BR0015333A - Derivados de isoxazol como inibidores de fosfodiesterase vii - Google Patents
Derivados de isoxazol como inibidores de fosfodiesterase viiInfo
- Publication number
- BR0015333A BR0015333A BR0015333-8A BR0015333A BR0015333A BR 0015333 A BR0015333 A BR 0015333A BR 0015333 A BR0015333 A BR 0015333A BR 0015333 A BR0015333 A BR 0015333A
- Authority
- BR
- Brazil
- Prior art keywords
- vii
- phosphodiesterase inhibitors
- isoxazole derivatives
- derivatives
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
Abstract
Patente de Invenção: "DERIVADOS DE ISOXAZOL COMO INIBIDORES DE FOSFODIESTERASE VII". A invenção refere-se a compostos de fórmula (I), em que R^ 1^, R^ 2^, R^ 3^, R^ 4^ e R^ 5^ têm os significados indicados na reivindicação 1 e aos seus sais e/ou solvatos fisiologicamente aceitáveis, que são usados como os inibidores de fosfodiesterase VII, e ao uso deles na produção de medicamentos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19953024A DE19953024A1 (de) | 1999-11-04 | 1999-11-04 | Isoxazolderivate als Phosphodiesterase VII-Hemmer |
| PCT/EP2000/010239 WO2001032175A1 (de) | 1999-11-04 | 2000-10-18 | Isoxazolderivate als phosphodiesterase vii-hemmer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0015333A true BR0015333A (pt) | 2002-07-09 |
Family
ID=7927860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0015333-8A BR0015333A (pt) | 1999-11-04 | 2000-10-18 | Derivados de isoxazol como inibidores de fosfodiesterase vii |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6531498B1 (pt) |
| EP (1) | EP1225896B1 (pt) |
| JP (1) | JP2003513042A (pt) |
| KR (1) | KR20020047329A (pt) |
| CN (1) | CN1384744A (pt) |
| AR (1) | AR026350A1 (pt) |
| AT (1) | ATE300945T1 (pt) |
| AU (1) | AU781607B2 (pt) |
| BR (1) | BR0015333A (pt) |
| CA (1) | CA2389647C (pt) |
| CZ (1) | CZ20021441A3 (pt) |
| DE (2) | DE19953024A1 (pt) |
| ES (1) | ES2243313T3 (pt) |
| HU (1) | HUP0203187A3 (pt) |
| MX (1) | MXPA02004441A (pt) |
| NO (1) | NO20022123L (pt) |
| PL (1) | PL355021A1 (pt) |
| RU (1) | RU2002113746A (pt) |
| SK (1) | SK5942002A3 (pt) |
| WO (1) | WO2001032175A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2255294T3 (es) * | 1998-08-07 | 2006-06-16 | Chiron Corporation | Derivados de isoxazol sustituidos como moduladores del receptor de estrogenos. |
| ES2217956B1 (es) * | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
| KR100666052B1 (ko) * | 2004-02-12 | 2007-01-09 | 조극래 | 원적외선이용한 건조장치 |
| ES2814200T3 (es) | 2005-07-29 | 2021-03-26 | Basf Se | Estabilización de productos para el cuidado del cuerpo y del hogar contra la degradación por radiación UV utilizando derivados de merocianina |
| US8637528B2 (en) * | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| RU2449790C2 (ru) * | 2007-03-27 | 2012-05-10 | Омерос Корпорейшен | Использование ингибиторов pde7 для лечения нарушений движения |
| WO2012064667A2 (en) | 2010-11-08 | 2012-05-18 | Omeros Corporation | Treatment of addiction and impulse-control disorders using pde7 inhibitors |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| CN104725329B (zh) * | 2015-01-13 | 2017-01-18 | 陕西科技大学 | 一种具有抗肿瘤活性的异恶唑羧酸类化合物及其合成方法 |
