BR0014115A - Métodos de produzir um panto-composto, pantotenato e beta-alanina, de aumentar a produção de um panto-composto e de edentificar compostos que modulam a atividade da pantotenato cinase, microorganismo recombinante, vetor, molécula de ácido nuleico isolada, polipetìdeo e proteìna da pantotenato cinase isolada - Google Patents

Métodos de produzir um panto-composto, pantotenato e beta-alanina, de aumentar a produção de um panto-composto e de edentificar compostos que modulam a atividade da pantotenato cinase, microorganismo recombinante, vetor, molécula de ácido nuleico isolada, polipetìdeo e proteìna da pantotenato cinase isolada

Info

Publication number
BR0014115A
BR0014115A BR0014115-1A BR0014115A BR0014115A BR 0014115 A BR0014115 A BR 0014115A BR 0014115 A BR0014115 A BR 0014115A BR 0014115 A BR0014115 A BR 0014115A
Authority
BR
Brazil
Prior art keywords
panto
pantothenate
methods
isolated
compound
Prior art date
Application number
BR0014115-1A
Other languages
English (en)
Other versions
BRPI0014115B8 (pt
BRPI0014115B1 (pt
Inventor
Rogers R Yocum
Thomas A Patterson
Theron Hermann
Janice G Pero
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of BR0014115A publication Critical patent/BR0014115A/pt
Publication of BRPI0014115B1 publication Critical patent/BRPI0014115B1/pt
Publication of BRPI0014115B8 publication Critical patent/BRPI0014115B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

"MéTODOS DE PRODUZIR UM PANTO-COMPOSTO, PANTOTENATO E BETA-ALANINA, DE AUMENTAR A PRODUçãO DE UM PANTO-COMPOSTO E DE IDENTIFICAR COMPOSTOS QUE MODULAM A ATIVIDADE DA PANTOTENATO CINASE, MICROORGANISMO RECOMBINANTE, VETOR, MOLéCULA DE áCIDO NUCLEICO ISOLADA, POLIPETìDEO E PROTEìNA DA PANTOTENATO CINASE ISOLADA". A presente invenção retrata métodos de produzir panto-compostos (por exemplo, pantotenato) usando microorganismos em que o caminho biossintétíco do pantotenato e/ou o caminho biossintético da isoleucina-valina e/ou o caminho biossintético da coenzimaA tenha sido manipulado. Métodos que retratam microorganismos que supraexpressam a cetopantoato reductase bem como microorganismos que supraexpressam a aspartato <244>-descarboxilase são fornecidos. Métodos de produzir panto-compostos em uma maneira independente de precursor e em alto rendimento são descritos. Microorganismos recombinantes, vetores, moléculas de ácido nucleico isoladas, genes e produtos de gene úteis na prática das metodologias acima também são fornecidos. A presente invenção também retrata um gene da pantotenato cinase microbiana não identificado anteriormente, coaX, bem como métodos de produzir panto-compostos que utilizam microorganismos tendo atividade modificada da pantotenato cinase. Microorganismos recombinantes, vetores, moléculas de ácido nucleico coaX isoladas e proteínas CoaX purificadas são retratados. Também são retratados métodos para identificar os moduladores da pantotenato cinase que utilizam os microorganismos recombinantes e/ou as proteínas CoaX purificadas da presente invenção.
BRPI0014115A 1999-09-21 2000-09-21 métodos de produzir um panto-composto, pantotenato e beta-alanina, de aumentar a produção de um panto-composto e de edentificar compostos que modulam a atividade da pantotenato cinase, micro-organismo recombinante, vetor recombinante, e, vetor BRPI0014115B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40049499A 1999-09-21 1999-09-21
US21007200P 2000-06-07 2000-06-07
US22183600P 2000-07-28 2000-07-28
US22786000P 2000-08-24 2000-08-24
PCT/US2000/025993 WO2001021772A2 (en) 1999-09-21 2000-09-21 Methods and microorganisms for production of panto-compounds

