BG105808A - Polymorphic crystalline forms of celecoxib - Google Patents

Polymorphic crystalline forms of celecoxib

Info

Publication number
BG105808A
BG105808A BG05808A BG10580801A BG105808A BG 105808 A BG105808 A BG 105808A BG 05808 A BG05808 A BG 05808A BG 10580801 A BG10580801 A BG 10580801A BG 105808 A BG105808 A BG 105808A
Authority
BG
Bulgaria
Prior art keywords
celecoxib
crystalline forms
compound
compositions
polymorphic crystalline
Prior art date
Application number
BG05808A
Other languages
Bulgarian (bg)
Other versions
BG65239B1 (en
Inventor
Leonard Ferro
Patricia Miyake
Original Assignee
Pharmacia Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2000/032760 external-priority patent/WO2001042222A1/en
Priority claimed from PCT/US2000/032434 external-priority patent/WO2001041760A2/en
Application filed by Pharmacia Corporation filed Critical Pharmacia Corporation
Publication of BG105808A publication Critical patent/BG105808A/en
Publication of BG65239B1 publication Critical patent/BG65239B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising a selectivecyclooxygenase-2 inhibitory compound of low water solubility in a therapeutically effective amount, wherein the compound is present in the form of solid particles, about 25 % to 100 % by weight of which are smaller than 1 mm. The compositions are useful in treatment or prophylaxis of cyclooxigenase-2 mediated conditions and disorders and have particular advantages where rapid onset of therapeutic effect is desired. The novel Form I and Form II crystalline forms of celecoxib are described. The crystalline forms have unique chemical and physical properties relative to other solid state forms of celecoxib and are characterized by their powder X-ray diffraction (PXRD) patterns, differential scanning calorimetric (DSC) thermograms, and other physical characterizations. 175 claims, 3 figures
BG105808A 1999-12-08 2001-08-09 Polymorphic crystalline forms of celecoxib BG65239B1 (en)

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US16985699P 1999-12-08 1999-12-08
PCT/US2000/032760 WO2001042222A1 (en) 1999-12-08 2000-12-01 Polymorphic crystalline forms of celecoxib
PCT/US2000/032434 WO2001041760A2 (en) 1999-12-08 2000-12-06 Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect

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BG105808A true BG105808A (en) 2002-09-30
BG65239B1 BG65239B1 (en) 2007-09-28

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CN103524416B (en) * 2013-10-29 2016-08-17 湖北华世通生物医药科技有限公司 A kind of Novel celecoxib crystal form A and preparation method thereof
CN103508958A (en) * 2013-10-30 2014-01-15 中美华世通生物医药科技（武汉）有限公司 Novel celecoxib crystal form C and preparation method thereof
CN103539739B (en) * 2013-10-30 2016-02-10 中美华世通生物医药科技（武汉）有限公司 A kind of Novel celecoxib crystal form B and preparation method thereof
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CO5251445A1 (en) 2003-02-28
WO2001041536A2 (en) 2001-06-14
ZA200107146B (en) 2002-08-29
OA11831A (en) 2005-08-23
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