MY128971A - Solid-state form of celecoxib having enhanced bioavailability - Google Patents

Solid-state form of celecoxib having enhanced bioavailability

Info

Publication number
MY128971A
MY128971A MYPI20005730A MYPI20005730A MY128971A MY 128971 A MY128971 A MY 128971A MY PI20005730 A MYPI20005730 A MY PI20005730A MY PI20005730 A MYPI20005730 A MY PI20005730A MY 128971 A MY128971 A MY 128971A
Authority
MY
Malaysia
Prior art keywords
celecoxib
amorphous
drug substance
composition
solid
Prior art date
Application number
MYPI20005730A
Inventor
Michael J Hageman
Xiaorong He
Tugrul T Kararli
Lesley A Mackin
Patricia J Miyake
Brian R Rohrs
Kevin J Stefanski
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of MY128971A publication Critical patent/MY128971A/en

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

THE SELECTIVE CYCLOOXYGENASE-2 INHIBITORY DRUG CELECOXIB IS PROVIDED IN AMORPHOUS FORM. ALSO PROVIDED IS A CELECOXIB DRUG SUBSTANCE WHEREIN THE CELECOXIB IS PRESENT, IN AT LEAST A DETECTABLE AMOUNT, AS AMORPHOUS CELECOXIB. ALSO PROVIDED IS A CELECOXIB-CRYSTALLIZATION INHIBITOR COMPOSITE COMPRISING PARTICLES OF AMORPHOUS CELECOXIB OR A CELECOXIB DRUG SUBSTANCE OF THE INVENTION IN INTIMATE ASSOCIATION WITH ONE OR MORE CRYSTALLIZATION INHIBITORS, FOR EXAMPLE POLYMERS. ALSO PROVIDED IS A PHARMACEUTICAL COMPOSITION COMPRISING SUCH A CELECOXIB-CRYSTALLIZATION INHIBITOR COMPOSITE AND ONE OR MORE EXCIPIENTS. ALSO PROVIDED ARE PROCESSES FOR PREPARING AMORPHOUS CELECOXIB, A CELECOXIB DRUG SUBSTANCE OF THE INVENTION, A CELECOXIB-CRYSTALLIZATION INHIBITOR COMPOSITION OF THE INVENTION, AND A PHARMACEUTICAL COMPOSITION OF THE INVENTION. ALSO PROVIDED IS A METHOD OF TREATING A MEDICAL CONDITION OR DISORDER IN A SUBJECT WHERE TREATMENT WITH A CYCLOOXYGENASE-2 INHIBITOR IS INDICATED, COMPRISING ADMINISTERING, FOR EXAMPLE ORALLY, A COMPOSITION OF THE INVENTION IN A THERAPEUTICALLY EFFECTIVE AMOUNT.(FIG 6)
MYPI20005730A 1999-12-08 2000-12-06 Solid-state form of celecoxib having enhanced bioavailability MY128971A (en)

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CN103508958A (en) * 2013-10-30 2014-01-15 中美华世通生物医药科技（武汉）有限公司 Novel celecoxib crystal form C and preparation method thereof
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TWI276435B (en) 2007-03-21
PT1150960E (en) 2005-06-30
ZA200107149B (en) 2003-02-28
AU2041201A (en) 2001-06-18
CO5251445A1 (en) 2003-02-28
WO2001041536A2 (en) 2001-06-14
ZA200107146B (en) 2002-08-29
OA11831A (en) 2005-08-23
KR20020002386A (en) 2002-01-09
AR030039A1 (en) 2003-08-13
BG105808A (en) 2002-09-30
MY128366A (en) 2007-01-31
NZ529933A (en) 2005-06-24
HUP0200580A2 (en) 2002-11-28
KR100717570B1 (en) 2007-05-15
AR027897A1 (en) 2003-04-16
CN1411447A (en) 2003-04-16
PE20010911A1 (en) 2001-09-10
YU57801A (en) 2005-07-19
CZ20012875A3 (en) 2002-02-13
SV2002000235A (en) 2002-06-13
EA200401397A1 (en) 2005-08-25
BG65239B1 (en) 2007-09-28
ECSP003807A (en) 2005-07-06
PT1150959E (en) 2008-04-21
ES2236011T3 (en) 2005-07-16
HUP0200580A3 (en) 2002-12-28

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