IT1211096B - Pirimidine e s.triazinici adattivita' ipolipidemizzante. - Google Patents

Pirimidine e s.triazinici adattivita' ipolipidemizzante.

Info

Publication number
IT1211096B
IT1211096B IT8123580A IT2358081A IT1211096B IT 1211096 B IT1211096 B IT 1211096B IT 8123580 A IT8123580 A IT 8123580A IT 2358081 A IT2358081 A IT 2358081A IT 1211096 B IT1211096 B IT 1211096B
Authority
IT
Italy
Prior art keywords
triazinics
hypolipidemizing
adaptity
pyrimidines
triazinics hypolipidemizing
Prior art date
Application number
IT8123580A
Other languages
English (en)
Other versions
IT8123580A0 (it
Original Assignee
Lpb Ist Farm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lpb Ist Farm filed Critical Lpb Ist Farm
Publication of IT8123580A0 publication Critical patent/IT8123580A0/it
Priority to IT8123580A priority Critical patent/IT1211096B/it
Priority to DE198282106347T priority patent/DE73328T1/de
Priority to EP82106347A priority patent/EP0073328A1/en
Priority to PH27601A priority patent/PH17607A/en
Priority to CA000407790A priority patent/CA1173036A/en
Priority to US06/400,434 priority patent/US4559345A/en
Priority to ES515104A priority patent/ES8401037A1/es
Priority to JP57144575A priority patent/JPS5869870A/ja
Priority to DK373782A priority patent/DK373782A/da
Priority to ES524185A priority patent/ES8504741A1/es
Priority to ES524186A priority patent/ES524186A0/es
Application granted granted Critical
Publication of IT1211096B publication Critical patent/IT1211096B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/44—One nitrogen atom with halogen atoms attached to the two other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT8123580A 1981-08-20 1981-08-20 Pirimidine e s.triazinici adattivita' ipolipidemizzante. IT1211096B (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT8123580A IT1211096B (it) 1981-08-20 1981-08-20 Pirimidine e s.triazinici adattivita' ipolipidemizzante.
DE198282106347T DE73328T1 (de) 1981-08-20 1982-07-15 Pyrimidin und s-triazin-derivate mit antilipidemischer wirkung.
EP82106347A EP0073328A1 (en) 1981-08-20 1982-07-15 Novel pyrimidine and s. triazine derivatives with antilipidemic activity
PH27601A PH17607A (en) 1981-08-20 1982-07-20 Novel pyrimidine and s.triazine derivatives with antilipidemic activity
CA000407790A CA1173036A (en) 1981-08-20 1982-07-21 Pyrimidine and s.triazine derivatives with antilipidemic activity
US06/400,434 US4559345A (en) 1981-08-20 1982-07-21 Pyrimidine and s-triazine derivatives with antilipidemic activity
ES515104A ES8401037A1 (es) 1981-08-20 1982-08-19 "procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina".
JP57144575A JPS5869870A (ja) 1981-08-20 1982-08-19 ピリミジン誘導体およびそれを有効成分とする高脂血症治療剤
DK373782A DK373782A (da) 1981-08-20 1982-08-20 Fremgangsmaade til fremstilling af hidtil ukendte pyrimidin- eller s-triazinderivater
ES524185A ES8504741A1 (es) 1981-08-20 1983-07-16 Procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina.
ES524186A ES524186A0 (es) 1981-08-20 1983-07-16 Procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8123580A IT1211096B (it) 1981-08-20 1981-08-20 Pirimidine e s.triazinici adattivita' ipolipidemizzante.

Publications (2)

Publication Number Publication Date
IT8123580A0 IT8123580A0 (it) 1981-08-20
IT1211096B true IT1211096B (it) 1989-09-29

Family

ID=11208290

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8123580A IT1211096B (it) 1981-08-20 1981-08-20 Pirimidine e s.triazinici adattivita' ipolipidemizzante.

Country Status (9)

