NO20082002L - Pyrimidinylamidforbindelser som inhiberer leukocyttadhesjon mediert ved VLA-4 - Google Patents

Pyrimidinylamidforbindelser som inhiberer leukocyttadhesjon mediert ved VLA-4

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Publication number
NO20082002L
NO20082002L NO20082002A NO20082002A NO20082002L NO 20082002 L NO20082002 L NO 20082002L NO 20082002 A NO20082002 A NO 20082002A NO 20082002 A NO20082002 A NO 20082002A NO 20082002 L NO20082002 L NO 20082002L
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NO
Norway
Prior art keywords
compounds
vla
leukocyte adhesion
pyrimidinylamide
adhesion mediated
Prior art date
Application number
NO20082002A
Other languages
English (en)
Inventor
Andrei W Konradi
Ying-Zi Xu
Frank Stappenbeck
Christopher Michael Semko
Jenifer Lea Smith
Kassandra Inez Rossiter
Juri Y Fukuda
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20082002L publication Critical patent/NO20082002L/no

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Det er beskrevet forbindelser som binder VLA-4. Noen av disse forbindelsene inhiberer også leukocyttadhesjon og særlig leukocyttadhesjon mediert av VLA-4. Slike forbindelser er anvendelige ved behandling av inflammatoriske sykdommer hos et menneskeeller dyresubjekt, slik som astma, Alzheimers sykdom, aterosklerose, AIDS demens, diabetes, inflammatorisk tarmsykdom, reumatoid artritt, vevstransplantasjon, tumormetastaser og myokardisk iskemi. Forbindelsene kan også administreres for behandling av inflammatoriske hjernesykdommer slik som multippel sklerose.
NO20082002A 2005-09-29 2008-04-28 Pyrimidinylamidforbindelser som inhiberer leukocyttadhesjon mediert ved VLA-4 NO20082002L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72235805P 2005-09-29 2005-09-29
PCT/US2006/038009 WO2007041270A1 (en) 2005-09-29 2006-09-28 Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (1)

Publication Number Publication Date
NO20082002L true NO20082002L (no) 2008-06-03

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Country Status (17)

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US (2) US7511052B2 (no)
EP (1) EP1940826B1 (no)
JP (1) JP5101512B2 (no)
KR (1) KR20080059268A (no)
CN (1) CN101273034B (no)
AT (1) ATE493405T1 (no)
AU (1) AU2006297220B8 (no)
BR (1) BRPI0616687A2 (no)
CA (1) CA2624450C (no)
DE (1) DE602006019296D1 (no)
DK (1) DK1940826T3 (no)
EA (1) EA015388B1 (no)
IL (1) IL190084A (no)
NO (1) NO20082002L (no)
NZ (1) NZ567270A (no)
WO (1) WO2007041270A1 (no)
ZA (2) ZA200803280B (no)

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ATE493405T1 (de) 2011-01-15
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