ECSP045425A - COMPUESTOS HETEROCÍCLICOS QUE INHIBEN LA ADHESIÓN DE LEUCOCITOS MEDIADA POR INTEGRINAS a4 - Google Patents
COMPUESTOS HETEROCÍCLICOS QUE INHIBEN LA ADHESIÓN DE LEUCOCITOS MEDIADA POR INTEGRINAS a4Info
- Publication number
- ECSP045425A ECSP045425A EC2004005425A ECSP045425A ECSP045425A EC SP045425 A ECSP045425 A EC SP045425A EC 2004005425 A EC2004005425 A EC 2004005425A EC SP045425 A ECSP045425 A EC SP045425A EC SP045425 A ECSP045425 A EC SP045425A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- sub
- integrins
- inhibit
- leukocytes
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen compuestos que se unen a las integrinas a4, con preferencia VLA-4. Algunos de estos compuestos también pueden inhibir la adhesión de leucocitos y, en particular, adhesión de leucocitos mediada por las integrinas a4, con preferencia VLA-4. Dichos compuestos son útiles en el tratamiento de enfermedades inflamatorias en un paciente mamífero, por ejemplo, humano, como asma, enfermedad de Alzheimer, ateroesclerosis, demencia producida por el SIDA, diabetes, enfermedad inflamatoria de intestinos, artritis reumatoide, transplante de tejidos, metástasis de tumores e isquemia de miocardio. Los compuestos también pueden administrarse para el tratamiento de enfermedades inflamatorias del cerebro como la esclerosis múltiple.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38302002P | 2002-05-24 | 2002-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP045425A true ECSP045425A (es) | 2005-03-10 |
Family
ID=29584493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2004005425A ECSP045425A (es) | 2002-05-24 | 2004-10-11 | COMPUESTOS HETEROCÍCLICOS QUE INHIBEN LA ADHESIÓN DE LEUCOCITOS MEDIADA POR INTEGRINAS a4 |
Country Status (23)
Country | Link |
---|---|
US (3) | US7135477B2 (es) |
EP (1) | EP1507775B1 (es) |
JP (1) | JP4469715B2 (es) |
KR (1) | KR100978832B1 (es) |
CN (1) | CN1314682C (es) |
AT (1) | ATE419243T1 (es) |
AU (1) | AU2003240823C1 (es) |
BR (1) | BR0308881A (es) |
CA (1) | CA2481926C (es) |
DE (1) | DE60325583D1 (es) |
DK (1) | DK1507775T3 (es) |
EA (1) | EA008256B1 (es) |
EC (1) | ECSP045425A (es) |
ES (1) | ES2320436T3 (es) |
HK (1) | HK1072608A1 (es) |
IL (2) | IL164225A0 (es) |
MX (1) | MXPA04010995A (es) |
NO (1) | NO329933B1 (es) |
NZ (1) | NZ535504A (es) |
TW (1) | TWI281470B (es) |
UA (1) | UA76339C2 (es) |
WO (1) | WO2003099809A1 (es) |
ZA (1) | ZA200407590B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
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KR100711840B1 (ko) * | 1999-01-22 | 2007-05-02 | 엘란 파마슈티칼스, 인크. | Vla-4 관련 질환 치료용 아실 유도체 |
TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
EP1635822A4 (en) * | 2003-06-25 | 2009-06-24 | Elan Pharm Inc | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS |
WO2005111020A2 (en) * | 2004-04-30 | 2005-11-24 | Elan Pharmaceuticals, Inc. | Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by vla-4 |
JP2008505927A (ja) * | 2004-07-08 | 2008-02-28 | イーラン ファーマスーティカルズ、インコーポレイテッド | ポリマー部分を含む多価vla−4拮抗薬 |
EP1881982B1 (en) * | 2005-05-20 | 2013-11-20 | Elan Pharmaceuticals Inc. | Imidazolone phenylalanine derivatives as vla-4 antagonists |
ZA200803016B (en) * | 2005-09-29 | 2009-10-28 | Elan Pharmaceuticals Inc Wyeth | Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4 |
EA015388B1 (ru) * | 2005-09-29 | 2011-08-30 | Элан Фамэсьютикэлс, Инк. | ПИРИМИДИНИЛАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), ВКЛЮЧАЮЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО α4-ИНТЕГРИНАМИ |
MY151045A (en) | 2006-02-27 | 2014-03-31 | Elan Pharm Inc | Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4 |
WO2007100770A2 (en) * | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
WO2007100763A2 (en) | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
