EA200100874A1 - Полиморфные кристаллические формы целекоксиба - Google Patents

Полиморфные кристаллические формы целекоксиба

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Publication number
EA200100874A1
EA200100874A1 EA200100874A EA200100874A EA200100874A1 EA 200100874 A1 EA200100874 A1 EA 200100874A1 EA 200100874 A EA200100874 A EA 200100874A EA 200100874 A EA200100874 A EA 200100874A EA 200100874 A1 EA200100874 A1 EA 200100874A1
Authority
EA
Eurasian Patent Office
Prior art keywords
celecoxib
compound
crystalline forms
cyclooxygenase
forms
Prior art date
Application number
EA200100874A
Other languages
English (en)
Other versions
EA003464B1 (ru
Inventor
Леонард Дж. Ферро
Патриция Дж. Майаке
Original Assignee
Фармасиа Корпорейшен
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармасиа Корпорейшен filed Critical Фармасиа Корпорейшен
Publication of EA200100874A1 publication Critical patent/EA200100874A1/ru
Publication of EA003464B1 publication Critical patent/EA003464B1/ru

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    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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Abstract

Предлагаются фармацевтические композиции, включающие в себя одну или более пероральных доз, каждая из которых включает в себя соединение с низкой растворимостью в воде, избирательно ингибирующее циклооксигеназу-2 в терапевтически эффективных количествах, где данное соединение присутствует в форме твердых частиц размером менее 1 мм в количестве примерно от 25 до 100 вес.%. Данные композиции полезны для лечения или профилактики состояний и заболеваний, опосредованных циклооксигеназой-2, и имеют особые преимущества в случаях, когда желателен быстрый терапевтический эффект. Описаны новые кристаллические формы целекоксиба - Форма I и Форма II. По сравнению с другими формами целекоксиба эти кристаллические формы обладают особыми химическими и физическими свойствами и характеризуются порошковыми рентгенограммами (РПД), термограммами дифференциальной сканирующей калориметрии (ДСК) и другими физическими характеристиками.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100874A 1999-12-08 2000-12-01 Полиморфные кристаллические формы целекоксиба EA003464B1 (ru)

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PCT/US2000/032760 WO2001042222A1 (en) 1999-12-08 2000-12-01 Polymorphic crystalline forms of celecoxib

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US7476744B2 (en) 2009-01-13
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DK1150960T3 (da) 2005-05-02
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US20040087640A1 (en) 2004-05-06
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NZ514059A (en) 2004-02-27
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