Publications (3)

Publication Number Publication Date
BR0014115A true BR0014115A (pt) 2002-05-21
BRPI0014115B1 BRPI0014115B1 (pt) 2015-05-05
BRPI0014115B8 BRPI0014115B8 (pt) 2021-05-25

Family

ID=27498789

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0014115A BRPI0014115B8 (pt) 1999-09-21 2000-09-21 métodos de produzir um panto-composto, pantotenato e beta-alanina, de aumentar a produção de um panto-composto e de edentificar compostos que modulam a atividade da pantotenato cinase, micro-organismo recombinante, vetor recombinante, e, vetor

Country Status (16)

Country Link
EP (2) EP1214420B1 (pt)
JP (1) JP5392957B2 (pt)
KR (1) KR20020092912A (pt)
CN (1) CN1420931A (pt)
AU (1) AU7708700A (pt)
BR (1) BRPI0014115B8 (pt)
CA (1) CA2385497A1 (pt)
CZ (1) CZ20021013A3 (pt)
HU (1) HU230509B1 (pt)
IL (1) IL148786A0 (pt)
MX (1) MXPA02003017A (pt)
NO (1) NO20021382L (pt)
PL (1) PL356566A1 (pt)
SK (1) SK5222002A3 (pt)
TR (1) TR200200751T2 (pt)
WO (1) WO2001021772A2 (pt)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6830898B2 (en) * 2000-08-24 2004-12-14 Omnigene Bioproducts, Inc. Microorganisms and assays for the identification of antibiotics
DE10101501A1 (de) * 2001-01-12 2002-08-01 Forschungszentrum Juelich Gmbh Verfahren zur fermentativen Herstellung von Pantothensäure
CZ20031886A3 (cs) * 2001-01-19 2003-10-15 Basf Aktiengesellschaft Způsob přípravy pantothenátu ve vyšším výtěžku a mikroorganizmy používané při tomto způsobu
PL373006A1 (en) * 2001-01-19 2005-08-08 Basf Aktiengesellschaft Processes for enhanced production of pantothenate
SK10422003A3 (sk) 2001-02-21 2004-02-03 Basf Aktiengesellschaft Príprava kyseliny D-pantoténovej a/alebo jej solí ako prísad do krmív
DE10108223A1 (de) 2001-02-21 2002-10-10 Basf Ag Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
MXPA03007455A (es) * 2001-02-21 2004-07-30 Basf Ag Metodo y produccion de acido d-pantotenico y las sales de este como adyuvante en productos alimenticios para animales.
DE10108225A1 (de) * 2001-02-21 2002-10-10 Basf Ag Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
EP1247868A3 (de) * 2001-04-03 2002-10-30 Degussa AG Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
WO2003004673A1 (en) * 2001-07-03 2003-01-16 Degussa Ag Process for the fermentative preparation of d-pantothenic acid and/or salts thereof
DE10132178A1 (de) 2001-07-03 2003-01-23 Degussa Verfahren zur fermantativen Herstellung von D-Pantothensäure und/oder deren Salzen
WO2003004672A1 (en) * 2001-07-03 2003-01-16 Degussa Ag Process for the fermentative preparation of d-pantothenic acid and/or salts thereof
AU2002316940A1 (en) * 2001-07-07 2003-01-29 Degussa Ag Process for the preparation of d-pantothenic acid and/or salts thereof
EP1672073A1 (en) * 2001-07-07 2006-06-21 Degussa AG Process for the preparation of D-pantothenic acid and/or salts thereof
JP4532116B2 (ja) * 2002-01-18 2010-08-25 ノボザイムズ エー／エス アラニン２，３−アミノムターゼ
CA2491145A1 (en) 2002-07-03 2004-01-15 Basf Aktiengesellschaft Microorganisms and processes for enhanced production of pantothenate
AU2002316575A1 (en) * 2002-07-03 2004-01-23 Basf Aktiengesellschaft Microorganisms and processes for enhanced production of pantothenate
KR101185656B1 (ko) * 2003-06-18 2012-09-24 디에스엠 아이피 어셋츠 비.브이. 포자를 형성할 수 없는 미생물을 사용한 판토텐산염의 제조방법
EP1876235A4 (en) * 2005-03-29 2008-07-09 Kaneka Corp NOVEL GENE OF PANTOTHENATE KINASE AND USE THEREOF
US8273558B2 (en) 2005-10-26 2012-09-25 Butamax(Tm) Advanced Biofuels Llc Fermentive production of four carbon alcohols
US9303225B2 (en) 2005-10-26 2016-04-05 Butamax Advanced Biofuels Llc Method for the production of isobutanol by recombinant yeast
UA96928C2 (ru) 2005-10-26 2011-12-26 Э.И. Дю Пон Де Немур Энд Компани Ферментативное продуцирование спиртов с четырьмя атомами углерода
DE112007001179T5 (de) 2006-05-16 2009-04-02 Dsm Ip Assets B.V. Verfahren zur Herstellung von Panthenol
