DK1507775T3 - Heterocykliske forbindelser som hæmmer leukocyt-adhæsion medieret af alfa-4-integriner - Google Patents
Heterocykliske forbindelser som hæmmer leukocyt-adhæsion medieret af alfa-4-integrinerInfo
- Publication number
- DK1507775T3 DK1507775T3 DK03731419T DK03731419T DK1507775T3 DK 1507775 T3 DK1507775 T3 DK 1507775T3 DK 03731419 T DK03731419 T DK 03731419T DK 03731419 T DK03731419 T DK 03731419T DK 1507775 T3 DK1507775 T3 DK 1507775T3
- Authority
- DK
- Denmark
- Prior art keywords
- integrins
- alpha
- compounds
- sub
- leukocyte adhesion
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38302002P | 2002-05-24 | 2002-05-24 | |
PCT/US2003/016804 WO2003099809A1 (en) | 2002-05-24 | 2003-05-27 | HETEROCYCLIC COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY α4 INTEGRINS |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1507775T3 true DK1507775T3 (da) | 2009-05-11 |
Family
ID=29584493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03731419T DK1507775T3 (da) | 2002-05-24 | 2003-05-27 | Heterocykliske forbindelser som hæmmer leukocyt-adhæsion medieret af alfa-4-integriner |
Country Status (23)
Country | Link |
---|---|
US (3) | US7026328B2 (da) |
EP (1) | EP1507775B1 (da) |
JP (1) | JP4469715B2 (da) |
KR (1) | KR100978832B1 (da) |
CN (1) | CN1314682C (da) |
AT (1) | ATE419243T1 (da) |
AU (1) | AU2003240823C1 (da) |
BR (1) | BR0308881A (da) |
CA (1) | CA2481926C (da) |
DE (1) | DE60325583D1 (da) |
DK (1) | DK1507775T3 (da) |
EA (1) | EA008256B1 (da) |
EC (1) | ECSP045425A (da) |
ES (1) | ES2320436T3 (da) |
HK (1) | HK1072608A1 (da) |
IL (2) | IL164225A0 (da) |
MX (1) | MXPA04010995A (da) |
NO (1) | NO329933B1 (da) |
NZ (1) | NZ535504A (da) |
TW (1) | TWI281470B (da) |
UA (1) | UA76339C2 (da) |
WO (1) | WO2003099809A1 (da) |
ZA (1) | ZA200407590B (da) |
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US20050074451A1 (en) * | 2003-06-25 | 2005-04-07 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating rheumatoid arthritis |
WO2005111020A2 (en) * | 2004-04-30 | 2005-11-24 | Elan Pharmaceuticals, Inc. | Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by vla-4 |
KR101273614B1 (ko) * | 2004-07-08 | 2013-06-12 | 엘란 파마슈티칼스, 인크. | 중합체 부분을 포함하는 다가 vla―4 길항제 |
WO2006127584A1 (en) * | 2005-05-20 | 2006-11-30 | Elan Pharmaceuticals, Inc. | Imidazolone phenylalanine derivatives as vla-4 antagonists |
AU2006297220B8 (en) | 2005-09-29 | 2013-01-31 | Elan Pharmaceuticals, Inc. | Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by VLA-4 |
BRPI0616643A2 (pt) | 2005-09-29 | 2011-06-28 | Elan Pharm Inc | compostos de carbamato que inibem a adesão leucocitária mediada por vla-4 |
EP1996559A1 (en) * | 2006-02-27 | 2008-12-03 | Elan Pharmaceuticals Inc. | Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4 |
EP2007392A4 (en) * | 2006-02-28 | 2010-04-07 | Elan Pharm Inc | METHOD FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES WITH ALPHA-4-INHIBITABLE COMPOUNDS |
DK2676967T3 (da) | 2006-02-28 | 2019-09-16 | Biogen Ma Inc | Fremgangsmåder til behandling af inflammatoriske og autoimmune sygdomme med natalizumab |
MX2008011176A (es) | 2006-03-03 | 2008-09-10 | Elan Pharm Inc | Metodos para tratar padecimientos inflamatorios y autoinmunes con natalizumab. |
EP2231185A4 (en) * | 2007-12-07 | 2012-06-27 | Elan Pharm Inc | METHOD AND COMPOSITIONS FOR TREATING LIQUID TUMORS |
EP2085407A1 (en) | 2008-02-04 | 2009-08-05 | Sahltech I Göteborg AB | Treatment of idiopathic thrombocytopenic purpura |
AU2009242092A1 (en) * | 2008-04-29 | 2009-11-05 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Modulators of dopamine neurotransmission |
MX2011011326A (es) * | 2009-04-27 | 2012-02-13 | Elan Pharm Inc | Antagonistas de piridinona de las integrinas alfa-4. |
DK3339865T5 (da) | 2010-01-11 | 2023-03-20 | Biogen Ma Inc | Assay for jc-virus-antistoffer |
US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
JP6080521B2 (ja) * | 2012-11-30 | 2017-02-15 | インターナショナル・ビジネス・マシーンズ・コーポレーションInternational Business Machines Corporation | 広域分散医療情報ネットワークのデータ管理機構 |
EP3004334A4 (en) | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHODS OF EVALUATION RISK OF DEVELOPMENT OF PML |
EP3738953A1 (en) * | 2015-12-30 | 2020-11-18 | Saint Louis University | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists with improved pharmacokinetic properties and methods for their manufacture |
AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
JP7214882B2 (ja) | 2018-10-30 | 2023-01-30 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4ベータ7インテグリン阻害剤としてのイミダゾピリジン誘導体 |
AU2019373245C1 (en) | 2018-10-30 | 2022-10-27 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4β7 integrin |
CN112969687A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
CN109541237A (zh) * | 2018-12-28 | 2019-03-29 | 吴江近岸蛋白质科技有限公司 | 纤维连接蛋白的生物学活性测定方法 |
KR20220047323A (ko) | 2019-08-14 | 2022-04-15 | 길리애드 사이언시즈, 인코포레이티드 | 알파 4 베타 7 인테그린의 저해용 화합물 |
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CN1294576A (zh) | 1998-01-23 | 2001-05-09 | 诺瓦提斯公司 | Vla-4拮抗剂 |
US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
KR20010087125A (ko) | 1998-04-16 | 2001-09-15 | 데이비드 비. 맥윌리암스 | 인테그린 수용체에 대한 인테그린의 결합을 억제하는 화합물 |
GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
US6479492B1 (en) | 1999-01-22 | 2002-11-12 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
WO2000043372A1 (en) | 1999-01-22 | 2000-07-27 | Elan Pharmaceuticals, Inc. | Acyl derivatives which treat vla-4 related disorders |
PE20020384A1 (es) * | 2000-07-21 | 2002-05-28 | Schering Corp | PEPTIDOS COMO INHIBIDORES DE LA PROTEASA SERINA NS3/NS4a DEL VIRUS DE LA HEPATITIS C |
TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
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- 2003-05-27 WO PCT/US2003/016804 patent/WO2003099809A1/en active IP Right Grant
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- 2003-05-27 DE DE60325583T patent/DE60325583D1/de not_active Expired - Lifetime
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- 2003-05-27 US US10/447,308 patent/US7026328B2/en not_active Expired - Fee Related
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