EA200100797A1 - Ацильные производные, используемые для лечения опосредованных vla-4 расстройств - Google Patents

Ацильные производные, используемые для лечения опосредованных vla-4 расстройств

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Publication number
EA200100797A1
EA200100797A1 EA200100797A EA200100797A EA200100797A1 EA 200100797 A1 EA200100797 A1 EA 200100797A1 EA 200100797 A EA200100797 A EA 200100797A EA 200100797 A EA200100797 A EA 200100797A EA 200100797 A1 EA200100797 A1 EA 200100797A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
vla
disorders
treatment
acyl derivatives
Prior art date
Application number
EA200100797A
Other languages
English (en)
Other versions
EA006301B1 (ru
Inventor
Андрей В. Конради
Майкл А. Плейсс
Юджин Д. Торсетт
Сюзн Эшвелл
Грегори С. Велмейкер
Энтони Крефт
Димитриос Сарантакис
Даррен Б. Дрессен
Фрэнсин С. Грант
Кристофер Семко
Йинг-зи Ксу
Original Assignee
Элан Фармасьютикалз, Инк.
Американ Хоум Продактс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элан Фармасьютикалз, Инк., Американ Хоум Продактс filed Critical Элан Фармасьютикалз, Инк.
Priority claimed from PCT/US2000/001686 external-priority patent/WO2000043372A1/en
Publication of EA200100797A1 publication Critical patent/EA200100797A1/ru
Publication of EA006301B1 publication Critical patent/EA006301B1/ru

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Описываются соединения, такие как Ia и Ib, которые присоединяются к VLA-4. Фактически эти соединения также ингибируют лейкоцитарную адгезию и, в частности лейкоцитарную адгезию, опосредованную VLA-4. Такие соединения используются для лечения воспалительных заболеваний у млекопитающих, например человека, таких как астма, болезнь Альцгеймера, атеросклероз, деменцию при СПИДе, диабет, воспалительные заболевания кишечника, ревматоидный артрит, трансплантация тканей, метастазирование опухолей и миокардиальную ишемию. Соединения также могут вводиться для лечения воспалительных заболеваний мозга, таких как рассеянный склероз.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100797A 1999-01-22 2000-01-21 Ацильные производные, используемые для лечения опосредованных vla-4 расстройств EA006301B1 (ru)

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PCT/US2000/001686 WO2000043372A1 (en) 1999-01-22 2000-01-21 Acyl derivatives which treat vla-4 related disorders

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JP2002535314A (ja) 2002-10-22
EP1144384B1 (en) 2007-10-31
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US7378529B2 (en) 2008-05-27
AR033643A1 (es) 2004-01-07
US7968547B2 (en) 2011-06-28
EA006301B1 (ru) 2005-10-27
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