BR0115478A - Aminotiazós e o uso dos mesmos como antagonistas do receptor da adenosina - Google Patents
Aminotiazós e o uso dos mesmos como antagonistas do receptor da adenosinaInfo
- Publication number
- BR0115478A BR0115478A BR0115478-8A BR0115478A BR0115478A BR 0115478 A BR0115478 A BR 0115478A BR 0115478 A BR0115478 A BR 0115478A BR 0115478 A BR0115478 A BR 0115478A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- receptor antagonists
- aminothiazoles
- Prior art date
Links
- RAIPHJJURHTUIC-UHFFFAOYSA-N 1,3-thiazol-2-amine Chemical class NC1=NC=CS1 RAIPHJJURHTUIC-UHFFFAOYSA-N 0.000 title 1
- 229940121359 adenosine receptor antagonist Drugs 0.000 title 1
- 239000000296 purinergic P1 receptor antagonist Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- -1 cyano, hydroxy Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Abstract
"AMINOTIAZóS E O USO DOS MESMOS COMO ANTAGONISTAS DO RECEPTOR DA ADENOSINA". Compostos da fórmula na forma livre ou na forma de sal, onde Ar é um grupo C~ 6~-C~ 15~ aromático monovalente, R^ 1^ é hidrogênio, fenila substituída de modo opcional com um ou mais substituintes selecionados a partir de halogênio, ciano, hidróxi, C~ 1~-C~ 8~ alquila, C~ 1~-C~ 8~ haloalquila, C~ 1~-C~ 8~ alcóxi, C~ 1~-C~ 8~ alcóxi- C~ 1~-C~ 8~ alquila ou acilóxi ou um grupo heterocíclico monovalente de 5 ou 6 elementos, R^ 2^ é hidrogênio, C~ 1~-C~ 8~ alquila, acila ou -CON(R^ 3^)R^ 4^, contanto que R^ 2^ seja C~ 1~-C~ 8~ alquila, acila ou -CON(R^ 3^)R^ 4^ quando R^ 1^ for hidrogênio, R^ 3^ e R^ 4^ são, cada um, de forma independente hidrogênio ou C~ 1~-C~ 8~ alquila, ou em conjunto com o átomo de nitrogênio ao qual eles estão ligados indica um grupo heterocíclico de 5 ou 6 elementos, e Z^ 1^, Z^ 2^, Z^ 3^ e Z^ 4^ são, cada um, de forma independente N ou CR^ 5^, pelo menos um deles sendo CR^ 5^, e R^ 5^ é hidrogênio, C~ 1~-C~ 8~ alquila ou C~ 1~-C~ 8~ alcóxi. Os compostos são úteis como produtos farmacêuticos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0028383.8A GB0028383D0 (en) | 2000-11-21 | 2000-11-21 | Organic compounds |
PCT/EP2001/013378 WO2002042298A1 (en) | 2000-11-21 | 2001-11-19 | Aminothiazoles and their use as adenosine receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0115478A true BR0115478A (pt) | 2004-02-17 |
Family
ID=9903594
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0115478-8A BR0115478A (pt) | 2000-11-21 | 2001-11-19 | Aminotiazós e o uso dos mesmos como antagonistas do receptor da adenosina |
Country Status (26)
Country | Link |
---|---|
US (1) | US7109202B2 (pt) |
EP (1) | EP1339711B1 (pt) |
JP (1) | JP3973556B2 (pt) |
KR (1) | KR20040007412A (pt) |
CN (1) | CN1244580C (pt) |
AR (1) | AR035371A1 (pt) |
AT (1) | ATE300536T1 (pt) |
AU (1) | AU2002237221A1 (pt) |
BR (1) | BR0115478A (pt) |
CA (1) | CA2429442A1 (pt) |
CZ (1) | CZ20031393A3 (pt) |
DE (1) | DE60112322T2 (pt) |
EC (1) | ECSP034611A (pt) |
ES (1) | ES2246346T3 (pt) |
GB (1) | GB0028383D0 (pt) |
HU (1) | HUP0302079A2 (pt) |
IL (1) | IL155712A0 (pt) |
MX (1) | MXPA03004439A (pt) |
NO (1) | NO20032277L (pt) |
NZ (1) | NZ525875A (pt) |
PE (1) | PE20020580A1 (pt) |
PL (1) | PL361842A1 (pt) |
RU (1) | RU2003117476A (pt) |
SK (1) | SK6032003A3 (pt) |
WO (1) | WO2002042298A1 (pt) |
