DK1940826T3 - Pyrimidinylamidforbindelser, der inhiberer leukocytadhæsion medieret gennem BLA-4 - Google Patents

Pyrimidinylamidforbindelser, der inhiberer leukocytadhæsion medieret gennem BLA-4

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Publication number
DK1940826T3
DK1940826T3 DK06804253.0T DK06804253T DK1940826T3 DK 1940826 T3 DK1940826 T3 DK 1940826T3 DK 06804253 T DK06804253 T DK 06804253T DK 1940826 T3 DK1940826 T3 DK 1940826T3
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DK
Denmark
Prior art keywords
compounds
leukocyte adhesion
pyrimidinylamide
bla
adhesion mediated
Prior art date
Application number
DK06804253.0T
Other languages
English (en)
Inventor
Christopher Michael Semko
Ying-Zi Xu
Juri Y Fukuda
Andrei W Konradi
Frank Stappenbeck
Jenifer Lea Smith
Kassandra Inez Rossiter
Original Assignee
Elan Pharm Inc
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, Wyeth Llc filed Critical Elan Pharm Inc
Application granted granted Critical
Publication of DK1940826T3 publication Critical patent/DK1940826T3/da

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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DK06804253.0T 2005-09-29 2006-09-28 Pyrimidinylamidforbindelser, der inhiberer leukocytadhæsion medieret gennem BLA-4 DK1940826T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72235805P 2005-09-29 2005-09-29
PCT/US2006/038009 WO2007041270A1 (en) 2005-09-29 2006-09-28 Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (1)

Publication Number Publication Date
DK1940826T3 true DK1940826T3 (da) 2011-04-18

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DK06804253.0T DK1940826T3 (da) 2005-09-29 2006-09-28 Pyrimidinylamidforbindelser, der inhiberer leukocytadhæsion medieret gennem BLA-4

Country Status (17)

Country Link
US (2) US7511052B2 (da)
EP (1) EP1940826B1 (da)
JP (1) JP5101512B2 (da)
KR (1) KR20080059268A (da)
CN (1) CN101273034B (da)
AT (1) ATE493405T1 (da)
AU (1) AU2006297220B8 (da)
BR (1) BRPI0616687A2 (da)
CA (1) CA2624450C (da)
DE (1) DE602006019296D1 (da)
DK (1) DK1940826T3 (da)
EA (1) EA015388B1 (da)
IL (1) IL190084A (da)
NO (1) NO20082002L (da)
NZ (1) NZ567270A (da)
WO (1) WO2007041270A1 (da)
ZA (2) ZA200803280B (da)

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