RU2002113746A - Производные изоксазола в качестве ингибиторов фосфодиэстеразы VII - Google Patents
Производные изоксазола в качестве ингибиторов фосфодиэстеразы VIIInfo
- Publication number
- RU2002113746A RU2002113746A RU2002113746/15A RU2002113746A RU2002113746A RU 2002113746 A RU2002113746 A RU 2002113746A RU 2002113746/15 A RU2002113746/15 A RU 2002113746/15A RU 2002113746 A RU2002113746 A RU 2002113746A RU 2002113746 A RU2002113746 A RU 2002113746A
- Authority
- RU
- Russia
- Prior art keywords
- solvates
- formula
- acceptable salts
- physiologically acceptable
- disorders
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
Claims (3)
1. Соединения формулы I
в которой R1, R2, R3, R4 каждый независимо друг от друга представляет собой Hal, ОА1, SA1, А, Н, СООА1, CN или CONA1A2,
R5 представляет собой СООА1, CN или CONA1A2,
А1, А2 каждый независимо друг от друга представляет собой Н, А, алкенил, циклоалкил или алкиленциклоалкил,
А представляет собой алкил, имеющий от 1 до 10 атомов С, Hal представляет собой F, Cl, Br или I,
а также их физиологически приемлемые соли и/или сольваты в качестве ингибиторов фосфодиэстеразы VII.
2. Фармацевтический препарат, отличающийся тем, что содержит по меньшей мере один ингибитор фосфодиэстеразы VII формулы I по п.1 и/или одну из его физиологически приемлемых солей и/или один из его сольватов.
3. Применение соединений формулы I по п.1 и/или их физиологически приемлемых солей или сольватов для получения фармацевтического препарата для контролирования аллергических расстройств, астмы, хронического бронхита, атонического дерматита, псориаза и других кожных нарушений, воспалительных расстройств, автоиммунных заболеваний, таких как, например, ревматоидный артрит, рассеянного склероза, болезни Крона, сахарного диабета или язвенного колита, остеопороза, реакции отторжения трансплантатов, кахексии, роста опухолей или метастаз опухолей, сепсиса, нарушений памяти, атеросклероза и СПИДа.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19953024.6 | 1999-11-04 | ||
| DE19953024A DE19953024A1 (de) | 1999-11-04 | 1999-11-04 | Isoxazolderivate als Phosphodiesterase VII-Hemmer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2002113746A true RU2002113746A (ru) | 2004-01-10 |
Family
ID=7927860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002113746/15A RU2002113746A (ru) | 1999-11-04 | 2000-10-18 | Производные изоксазола в качестве ингибиторов фосфодиэстеразы VII |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6531498B1 (ru) |
| EP (1) | EP1225896B1 (ru) |
| JP (1) | JP2003513042A (ru) |
| KR (1) | KR20020047329A (ru) |
| CN (1) | CN1384744A (ru) |
| AR (1) | AR026350A1 (ru) |
| AT (1) | ATE300945T1 (ru) |
| AU (1) | AU781607B2 (ru) |
| BR (1) | BR0015333A (ru) |
| CA (1) | CA2389647C (ru) |
| CZ (1) | CZ20021441A3 (ru) |
| DE (2) | DE19953024A1 (ru) |
| ES (1) | ES2243313T3 (ru) |
| HU (1) | HUP0203187A3 (ru) |
| MX (1) | MXPA02004441A (ru) |
| NO (1) | NO20022123L (ru) |
| PL (1) | PL355021A1 (ru) |
| RU (1) | RU2002113746A (ru) |
| SK (1) | SK5942002A3 (ru) |
| WO (1) | WO2001032175A1 (ru) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1102755B1 (en) * | 1998-08-07 | 2006-01-04 | Chiron Corporation | Substituted isoxazole derivatives as estrogen receptor modulators |
| ES2217956B1 (es) * | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
| KR100666052B1 (ko) * | 2004-02-12 | 2007-01-09 | 조극래 | 원적외선이용한 건조장치 |
| JP2009503172A (ja) | 2005-07-29 | 2009-01-29 | チバ ホールディング インコーポレーテッド | メロシアニン誘導体を使用することによる紫外線による劣化に対するボディケア及び家庭用品の安定化 |