ZA (1) | ZA200303721B (pt) |
Families Citing this family (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020115635A1 (en) * | 2001-02-21 | 2002-08-22 | Pnina Fishman | Modulation of GSK-3beta activity and its different uses |
WO2003048140A1 (fr) * | 2001-12-03 | 2003-06-12 | Japan Tobacco Inc. | Compose azole et utilisation medicinale de celui-ci |
CA2472711C (en) | 2002-01-18 | 2012-03-20 | Yamanouchi Pharmaceutical Co., Ltd. | 2-acylaminothiazole derivative or salt thereof |
TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
TW200524887A (en) * | 2003-10-27 | 2005-08-01 | Lundbeck & Co As H | N-thiazol-2-yl-benzamide derivatives |
CN1902196B (zh) * | 2003-12-26 | 2010-12-29 | 协和发酵麒麟株式会社 | 噻唑衍生物 |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
GB0401336D0 (en) * | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
PE20060272A1 (es) * | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
GB0417910D0 (en) * | 2004-08-11 | 2004-09-15 | Novartis Ag | Organic compounds |
CN101061115A (zh) * | 2004-09-22 | 2007-10-24 | H.隆德贝克有限公司 | 2-酰氨基噻唑衍生物 |
WO2006032273A1 (en) | 2004-09-22 | 2006-03-30 | H. Lundbeck A/S | 2-acylaminothiazole derivatives |
GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
US7674912B2 (en) | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
SG159561A1 (en) * | 2005-05-09 | 2010-03-30 | Achillion Pharmaceuticals Inc | Thiazole compounds and methods of use |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
US20090233896A1 (en) * | 2005-06-09 | 2009-09-17 | Arrington Kenneth L | Inhibitors of checkpoint kinases |
EP1894930A4 (en) * | 2005-06-23 | 2010-06-23 | Kyowa Hakko Kirin Co Ltd | THIAZOLE DERIVATIVE |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
ES2270715B1 (es) | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
PL1921077T3 (pl) * | 2005-08-02 | 2018-01-31 | Kyowa Hakko Kirin Co Ltd | Środek do zapobiegania i/lub leczenia zaburzenia snu |
GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
WO2007017670A1 (en) | 2005-08-08 | 2007-02-15 | Argenta Discovery Ltd. | Bicyclo[2.2.]hept-7-ylamine derivatives and their uses |
CA2617394C (en) | 2005-09-13 | 2014-06-03 | Janssen Pharmaceutica N.V. | 2-aniline-4-aryl substituted thiazole derivatives |
ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
WO2007045477A2 (en) | 2005-10-21 | 2007-04-26 | Novartis Ag | Human antibodies against il-13 and therapeutic uses |
KR20080074166A (ko) * | 2005-11-08 | 2008-08-12 | 아스테라스 세이야쿠 가부시키가이샤 | 혈소판감소증을 치료하는 조성물 및 방법 |
GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
US7795268B2 (en) | 2006-03-17 | 2010-09-14 | Gilead Palo Alto, Inc. | Method of treating hepatic disease using A2B adenosine receptor antagonists |
US8217037B2 (en) * | 2006-04-07 | 2012-07-10 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers |
ATE549337T1 (de) | 2006-04-21 | 2012-03-15 | Novartis Ag | Purinderivate zur verwendung als adenosin-a2a- rezeptoragonisten |
ES2452032T3 (es) * | 2006-08-08 | 2014-03-31 | Akarx, Inc. | Composiciones y métodos para aumentar los niveles de plaquetas de la sangre en humanos |
AU2007302263A1 (en) | 2006-09-29 | 2008-04-03 | Novartis Ag | Pyrazolopyrimidines as P13K lipid kinase inhibitors |
WO2008052734A1 (en) | 2006-10-30 | 2008-05-08 | Novartis Ag | Heterocyclic compounds as antiinflammatory agents |