EP1918383A1 (en) * 2006-11-02 2008-05-07 DSMIP Assets B.V. Semi-continuous fermentation process for pantothenate production
KR20090117739A (ko) 2007-02-09 2009-11-12 더 리전트 오브 더 유니버시티 오브 캘리포니아 재조합 미생물을 이용한 생물연료의 생산
EP2164975B1 (de) 2007-07-06 2012-02-01 Basf Se Verfahren zur Herstellung einer konzentrierten wässrigen Glukoselösung aus Mais
CN103555643B (zh) * 2008-03-27 2016-08-10 基因组股份公司 用于产生己二酸和其他化合物的微生物
EP2157174A1 (en) 2008-08-12 2010-02-24 DSM IP Assets B.V. Increased production of pantothenate (vitamin B5)
EP2673369B1 (en) * 2011-02-07 2017-04-05 William Marsh Rice University Reverse beta oxidation pathway
US8765426B2 (en) * 2011-04-07 2014-07-01 E I Du Pont De Nemours And Company Pantothenic acid biosynthesis in zymomonas
WO2012175574A1 (en) 2011-06-21 2012-12-27 Dsm Ip Assets B.V. Increased pantothenate (vitamin b5) production
EP2723878B1 (en) 2011-06-21 2020-05-20 DSM IP Assets B.V. Vitamin b5 production
WO2014087184A1 (en) * 2012-12-03 2014-06-12 Metabolic Explorer Neopentyl glycol fermentative production by a recombinant microorganism
US9896464B2 (en) 2013-10-25 2018-02-20 Retrophin, Inc. Pantothenate derivatives for the treatment of neurological disorders
CN104593398B (zh) * 2013-11-01 2017-06-06 中国科学院微生物研究所 一种高L‑天冬氨酸α羧化酶活性的工程菌及其在生产β‑丙氨酸中的应用
CN105368758B (zh) * 2015-03-16 2018-06-19 鲁东大学 一株高产天冬氨酸脱羧酶的菌株及用于生产丙氨酸的方法
CN108486110A (zh) * 2015-03-31 2018-09-04 中国农业科学院生物技术研究所 一种启动子和重组表达载体及其用途
KR20180094942A (ko) 2015-12-08 2018-08-24 레트로핀, 인코포레이티드 신경질환의 치료를 위한 사이클릭 포스페이트 및 사이클릭 포스포아미데이트
KR102683624B1 (ko) 2017-06-30 2024-07-11 피티티 글로벌 케미칼 피씨엘 기능적 dna 서열의 안정화된 카피 수를 갖는 미생물 및 관련 방법
CN108456701B (zh) * 2018-03-23 2020-10-16 精晶药业股份有限公司 一种d-泛解酸内酯的制备方法
AU2019292164A1 (en) * 2018-06-25 2021-01-21 Lygos, Inc. Recombinant host cells and methods for the production of aspartic acid and beta-alanine
CA3103819A1 (en) 2018-07-09 2020-01-16 Codexis, Inc. Engineered pantothenate kinase variant enzymes
CN113846127B (zh) * 2020-06-28 2023-11-10 元素驱动(杭州)生物科技有限公司 一种泛解酸、泛酸、泛醇及其盐的制备方法
KR102389327B1 (ko) * 2020-07-01 2022-04-20 씨제이제일제당 (주) 3-메틸-2-옥소뷰타노에이트 하이드록시 메틸트랜스퍼라아제의 활성이 강화된 미생물, 및 이의 용도
CN115109736B (zh) * 2021-03-23 2024-05-07 中国科学院天津工业生物技术研究所 一种产泛解酸的微生物及其构建方法和应用
EP4108654A1 (en) 2021-06-23 2022-12-28 DSM IP Assets B.V. Production of panthenol
EP4323331A1 (en) 2021-04-15 2024-02-21 DSM IP Assets B.V. Production of panthenol
CN114085820B (zh) * 2021-11-19 2023-10-20 万华化学集团股份有限公司 来源于Candida viswanathii的酮基泛解酸内酯还原酶
CN114437988B (zh) * 2022-02-28 2023-05-23 贵州医科大学 纤维素降解菌及菌剂、制备方法、应用和降解酒糟的方法
CN115595328A (zh) * 2022-03-07 2023-01-13 中国科学院微生物研究所（Cn） 天冬氨酸脱羧酶在发酵生产维生素b5中的应用
CN115595314A (zh) * 2022-03-07 2023-01-13 中国科学院微生物研究所（Cn） 表达天冬氨酸脱氢酶的工程菌及发酵生产维生素b5的方法
WO2024110278A1 (en) 2022-11-21 2024-05-30 Dsm Ip Assets B.V. Production of panthenol
EP4378923A1 (en) 2022-12-01 2024-06-05 DSM IP Assets B.V. Production of panthenol
KR20240118944A (ko) 2023-01-27 2024-08-06 씨제이제일제당 (주) 아르카노박테리움 포시시마일 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도
KR20240118943A (ko) 2023-01-27 2024-08-06 씨제이제일제당 (주) 글루타미시박터 할로피토콜라 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5024943A (en) * 1985-11-07 1991-06-18 Gist-Brocades Regulatory region cloning and analysis plasmid for bacillus
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JP3710497B2 (ja) 1992-09-25 2005-10-26 ビーエーエスエフ アクチェンゲゼルシャフト Ｄ−パント酸、ｄ−パントテン酸およびそれらの塩の製造法
US5932457A (en) 1995-09-13 1999-08-03 Takeda Chemical Industries, Ltd Process for producing D-pantoic acid and D-pantothenic acid or salts thereof
US5834259A (en) * 1996-10-28 1998-11-10 Monsanto Company Process and composition for preparing D-aspartic acid
DE19855313A1 (de) * 1998-12-01 2000-06-08 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen
DE19855312A1 (de) * 1998-12-01 2000-06-08 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien

