MA30318B1 - Composes de sulfonamide de pyrimidinyle inhibant l'adhesion leucocytaire mediee par vla-4 - Google Patents
Composes de sulfonamide de pyrimidinyle inhibant l'adhesion leucocytaire mediee par vla-4Info
- Publication number
- MA30318B1 MA30318B1 MA31231A MA31231A MA30318B1 MA 30318 B1 MA30318 B1 MA 30318B1 MA 31231 A MA31231 A MA 31231A MA 31231 A MA31231 A MA 31231A MA 30318 B1 MA30318 B1 MA 30318B1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- mediated
- vla
- sulfonamide compounds
- adhesion
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La présente invention concerne des composés qui se lient à VLA-4. Certains de ces composés inhibent également l'adhésion leucocytaire et notamment l'adhésion leucocytaire médiée par VLA-4. De tels composés sont utiles pour le traitement des maladies inflammatoires chez l'être humain ou l'animal telles que l'asthme, la maladie d'Alzheimer, l'athérosclérose, la démence du SIDA, le diabète, la maladie inflammatoire des intestins, la maladie de Crohn, la polyarthrite rhumatoïde, la greffe de tissus, les métastases tumorales et l'ischémie myocardique. Les composés peuvent également être administrés pour le traitement de maladies inflammatoires cérébrales telles que la sclérose en plaques.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77759506P | 2006-02-27 | 2006-02-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30318B1 true MA30318B1 (fr) | 2009-04-01 |
Family
ID=38215011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31231A MA30318B1 (fr) | 2006-02-27 | 2008-09-11 | Composes de sulfonamide de pyrimidinyle inhibant l'adhesion leucocytaire mediee par vla-4 |
Country Status (20)
Country | Link |
---|---|
US (2) | US7579466B2 (fr) |
EP (1) | EP1996559A1 (fr) |
JP (1) | JP5135235B2 (fr) |
KR (1) | KR20080100271A (fr) |
CN (1) | CN101389611B (fr) |
AR (1) | AR059671A1 (fr) |
AU (1) | AU2007220068B2 (fr) |
BR (1) | BRPI0708331A2 (fr) |
CA (1) | CA2643838A1 (fr) |
EA (1) | EA017110B1 (fr) |
EC (1) | ECSP088701A (fr) |
IL (1) | IL193425A (fr) |
MA (1) | MA30318B1 (fr) |
MX (1) | MX2008010988A (fr) |
MY (1) | MY151045A (fr) |
NO (1) | NO20083743L (fr) |
NZ (1) | NZ570679A (fr) |
TW (1) | TWI389904B (fr) |
WO (1) | WO2007101165A1 (fr) |
ZA (1) | ZA200807188B (fr) |
Families Citing this family (25)
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ES2339738T3 (es) * | 1999-01-22 | 2010-05-25 | Elan Pharmaceuticals, Inc. | Derivados de acilo los cuales tratan trastornos relacionados con vla-4. |
CN102241769B (zh) * | 2004-05-27 | 2016-08-10 | 克鲁塞尔荷兰公司 | 能中和狂犬病病毒的结合分子及其应用 |
CA2624450C (fr) * | 2005-09-29 | 2014-02-04 | Elan Pharmaceuticals, Inc. | Composes de pyrimidinyl amide qui inhibent l'adherence leucocytaire a mediation par vla-4 |
BRPI0616643A2 (pt) | 2005-09-29 | 2011-06-28 | Elan Pharm Inc | compostos de carbamato que inibem a adesão leucocitária mediada por vla-4 |
BRPI0708331A2 (pt) | 2006-02-27 | 2011-05-24 | Elan Pharm Inc | compostos de pirimidinil sulfonamida que inibem a adesão leucocitária mediada por vla-4 |