JP2010515729A (ja) | 2007-01-10 | 2010-05-13 | アイアールエム・リミテッド・ライアビリティ・カンパニー | チャネル活性化プロテアーゼ阻害剤としての化合物および組成物 |
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-
2000
- 2000-11-21 GB GBGB0028383.8A patent/GB0028383D0/en not_active Ceased
-
2001
- 2001-11-19 BR BR0115478-8A patent/BR0115478A/pt not_active Application Discontinuation
- 2001-11-19 EP EP01986395A patent/EP1339711B1/en not_active Expired - Lifetime
- 2001-11-19 CA CA002429442A patent/CA2429442A1/en not_active Abandoned
- 2001-11-19 SK SK603-2003A patent/SK6032003A3/sk unknown
- 2001-11-19 IL IL15571201A patent/IL155712A0/xx unknown
- 2001-11-19 US US10/432,302 patent/US7109202B2/en not_active Expired - Fee Related
- 2001-11-19 KR KR10-2003-7006156A patent/KR20040007412A/ko not_active Application Discontinuation
- 2001-11-19 NZ NZ525875A patent/NZ525875A/en unknown
- 2001-11-19 MX MXPA03004439A patent/MXPA03004439A/es unknown
- 2001-11-19 HU HU0302079A patent/HUP0302079A2/hu unknown
- 2001-11-19 JP JP2002544432A patent/JP3973556B2/ja not_active Expired - Fee Related
- 2001-11-19 AU AU2002237221A patent/AU2002237221A1/en not_active Abandoned
- 2001-11-19 CZ CZ20031393A patent/CZ20031393A3/cs unknown
- 2001-11-19 WO PCT/EP2001/013378 patent/WO2002042298A1/en active IP Right Grant
- 2001-11-19 CN CNB018192882A patent/CN1244580C/zh not_active Expired - Fee Related
- 2001-11-19 DE DE60112322T patent/DE60112322T2/de not_active Expired - Lifetime
- 2001-11-19 AT AT01986395T patent/ATE300536T1/de not_active IP Right Cessation
- 2001-11-19 PL PL01361842A patent/PL361842A1/xx not_active Application Discontinuation
- 2001-11-19 RU RU2003117476/04A patent/RU2003117476A/ru not_active Application Discontinuation
- 2001-11-19 AR ARP010105397A patent/AR035371A1/es unknown
- 2001-11-19 ES ES01986395T patent/ES2246346T3/es not_active Expired - Lifetime
- 2001-11-20 PE PE2001001159A patent/PE20020580A1/es not_active Application Discontinuation
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2003
- 2003-05-14 ZA ZA200303721A patent/ZA200303721B/en unknown
- 2003-05-16 EC EC2003004611A patent/ECSP034611A/es unknown
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DE60112322D1 (de) | 2005-09-01 |
CA2429442A1 (en) | 2002-05-30 |
RU2003117476A (ru) | 2005-02-10 |
EP1339711B1 (en) | 2005-07-27 |
KR20040007412A (ko) | 2004-01-24 |
CN1244580C (zh) | 2006-03-08 |
CZ20031393A3 (cs) | 2003-08-13 |
NZ525875A (en) | 2004-11-26 |
PL361842A1 (en) | 2004-10-04 |
ECSP034611A (es) | 2003-06-25 |
ZA200303721B (en) | 2004-05-10 |
US20040053982A1 (en) | 2004-03-18 |
ATE300536T1 (de) | 2005-08-15 |
AU2002237221A1 (en) | 2002-06-03 |
GB0028383D0 (en) | 2001-01-03 |
IL155712A0 (en) | 2003-11-23 |
AR035371A1 (es) | 2004-05-12 |
NO20032277L (no) | 2003-07-21 |
WO2002042298A1 (en) | 2002-05-30 |
NO20032277D0 (no) | 2003-05-20 |
PE20020580A1 (es) | 2002-08-13 |
DE60112322T2 (de) | 2006-05-24 |
CN1476447A (zh) | 2004-02-18 |
ES2246346T3 (es) | 2006-02-16 |
JP3973556B2 (ja) | 2007-09-12 |
EP1339711A1 (en) | 2003-09-03 |
JP2004521871A (ja) | 2004-07-22 |
MXPA03004439A (es) | 2003-08-19 |
HUP0302079A2 (hu) | 2003-09-29 |
SK6032003A3 (en) | 2004-01-08 |
US7109202B2 (en) | 2006-09-19 |
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