MXPA01007335A - Derivados de acilo los cuales tratan trastornos relacionados con alfa4 beta1 integrina y cd49d/cd29 (vla-4). - Google Patents

Derivados de acilo los cuales tratan trastornos relacionados con alfa4 beta1 integrina y cd49d/cd29 (vla-4).

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Publication number
MXPA01007335A
MXPA01007335A MXPA01007335A MXPA01007335A MXPA01007335A MX PA01007335 A MXPA01007335 A MX PA01007335A MX PA01007335 A MXPA01007335 A MX PA01007335A MX PA01007335 A MXPA01007335 A MX PA01007335A MX PA01007335 A MXPA01007335 A MX PA01007335A
Authority
MX
Mexico
Prior art keywords
compounds
vla
related disorders
acyl derivatives
inflammatory
Prior art date
Application number
MXPA01007335A
Other languages
English (en)
Inventor
Francine S Grant
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Priority claimed from PCT/US2000/001686 external-priority patent/WO2000043372A1/en
Publication of MXPA01007335A publication Critical patent/MXPA01007335A/es

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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Abstract

Se describen compuestos tales como Ia y Ib, los cuales se enlazan a VLA-4. Ciertos de estos compuestos tambien inhiben la adhesion de los leucocitos y, en particular la adhesion de leucocitos mediada por VLA-4. Tales compuestos son utiles en el tratamiento de enfermedades inflamatorias en un paciente mamifero, por ejemplo, un humano, tal como el asma, enfermedad de Alzheimer, arterosclerosis, SIDA, demencia, diabetes, enfermedad inflamatoria del hueso, artritis reumatoide, transplante de tejido, metastasis de tumores e isquemia al miocardio. Los compuestos pueden ser tambien administrados para el tratamiento de enfermedades inflamatorias del cerebro tales como esclerosis multiple.
MXPA01007335A 1999-01-22 2000-01-21 Derivados de acilo los cuales tratan trastornos relacionados con alfa4 beta1 integrina y cd49d/cd29 (vla-4). MXPA01007335A (es)

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US11692399P 1999-01-22 1999-01-22
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PCT/US2000/001686 WO2000043372A1 (en) 1999-01-22 2000-01-21 Acyl derivatives which treat vla-4 related disorders

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