WO2007103112A2 (en) * | 2006-03-03 | 2007-09-13 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
US8269009B2 (en) | 2007-12-07 | 2012-09-18 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating liquid tumors |
EP2085407A1 (en) | 2008-02-04 | 2009-08-05 | Sahltech I Göteborg AB | Treatment of idiopathic thrombocytopenic purpura |
RU2010141964A (ru) * | 2008-04-29 | 2012-06-10 | НСАБ, Филиаль аф НьюроСерч Свиден АБ, Сверийе (DK) | Модуляторы дофаминовой нейротрансмиссии |
CN102459179A (zh) * | 2009-04-27 | 2012-05-16 | 艾伦药物公司 | α-4整联蛋白的吡啶酮拮抗剂 |
US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
PT2524060T (pt) | 2010-01-11 | 2018-03-28 | Biogen Ma Inc | Ensaio para a deteção de anticorpos contra o vírus jc |
RS63989B1 (sr) | 2011-05-31 | 2023-03-31 | Biogen Ma Inc | Postupak evaluacije rizika za pml |
JP6080521B2 (ja) * | 2012-11-30 | 2017-02-15 | インターナショナル・ビジネス・マシーンズ・コーポレーションInternational Business Machines Corporation | 広域分散医療情報ネットワークのデータ管理機構 |
EP3004334A4 (en) | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHODS OF EVALUATION RISK OF DEVELOPMENT OF PML |
EP3294716B1 (en) * | 2015-12-30 | 2020-04-15 | Saint Louis University | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists |
CA3114240C (en) | 2018-10-30 | 2023-09-05 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
SG11202103484RA (en) | 2018-10-30 | 2021-05-28 | Gilead Sciences Inc | Quinoline derivatives as alpha4beta7 integrin inhibitors |
JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4ベータ7インテグリンの阻害のための化合物 |
CN112969504B (zh) | 2018-10-30 | 2024-04-09 | 吉利德科学公司 | 用于抑制α4β7整合素的化合物 |
CN109541237A (zh) * | 2018-12-28 | 2019-03-29 | 吴江近岸蛋白质科技有限公司 | 纤维连接蛋白的生物学活性测定方法 |
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-
2003
- 2003-05-26 TW TW092114183A patent/TWI281470B/zh not_active IP Right Cessation
- 2003-05-27 ES ES03731419T patent/ES2320436T3/es not_active Expired - Lifetime
- 2003-05-27 ZA ZA200407590A patent/ZA200407590B/en unknown
- 2003-05-27 JP JP2004507466A patent/JP4469715B2/ja not_active Expired - Fee Related
- 2003-05-27 DE DE60325583T patent/DE60325583D1/de not_active Expired - Lifetime
- 2003-05-27 CA CA2481926A patent/CA2481926C/en not_active Expired - Fee Related
- 2003-05-27 AU AU2003240823A patent/AU2003240823C1/en not_active Ceased
- 2003-05-27 WO PCT/US2003/016804 patent/WO2003099809A1/en active IP Right Grant
- 2003-05-27 US US10/494,790 patent/US7135477B2/en not_active Expired - Fee Related
- 2003-05-27 MX MXPA04010995A patent/MXPA04010995A/es active IP Right Grant
- 2003-05-27 KR KR1020047018173A patent/KR100978832B1/ko not_active IP Right Cessation
- 2003-05-27 BR BR0308881-2A patent/BR0308881A/pt active Search and Examination
- 2003-05-27 NZ NZ535504A patent/NZ535504A/en not_active IP Right Cessation
- 2003-05-27 DK DK03731419T patent/DK1507775T3/da active
- 2003-05-27 IL IL16422503A patent/IL164225A0/xx unknown
- 2003-05-27 EP EP03731419A patent/EP1507775B1/en not_active Expired - Lifetime
- 2003-05-27 EA EA200401562A patent/EA008256B1/ru not_active IP Right Cessation
- 2003-05-27 US US10/447,308 patent/US7026328B2/en not_active Expired - Fee Related
- 2003-05-27 UA UA20041008397A patent/UA76339C2/uk unknown
- 2003-05-27 CN CNB038115484A patent/CN1314682C/zh not_active Expired - Fee Related
- 2003-05-27 AT AT03731419T patent/ATE419243T1/de not_active IP Right Cessation
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2004
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- 2004-09-22 IL IL164225A patent/IL164225A/en not_active IP Right Cessation
- 2004-10-11 EC EC2004005425A patent/ECSP045425A/es unknown
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2005
- 2005-07-15 HK HK05106028.8A patent/HK1072608A1/xx not_active IP Right Cessation
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