DE69807672D1 - Von milchsäure abgeleitete butyrat-prodrugs - Google Patents
Von milchsäure abgeleitete butyrat-prodrugsInfo
- Publication number
- DE69807672D1 DE69807672D1 DE69807672T DE69807672T DE69807672D1 DE 69807672 D1 DE69807672 D1 DE 69807672D1 DE 69807672 T DE69807672 T DE 69807672T DE 69807672 T DE69807672 T DE 69807672T DE 69807672 D1 DE69807672 D1 DE 69807672D1
- Authority
- DE
- Germany
- Prior art keywords
- prodrugs
- relates
- lactic acid
- methods
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title abstract 4
- 239000000651 prodrug Substances 0.000 title abstract 4
- 229940002612 prodrug Drugs 0.000 title abstract 4
- 239000004310 lactic acid Substances 0.000 title abstract 2
- 235000014655 lactic acid Nutrition 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000003211 malignant effect Effects 0.000 abstract 2
- 208000011580 syndromic disease Diseases 0.000 abstract 2
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 abstract 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 abstract 1
- 108010044495 Fetal Hemoglobin Proteins 0.000 abstract 1
- 108091005886 Hemoglobin subunit gamma Proteins 0.000 abstract 1
- 102100038617 Hemoglobin subunit gamma-2 Human genes 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000005980 beta thalassemia Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000014951 hematologic disease Diseases 0.000 abstract 1
- 208000034737 hemoglobinopathy Diseases 0.000 abstract 1
- 208000018337 inherited hemoglobinopathy Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
- C07C69/68—Lactic acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Image Processing (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/814,945 US5880152A (en) | 1995-10-06 | 1997-03-10 | Butyrate prodrugs derived from lactic acid |
| PCT/US1998/004413 WO1998040064A1 (en) | 1997-03-10 | 1998-03-10 | Butyrate prodrugs derived from lactic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69807672D1 true DE69807672D1 (de) | 2002-10-10 |
| DE69807672T2 DE69807672T2 (de) | 2003-09-18 |
Family
ID=25216421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69807672T Expired - Lifetime DE69807672T2 (de) | 1997-03-10 | 1998-03-10 | Von milchsäure abgeleitete butyrat-prodrugs |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5880152A (de) |
| EP (1) | EP0969828B1 (de) |
| JP (1) | JP2001513087A (de) |
| AT (1) | ATE223214T1 (de) |
| AU (1) | AU6450098A (de) |
| CA (1) | CA2283198C (de) |
| DE (1) | DE69807672T2 (de) |
| DK (1) | DK0969828T3 (de) |
| ES (1) | ES2182283T3 (de) |
| PT (1) | PT969828E (de) |
| WO (1) | WO1998040064A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6225350B1 (en) | 1998-03-10 | 2001-05-01 | Vertex Pharmaceuticals, Inc. | Butyrate prodrugs derived from lactic acid |
| IL145509A0 (en) * | 1999-03-19 | 2002-06-30 | Vertex Pharma | Oral butyrate compositions |
| AU2001287157A1 (en) * | 2000-09-12 | 2002-03-26 | Virginia Commonwealth University | Promotion of adoptosis in cancer cells by co-administration of cyclin dependent kinase inhibitors and cellular differentiation agents |
| US6562995B1 (en) | 2000-12-21 | 2003-05-13 | Beacon Laboratories, Inc. | Delta dicarbonyl compounds and methods for using the same |
| WO2003016259A2 (de) * | 2001-08-16 | 2003-02-27 | Pharmacon-Forschung Und Beratung Gmbh | Milchsäureelemente enthaltende verbindungen, deren herstellung sowie deren verwendung als pharmazeutische wirkstoffe |
| US20070066512A1 (en) * | 2005-09-12 | 2007-03-22 | Dominique Verhelle | Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels |
| ITRM20080214A1 (it) * | 2008-04-21 | 2009-10-22 | Uni Degli Studi Di Napoli Federico Ii | Derivati dell'acido butirrico somministrabili per via orale, formulazioni che li contengono e loro uso clinico. |
| IT202000007423A1 (it) * | 2020-04-07 | 2021-10-07 | Caprika Srl | Composizione per supposte per il trattamento delle patologie prostatiche |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE824041C (de) * | 1945-10-22 | 1951-12-10 | Howards & Sons Ltd | Verfahren zur Herstellung von aliphatischen a -Acyloxymonocarbonsaeuren |
| US3526518A (en) * | 1967-07-12 | 1970-09-01 | Morton Kleiman | Control of apple storage scald using certain diphenylamine compositions |
| GB1197012A (en) * | 1968-05-20 | 1970-07-01 | Nat Starch Chem Corp | Acyl Derivatives of Alpha-Hydroxy Isobutyric Acid |
| US4479957A (en) * | 1973-04-02 | 1984-10-30 | Eli Lilly And Company | Use of vindesine in treating acute lymphatic leukemia and _other susceptible neoplasms |
| US5196136A (en) * | 1991-06-20 | 1993-03-23 | E. I. Du Pont De Nemours And Company | Cleaning composition of hydrocarbon component, surfactant and multibasic ester additive |
| US5454806A (en) * | 1992-11-06 | 1995-10-03 | Terumo Kabushiki Kaisha | Medical device |
| US5569675A (en) * | 1994-03-07 | 1996-10-29 | Bar Ilan University | Methods of using carboxylic acid esters to increase fetal-hemoglobin levels |
| BR9610850A (pt) * | 1995-10-06 | 1999-07-13 | Vertex Pharma | Pró-drogas de butirato de ácido láctico |
-
1997
- 1997-03-10 US US08/814,945 patent/US5880152A/en not_active Expired - Lifetime
-
1998
- 1998-03-10 AT AT98910204T patent/ATE223214T1/de not_active IP Right Cessation
- 1998-03-10 WO PCT/US1998/004413 patent/WO1998040064A1/en active IP Right Grant
- 1998-03-10 JP JP53705398A patent/JP2001513087A/ja active Pending
- 1998-03-10 EP EP98910204A patent/EP0969828B1/de not_active Expired - Lifetime
- 1998-03-10 CA CA002283198A patent/CA2283198C/en not_active Expired - Fee Related
- 1998-03-10 AU AU64500/98A patent/AU6450098A/en not_active Abandoned
- 1998-03-10 PT PT98910204T patent/PT969828E/pt unknown
- 1998-03-10 DK DK98910204T patent/DK0969828T3/da active
- 1998-03-10 DE DE69807672T patent/DE69807672T2/de not_active Expired - Lifetime
- 1998-03-10 ES ES98910204T patent/ES2182283T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2283198C (en) | 2007-07-17 |
| WO1998040064A1 (en) | 1998-09-17 |
| DE69807672T2 (de) | 2003-09-18 |
| ATE223214T1 (de) | 2002-09-15 |
| AU6450098A (en) | 1998-09-29 |
| EP0969828A1 (de) | 2000-01-12 |
| PT969828E (pt) | 2003-01-31 |
| ES2182283T3 (es) | 2003-03-01 |
| US5880152A (en) | 1999-03-09 |
| JP2001513087A (ja) | 2001-08-28 |
| CA2283198A1 (en) | 1998-09-17 |
| EP0969828B1 (de) | 2002-09-04 |
| DK0969828T3 (da) | 2002-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de | ||
| 8370 | Indication related to discontinuation of the patent is to be deleted | ||
| 8364 | No opposition during term of opposition |