Also Published As

Publication number Publication date
EP2163629A3 (en) 2010-06-02
SK5222002A3 (en) 2003-03-04
WO2001021772A9 (en) 2002-12-05
IL148786A0 (en) 2002-09-12
BRPI0014115B8 (pt) 2021-05-25
NO20021382D0 (no) 2002-03-20
PL356566A1 (en) 2004-06-28
CA2385497A1 (en) 2001-03-29
AU7708700A (en) 2001-04-24
BRPI0014115B1 (pt) 2015-05-05
EP2163629A2 (en) 2010-03-17
HUP0202705A2 (hu) 2002-12-28
WO2001021772A3 (en) 2002-03-07
EP1214420A2 (en) 2002-06-19
JP5392957B2 (ja) 2014-01-22
KR20020092912A (ko) 2002-12-12
NO20021382L (no) 2002-05-16
TR200200751T2 (tr) 2004-08-23
CZ20021013A3 (en) 2002-12-11
JP2003527828A (ja) 2003-09-24
HU230509B1 (hu) 2016-09-28
HUP0202705A3 (en) 2011-02-28
CN1420931A (zh) 2003-05-28
EP2163629B1 (en) 2017-03-08
MXPA02003017A (es) 2004-09-06
WO2001021772A2 (en) 2001-03-29
EP1214420B1 (en) 2016-03-23