Country Link
US (1) US4559345A (it)
EP (1) EP0073328A1 (it)
JP (1) JPS5869870A (it)
CA (1) CA1173036A (it)
DE (1) DE73328T1 (it)
DK (1) DK373782A (it)
ES (3) ES8401037A1 (it)
IT (1) IT1211096B (it)
PH (1) PH17607A (it)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK130584A (da) * 1983-04-08 1984-10-09 Ciba Geigy Ag N-(2-nitrophenyl)-4-amino-pyrimidin-derivater samt deres fremstilling og anvendelse som mikrobicider
US4542216A (en) * 1984-03-27 1985-09-17 Ciba Geigy Corporation Process for producing fluoroalkoxyaminopyrimidines
DE3445293A1 (de) * 1984-12-12 1986-06-12 Bayer Ag, 5090 Leverkusen Neue 2,4-diaminopyrimidine
JPH0631238B2 (ja) * 1985-08-01 1994-04-27 日産化学工業株式会社 ピラゾロ〔４，３−ｄ〕ピリミジン誘導体
GB8911287D0 (en) * 1989-05-17 1989-07-05 Ciba Geigy Ag Lubricant compositions
DE4104466A1 (de) * 1990-03-09 1991-09-12 Huels Chemische Werke Ag Quartaere ammoniumsalze von thiobarbitursaeuren und verfahren zu deren herstellung
WO1999031073A1 (fr) 1997-12-15 1999-06-24 Yamanouchi Pharmaceutical Co., Ltd. Nouveaux derives de pyrimidine-5-carboxamide
JP4754693B2 (ja) * 1999-01-22 2011-08-24 エラン ファーマシューティカルズ，インコーポレイテッド Ｖｌａ−４関連障害を処置するアシル誘導体
HK1045495A1 (zh) 1999-01-22 2002-11-29 依兰制药公司 抑制vla-4介导的白细胞粘着的多环化合物
TW593284B (en) * 1999-01-22 2004-06-21 Elan Pharm Inc Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by VLA-4
US6436904B1 (en) 1999-01-25 2002-08-20 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
EP1161416B1 (en) 1999-03-01 2004-04-14 Elan Pharmaceuticals, Inc. Alpha-aminoacetic acid derivatives useful as alpha 4 beta 7 - receptor antagonists
EP1341773A2 (en) 2000-12-07 2003-09-10 Cv Therapeutics, Inc. Substituted 1,3,5-triazines and pyrimidines as abca-1 elevating compounds against coronary artery disease or atherosclerosis
EP1399426A2 (en) * 2001-06-12 2004-03-24 Active Pass Pharmaceuticals, Inc. Compounds, compositions and methods for modulating beta-amyloid production
TWI281470B (en) * 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en) * 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
DE102005025161A1 (de) * 2005-06-01 2006-12-07 Phenion Gmbh & Co. Kg Derivate des Pyrimidins und Triazins und deren Verwendung
BRPI0616687A2 (pt) * 2005-09-29 2011-06-28 Elan Pharm Inc compostos de pirimidinil amida que inibem a adesão leucocitária mediada por vla-4
DE602006020754D1 (de) * 2005-09-29 2011-04-28 Elan Pharm Inc Carbamatverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren
US7579466B2 (en) * 2006-02-27 2009-08-25 Elan Pharmaceuticals, Inc. Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by VLA-4
JP2012525336A (ja) * 2009-04-27 2012-10-22 エラン ファーマシューティカルズ，インコーポレイテッド α−４インテグリンのピリジノンアンタゴニスト
EP4242203A4 (en) * 2020-11-06 2024-12-25 Pelemed Co., Ltd. NEW CAPSIDIC ASSEMBLY INHIBITOR

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB744867A (en) * 1952-10-29 1956-02-15 American Cyanamid Co Improvements relating to 2-substituted-mercapto-4-amino-6-disubstituted-aminopyrimidines and acid addition salts thereof
US3321478A (en) * 1963-09-20 1967-05-23 American Cyanamid Co Aminoethoxyphenyl amine, ether, and sulfide derivatives of pyrimidine
FR1413722A (fr) * 1963-11-12 1965-10-08 Geigy Ag J R Nouveaux dérivés de la pyrimidine, leur préparation et leurs applications
CH481986A (de) * 1967-05-24 1969-11-30 Geigy Ag J R Verfahren zur Herstellung von wasserlöslichen Farbsalzen von Azopyrimidinfarbstoffen
US3814761A (en) * 1972-03-31 1974-06-04 American Home Prod (2-pyrimidinylthio)alkanoic acids,esters,amides and hydrazides
US3974162A (en) * 1972-12-21 1976-08-10 American Home Products Corporation 4-Pyrimidinylthioacetic acid derivatives
DE2549161A1 (de) * 1975-11-03 1977-05-12 Henkel & Cie Gmbh Farbentwickler fuer farbphotographische entwicklungsverfahren
IT1063074B (it) * 1976-03-17 1985-02-11 Lpb Ist Farm Ammidi di acidi(z-pirimidiniltio)al canoici quali agent antilipemici

Also Published As

Publication number Publication date
US4559345A (en) 1985-12-17
ES515104A0 (es) 1983-12-16
DK373782A (da) 1983-02-21
IT8123580A0 (it) 1981-08-20
ES8500912A1 (es) 1984-11-16
DE73328T1 (de) 1983-07-21
ES524185A0 (es) 1985-05-01
ES524186A0 (es) 1984-11-16
EP0073328A1 (en) 1983-03-09
JPS5869870A (ja) 1983-04-26
ES8401037A1 (es) 1983-12-16
CA1173036A (en) 1984-08-21
PH17607A (en) 1984-10-05
ES8504741A1 (es) 1985-05-01

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