NO20083743L - Pyrimidinylsulfonamidforbindelser som inhiberer leukocyttadhesjon mediert av VLA-4 - Google Patents

Pyrimidinylsulfonamidforbindelser som inhiberer leukocyttadhesjon mediert av VLA-4

Info

Publication number
NO20083743L
NO20083743L NO20083743A NO20083743A NO20083743L NO 20083743 L NO20083743 L NO 20083743L NO 20083743 A NO20083743 A NO 20083743A NO 20083743 A NO20083743 A NO 20083743A NO 20083743 L NO20083743 L NO 20083743L
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NO
Norway
Prior art keywords
compounds
vla
leukocyte adhesion
pyrimidinylsulfonamide
adhesion mediated
Prior art date
Application number
NO20083743A
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English (en)
Inventor
Andrei W Konradi
Ying-Zi Xu
Jennifer L Smith
Christopher Semko
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Elan Pharm Inc
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Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of NO20083743L publication Critical patent/NO20083743L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Det beskrives forbindelser som binder VLA-4. Visse av disse forbindelser inhiberer også leukocyttadhesjon og spesielt leukocyttadhesjon mediert av VLA-4. Slike forbindelser er nyttige ved behandling av inflammatoriske sykdommer i et menneske- eller dyreindivid, så som asthma, Alzheimer's sykdom, aterosklerose, AIDS-demens, diabetes, inflammatorisk tarmsykdom, Crohn's sykdom, rheumatoid artritt, vevtransplan-tasjon, svulstmetastase og myokardial iskjemi. Forbindelsene kan også administreres for behandling av inflammatoriske hjemesykdommer så som multippel sklerose.
NO20083743A 2006-02-27 2008-08-29 Pyrimidinylsulfonamidforbindelser som inhiberer leukocyttadhesjon mediert av VLA-4 NO20083743L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77759506P 2006-02-27 2006-02-27
PCT/US2007/062824 WO2007101165A1 (en) 2006-02-27 2007-02-26 Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (1)

Publication Number Publication Date
NO20083743L true NO20083743L (no) 2008-11-19

Family

ID=38215011

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083743A NO20083743L (no) 2006-02-27 2008-08-29 Pyrimidinylsulfonamidforbindelser som inhiberer leukocyttadhesjon mediert av VLA-4

Country Status (20)

Country Link
US (2) US7579466B2 (no)
EP (1) EP1996559A1 (no)
JP (1) JP5135235B2 (no)
KR (1) KR20080100271A (no)
CN (1) CN101389611B (no)
AR (1) AR059671A1 (no)
AU (1) AU2007220068B2 (no)
BR (1) BRPI0708331A2 (no)
CA (1) CA2643838A1 (no)
EA (1) EA017110B1 (no)
EC (1) ECSP088701A (no)
IL (1) IL193425A (no)
MA (1) MA30318B1 (no)
MX (1) MX2008010988A (no)
MY (1) MY151045A (no)
NO (1) NO20083743L (no)
NZ (1) NZ570679A (no)
TW (1) TWI389904B (no)
WO (1) WO2007101165A1 (no)
ZA (1) ZA200807188B (no)

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AU2007220068B2 (en) 2012-09-13
US20080058357A1 (en) 2008-03-06
ECSP088701A (es) 2008-11-27
TWI389904B (zh) 2013-03-21
CA2643838A1 (en) 2007-09-07
JP2009528296A (ja) 2009-08-06
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TW200811142A (en) 2008-03-01
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US7579466B2 (en) 2009-08-25
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MA30318B1 (fr) 2009-04-01
AU2007220068A1 (en) 2007-09-07
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