| AU2018300091B2 (en) | 2017-07-12 | 2023-06-22 | Dart Neuroscience, Llc | Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors |
| WO2024038090A1 (en) | 2022-08-18 | 2024-02-22 | Mitodicure Gmbh | Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU658629B2 (en) * | 1991-05-01 | 1995-04-27 | Taiho Pharmaceutical Co., Ltd. | Novel isoxazole derivative and salt thereof |
| KR0182324B1 (ko) * | 1993-11-26 | 1999-05-01 | 알렌 제이. 스피겔 | 항염증제로서의 이속사졸린 화합물 |
| CA2177375A1 (en) * | 1993-11-26 | 1995-06-01 | Edward F. Kleinman | 3-aryl-2-isoxazolines as antiinflammatory agents |
-
1999
- 1999-11-04 DE DE19953024A patent/DE19953024A1/de not_active Withdrawn
-
2000
- 2000-10-18 CZ CZ20021441A patent/CZ20021441A3/cs unknown
- 2000-10-18 US US10/129,270 patent/US6531498B1/en not_active Expired - Fee Related
- 2000-10-18 EP EP00971393A patent/EP1225896B1/de not_active Expired - Lifetime
- 2000-10-18 BR BR0015333-8A patent/BR0015333A/pt not_active Application Discontinuation
- 2000-10-18 AU AU10262/01A patent/AU781607B2/en not_active Ceased
- 2000-10-18 DE DE50010885T patent/DE50010885D1/de not_active Expired - Lifetime
- 2000-10-18 ES ES00971393T patent/ES2243313T3/es not_active Expired - Lifetime
- 2000-10-18 CN CN00814943A patent/CN1384744A/zh active Pending
- 2000-10-18 JP JP2001534380A patent/JP2003513042A/ja active Pending
- 2000-10-18 KR KR1020027005728A patent/KR20020047329A/ko not_active Application Discontinuation
- 2000-10-18 AT AT00971393T patent/ATE300945T1/de not_active IP Right Cessation
- 2000-10-18 RU RU2002113746/15A patent/RU2002113746A/ru unknown
- 2000-10-18 PL PL00355021A patent/PL355021A1/xx unknown
- 2000-10-18 CA CA2389647A patent/CA2389647C/en not_active Expired - Fee Related
- 2000-10-18 SK SK594-2002A patent/SK5942002A3/sk not_active Application Discontinuation
- 2000-10-18 WO PCT/EP2000/010239 patent/WO2001032175A1/de active IP Right Grant
- 2000-10-18 HU HU0203187A patent/HUP0203187A3/hu unknown
- 2000-11-03 AR ARP000105799A patent/AR026350A1/es unknown
-
2002
- 2002-05-03 MX MXPA02004441A patent/MXPA02004441A/es unknown
- 2002-05-03 NO NO20022123A patent/NO20022123L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL355021A1 (en) | 2004-03-22 |
| KR20020047329A (ko) | 2002-06-21 |
| MXPA02004441A (es) | 2004-09-10 |
| CA2389647C (en) | 2010-08-10 |
| AU781607B2 (en) | 2005-06-02 |
| NO20022123D0 (no) | 2002-05-03 |
| CA2389647A1 (en) | 2001-05-10 |
| ES2243313T3 (es) | 2005-12-01 |
| HUP0203187A3 (en) | 2004-12-28 |
| CN1384744A (zh) | 2002-12-11 |
| DE19953024A1 (de) | 2001-05-10 |
| RU2002113746A (ru) | 2004-01-10 |
| HUP0203187A2 (hu) | 2003-01-28 |
| EP1225896B1 (de) | 2005-08-03 |
| WO2001032175A1 (de) | 2001-05-10 |
| CZ20021441A3 (cs) | 2002-07-17 |
| NO20022123L (no) | 2002-05-03 |
| EP1225896A1 (de) | 2002-07-31 |
| US6531498B1 (en) | 2003-03-11 |
| SK5942002A3 (en) | 2002-09-10 |
| AU1026201A (en) | 2001-05-14 |
| JP2003513042A (ja) | 2003-04-08 |
| AR026350A1 (es) | 2003-02-05 |
| ATE300945T1 (de) | 2005-08-15 |
| DE50010885D1 (de) | 2005-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |