BR0207216A - Derivados de tieno 2,3-d-pirimidindiona como inibidores de metaloproteinase matriz - Google Patents

Derivados de tieno 2,3-d-pirimidindiona como inibidores de metaloproteinase matriz

Info

Publication number
BR0207216A
BR0207216A BR0207216-5A BR0207216A BR0207216A BR 0207216 A BR0207216 A BR 0207216A BR 0207216 A BR0207216 A BR 0207216A BR 0207216 A BR0207216 A BR 0207216A
Authority
BR
Brazil
Prior art keywords
derivatives
alkyl
pyrimidindione
thiene
matrix metalloproteinase
Prior art date
Application number
BR0207216-5A
Other languages
English (en)
Inventor
William Glen Harter
Jie Jack Li
Daniel Fred Ortwine
Kevon Ray Shuler
We-Song Yue
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR0207216A publication Critical patent/BR0207216A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

"DERIVADOS DE TIENO 2,3-D-PIRIMIDINDIONA COMO INIBIDORES DE METALOPROTEINASE MATRIZ". Inibidores de MMP-13 seletivos são pirimidinonas fundidas da fórmula ou um seu sal farmaceuticamente aceitável; em que: W, em conjunto com os átomos de carbono aos quais ele está ligado, forma um dirradical em anel de 5 membros Y é O, S, SO, SO~ 2~, NR^ 5^ ou CH~ 2~; O (O)~ n~ A é ou B é O ou NR^ 5^ ou A e B são considerados em conjunto para formar -C<sym>C-; R^ 1^, R^ 4^ e R^ 5^ são independentemente hidrogênio, alquila, alquenila, alquinila, (CH~ 2~)~ n~-arila, (CH~ 2~)~ n~-cicloalquila, alcanoílo C~ 1~-C~ 6~ ou (CH~ 2~)~ n~heteroarila; R^ 2^ e R^ 3^ são independentemente hidrogênio, alquila, alquenila , alquinila, CN, NO~ 2~, NR^ 4^R^ 5^, (CH~ 2~)~ n~-cicloalquila, (CH~ 2~)~ n~-arila ou (CH~ 2~)~ n~heteroarila; R^ 2^ pode ainda ser halo ; n é um número inteiro de 0 até 5; e R^ 4^ e R^ 5^ quando considerados em conjunto com o nitrogênio ao qual eles estão ligados completam um anel de 3 a 8 membros contendo átomos de carbono e contendo opcionalmente O, S ou N, e substituído ou não substituído; com a condição de que R^ 1^ e R^ 3^ não são ambos selecionados dentre hidrogênio e alquila C~ 1~-C~ 6~.
BR0207216-5A 2001-02-14 2002-01-18 Derivados de tieno 2,3-d-pirimidindiona como inibidores de metaloproteinase matriz BR0207216A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26875601P 2001-02-14 2001-02-14
PCT/IB2002/000204 WO2002064598A1 (en) 2001-02-14 2002-01-18 Thieno'2,3-d pyrimidindione derivatives as matrix metalloproteinase inhibitors

Publications (1)

Publication Number Publication Date
BR0207216A true BR0207216A (pt) 2004-03-09

Family

ID=23024328

Family Applications (1)

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BR0207216-5A BR0207216A (pt) 2001-02-14 2002-01-18 Derivados de tieno 2,3-d-pirimidindiona como inibidores de metaloproteinase matriz

Country Status (15)

Country Link
US (1) US20030004172A1 (pt)
EP (1) EP1370562A1 (pt)
JP (1) JP2004518732A (pt)
BR (1) BR0207216A (pt)
CA (1) CA2433778A1 (pt)
DO (1) DOP2002000337A (pt)
GT (1) GT200200017A (pt)
HN (1) HN2002000029A (pt)
MX (1) MXPA03004926A (pt)
PA (1) PA8538301A1 (pt)
PE (1) PE20020957A1 (pt)
SV (1) SV2003000882A (pt)
TN (1) TNSN02009A1 (pt)
UY (1) UY27159A1 (pt)
WO (1) WO2002064598A1 (pt)

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Also Published As

Publication number Publication date
MXPA03004926A (es) 2005-02-14
DOP2002000337A (es) 2002-08-15
US20030004172A1 (en) 2003-01-02
HN2002000029A (es) 2003-02-14
PA8538301A1 (es) 2002-09-17
GT200200017A (es) 2002-11-15
SV2003000882A (es) 2003-01-13
PE20020957A1 (es) 2002-11-08
UY27159A1 (es) 2002-09-30
TNSN02009A1 (fr) 2005-12-23
CA2433778A1 (en) 2002-08-22
WO2002064598A1 (en) 2002-08-22
EP1370562A1 (en) 2003-12-17
JP2004518732A (ja) 2004-06-24

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