXPA02003017A (es) 2004-09-06

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