AR030039A1 - PHARMACEUTICAL COMPOSITION THAT INCLUDES A SELECTIVE INHIBITOR DRUG OF CYCLOOXYGENASA-2, ITS USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT TO TREAT OR PREVENT AFFECTIONS THROUGH CYCLOOXYGENASE-2 AND METHOD TO MAKE SUCH MEDICINAL PRODUCT - Google Patents

PHARMACEUTICAL COMPOSITION THAT INCLUDES A SELECTIVE INHIBITOR DRUG OF CYCLOOXYGENASA-2, ITS USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT TO TREAT OR PREVENT AFFECTIONS THROUGH CYCLOOXYGENASE-2 AND METHOD TO MAKE SUCH MEDICINAL PRODUCT

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Publication number
AR030039A1
AR030039A1 ARP000106475A ARP000106475A AR030039A1 AR 030039 A1 AR030039 A1 AR 030039A1 AR P000106475 A ARP000106475 A AR P000106475A AR P000106475 A ARP000106475 A AR P000106475A AR 030039 A1 AR030039 A1 AR 030039A1
Authority
AR
Argentina
Prior art keywords
cyclooxygenase
medicinal product
drug
manufacture
pharmaceutical composition
Prior art date
Application number
ARP000106475A
Other languages
Spanish (es)
Inventor
Tugrul T Kararli
Mark Kontny
Subhash Desai
Michael Hageman
Royal Haskell
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of AR030039A1 publication Critical patent/AR030039A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

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Abstract

Composicion farmacéutica que comprende una o más unidades de dosificacion de administracion oral, cada una de las cuales comprende una droga inhibidora selectiva de la ciclooxigenasa-2 de baja solubilidad en agua en una cantidad terapéuticamente efectiva, donde la droga está presente en partículas solidas que tienen un tamano promedio de partícula de 500 nm a 900 nm y donde la droga inhibidora selectiva de la ciclooxigenasa-2 es un compuesto de formula (1) donde: R3 es un grupo metilo o amino; R4 es hidrogeno o un grupo alquilo C1-4 o alcoxilo; X es N o CR5, donde R5 es hidrogeno o halogeno; e Y y Z son independientemente átomos de carbono o de nitrogeno que definen con los átomos adyacentes un anillo de 5 a 6 miembros que no está sustituido o que está sustituido en una o más posiciones con grupos oxo, halo, metilo o halometilo. El uso de dicha composicion en la fabricacion de un medicamento para tratar oralmente de una a seis veces por día mediante una o más unidades de dosificacion, una condicion o una afeccion médica en un sujeto para la cual está indicado el tratamiento con un inhibidor de la ciclooxigenasa-2 y el método para obtener dicho medicamento.Pharmaceutical composition comprising one or more orally administered dosage units, each of which comprises a selective inhibitor drug of low water solubility cyclooxygenase-2 in a therapeutically effective amount, where the drug is present in solid particles having an average particle size of 500 nm to 900 nm and where the selective cyclooxygenase-2 inhibitor drug is a compound of formula (1) where: R3 is a methyl or amino group; R4 is hydrogen or a C1-4 alkyl or alkoxy group; X is N or CR5, where R5 is hydrogen or halogen; and Y and Z are independently carbon or nitrogen atoms that define with the adjacent atoms a 5- to 6-membered ring that is unsubstituted or that is substituted in one or more positions with oxo, halo, methyl or halomethyl groups. The use of said composition in the manufacture of a medicament to treat orally one to six times per day by means of one or more dosage units, a condition or a medical condition in a subject for which treatment with a drug inhibitor is indicated. cyclooxygenase-2 and the method to obtain said medication.

ARP000106475A 1999-12-08 2000-12-06 PHARMACEUTICAL COMPOSITION THAT INCLUDES A SELECTIVE INHIBITOR DRUG OF CYCLOOXYGENASA-2, ITS USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT TO TREAT OR PREVENT AFFECTIONS THROUGH CYCLOOXYGENASE-2 AND METHOD TO MAKE SUCH MEDICINAL PRODUCT AR030039A1 (en)

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ARP000106473A AR027897A1 (en) 1999-12-08 2000-12-05 FORM OF CELECOXIB IN SOLID STATE THAT EXHIBIT INCREASED BIODISPONIBILITY
ARP000106475A AR030039A1 (en) 1999-12-08 2000-12-06 PHARMACEUTICAL COMPOSITION THAT INCLUDES A SELECTIVE INHIBITOR DRUG OF CYCLOOXYGENASA-2, ITS USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT TO TREAT OR PREVENT AFFECTIONS THROUGH CYCLOOXYGENASE-2 AND METHOD TO MAKE SUCH MEDICINAL PRODUCT

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ARP000106473A AR027897A1 (en) 1999-12-08 2000-12-05 FORM OF CELECOXIB IN SOLID STATE THAT EXHIBIT INCREASED BIODISPONIBILITY

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WO2004061433A1 (en) * 2002-12-30 2004-07-22 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
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US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
CA2477923C (en) 2002-03-01 2021-02-23 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
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MXPA05000232A (en) * 2002-06-21 2005-06-17 Transform Pharmaceuticals Inc Pharmaceutical compositions with improved dissolution.
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CN103524416B (en) * 2013-10-29 2016-08-17 湖北华世通生物医药科技有限公司 A kind of Novel celecoxib crystal form A and preparation method thereof
CN103508958A (en) * 2013-10-30 2014-01-15 中美华世通生物医药科技（武汉）有限公司 Novel celecoxib crystal form C and preparation method thereof
CN103539739B (en) * 2013-10-30 2016-02-10 中美华世通生物医药科技（武汉）有限公司 A kind of Novel celecoxib crystal form B and preparation method thereof
KR101476096B1 (en) * 2014-03-28 2014-12-24 대원제약주식회사 Pharmaceutical composition comprising celecoxib with improved solubility

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KR100717570B1 (en) 2007-05-15
ES2236011T3 (en) 2005-07-16
MY128971A (en) 2007-03-30
ZA200107146B (en) 2002-08-29
OA11831A (en) 2005-08-23
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CZ20012875A3 (en) 2002-02-13
EA200401397A1 (en) 2005-08-25
ECSP003807A (en) 2005-07-06
PT1150959E (en) 2008-04-21
KR20020002386A (en) 2002-01-09
CN1216869C (en) 2005-08-31
BG105808A (en) 2002-09-30
PT1150960E (en) 2005-06-30
SV2002000235A (en) 2002-06-13
AU2041201A (en) 2001-06-18
AR027897A1 (en) 2003-04-16
TWI276435B (en) 2007-03-21
YU57801A (en) 2005-07-19
WO2001041536A2 (en) 2001-06-14
CN1411447A (en) 2003-04-16
BG65239B1 (en) 2007-09-28
CO5251445A1 (en) 2003-02-28
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