BR0014115A - Métodos de produzir um panto-composto, pantotenato e beta-alanina, de aumentar a produção de um panto-composto e de edentificar compostos que modulam a atividade da pantotenato cinase, microorganismo recombinante, vetor, molécula de ácido nuleico isolada, polipetìdeo e proteìna da pantotenato cinase isolada - Google Patents
Métodos de produzir um panto-composto, pantotenato e beta-alanina, de aumentar a produção de um panto-composto e de edentificar compostos que modulam a atividade da pantotenato cinase, microorganismo recombinante, vetor, molécula de ácido nuleico isolada, polipetìdeo e proteìna da pantotenato cinase isoladaInfo
- Publication number
- BR0014115A BR0014115A BR0014115-1A BR0014115A BR0014115A BR 0014115 A BR0014115 A BR 0014115A BR 0014115 A BR0014115 A BR 0014115A BR 0014115 A BR0014115 A BR 0014115A
- Authority
- BR
- Brazil
- Prior art keywords
- panto
- pantothenate
- methods
- isolated
- compound
- Prior art date
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- C12P13/00—Preparation of nitrogen-containing organic compounds
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- C12N15/09—Recombinant DNA-technology
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- C12N9/10—Transferases (2.)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- C12N9/93—Ligases (6)
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- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
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- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
"MéTODOS DE PRODUZIR UM PANTO-COMPOSTO, PANTOTENATO E BETA-ALANINA, DE AUMENTAR A PRODUçãO DE UM PANTO-COMPOSTO E DE IDENTIFICAR COMPOSTOS QUE MODULAM A ATIVIDADE DA PANTOTENATO CINASE, MICROORGANISMO RECOMBINANTE, VETOR, MOLéCULA DE áCIDO NUCLEICO ISOLADA, POLIPETìDEO E PROTEìNA DA PANTOTENATO CINASE ISOLADA". A presente invenção retrata métodos de produzir panto-compostos (por exemplo, pantotenato) usando microorganismos em que o caminho biossintétíco do pantotenato e/ou o caminho biossintético da isoleucina-valina e/ou o caminho biossintético da coenzimaA tenha sido manipulado. Métodos que retratam microorganismos que supraexpressam a cetopantoato reductase bem como microorganismos que supraexpressam a aspartato <244>-descarboxilase são fornecidos. Métodos de produzir panto-compostos em uma maneira independente de precursor e em alto rendimento são descritos. Microorganismos recombinantes, vetores, moléculas de ácido nucleico isoladas, genes e produtos de gene úteis na prática das metodologias acima também são fornecidos. A presente invenção também retrata um gene da pantotenato cinase microbiana não identificado anteriormente, coaX, bem como métodos de produzir panto-compostos que utilizam microorganismos tendo atividade modificada da pantotenato cinase. Microorganismos recombinantes, vetores, moléculas de ácido nucleico coaX isoladas e proteínas CoaX purificadas são retratados. Também são retratados métodos para identificar os moduladores da pantotenato cinase que utilizam os microorganismos recombinantes e/ou as proteínas CoaX purificadas da presente invenção.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40049499A | 1999-09-21 | 1999-09-21 | |
US21007200P | 2000-06-07 | 2000-06-07 | |
US22183600P | 2000-07-28 | 2000-07-28 | |
US22786000P | 2000-08-24 | 2000-08-24 | |
PCT/US2000/025993 WO2001021772A2 (en) | 1999-09-21 | 2000-09-21 | Methods and microorganisms for production of panto-compounds |
Publications (3)
Publication Number | Publication Date |