| MX2009010450A (es) * | 2007-03-27 | 2009-11-23 | Omeros Corp | El uso de inhibidores de la fosfodiesterasa 7 para el tratamiento transtornos del movimiento. |
| US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| EP2640395A4 (en) | 2010-11-08 | 2014-01-22 | Omeros Corp | TREATMENT OF DISEASES ASSOCIATED WITH SEARCH AND PULSE CONTROL BY PDE7 INHIBITORS |
| CN104725329B (zh) * | 2015-01-13 | 2017-01-18 | 陕西科技大学 | 一种具有抗肿瘤活性的异恶唑羧酸类化合物及其合成方法 |
| US11685745B2 (en) | 2017-07-12 | 2023-06-27 | Dart Neuroscience, Llc | Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors |
| WO2024038090A1 (en) | 2022-08-18 | 2024-02-22 | Mitodicure Gmbh | Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399577A (en) * | 1991-05-01 | 1995-03-21 | Taiho Pharmaceutical Co., Ltd. | Isoxazole derivatives and salts thereof |
| WO1995014681A1 (en) * | 1993-11-26 | 1995-06-01 | Pfizer Inc. | Isoxazoline compounds as antiinflammatory agents |
| ATE187447T1 (de) * | 1993-11-26 | 1999-12-15 | Pfizer | 3-phenyl-2-isoxazoline derivate als entzündugshemmende mittel |
-
1999
- 1999-11-04 DE DE19953024A patent/DE19953024A1/de not_active Withdrawn
-
2000
- 2000-10-18 SK SK594-2002A patent/SK5942002A3/sk not_active Application Discontinuation
- 2000-10-18 CA CA2389647A patent/CA2389647C/en not_active Expired - Fee Related
- 2000-10-18 JP JP2001534380A patent/JP2003513042A/ja active Pending
- 2000-10-18 BR BR0015333-8A patent/BR0015333A/pt not_active Application Discontinuation
- 2000-10-18 EP EP00971393A patent/EP1225896B1/de not_active Expired - Lifetime
- 2000-10-18 CZ CZ20021441A patent/CZ20021441A3/cs unknown
- 2000-10-18 WO PCT/EP2000/010239 patent/WO2001032175A1/de active IP Right Grant
- 2000-10-18 CN CN00814943A patent/CN1384744A/zh active Pending
- 2000-10-18 RU RU2002113746/15A patent/RU2002113746A/ru unknown
- 2000-10-18 AT AT00971393T patent/ATE300945T1/de not_active IP Right Cessation
- 2000-10-18 ES ES00971393T patent/ES2243313T3/es not_active Expired - Lifetime
- 2000-10-18 HU HU0203187A patent/HUP0203187A3/hu unknown
- 2000-10-18 US US10/129,270 patent/US6531498B1/en not_active Expired - Fee Related
- 2000-10-18 KR KR1020027005728A patent/KR20020047329A/ko not_active Application Discontinuation
- 2000-10-18 AU AU10262/01A patent/AU781607B2/en not_active Ceased
- 2000-10-18 PL PL00355021A patent/PL355021A1/xx unknown
- 2000-10-18 DE DE50010885T patent/DE50010885D1/de not_active Expired - Lifetime
- 2000-11-03 AR ARP000105799A patent/AR026350A1/es unknown
-
2002
- 2002-05-03 MX MXPA02004441A patent/MXPA02004441A/es unknown
- 2002-05-03 NO NO20022123A patent/NO20022123L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU1026201A (en) | 2001-05-14 |
| MXPA02004441A (es) | 2004-09-10 |
| AU781607B2 (en) | 2005-06-02 |
| HUP0203187A2 (hu) | 2003-01-28 |
| CA2389647C (en) | 2010-08-10 |
| CA2389647A1 (en) | 2001-05-10 |
| JP2003513042A (ja) | 2003-04-08 |
| KR20020047329A (ko) | 2002-06-21 |
| CN1384744A (zh) | 2002-12-11 |
| CZ20021441A3 (cs) | 2002-07-17 |
| EP1225896A1 (de) | 2002-07-31 |
| PL355021A1 (en) | 2004-03-22 |
| AR026350A1 (es) | 2003-02-05 |
| EP1225896B1 (de) | 2005-08-03 |
| DE19953024A1 (de) | 2001-05-10 |
| DE50010885D1 (de) | 2005-09-08 |
| ATE300945T1 (de) | 2005-08-15 |
| US6531498B1 (en) | 2003-03-11 |
| NO20022123D0 (no) | 2002-05-03 |
| NO20022123L (no) | 2002-05-03 |
| ES2243313T3 (es) | 2005-12-01 |
| BR0015333A (pt) | 2002-07-09 |
| SK5942002A3 (en) | 2002-09-10 |
| HUP0203187A3 (en) | 2004-12-28 |
| WO2001032175A1 (de) | 2001-05-10 |
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