HUP0202705A2 - Eljárások és mikroorganizmusok pantovegyületek előállítására - Google Patents

Eljárások és mikroorganizmusok pantovegyületek előállítására

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Publication number
HUP0202705A2
HUP0202705A2 HU0202705A HUP0202705A HUP0202705A2 HU P0202705 A2 HUP0202705 A2 HU P0202705A2 HU 0202705 A HU0202705 A HU 0202705A HU P0202705 A HUP0202705 A HU P0202705A HU P0202705 A2 HUP0202705 A2 HU P0202705A2
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HU
Hungary
Prior art keywords
microorganisms
subject
panto
pantothenate
compounds
Prior art date
Application number
HU0202705A
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English (en)
Inventor
Theron Hermann
Thomas A. Patterson
Janice G. Pero
Rogers R. Yocum
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Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of HUP0202705A2 publication Critical patent/HUP0202705A2/hu
Publication of HUP0202705A3 publication Critical patent/HUP0202705A3/hu
Publication of HU230509B1 publication Critical patent/HU230509B1/hu

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    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/02Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1003Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014Hydroxymethyl-, formyl-transferases (2.1.2)
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
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    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/06Alanine; Leucine; Isoleucine; Serine; Homoserine
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    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/04Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
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    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

A találmány tárgyát képezik eljárások pantovegyületek (példáulpantotenát) előállítására olyan mikroorganizmusok alkalmazásával,amelyekben a pantotenát bioszintetikus folyamatsor és/vagy azizoleucin-valin bioszintetikus folyamatsor és/vagy koenzim-Abioszintetikus folyamatsor manipulálva van. A találmány tárgyátképezik ketopantoát reduktázt és aszpartát a-dekarboxilázt túltermelniképes mikroorganizmusok, továbbá eljárások pantovegyületekelőállítására prekurzor-független módon és nagy hozamban. Szintén atalálmány tárgyát képezik a fentebb leírt eljárásokban alkalmazhatórekombináns mikroorganizmusok, vektorok, izolált nukleinsavmolekulák,gének és géntermékek. A találmány tárgyát képezik előzőleg nemazonosított, mikroorganizmusból származó, coaX-jelű pantotenát kináz-gén, valamint eljárások panto-vegyületek termelésére módosítottpantotenát kipáz aktivitással rendelkező mikroorganizmusokalkalmazásával. Szintén a találmány tárgyát képezi eljárás pantotenátkináz modulátorok azonosítására, a találmány szerinti rekombinánsmikroorganizmusok és/vagy tisztított CoaX-fehérjék alkalmazásával. Ó
HU0202705A 1999-09-21 2000-09-21 Eljárások és mikroorganizmusok panto-vegyületek előállítására HU230509B1 (hu)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US40049499A 1999-09-21 1999-09-21
US09/400,494 1999-09-21
US21007200P 2000-06-07 2000-06-07
US60/210,072 2000-06-07
US22183600P 2000-07-28 2000-07-28
US60/221,836 2000-07-28
US22786000P 2000-08-24 2000-08-24
US60/227,860 2000-08-24
PCT/US2000/025993 WO2001021772A2 (en) 1999-09-21 2000-09-21 Methods and microorganisms for production of panto-compounds

Publications (3)

Publication Number Publication Date
HUP0202705A2 true HUP0202705A2 (hu) 2002-12-28
HUP0202705A3 HUP0202705A3 (en) 2011-02-28
HU230509B1 HU230509B1 (hu) 2016-09-28

Family

ID=27498789

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202705A HU230509B1 (hu) 1999-09-21 2000-09-21 Eljárások és mikroorganizmusok panto-vegyületek előállítására

Country Status (16)

Country Link
EP (2) EP1214420B1 (hu)
JP (1) JP5392957B2 (hu)
KR (1) KR20020092912A (hu)
CN (1) CN1420931A (hu)
AU (1) AU7708700A (hu)
BR (1) BRPI0014115B8 (hu)
CA (1) CA2385497A1 (hu)
CZ (1) CZ20021013A3 (hu)
HU (1) HU230509B1 (hu)
IL (1) IL148786A0 (hu)
MX (1) MXPA02003017A (hu)
NO (1) NO20021382L (hu)
PL (1) PL356566A1 (hu)
SK (1) SK5222002A3 (hu)
TR (1) TR200200751T2 (hu)
WO (1) WO2001021772A2 (hu)

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Also Published As

Publication number Publication date
BR0014115A (pt) 2002-05-21
EP2163629A3 (en) 2010-06-02
SK5222002A3 (en) 2003-03-04
WO2001021772A9 (en) 2002-12-05
IL148786A0 (en) 2002-09-12
BRPI0014115B8 (pt) 2021-05-25
NO20021382D0 (no) 2002-03-20
PL356566A1 (en) 2004-06-28
CA2385497A1 (en) 2001-03-29
AU7708700A (en) 2001-04-24
BRPI0014115B1 (pt) 2015-05-05
EP2163629A2 (en) 2010-03-17
WO2001021772A3 (en) 2002-03-07
EP1214420A2 (en) 2002-06-19
JP5392957B2 (ja) 2014-01-22
KR20020092912A (ko) 2002-12-12
NO20021382L (no) 2002-05-16
TR200200751T2 (tr) 2004-08-23
CZ20021013A3 (en) 2002-12-11
JP2003527828A (ja) 2003-09-24
HU230509B1 (hu) 2016-09-28
HUP0202705A3 (en) 2011-02-28
CN1420931A (zh) 2003-05-28
EP2163629B1 (en) 2017-03-08
MXPA02003017A (es) 2004-09-06
WO2001021772A2 (en) 2001-03-29
EP1214420B1 (en) 2016-03-23

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