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BR0014115A true BR0014115A (pt) | 2002-05-21 |
BRPI0014115B1 BRPI0014115B1 (pt) | 2015-05-05 |
BRPI0014115B8 BRPI0014115B8 (pt) | 2021-05-25 |
Family
ID=27498789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BRPI0014115A BRPI0014115B8 (pt) | 1999-09-21 | 2000-09-21 | métodos de produzir um panto-composto, pantotenato e beta-alanina, de aumentar a produção de um panto-composto e de edentificar compostos que modulam a atividade da pantotenato cinase, micro-organismo recombinante, vetor recombinante, e, vetor |
Country Status (16)
Country | Link |
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EP (2) | EP1214420B1 (pt) |
JP (1) | JP5392957B2 (pt) |
KR (1) | KR20020092912A (pt) |
CN (1) | CN1420931A (pt) |
AU (1) | AU7708700A (pt) |
BR (1) | BRPI0014115B8 (pt) |
CA (1) | CA2385497A1 (pt) |
CZ (1) | CZ20021013A3 (pt) |
HU (1) | HU230509B1 (pt) |
IL (1) | IL148786A0 (pt) |
MX (1) | MXPA02003017A (pt) |
NO (1) | NO20021382L (pt) |
PL (1) | PL356566A1 (pt) |
SK (1) | SK5222002A3 (pt) |
TR (1) | TR200200751T2 (pt) |
WO (1) | WO2001021772A2 (pt) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6830898B2 (en) * | 2000-08-24 | 2004-12-14 | Omnigene Bioproducts, Inc. | Microorganisms and assays for the identification of antibiotics |
DE10101501A1 (de) * | 2001-01-12 | 2002-08-01 | Forschungszentrum Juelich Gmbh | Verfahren zur fermentativen Herstellung von Pantothensäure |
CZ20031886A3 (cs) * | 2001-01-19 | 2003-10-15 | Basf Aktiengesellschaft | Způsob přípravy pantothenátu ve vyšším výtěžku a mikroorganizmy používané při tomto způsobu |
PL373006A1 (en) * | 2001-01-19 | 2005-08-08 | Basf Aktiengesellschaft | Processes for enhanced production of pantothenate |
SK10422003A3 (sk) | 2001-02-21 | 2004-02-03 | Basf Aktiengesellschaft | Príprava kyseliny D-pantoténovej a/alebo jej solí ako prísad do krmív |
DE10108223A1 (de) | 2001-02-21 | 2002-10-10 | Basf Ag | Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln |
MXPA03007455A (es) * | 2001-02-21 | 2004-07-30 | Basf Ag | Metodo y produccion de acido d-pantotenico y las sales de este como adyuvante en productos alimenticios para animales. |
DE10108225A1 (de) * | 2001-02-21 | 2002-10-10 | Basf Ag | Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln |
EP1247868A3 (de) * | 2001-04-03 | 2002-10-30 | Degussa AG | Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen |
WO2003004673A1 (en) * | 2001-07-03 | 2003-01-16 | Degussa Ag | Process for the fermentative preparation of d-pantothenic acid and/or salts thereof |
DE10132178A1 (de) | 2001-07-03 | 2003-01-23 | Degussa | Verfahren zur fermantativen Herstellung von D-Pantothensäure und/oder deren Salzen |
WO2003004672A1 (en) * | 2001-07-03 | 2003-01-16 | Degussa Ag | Process for the fermentative preparation of d-pantothenic acid and/or salts thereof |
AU2002316940A1 (en) * | 2001-07-07 | 2003-01-29 | Degussa Ag | Process for the preparation of d-pantothenic acid and/or salts thereof |
EP1672073A1 (en) * | 2001-07-07 | 2006-06-21 | Degussa AG | Process for the preparation of D-pantothenic acid and/or salts thereof |
JP4532116B2 (ja) * | 2002-01-18 | 2010-08-25 | ノボザイムズ エー/エス | アラニン2,3−アミノムターゼ |
CA2491145A1 (en) | 2002-07-03 | 2004-01-15 | Basf Aktiengesellschaft | Microorganisms and processes for enhanced production of pantothenate |
AU2002316575A1 (en) * | 2002-07-03 | 2004-01-23 | Basf Aktiengesellschaft | Microorganisms and processes for enhanced production of pantothenate |
KR101185656B1 (ko) * | 2003-06-18 | 2012-09-24 | 디에스엠 아이피 어셋츠 비.브이. | 포자를 형성할 수 없는 미생물을 사용한 판토텐산염의 제조방법 |