Similar Documents

Publication Publication Date Title
BR0014115A (pt) Métodos de produzir um panto-composto, pantotenato e beta-alanina, de aumentar a produção de um panto-composto e de edentificar compostos que modulam a atividade da pantotenato cinase, microorganismo recombinante, vetor, molécula de ácido nuleico isolada, polipetìdeo e proteìna da pantotenato cinase isolada
Foley et al. Site-specific protein modification: advances and applications
Jakubowski Aminoacyl thioester chemistry of class II aminoacyl-tRNA synthetases
BR0015114A (pt) Sequências de ácido nucléico e de aminoácido, construção de ácido nucleico, vetor, microorganismo, l-pantolactona hidrolase, e, processo para preparar d-pantolactona
BR9804896A (pt) Dna isolado e purificado, célula hospedeira, vetor, polinucleotídeo quimérico, plasmídeo e processo para aumentar a transcrição de um gene de interesse em uma célula hospedeira
McLaughlin et al. Stereospecific radical-mediated B12-dependent methyl transfer by the fosfomycin biosynthesis enzyme Fom3
BR9904955A (pt) Dna bactéria pertencendo ao gênero escherichia, e, processo para produzir um aminoácido.
EP2258722A3 (en) Antibodies to fibroblast growth factor-like (FGF-like) polypeptides
CA2396052A1 (en) Increased lysine production by gene amplification
BR9913360B1 (pt) proteÍna de uricase recombinante quimÉrica, molÉcula de Ácido nuclÉico isolada e purificada, vetor e cÉlula hospedeira transformada.
ATE342350T1 (de) Modifizierte adenoviren welche ein faserersatzprotein enthalten
EP1446500A4 (en) PROCESS FOR REGULATING THE IMMUNE FUNCTION IN PRIMATES USING THE FOXP3 PROTEIN
Go et al. Glycine decarboxylase is an unusual amino acid decarboxylase involved in tumorigenesis
RU2579689C1 (ru) Способ получения цистеина или его производного с использованием новой о-фосфосеринсульфгидрилазы
Antonczak et al. Advances in the mechanism and understanding of site-selective noncanonical amino acid incorporation
Tashiro et al. A protein semisynthesis-based strategy to investigate the functional impact of linker histone serine ADP-ribosylation
Catala et al. 1 H, 15 N chemical shift assignments of the imino groups of yeast tRNA Phe: Influence of the post-transcriptional modifications
WO2004011595A3 (fr) Vecteurs destines au transfert de molecules d&#39;interet dans des cellules cibles
BR9816106A (pt) Carboxilase de piruvato de corynebacterium glutamicum
Sun et al. Overproduction of α-lipoic acid by gene manipulated Escherichia coli
ATE371732T1 (de) Verfahren zur genexpression
Agris et al. The modified nucleosides in transfer RNA
AU2001238064A1 (en) 18477, a human protein kinase and uses therefor
Finkler et al. Full incorporation of the noncanonical amino acid hydroxylysine as a surrogate for lysine in green fluorescent protein
BR0215958A (pt) Métodos de modulação da produção de um composto contendo enxofre por um microorganismo e de produção de metionina, cassete de expressão transgênico, vetor, e, célula hospedeira transgênica

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 05/05/2015, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/09/2000 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 21/09/2020