NO20000414L - Benzylforbindelser som inhiberer leukocytt adhesjon mediert av VLA-4 - Google Patents

Benzylforbindelser som inhiberer leukocytt adhesjon mediert av VLA-4

Info

Publication number
NO20000414L
NO20000414L NO20000414A NO20000414A NO20000414L NO 20000414 L NO20000414 L NO 20000414L NO 20000414 A NO20000414 A NO 20000414A NO 20000414 A NO20000414 A NO 20000414A NO 20000414 L NO20000414 L NO 20000414L
Authority
NO
Norway
Prior art keywords
vla
compounds
leukocyte adhesion
adhesion mediated
inhibit leukocyte
Prior art date
Application number
NO20000414A
Other languages
English (en)
Other versions
NO20000414D0 (no
Inventor
Eugene D Thorsett
Christopher M Semko
Michael A Pleiss
Louis John Lombardo
Andrei W Konradi
Francine S Grant
Darren B Dressen
Michael S Dappen
Original Assignee
Elan Pharm Inc
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, American Home Prod filed Critical Elan Pharm Inc
Publication of NO20000414D0 publication Critical patent/NO20000414D0/no
Publication of NO20000414L publication Critical patent/NO20000414L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Abstract

Det er beskrevet forbindelser som binder VLA-4. Noen av disse forbindelsene inhiberer også leukocytt-adhesjon og spesielt leukocytt-adhesjon mediert av VLA-4. Slike forbindelser er nyttige for behandling av inflammatoriske sykdommer i en pattedyrpasient, for eksempel et menneske, hvori sykdommen for eksempel kan være astma, Alzheimer's sykdom, aterosklerose, AIDS-demens, diabetes, inflammatorisk tarmsykdom, leddgikt, vevstransplantasjon, tumor- metastase og myokardial ischemi. Forbindelsene kan også bli administrert for behandling av inflammatoriske hjernesykdommer så som multippel sklerose.
NO20000414A 1997-07-31 2000-01-27 Benzylforbindelser som inhiberer leukocytt adhesjon mediert av VLA-4 NO20000414L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90358597A 1997-07-31 1997-07-31
PCT/US1998/015327 WO1999006436A1 (en) 1997-07-31 1998-07-31 Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (2)

Publication Number Publication Date
NO20000414D0 NO20000414D0 (no) 2000-01-27
NO20000414L true NO20000414L (no) 2000-03-28

Family

ID=25417733

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20000414A NO20000414L (no) 1997-07-31 2000-01-27 Benzylforbindelser som inhiberer leukocytt adhesjon mediert av VLA-4

Country Status (12)

Country Link
EP (1) EP1001975A1 (no)
JP (1) JP2001512138A (no)
KR (1) KR20010022413A (no)
CN (1) CN1265675A (no)
AU (1) AU8585198A (no)
BR (1) BR9811573A (no)
CA (1) CA2291473A1 (no)
HU (1) HUP0002680A3 (no)
IL (1) IL133635A0 (no)
NO (1) NO20000414L (no)
PL (1) PL338510A1 (no)
WO (1) WO1999006436A1 (no)

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US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
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Also Published As

Publication number Publication date
CN1265675A (zh) 2000-09-06
KR20010022413A (ko) 2001-03-15
CA2291473A1 (en) 1999-02-11
WO1999006436A1 (en) 1999-02-11
HUP0002680A3 (en) 2001-12-28
NO20000414D0 (no) 2000-01-27
IL133635A0 (en) 2001-04-30
HUP0002680A2 (hu) 2001-07-30
JP2001512138A (ja) 2001-08-21
BR9811573A (pt) 2000-09-19
EP1001975A1 (en) 2000-05-24
AU8585198A (en) 1999-02-22
PL338510A1 (en) 2000-11-06

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