EP1876235A4 (en) * | 2005-03-29 | 2008-07-09 | Kaneka Corp | NOVEL GENE OF PANTOTHENATE KINASE AND USE THEREOF |
US8273558B2 (en) | 2005-10-26 | 2012-09-25 | Butamax(Tm) Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
US9303225B2 (en) | 2005-10-26 | 2016-04-05 | Butamax Advanced Biofuels Llc | Method for the production of isobutanol by recombinant yeast |
UA96928C2 (ru) | 2005-10-26 | 2011-12-26 | Э.И. Дю Пон Де Немур Энд Компани | Ферментативное продуцирование спиртов с четырьмя атомами углерода |
DE112007001179T5 (de) | 2006-05-16 | 2009-04-02 | Dsm Ip Assets B.V. | Verfahren zur Herstellung von Panthenol |
EP1918383A1 (en) * | 2006-11-02 | 2008-05-07 | DSMIP Assets B.V. | Semi-continuous fermentation process for pantothenate production |
KR20090117739A (ko) | 2007-02-09 | 2009-11-12 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 재조합 미생물을 이용한 생물연료의 생산 |
EP2164975B1 (de) | 2007-07-06 | 2012-02-01 | Basf Se | Verfahren zur Herstellung einer konzentrierten wässrigen Glukoselösung aus Mais |
CN103555643B (zh) * | 2008-03-27 | 2016-08-10 | 基因组股份公司 | 用于产生己二酸和其他化合物的微生物 |
EP2157174A1 (en) | 2008-08-12 | 2010-02-24 | DSM IP Assets B.V. | Increased production of pantothenate (vitamin B5) |
EP2673369B1 (en) * | 2011-02-07 | 2017-04-05 | William Marsh Rice University | Reverse beta oxidation pathway |
US8765426B2 (en) * | 2011-04-07 | 2014-07-01 | E I Du Pont De Nemours And Company | Pantothenic acid biosynthesis in zymomonas |
WO2012175574A1 (en) | 2011-06-21 | 2012-12-27 | Dsm Ip Assets B.V. | Increased pantothenate (vitamin b5) production |
EP2723878B1 (en) | 2011-06-21 | 2020-05-20 | DSM IP Assets B.V. | Vitamin b5 production |
WO2014087184A1 (en) * | 2012-12-03 | 2014-06-12 | Metabolic Explorer | Neopentyl glycol fermentative production by a recombinant microorganism |
US9896464B2 (en) | 2013-10-25 | 2018-02-20 | Retrophin, Inc. | Pantothenate derivatives for the treatment of neurological disorders |
CN104593398B (zh) * | 2013-11-01 | 2017-06-06 | 中国科学院微生物研究所 | 一种高L‑天冬氨酸α羧化酶活性的工程菌及其在生产β‑丙氨酸中的应用 |
CN105368758B (zh) * | 2015-03-16 | 2018-06-19 | 鲁东大学 | 一株高产天冬氨酸脱羧酶的菌株及用于生产丙氨酸的方法 |
CN108486110A (zh) * | 2015-03-31 | 2018-09-04 | 中国农业科学院生物技术研究所 | 一种启动子和重组表达载体及其用途 |
KR20180094942A (ko) | 2015-12-08 | 2018-08-24 | 레트로핀, 인코포레이티드 | 신경질환의 치료를 위한 사이클릭 포스페이트 및 사이클릭 포스포아미데이트 |
KR102683624B1 (ko) | 2017-06-30 | 2024-07-11 | 피티티 글로벌 케미칼 피씨엘 | 기능적 dna 서열의 안정화된 카피 수를 갖는 미생물 및 관련 방법 |
CN108456701B (zh) * | 2018-03-23 | 2020-10-16 | 精晶药业股份有限公司 | 一种d-泛解酸内酯的制备方法 |
AU2019292164A1 (en) * | 2018-06-25 | 2021-01-21 | Lygos, Inc. | Recombinant host cells and methods for the production of aspartic acid and beta-alanine |
CA3103819A1 (en) | 2018-07-09 | 2020-01-16 | Codexis, Inc. | Engineered pantothenate kinase variant enzymes |
CN113846127B (zh) * | 2020-06-28 | 2023-11-10 | 元素驱动(杭州)生物科技有限公司 | 一种泛解酸、泛酸、泛醇及其盐的制备方法 |
KR102389327B1 (ko) * | 2020-07-01 | 2022-04-20 | 씨제이제일제당 (주) | 3-메틸-2-옥소뷰타노에이트 하이드록시 메틸트랜스퍼라아제의 활성이 강화된 미생물, 및 이의 용도 |
CN115109736B (zh) * | 2021-03-23 | 2024-05-07 | 中国科学院天津工业生物技术研究所 | 一种产泛解酸的微生物及其构建方法和应用 |
EP4108654A1 (en) | 2021-06-23 | 2022-12-28 | DSM IP Assets B.V. | Production of panthenol |
EP4323331A1 (en) | 2021-04-15 | 2024-02-21 | DSM IP Assets B.V. | Production of panthenol |
CN114085820B (zh) * | 2021-11-19 | 2023-10-20 | 万华化学集团股份有限公司 | 来源于Candida viswanathii的酮基泛解酸内酯还原酶 |
CN114437988B (zh) * | 2022-02-28 | 2023-05-23 | 贵州医科大学 | 纤维素降解菌及菌剂、制备方法、应用和降解酒糟的方法 |
CN115595328A (zh) * | 2022-03-07 | 2023-01-13 | 中国科学院微生物研究所(Cn) | 天冬氨酸脱羧酶在发酵生产维生素b5中的应用 |
CN115595314A (zh) * | 2022-03-07 | 2023-01-13 | 中国科学院微生物研究所(Cn) | 表达天冬氨酸脱氢酶的工程菌及发酵生产维生素b5的方法 |
