TR200000481T2 - N-Alkonoilfenilalenin türevleri. - Google Patents

N-Alkonoilfenilalenin türevleri.

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Publication number
TR200000481T2
TR200000481T2 TR2000/00481T TR200000481T TR200000481T2 TR 200000481 T2 TR200000481 T2 TR 200000481T2 TR 2000/00481 T TR2000/00481 T TR 2000/00481T TR 200000481 T TR200000481 T TR 200000481T TR 200000481 T2 TR200000481 T2 TR 200000481T2
Authority
TR
Turkey
Prior art keywords
alkoxyphenylalanine
derivatives
vla
binding
vcam
Prior art date
Application number
TR2000/00481T
Other languages
English (en)
Inventor
Chen Li
William Guthrie Robert
Huang Tai-Nang
G. Hull Kenneth
Sidduri Achytharao
Wright Tilley Jefferson
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR200000481T2 publication Critical patent/TR200000481T2/tr

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    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07C275/18—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
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Abstract

Formül (I)'in bilesimleri, açiklanmaktadir, bunlar VCAM-1 ve VLA-4'ü ifade eden hücreler arasinda baglama önleyicileri olarak aktiviteye sahiptirler. Bu tür bilesimler, semptom ve/veya hasarlari VCAM-1 ve VLA-4'ü ifade eden hücrelere baglanmasi ile ilgili oldugu hastaliklarin tedavisi için yararlidir.
TR2000/00481T 1997-08-22 1998-08-13 N-Alkonoilfenilalenin türevleri. TR200000481T2 (tr)

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EP1005446A1 (en) 2000-06-07
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AU742928B2 (en) 2002-01-17
ATE260243T1 (de) 2004-03-15
TW515792B (en) 2003-01-01
AU742928C (en) 2003-02-20
UY25150A1 (es) 2001-01-31
JP2001514163A (ja) 2001-09-11
BR9811988A (pt) 2000-09-05
DE69821950D1 (en) 2004-04-01
KR100615760B1 (ko) 2006-08-25
KR20010023126A (ko) 2001-03-26
ZA987602B (en) 1999-05-04
AU9341998A (en) 1999-03-16
CN1276785A (zh) 2000-12-13
CO4990936A1 (es) 2000-12-26
DE69821950T2 (de) 2004-12-16
DK1005446T3 (da) 2004-06-07
CA2300121A1 (en) 1999-03-04
ES2214728T3 (es) 2004-09-16
SA98190482B1 (ar) 2006-08-20
EP1005446B1 (en) 2004-02-25
AR015935A1 (es) 2001-05-30
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