EP3620469A1 (fr) | 2006-02-28 | 2020-03-11 | Biogen MA Inc. | Procédés de traitement de maladies inflammatoires et auto-immunes avec du natalizumab |
JP2009531304A (ja) * | 2006-02-28 | 2009-09-03 | エラン ファーマシューティカルズ,インコーポレイテッド | α−4阻害剤化合物を用いて炎症性疾患および自己免疫疾患を治療する方法 |
CN101437541A (zh) | 2006-03-03 | 2009-05-20 | 伊兰药品公司 | 用那他珠单抗治疗炎性疾病和自身免疫病的方法 |
WO2009075806A1 (fr) * | 2007-12-07 | 2009-06-18 | Elan Pharmaceuticals, Inc. | Procédés et compositions pour traiter des tumeurs liquides |
CA2760151A1 (fr) * | 2009-04-27 | 2010-11-04 | Elan Pharmaceuticals, Inc. | Antagonistes a base de pyridinone d'integrines alpha-4 |
EP2467159A1 (fr) | 2009-08-20 | 2012-06-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Vla-4 en tant que biomarqueur pour le pronostic et le ciblage pour thérapie dans la dystrophie musculaire de duchenne |
US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
HRP20221390T1 (hr) | 2010-01-11 | 2023-01-06 | Biogen Ma Inc. | Analiza za antitijela jc virusa |
US10119976B2 (en) | 2013-05-28 | 2018-11-06 | Biogen Ma Inc. | Method of assessing risk of PML |
US20180164221A1 (en) | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
US20200253506A1 (en) | 2016-12-14 | 2020-08-13 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
EP3810085A1 (fr) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Traitement d'une maladie du tractus gastro-intestinal par un inhibiteur de l'intégrine |
KR102652797B1 (ko) | 2018-10-30 | 2024-04-02 | 길리애드 사이언시즈, 인코포레이티드 | 알파4베타7 인테그린의 억제를 위한 화합물 |
CN112969687A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
EP3873605A1 (fr) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Composés pour inhibition de l'intégrine alpha4beta7 |
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CN116726361A (zh) | 2018-11-19 | 2023-09-12 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
EP4013499A1 (fr) | 2019-08-14 | 2022-06-22 | Gilead Sciences, Inc. | Composés pour l'inhibition de l'intégrine alpha 4 bêta 7 |
WO2021119482A1 (fr) | 2019-12-13 | 2021-06-17 | Progenity, Inc. | Dispositif ingérable pour administrer un agent thérapeutique dans le tractus gastro-intestinal |
WO2022162164A1 (fr) | 2021-01-29 | 2022-08-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procedes d'évaluation du risque de développement d'une leuco-entéphalopathie multifocale progressive chez les patients traités par des antagonistes de la vla-4 |
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US6544994B2 (en) | 2000-06-07 | 2003-04-08 | Eprov Ag | Pharmaceutical preparation for treating or preventing cardiovascular or neurological disorders by modulating of the activity of nitric oxide synthase |
US6689781B2 (en) | 2000-07-21 | 2004-02-10 | Elan Pharmaceuticals, Inc. | Phenylalanine derivatives as alpha 4 integrin inhibitors |
US6794506B2 (en) | 2000-07-21 | 2004-09-21 | Elan Pharmaceuticals, Inc. | 3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by VLA-4 |
TW200307671A (en) | 2002-05-24 | 2003-12-16 | Elan Pharm Inc | Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins |
TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
CN101035563B (zh) | 2004-07-08 | 2012-03-28 | 艾伦药物公司 | 包括聚合物部分的多价vla-4拮抗剂 |
