HUP0302079A2 - Amino-tiazolok, eljárás elżállításukra és adenozin receptor antagonistákként történż felhasználásuk - Google Patents

Amino-tiazolok, eljárás elżállításukra és adenozin receptor antagonistákként történż felhasználásuk

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Publication number
HUP0302079A2
HUP0302079A2 HU0302079A HUP0302079A HUP0302079A2 HU P0302079 A2 HUP0302079 A2 HU P0302079A2 HU 0302079 A HU0302079 A HU 0302079A HU P0302079 A HUP0302079 A HU P0302079A HU P0302079 A2 HUP0302079 A2 HU P0302079A2
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HU
Hungary
Prior art keywords
group
general formula
alkyl
hydrogen atom
alkoxy
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HU0302079A
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English (en)
Inventor
Neil John Press
Roger John Taylor
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Novartis Ag.
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Publication date
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Publication of HUP0302079A2 publication Critical patent/HUP0302079A2/hu

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Abstract

A találmány olyan, szabad formában vagy só formájában lévő (I)általános képletű vegyületekre vonatkozik amelyek képletében Arjelentése 6-15 szénatomos, egy vegyértékű aromás csoport; R1 jelentésehidrogénatom; adott esetben a következő atomok és/vagy csoportok közülkiválasztott egy vagy több szubsztituenst hordozó fenilcsoport:halogénatom, ciano-, hidroxicsoport, 1-8 szénatomos alkilcsoport, 1-8szénatomos halogén-alkil-csoport, 1-8 szénatomos alkoxicsoport, (1-8szénatomos alkoxi)-(1-8 szénatomos alkil)-csoport vagy acil-oxi-csoport: vagy egy öt- vagy hattagú, egyvegyértékű heterociklusoscsoport; R2 jelentése hidrogénatom, 1-8 szénatomos alkílcsoport,acilcsoport vagy -CON(R3)R4 általános képletű csoport, azzal amegkötéssel, hogy ha R1 jelentése hidrogénatom, akkor R2 jelentése 1-8szénatomos alkilcsoport, acilcsoport vagy -CON(R3)R4 általános képletűcsoport; R3 és R4 mindegyikének jelentése egymástól függetlenülhidrogénatom vagy 1-8 szénatomos alkilcsoport, vagy azzal anitrogénatommal együtt, amelyhez kapcsolódik, egy öt- vagy hattagúheterociklusos csoportot képez; Z1, Z2, Z3 és Z4 mindegyikénekjelentése egymástól függetlenül nitrogénatom vagy =C(R5)- általánosképletű csoport, ahol Z1, Z2, Z3 és Z4 közül legalább egynek ajelentése =C(R5)- általános képletű csoport; és R5 jelentésehidrogénatom, 1-8 szénatomos alkilcsoport vagy 1-8 szénatomosalkoxicsoport. A találmány szerinti vegyületek adenozin receptorantagonistákként, különösen gyulladásos vagy obstruktív légútibetegségek kezelésére alkalmazhatók. Ó
HU0302079A 2000-11-21 2001-11-19 Amino-tiazolok, eljárás elżállításukra és adenozin receptor antagonistákként történż felhasználásuk HUP0302079A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0028383.8A GB0028383D0 (en) 2000-11-21 2000-11-21 Organic compounds
PCT/EP2001/013378 WO2002042298A1 (en) 2000-11-21 2001-11-19 Aminothiazoles and their use as adenosine receptor antagonists

Publications (1)

Publication Number Publication Date
HUP0302079A2 true HUP0302079A2 (hu) 2003-09-29

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HU0302079A HUP0302079A2 (hu) 2000-11-21 2001-11-19 Amino-tiazolok, eljárás elżállításukra és adenozin receptor antagonistákként történż felhasználásuk

Country Status (26)

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US (1) US7109202B2 (hu)
EP (1) EP1339711B1 (hu)
JP (1) JP3973556B2 (hu)
KR (1) KR20040007412A (hu)
CN (1) CN1244580C (hu)
AR (1) AR035371A1 (hu)
AT (1) ATE300536T1 (hu)
AU (1) AU2002237221A1 (hu)
BR (1) BR0115478A (hu)
CA (1) CA2429442A1 (hu)
CZ (1) CZ20031393A3 (hu)
DE (1) DE60112322T2 (hu)
EC (1) ECSP034611A (hu)
ES (1) ES2246346T3 (hu)
GB (1) GB0028383D0 (hu)
HU (1) HUP0302079A2 (hu)
IL (1) IL155712A0 (hu)
MX (1) MXPA03004439A (hu)
NO (1) NO20032277L (hu)
NZ (1) NZ525875A (hu)
PE (1) PE20020580A1 (hu)
PL (1) PL361842A1 (hu)
RU (1) RU2003117476A (hu)
SK (1) SK6032003A3 (hu)
WO (1) WO2002042298A1 (hu)
ZA (1) ZA200303721B (hu)

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