ES8401037A1 - "procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina". - Google Patents

"procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina".

Info

Publication number
ES8401037A1
ES8401037A1 ES515104A ES515104A ES8401037A1 ES 8401037 A1 ES8401037 A1 ES 8401037A1 ES 515104 A ES515104 A ES 515104A ES 515104 A ES515104 A ES 515104A ES 8401037 A1 ES8401037 A1 ES 8401037A1
Authority
ES
Spain
Prior art keywords
triazine derivatives
novel pyrimidine
activity
antilipidemic activity
antilipidemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515104A
Other languages
English (en)
Other versions
ES515104A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LPB INSTITUTO FARMACEUTICO SpA
Lpb Istituto Farmaceutico SpA
Original Assignee
LPB INSTITUTO FARMACEUTICO SpA
Lpb Istituto Farmaceutico SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LPB INSTITUTO FARMACEUTICO SpA, Lpb Istituto Farmaceutico SpA filed Critical LPB INSTITUTO FARMACEUTICO SpA
Publication of ES8401037A1 publication Critical patent/ES8401037A1/es
Publication of ES515104A0 publication Critical patent/ES515104A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/44—One nitrogen atom with halogen atoms attached to the two other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE PIRIMIDINA O S-TRIACINA.SE HACE REACCIONAR PIRIMIDINAS O S-TRIACINAS (II) EN LAS QUE A ES CLORO, O EL GRUPO CH3SO2 SON COMPUESTOS WH O CON LOS CORRESPONDIENTES ANIONES W- PARA EVENTUALMENTE, TRANSFORMARSE POR HIDROLISIS, HIDRACINOLISIS O AMINOLISIS CON AMINAS HNRR LOS COMPUESTOS (I) OBTENIDOS, EN LOS CUALES W ES Q-CH2-COR Y R ES ALCOXILO. W ES UN RADICAL Q-CH2-COR, NR R O SR; Y ES HALOGENO; X ES CH3 O N Y Z SON LOS RADICALES (III) O (IV).
ES515104A 1981-08-20 1982-08-19 "procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina". Granted ES515104A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8123580A IT1211096B (it) 1981-08-20 1981-08-20 Pirimidine e s.triazinici adattivita' ipolipidemizzante.

Publications (2)

Publication Number Publication Date
ES8401037A1 true ES8401037A1 (es) 1983-12-16
ES515104A0 ES515104A0 (es) 1983-12-16

Family

ID=11208290

Family Applications (3)

Application Number Title Priority Date Filing Date
ES515104A Granted ES515104A0 (es) 1981-08-20 1982-08-19 "procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina".
ES524186A Expired ES8500912A1 (es) 1981-08-20 1983-07-16 Procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina.
ES524185A Granted ES524185A0 (es) 1981-08-20 1983-07-16 Procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES524186A Expired ES8500912A1 (es) 1981-08-20 1983-07-16 Procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina.
ES524185A Granted ES524185A0 (es) 1981-08-20 1983-07-16 Procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina.

Country Status (9)

Country Link
US (1) US4559345A (es)
EP (1) EP0073328A1 (es)
JP (1) JPS5869870A (es)
CA (1) CA1173036A (es)
DE (1) DE73328T1 (es)
DK (1) DK373782A (es)
ES (3) ES515104A0 (es)
IT (1) IT1211096B (es)
PH (1) PH17607A (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK130584A (da) * 1983-04-08 1984-10-09 Ciba Geigy Ag N-(2-nitrophenyl)-4-amino-pyrimidin-derivater samt deres fremstilling og anvendelse som mikrobicider
US4542216A (en) * 1984-03-27 1985-09-17 Ciba Geigy Corporation Process for producing fluoroalkoxyaminopyrimidines
DE3445293A1 (de) * 1984-12-12 1986-06-12 Bayer Ag, 5090 Leverkusen Neue 2,4-diaminopyrimidine
JPH0631238B2 (ja) * 1985-08-01 1994-04-27 日産化学工業株式会社 ピラゾロ〔４，３−ｄ〕ピリミジン誘導体
GB8911287D0 (en) * 1989-05-17 1989-07-05 Ciba Geigy Ag Lubricant compositions
DE4104466A1 (de) * 1990-03-09 1991-09-12 Huels Chemische Werke Ag Quartaere ammoniumsalze von thiobarbitursaeuren und verfahren zu deren herstellung
DE69839735D1 (de) 1997-12-15 2008-08-28 Astellas Pharma Inc Pyrimidin-5-carboxamid-derivate
EP1147091A2 (en) 1999-01-22 2001-10-24 Elan Pharmaceuticals, Inc. Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by vla-4
DE60021251D1 (de) 1999-01-22 2005-08-18 Elan Pharm Inc Multizyklische verbindungen zur hemmung der durch vla-4 vermittelten leukozytenadhäsion
NZ529822A (en) 1999-01-22 2005-11-25 Elan Pharm Inc Acyl derivatives which treat VLA-4 related disorders
US6436904B1 (en) * 1999-01-25 2002-08-20 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
ATE264298T1 (de) 1999-03-01 2004-04-15 Elan Pharm Inc Alpha-aminoessigsäure derivate als alpha 4 beta 7-rezeptor antagonisten
AU2002239508B9 (en) * 2000-12-07 2005-09-08 Gilead Palo Alto, Inc. Substituted 1, 3, 5-triazines and pyrimidines as ABCA-1 elevating compounds against coronary artery disease or atherosclerosis
WO2002100836A2 (en) * 2001-06-12 2002-12-19 Active Pass Pharmaceuticals, Inc. Compounds, compositions and methods for modulating beta-amyloid production
TW200307671A (en) * 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
TWI281470B (en) * 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
DE102005025161A1 (de) * 2005-06-01 2006-12-07 Phenion Gmbh & Co. Kg Derivate des Pyrimidins und Triazins und deren Verwendung
CN101273035A (zh) * 2005-09-29 2008-09-24 伊兰制药公司 抑制由vla-4介导的白细胞粘附的氨基甲酸酯化合物
DK1940826T3 (da) * 2005-09-29 2011-04-18 Elan Pharm Inc Pyrimidinylamidforbindelser, der inhiberer leukocytadhæsion medieret gennem BLA-4
MX2008010988A (es) 2006-02-27 2008-10-20 Elan Pharm Inc Compuestos de pirimidinil sulfonamida que inhiben la adhesion de los leucocitos mediada por vla-4.
CA2760151A1 (en) * 2009-04-27 2010-11-04 Elan Pharmaceuticals, Inc. Pyridinone antagonists of alpha-4 integrins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB744867A (en) * 1952-10-29 1956-02-15 American Cyanamid Co Improvements relating to 2-substituted-mercapto-4-amino-6-disubstituted-aminopyrimidines and acid addition salts thereof
US3321478A (en) * 1963-09-20 1967-05-23 American Cyanamid Co Aminoethoxyphenyl amine, ether, and sulfide derivatives of pyrimidine
FR1413722A (fr) * 1963-11-12 1965-10-08 Geigy Ag J R Nouveaux dérivés de la pyrimidine, leur préparation et leurs applications
CH481986A (de) * 1967-05-24 1969-11-30 Geigy Ag J R Verfahren zur Herstellung von wasserlöslichen Farbsalzen von Azopyrimidinfarbstoffen
US3814761A (en) * 1972-03-31 1974-06-04 American Home Prod (2-pyrimidinylthio)alkanoic acids,esters,amides and hydrazides
US3974162A (en) * 1972-12-21 1976-08-10 American Home Products Corporation 4-Pyrimidinylthioacetic acid derivatives
DE2549161A1 (de) * 1975-11-03 1977-05-12 Henkel & Cie Gmbh Farbentwickler fuer farbphotographische entwicklungsverfahren
IT1063074B (it) * 1976-03-17 1985-02-11 Lpb Ist Farm Ammidi di acidi(z-pirimidiniltio)al canoici quali agent antilipemici