BRPI0616643A2 (pt) | 2005-09-29 | 2011-06-28 | Elan Pharm Inc | compostos de carbamato que inibem a adesão leucocitária mediada por vla-4 |
CA2624450C (fr) | 2005-09-29 | 2014-02-04 | Elan Pharmaceuticals, Inc. | Composes de pyrimidinyl amide qui inhibent l'adherence leucocytaire a mediation par vla-4 |
BRPI0708331A2 (pt) | 2006-02-27 | 2011-05-24 | Elan Pharm Inc | compostos de pirimidinil sulfonamida que inibem a adesão leucocitária mediada por vla-4 |
-
2007
- 2007-02-26 BR BRPI0708331-9A patent/BRPI0708331A2/pt not_active IP Right Cessation
- 2007-02-26 KR KR1020087023333A patent/KR20080100271A/ko not_active Application Discontinuation
- 2007-02-26 CN CN2007800065837A patent/CN101389611B/zh not_active Expired - Fee Related
- 2007-02-26 MY MYPI20083293 patent/MY151045A/en unknown
- 2007-02-26 MX MX2008010988A patent/MX2008010988A/es active IP Right Grant
- 2007-02-26 WO PCT/US2007/062824 patent/WO2007101165A1/fr active Application Filing
- 2007-02-26 EP EP07757498A patent/EP1996559A1/fr not_active Withdrawn
- 2007-02-26 JP JP2008556582A patent/JP5135235B2/ja not_active Expired - Fee Related
- 2007-02-26 US US11/679,042 patent/US7579466B2/en not_active Expired - Fee Related
- 2007-02-26 NZ NZ570679A patent/NZ570679A/en not_active IP Right Cessation
- 2007-02-26 AU AU2007220068A patent/AU2007220068B2/en not_active Ceased
- 2007-02-26 TW TW096106544A patent/TWI389904B/zh not_active IP Right Cessation
- 2007-02-26 EA EA200801906A patent/EA017110B1/ru not_active IP Right Cessation
- 2007-02-26 CA CA002643838A patent/CA2643838A1/fr not_active Abandoned
- 2007-02-27 AR ARP070100812A patent/AR059671A1/es not_active Application Discontinuation
-
2008
- 2008-08-13 IL IL193425A patent/IL193425A/en not_active IP Right Cessation
- 2008-08-22 ZA ZA2008/07188A patent/ZA200807188B/en unknown
- 2008-08-27 EC EC2008008701A patent/ECSP088701A/es unknown
- 2008-08-29 NO NO20083743A patent/NO20083743L/no not_active Application Discontinuation
- 2008-09-11 MA MA31231A patent/MA30318B1/fr unknown
-
2009
- 2009-07-17 US US12/505,383 patent/US7820687B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7820687B2 (en) | 2010-10-26 |
EA200801906A1 (ru) | 2009-02-27 |
US20080058357A1 (en) | 2008-03-06 |
IL193425A (en) | 2013-02-28 |
NZ570679A (en) | 2011-01-28 |
CA2643838A1 (fr) | 2007-09-07 |
TWI389904B (zh) | 2013-03-21 |
WO2007101165A1 (fr) | 2007-09-07 |
EA017110B1 (ru) | 2012-09-28 |
CN101389611B (zh) | 2012-07-18 |
JP2009528296A (ja) | 2009-08-06 |
ECSP088701A (es) | 2008-11-27 |
AU2007220068A1 (en) | 2007-09-07 |
TW200811142A (en) | 2008-03-01 |
MY151045A (en) | 2014-03-31 |
NO20083743L (no) | 2008-11-19 |
KR20080100271A (ko) | 2008-11-14 |
US7579466B2 (en) | 2009-08-25 |
MX2008010988A (es) | 2008-10-20 |
CN101389611A (zh) | 2009-03-18 |
JP5135235B2 (ja) | 2013-02-06 |
US20100016345A1 (en) | 2010-01-21 |
ZA200807188B (en) | 2009-12-30 |
EP1996559A1 (fr) | 2008-12-03 |
AR059671A1 (es) | 2008-04-23 |
BRPI0708331A2 (pt) | 2011-05-24 |
IL193425A0 (en) | 2009-05-04 |
AU2007220068B2 (en) | 2012-09-13 |
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