WO2024110278A1 (en) | 2022-11-21 | 2024-05-30 | Dsm Ip Assets B.V. | Production of panthenol |
EP4378923A1 (en) | 2022-12-01 | 2024-06-05 | DSM IP Assets B.V. | Production of panthenol |
KR20240118944A (ko) | 2023-01-27 | 2024-08-06 | 씨제이제일제당 (주) | 아르카노박테리움 포시시마일 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도 |
KR20240118943A (ko) | 2023-01-27 | 2024-08-06 | 씨제이제일제당 (주) | 글루타미시박터 할로피토콜라 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5024943A (en) * | 1985-11-07 | 1991-06-18 | Gist-Brocades | Regulatory region cloning and analysis plasmid for bacillus |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
JP3710497B2 (ja) | 1992-09-25 | 2005-10-26 | ビーエーエスエフ アクチェンゲゼルシャフト | D−パント酸、d−パントテン酸およびそれらの塩の製造法 |
US5932457A (en) | 1995-09-13 | 1999-08-03 | Takeda Chemical Industries, Ltd | Process for producing D-pantoic acid and D-pantothenic acid or salts thereof |
US5834259A (en) * | 1996-10-28 | 1998-11-10 | Monsanto Company | Process and composition for preparing D-aspartic acid |
DE19855313A1 (de) * | 1998-12-01 | 2000-06-08 | Degussa | Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen |
DE19855312A1 (de) * | 1998-12-01 | 2000-06-08 | Degussa | Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien |
-
2000
- 2000-09-21 IL IL14878600A patent/IL148786A0/xx unknown
- 2000-09-21 MX MXPA02003017A patent/MXPA02003017A/es unknown
- 2000-09-21 SK SK522-2002A patent/SK5222002A3/sk unknown
- 2000-09-21 WO PCT/US2000/025993 patent/WO2001021772A2/en not_active Application Discontinuation
- 2000-09-21 BR BRPI0014115A patent/BRPI0014115B8/pt not_active IP Right Cessation
- 2000-09-21 CA CA002385497A patent/CA2385497A1/en not_active Abandoned
- 2000-09-21 CZ CZ20021013A patent/CZ20021013A3/cs unknown
- 2000-09-21 TR TR2002/00751T patent/TR200200751T2/xx unknown
- 2000-09-21 CN CN00815771A patent/CN1420931A/zh active Pending
- 2000-09-21 AU AU77087/00A patent/AU7708700A/en not_active Abandoned
- 2000-09-21 JP JP2001525331A patent/JP5392957B2/ja not_active Expired - Fee Related
- 2000-09-21 EP EP00966799.9A patent/EP1214420B1/en not_active Expired - Lifetime
- 2000-09-21 KR KR1020027003732A patent/KR20020092912A/ko not_active Application Discontinuation
- 2000-09-21 EP EP09179840.5A patent/EP2163629B1/en not_active Expired - Lifetime
- 2000-09-21 HU HU0202705A patent/HU230509B1/hu not_active IP Right Cessation
- 2000-09-21 PL PL00356566A patent/PL356566A1/xx not_active Application Discontinuation
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2002
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Also Published As
Publication number | Publication date |
---|---|
EP2163629A3 (en) | 2010-06-02 |
SK5222002A3 (en) | 2003-03-04 |
WO2001021772A9 (en) | 2002-12-05 |
IL148786A0 (en) | 2002-09-12 |
BRPI0014115B8 (pt) | 2021-05-25 |
NO20021382D0 (no) | 2002-03-20 |
PL356566A1 (en) | 2004-06-28 |
CA2385497A1 (en) | 2001-03-29 |
AU7708700A (en) | 2001-04-24 |
BRPI0014115B1 (pt) | 2015-05-05 |
EP2163629A2 (en) | 2010-03-17 |
HUP0202705A2 (hu) | 2002-12-28 |
WO2001021772A3 (en) | 2002-03-07 |
EP1214420A2 (en) | 2002-06-19 |
JP5392957B2 (ja) | 2014-01-22 |
KR20020092912A (ko) | 2002-12-12 |
NO20021382L (no) | 2002-05-16 |
TR200200751T2 (tr) | 2004-08-23 |
CZ20021013A3 (en) | 2002-12-11 |
JP2003527828A (ja) | 2003-09-24 |
HU230509B1 (hu) | 2016-09-28 |
HUP0202705A3 (en) | 2011-02-28 |
CN1420931A (zh) | 2003-05-28 |
EP2163629B1 (en) | 2017-03-08 |
MXPA02003017A (es) | 2004-09-06 |
WO2001021772A2 (en) | 2001-03-29 |
EP1214420B1 (en) | 2016-03-23 |
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