Also Published As

Publication number Publication date
ES8504741A1 (es) 1985-05-01
ES524186A0 (es) 1984-11-16
US4559345A (en) 1985-12-17
CA1173036A (en) 1984-08-21
ES524185A0 (es) 1985-05-01
EP0073328A1 (en) 1983-03-09
ES515104A0 (es) 1983-12-16
PH17607A (en) 1984-10-05
JPS5869870A (ja) 1983-04-26
ES8500912A1 (es) 1984-11-16
DE73328T1 (de) 1983-07-21
IT1211096B (it) 1989-09-29
DK373782A (da) 1983-02-21
IT8123580A0 (it) 1981-08-20

Similar Documents

Publication Publication Date Title
ES8504741A1 (es) Procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina.
IL73258A (en) 6-(ar)alkyl-7-aminoazolo(1,5-a)pyrimidines,their preparation and their use as fungicides
DK0590428T3 (da) Azaquinoxaliner, fremgangsmåde til deres fremstilling og deres anvendelse
IL99780A0 (en) Herbicidal substituted aryl-haloalkylpyrazoles
MY109937A (en) Substituted azoles, processes for the preparation thereof, agents containing these, and the use thereof.
IL71118A (en) Pyridinyl,pyrimidinyl and triazinyl derivatives,their preparation and herbicidal compositions comprising them
FI853625L (fi) Tetralinderivat, deras framstaellning och anvaendning.
CA2027206A1 (en) Sulphonylaminocarbonyltriazolinones
ES2164639T3 (es) Quinoxalinas, procedimiento para su preparacion y su empleo.
IL70744A (en) 6-aryl-3(2h)-pyridazinone derivatives and pharmaceutical compositions containing them
FI853624A0 (fi) 1-substituerade tetralinderivat, deras framstaellning och anvaendning.
IL66779A0 (en) Pyrimidine(triazine)substituted phenylsulfonylurea derivatives,their preparation and their use as herbicides
MY102973A (en) Isoindolinyl alkyl piperazines
DE3266708D1 (en) Pyridazinone derivatives, process for their preparation and their use as fungicides
PH31682A (en) 4-Iminoquinolines, process for their preparation, and their use.
ES8705421A1 (es) Un procedimiento para la preparacion de 4-amino-2-fenil-quinolinas
ES8604520A1 (es) Procedimiento para preparar derivados de 2(1h)-piridona
DE3465082D1 (en) Pyridazinone derivatives, process for their preparation and their use as fungicides
ES8601916A1 (es) Un procedimiento para la preparacion de nuevos derivados de 4,5-dihidro-2h-piridazin-3-ona.
ZA821785B (en) Novel soluble n2 substituted derivatives of 2,4-diamino 5-benzyl pyrimidine, process for their preparation and medicaments containing them
ES8707212A1 (es) Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas
PT74305A (en) Process for the preparation of an herbicidal composition con- taining novel 2-pyridyloxyacetanilide derivatives
ZA874596B (en) 3-substituted 1-(2-halogenoalkoxy-benzenesulphonyl)-3-heteroaryl-(thio)ureas
DE59106660D1 (de) Trifluor- bzw. Chlordifluormethoxy-1,3,5,-triazine und Verfahren zu ihrer Herstellung.
PT74515B (en) Process for the preparation of 2-pyridyloxy-acetanilides having an herbicidal effect